From a12862909e47a366cca711f621eed197fe6df3c8 Mon Sep 17 00:00:00 2001 From: IAlibay Date: Thu, 1 Jun 2023 18:24:39 +0100 Subject: [PATCH 01/12] Add eg5 cofactors files --- cofactors/eg5_cofactor.sdf | 87 + cofactors/eg5_ligands.sdf | 6968 +++++++++++++++++++++++++++ cofactors/eg5_ligands_positive.sdf | 4864 +++++++++++++++++++ cofactors/eg5_protein.pdb | 5917 +++++++++++++++++++++++ cofactors/eg5_python_tutorial.ipynb | 629 +++ 5 files changed, 18465 insertions(+) create mode 100644 cofactors/eg5_cofactor.sdf create mode 100644 cofactors/eg5_ligands.sdf create mode 100644 cofactors/eg5_ligands_positive.sdf create mode 100644 cofactors/eg5_protein.pdb create mode 100644 cofactors/eg5_python_tutorial.ipynb diff --git a/cofactors/eg5_cofactor.sdf b/cofactors/eg5_cofactor.sdf new file mode 100644 index 0000000..c0529b6 --- /dev/null +++ b/cofactors/eg5_cofactor.sdf @@ -0,0 +1,87 @@ +3L9H + 3D + Schrodinger Suite 2021-1. + 39 41 0 0 1 0 999 V2000 + 17.7103 1.3810 16.7258 P 0 0 0 0 0 0 + 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33.9852 8.5108 14.2434 H 0 0 0 0 0 0 + 31.8431 8.6608 14.4362 C 0 0 0 0 0 0 + 31.7395 9.3024 13.5739 H 0 0 0 0 0 0 + 30.7042 8.2819 15.1795 C 0 0 0 0 0 0 + 29.3329 8.8036 14.7827 C 0 0 2 0 0 0 + 28.6015 8.3693 15.4668 H 0 0 0 0 0 0 + 28.9740 8.3392 13.4481 N 0 0 0 0 0 0 + 29.1600 7.3678 13.2234 H 0 0 0 0 0 0 + 27.9519 8.9926 12.7444 C 0 0 0 0 0 0 + 27.4978 8.4503 11.5275 C 0 0 0 0 0 0 + 27.9850 7.2801 11.1189 F 0 0 0 0 0 0 + 26.5126 9.0763 10.7531 C 0 0 0 0 0 0 + 26.1593 8.6230 9.8392 H 0 0 0 0 0 0 + 25.9663 10.2751 11.2173 C 0 0 0 0 0 0 + 24.5301 11.1112 10.3189 Br 0 0 0 0 0 0 + 26.3846 10.8297 12.4393 C 0 0 0 0 0 0 + 25.9347 11.7477 12.7869 H 0 0 0 0 0 0 + 27.3768 10.1948 13.2084 C 0 0 0 0 0 0 + 27.8322 10.8314 14.5056 C 0 0 1 0 0 0 + 27.8542 11.9112 14.3444 H 0 0 0 0 0 0 + 26.9119 10.5394 15.5582 O 0 0 0 0 0 0 + 27.1871 11.2368 16.7664 C 0 0 1 0 0 0 + 27.2533 12.2986 16.5203 H 0 0 0 0 0 0 + 25.9646 11.0756 17.7107 C 0 0 0 0 0 0 + 25.7435 12.0295 18.1935 H 0 0 0 0 0 0 + 25.0828 10.8430 17.1121 H 0 0 0 0 0 0 + 26.1084 10.0349 18.7547 N 0 3 0 0 0 0 + 25.1934 9.6416 18.9279 H 0 0 0 0 0 0 + 26.6327 10.5135 20.0519 C 0 0 0 0 0 0 + 27.5335 11.1056 19.9073 H 0 0 0 0 0 0 + 25.8953 11.1729 20.5131 H 0 0 0 0 0 0 + 26.9337 9.3346 20.9797 C 0 0 0 0 0 0 + 26.0086 8.8027 21.2109 H 0 0 0 0 0 0 + 27.5913 8.6278 20.4745 H 0 0 0 0 0 0 + 27.5915 9.7745 22.2033 N 0 0 0 0 0 0 + 28.1183 10.6349 22.1777 H 0 0 0 0 0 0 + 27.5845 9.0812 23.3501 C 0 0 0 0 0 0 + 26.9602 8.0341 23.4991 O 0 0 0 0 0 0 + 28.4080 9.6461 24.5016 C 0 0 0 0 0 0 + 28.7872 10.6444 24.2772 H 0 0 0 0 0 0 + 29.2581 8.9934 24.7029 H 0 0 0 0 0 0 + 27.8018 9.7048 25.4067 H 0 0 0 0 0 0 + 28.5584 10.7639 17.3032 C 0 0 0 0 0 0 + 28.8426 11.3272 18.1901 H 0 0 0 0 0 0 + 28.5175 9.7113 17.5858 H 0 0 0 0 0 0 + 29.6536 10.9530 16.2469 C 0 0 0 0 0 0 + 29.8320 12.0218 16.1159 H 0 0 0 0 0 0 + 30.5966 10.5408 16.6027 H 0 0 0 0 0 0 + 29.2441 10.3500 14.8882 C 0 0 1 0 0 0 + 29.9353 10.7553 14.1469 H 0 0 0 0 0 0 + 30.8534 7.4269 16.2913 C 0 0 0 0 0 0 + 29.9891 7.1119 16.8557 H 0 0 0 0 0 0 + 32.1359 6.9881 16.6735 C 0 0 0 0 0 0 + 32.2478 6.3369 17.5280 H 0 0 0 0 0 0 + 26.6930 9.2959 18.3885 H 0 0 0 0 0 0 + 1 2 1 0 0 0 + 2 56 1 0 0 0 + 2 3 2 0 0 0 + 3 4 1 0 0 0 + 3 5 1 0 0 0 + 5 6 1 0 0 0 + 5 7 2 0 0 0 + 7 8 1 0 0 0 + 7 54 1 0 0 0 + 8 52 1 0 0 0 + 8 9 1 0 0 0 + 8 10 1 0 0 0 + 10 11 1 0 0 0 + 10 12 1 0 0 0 + 12 21 1 0 0 0 + 12 13 2 0 0 0 + 13 14 1 0 0 0 + 13 15 1 0 0 0 + 15 16 1 0 0 0 + 15 17 2 0 0 0 + 17 18 1 0 0 0 + 17 19 1 0 0 0 + 19 20 1 0 0 0 + 19 21 2 0 0 0 + 21 22 1 0 0 0 + 22 52 1 0 0 0 + 22 23 1 0 0 0 + 22 24 1 0 0 0 + 24 25 1 0 0 0 + 25 26 1 0 0 0 + 25 27 1 0 0 0 + 25 46 1 0 0 0 + 27 28 1 0 0 0 + 27 29 1 0 0 0 + 27 30 1 0 0 0 + 30 31 1 0 0 0 + 30 32 1 0 0 0 + 30 58 1 0 0 0 + 32 33 1 0 0 0 + 32 34 1 0 0 0 + 32 35 1 0 0 0 + 35 36 1 0 0 0 + 35 37 1 0 0 0 + 35 38 1 0 0 0 + 38 39 1 0 0 0 + 38 40 1 0 0 0 + 40 41 2 0 0 0 + 40 42 1 0 0 0 + 42 43 1 0 0 0 + 42 44 1 0 0 0 + 42 45 1 0 0 0 + 46 47 1 0 0 0 + 46 48 1 0 0 0 + 46 49 1 0 0 0 + 49 50 1 0 0 0 + 49 51 1 0 0 0 + 49 52 1 0 0 0 + 52 53 1 0 0 0 + 54 55 1 0 0 0 + 54 56 2 0 0 0 + 56 57 1 0 0 0 +M CHG 1 30 1 +M END +> +ligprep_eg5.smi + +> +7 + +> +53161 + +> +0 + +> +RmMxW2NIXWMoQnIpW2NIXWMoYzEyKVtDQEBIXTNbQ0BIXShbQ0BASF0oW05IXTIpYzRbY0hdW2NIXVtjSF1bY0hdW2NIXTQpW0NIMl1bQ0gyXVtDQEBIXShPMylbQ0gyXVtOSF1bQ0gyXVtDSDJdW05IXUMoPU8pW0NIM10= + +> +J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= + +> +1 + +> + 0.0077 + +> + 0.0077 + +> + 0.0000 + +> + -0.0000 + +> +0.00765215 + +> +1 + +> +1 + +> +S-OPLS + +> +33.3357 + +> +1 + +> +lig_CHEMBL1082249-1 + +> +glide-grid_EG5-3L9H + +> +7 + +> +7 + +> +-7.11232702404811 + +> +-0.23707756746827 + +> +-0.736655123234709 + +> +-1.61599819487352 + +> +-7.11232702404811 + +> +-4.55664998253593 + +> +-0.0816780435388489 + +> +-0 + +> +-0.348176918870169 + +> +-46.5956993103027 + +> +-2.19561052322388 + +> +0.533304464895562 + +> +0 + +> +-67.8709711424982 + +> +-48.7913098335266 + +> +0.845360338687897 + +> +30 + +> +28 + +> +-0 + +> +0.0850935331009369 + +> +snapped_core_restrain + +$$$$ diff --git a/cofactors/eg5_protein.pdb b/cofactors/eg5_protein.pdb new file mode 100644 index 0000000..01ca8bb --- /dev/null +++ b/cofactors/eg5_protein.pdb @@ -0,0 +1,5917 @@ +HEADER MOTOR PROTEIN 05-JAN-10 3L9H +TITLE X-RAY STRUCTURE OF MITOTIC KINESIN-5 (KSP, KIF11, EG5)IN +TITLE 2 COMPLEX WITH THE HEXAHYDRO-2H-PYRANO[3,2-C]QUINOLINE EMD +TITLE 3 534085 +EXPDTA X-RAY DIFFRACTION +REMARK 2 RESOLUTION. 2.00 ANGSTROMS +REMARK 3 R VALUE : 0.234000 +REMARK 3 FREE R VALUE : 0.258000 +REMARK 4 3L9H COMPLIES WITH FORMAT V. 3.20, 01-DEC-08 +REMARK 200 TEMPERATURE (KELVIN) : 100.00 +REMARK 200 PH : 7.00 +REMARK 350 BIOMOLECULE: 1 +REMARK 350 APPLY THE FOLLOWING TO CHAINS: A +REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.000000 +REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.000000 +REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.000000 +REMARK 350 BIOMOLECULE: 2 +REMARK 350 APPLY THE FOLLOWING TO CHAINS: B +REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.000000 +REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.000000 +REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.000000 +REMARK 888 +REMARK 888 WRITTEN BY MAESTRO (A PRODUCT OF SCHRODINGER, LLC) +SEQRES 1 A 349 ACE GLY LYS ASN ILE GLN VAL VAL VAL ARG CYS ARG PRO +SEQRES 2 A 349 PHE ASN LEU ALA GLU ARG LYS ALA SER ALA HIS SER ILE +SEQRES 3 A 349 VAL GLU CYS ASP PRO VAL ARG LYS GLU VAL SER VAL ARG +SEQRES 4 A 349 THR GLY GLY LEU ALA ASP LYS SER SER ARG LYS THR TYR +SEQRES 5 A 349 THR PHE ASP MET VAL PHE GLY ALA SER THR LYS GLN ILE +SEQRES 6 A 349 ASP VAL TYR ARG SER VAL VAL CYS PRO ILE LEU ASP GLU +SEQRES 7 A 349 VAL ILE MET GLY TYR ASN CYS THR ILE PHE ALA TYR GLY +SEQRES 8 A 349 GLN THR GLY THR GLY LYS THR PHE THR MET GLU GLY GLU +SEQRES 9 A 349 ARG SER PRO ASN GLU GLU TYR THR TRP GLU GLU ASP PRO +SEQRES 10 A 349 LEU ALA GLY ILE ILE PRO ARG THR LEU HIS GLN ILE PHE +SEQRES 11 A 349 GLU LYS LEU THR ASP ASN GLY THR GLU PHE SER VAL LYS +SEQRES 12 A 349 VAL SER LEU LEU GLU ILE TYR ASN GLU GLU LEU PHE ASP +SEQRES 13 A 349 LEU LEU ASN PRO SER SER ASP VAL SER GLU ARG LEU GLN +SEQRES 14 A 349 MET PHE ASP ASP PRO ARG ASN LYS ARG GLY VAL ILE ILE +SEQRES 15 A 349 LYS GLY LEU GLU GLU ILE THR VAL HIS ASN LYS ASP GLU +SEQRES 16 A 349 VAL TYR GLN ILE LEU GLU LYS GLY ALA ALA LYS ARG THR +SEQRES 17 A 349 THR ALA ALA THR LEU MET ASN ALA TYR SER SER ARG SER +SEQRES 18 A 349 HIS SER VAL PHE SER VAL THR ILE HIS MET LYS GLU THR +SEQRES 19 A 349 THR ILE ASP GLY GLU GLU LEU VAL LYS ILE GLY LYS LEU +SEQRES 20 A 349 ASN LEU VAL ASP LEU ALA GLY SER GLU ASN ILE GLY ARG +SEQRES 21 A 349 SER GLY ALA VAL ASP LYS ARG ALA ARG GLU ALA GLY ASN +SEQRES 22 A 349 ILE ASN GLN SER LEU LEU THR LEU GLY ARG VAL ILE THR +SEQRES 23 A 349 ALA LEU VAL GLU ARG THR PRO HIS VAL PRO TYR ARG GLU +SEQRES 24 A 349 SER LYS LEU THR ARG ILE LEU GLN ASP SER LEU GLY GLY +SEQRES 25 A 349 ARG THR ARG THR SER ILE ILE ALA THR ILE SER PRO ALA +SEQRES 26 A 349 SER LEU ASN LEU GLU GLU THR LEU SER THR LEU GLU TYR +SEQRES 27 A 349 ALA HIS ARG ALA LYS ASN ILE LEU ASN LYS NME +FORMUL 2 HOH *7(H2 0) +HELIX 1 1 LEU A 30 LEU A 30 1 +HELIX 2 2 ALA A 31 ALA A 31 1 +HELIX 3 3 GLU A 32 GLU A 32 1 +HELIX 4 4 ARG A 33 ARG A 33 1 +HELIX 5 5 GLN A 78 GLN A 78 1 +HELIX 6 6 ILE A 79 ILE A 79 1 +HELIX 7 7 ASP A 80 ASP A 80 1 +HELIX 8 8 VAL A 81 VAL A 81 1 +HELIX 9 9 TYR A 82 TYR A 82 1 +HELIX 10 10 ARG A 83 ARG A 83 1 +HELIX 11 11 SER A 84 SER A 84 1 +HELIX 12 12 CYS A 87 CYS A 87 1 +HELIX 13 13 PRO A 88 PRO A 88 1 +HELIX 14 14 ILE A 89 ILE A 89 1 +HELIX 15 15 LEU A 90 LEU A 90 1 +HELIX 16 16 ASP A 91 ASP A 91 1 +HELIX 17 17 GLU A 92 GLU A 92 1 +HELIX 18 18 VAL A 93 VAL A 93 1 +HELIX 19 19 ILE A 94 ILE A 94 1 +HELIX 20 20 LYS A 111 LYS A 111 1 +HELIX 21 21 THR A 112 THR A 112 1 +HELIX 22 22 PHE A 113 PHE A 113 1 +HELIX 23 23 THR A 114 THR A 114 1 +HELIX 24 24 MET A 115 MET A 115 1 +HELIX 25 25 ILE A 136 ILE A 136 1 +HELIX 26 26 PRO A 137 PRO A 137 1 +HELIX 27 27 ARG A 138 ARG A 138 1 +HELIX 28 28 THR A 139 THR A 139 1 +HELIX 29 29 LEU A 140 LEU A 140 1 +HELIX 30 30 HIS A 141 HIS A 141 1 +HELIX 31 31 GLN A 142 GLN A 142 1 +HELIX 32 32 ILE A 143 ILE A 143 1 +HELIX 33 33 PHE A 144 PHE A 144 1 +HELIX 34 34 GLU A 145 GLU A 145 1 +HELIX 35 35 LYS A 146 LYS A 146 1 +HELIX 36 36 VAL A 210 VAL A 210 1 +HELIX 37 37 TYR A 211 TYR A 211 1 +HELIX 38 38 GLN A 212 GLN A 212 1 +HELIX 39 39 ILE A 213 ILE A 213 1 +HELIX 40 40 LEU A 214 LEU A 214 1 +HELIX 41 41 GLU A 215 GLU A 215 1 +HELIX 42 42 LYS A 216 LYS A 216 1 +HELIX 43 43 GLY A 217 GLY A 217 1 +HELIX 44 44 ALA A 218 ALA A 218 1 +HELIX 45 45 ALA A 219 ALA A 219 1 +HELIX 46 46 LYS A 220 LYS A 220 1 +HELIX 47 47 ARG A 221 ARG A 221 1 +HELIX 48 48 THR A 222 THR A 222 1 +HELIX 49 49 THR A 223 THR A 223 1 +HELIX 50 50 ALA A 224 ALA A 224 1 +HELIX 51 51 ALA A 225 ALA A 225 1 +HELIX 52 52 THR A 226 THR A 226 1 +HELIX 53 53 LEU A 227 LEU A 227 1 +HELIX 54 54 TYR A 231 TYR A 231 1 +HELIX 55 55 SER A 232 SER A 232 1 +HELIX 56 56 SER A 233 SER A 233 1 +HELIX 57 57 ARG A 234 ARG A 234 1 +HELIX 58 58 GLN A 290 GLN A 290 1 +HELIX 59 59 SER A 291 SER A 291 1 +HELIX 60 60 LEU A 292 LEU A 292 1 +HELIX 61 61 LEU A 293 LEU A 293 1 +HELIX 62 62 THR A 294 THR A 294 1 +HELIX 63 63 LEU A 295 LEU A 295 1 +HELIX 64 64 GLY A 296 GLY A 296 1 +HELIX 65 65 ARG A 297 ARG A 297 1 +HELIX 66 66 VAL A 298 VAL A 298 1 +HELIX 67 67 ILE A 299 ILE A 299 1 +HELIX 68 68 THR A 300 THR A 300 1 +HELIX 69 69 ALA A 301 ALA A 301 1 +HELIX 70 70 LEU A 302 LEU A 302 1 +HELIX 71 71 VAL A 303 VAL A 303 1 +HELIX 72 72 LYS A 315 LYS A 315 1 +HELIX 73 73 LEU A 316 LEU A 316 1 +HELIX 74 74 THR A 317 THR A 317 1 +HELIX 75 75 ARG A 318 ARG A 318 1 +HELIX 76 76 ILE A 319 ILE A 319 1 +HELIX 77 77 LEU A 343 LEU A 343 1 +HELIX 78 78 GLU A 344 GLU A 344 1 +HELIX 79 79 GLU A 345 GLU A 345 1 +HELIX 80 80 THR A 346 THR A 346 1 +HELIX 81 81 LEU A 347 LEU A 347 1 +HELIX 82 82 SER A 348 SER A 348 1 +HELIX 83 83 THR A 349 THR A 349 1 +HELIX 84 84 LEU A 350 LEU A 350 1 +HELIX 85 85 GLU A 351 GLU A 351 1 +HELIX 86 86 TYR A 352 TYR A 352 1 +HELIX 87 87 ALA A 353 ALA A 353 1 +HELIX 88 88 HIS A 354 HIS A 354 1 +HELIX 89 89 ARG A 355 ARG A 355 1 +HELIX 90 90 ALA A 356 ALA A 356 1 +TURN 1 1 GLY A 16 GLY A 16 +TURN 2 2 LYS A 17 LYS A 17 +TURN 3 3 ASN A 18 ASN A 18 +TURN 4 4 ILE A 19 ILE A 19 +TURN 5 5 GLN A 20 GLN A 20 +TURN 6 6 VAL A 21 VAL A 21 +TURN 7 7 CYS A 25 CYS A 25 +TURN 8 8 ARG A 26 ARG A 26 +TURN 9 9 PRO A 27 PRO A 27 +TURN 10 10 PHE A 28 PHE A 28 +TURN 11 11 ASN A 29 ASN A 29 +TURN 12 12 LYS A 34 LYS A 34 +TURN 13 13 ALA A 35 ALA A 35 +TURN 14 14 SER A 36 SER A 36 +TURN 15 15 ALA A 37 ALA A 37 +TURN 16 16 HIS A 38 HIS A 38 +TURN 17 17 SER A 39 SER A 39 +TURN 18 18 ILE A 40 ILE A 40 +TURN 19 19 PRO A 45 PRO A 45 +TURN 20 20 VAL A 46 VAL A 46 +TURN 21 21 ARG A 47 ARG A 47 +TURN 22 22 LYS A 48 LYS A 48 +TURN 23 23 LEU A 57 LEU A 57 +TURN 24 24 ALA A 58 ALA A 58 +TURN 25 25 ASP A 59 ASP A 59 +TURN 26 26 LYS A 60 LYS A 60 +TURN 27 27 PHE A 68 PHE A 68 +TURN 28 28 ASP A 69 ASP A 69 +TURN 29 29 GLY A 73 GLY A 73 +TURN 30 30 ALA A 74 ALA A 74 +TURN 31 31 SER A 75 SER A 75 +TURN 32 32 THR A 76 THR A 76 +TURN 33 33 LYS A 77 LYS A 77 +TURN 34 34 VAL A 85 VAL A 85 +TURN 35 35 VAL A 86 VAL A 86 +TURN 36 36 MET A 95 MET A 95 +TURN 37 37 GLY A 96 GLY A 96 +TURN 38 38 TYR A 97 TYR A 97 +TURN 39 39 TYR A 104 TYR A 104 +TURN 40 40 GLY A 105 GLY A 105 +TURN 41 41 GLN A 106 GLN A 106 +TURN 42 42 THR A 107 THR A 107 +TURN 43 43 GLY A 108 GLY A 108 +TURN 44 44 THR A 109 THR A 109 +TURN 45 45 GLY A 110 GLY A 110 +TURN 46 46 GLU A 116 GLU A 116 +TURN 47 47 GLY A 117 GLY A 117 +TURN 48 48 GLU A 118 GLU A 118 +TURN 49 49 ARG A 119 ARG A 119 +TURN 50 50 SER A 120 SER A 120 +TURN 51 51 PRO A 121 PRO A 121 +TURN 52 52 ASN A 122 ASN A 122 +TURN 53 53 GLU A 123 GLU A 123 +TURN 54 54 GLU A 124 GLU A 124 +TURN 55 55 TYR A 125 TYR A 125 +TURN 56 56 THR A 126 THR A 126 +TURN 57 57 TRP A 127 TRP A 127 +TURN 58 58 GLU A 128 GLU A 128 +TURN 59 59 GLU A 129 GLU A 129 +TURN 60 60 ASP A 130 ASP A 130 +TURN 61 61 PRO A 131 PRO A 131 +TURN 62 62 LEU A 132 LEU A 132 +TURN 63 63 ALA A 133 ALA A 133 +TURN 64 64 GLY A 134 GLY A 134 +TURN 65 65 ILE A 135 ILE A 135 +TURN 66 66 LEU A 147 LEU A 147 +TURN 67 67 THR A 148 THR A 148 +TURN 68 68 ASP A 149 ASP A 149 +TURN 69 69 ASN A 150 ASN A 150 +TURN 70 70 GLY A 151 GLY A 151 +TURN 71 71 THR A 152 THR A 152 +TURN 72 72 ASN A 165 ASN A 165 +TURN 73 73 GLU A 166 GLU A 166 +TURN 74 74 LEU A 171 LEU A 171 +TURN 75 75 LEU A 172 LEU A 172 +TURN 76 76 ASN A 173 ASN A 173 +TURN 77 77 PRO A 174 PRO A 174 +TURN 78 78 SER A 175 SER A 175 +TURN 79 79 SER A 176 SER A 176 +TURN 80 80 ASP A 177 ASP A 177 +TURN 81 81 VAL A 178 VAL A 178 +TURN 82 82 SER A 179 SER A 179 +TURN 83 83 GLU A 180 GLU A 180 +TURN 84 84 ASP A 187 ASP A 187 +TURN 85 85 PRO A 188 PRO A 188 +TURN 86 86 ARG A 189 ARG A 189 +TURN 87 87 ASN A 190 ASN A 190 +TURN 88 88 LYS A 191 LYS A 191 +TURN 89 89 ARG A 192 ARG A 192 +TURN 90 90 GLY A 193 GLY A 193 +TURN 91 91 GLY A 198 GLY A 198 +TURN 92 92 LEU A 199 LEU A 199 +TURN 93 93 GLU A 200 GLU A 200 +TURN 94 94 GLU A 201 GLU A 201 +TURN 95 95 VAL A 204 VAL A 204 +TURN 96 96 HIS A 205 HIS A 205 +TURN 97 97 ASN A 206 ASN A 206 +TURN 98 98 LYS A 207 LYS A 207 +TURN 99 99 ASP A 208 ASP A 208 +TURN 100 100 GLU A 209 GLU A 209 +TURN 101 101 MET A 228 MET A 228 +TURN 102 102 ASN A 229 ASN A 229 +TURN 103 103 ALA A 230 ALA A 230 +TURN 104 104 SER A 235 SER A 235 +TURN 105 105 THR A 249 THR A 249 +TURN 106 106 ILE A 250 ILE A 250 +TURN 107 107 ASP A 251 ASP A 251 +TURN 108 108 GLY A 252 GLY A 252 +TURN 109 109 GLU A 253 GLU A 253 +TURN 110 110 LEU A 266 LEU A 266 +TURN 111 111 ALA A 267 ALA A 267 +TURN 112 112 GLY A 268 GLY A 268 +TURN 113 113 SER A 269 SER A 269 +TURN 114 114 GLU A 270 GLU A 270 +TURN 115 115 ASN A 271 ASN A 271 +TURN 116 116 ILE A 272 ILE A 272 +TURN 117 117 GLY A 273 GLY A 273 +TURN 118 118 ARG A 274 ARG A 274 +TURN 119 119 SER A 275 SER A 275 +TURN 120 120 GLY A 276 GLY A 276 +TURN 121 121 ALA A 277 ALA A 277 +TURN 122 122 VAL A 278 VAL A 278 +TURN 123 123 ASP A 279 ASP A 279 +TURN 124 124 LYS A 280 LYS A 280 +TURN 125 125 ARG A 281 ARG A 281 +TURN 126 126 ALA A 282 ALA A 282 +TURN 127 127 ARG A 283 ARG A 283 +TURN 128 128 GLU A 284 GLU A 284 +TURN 129 129 ALA A 285 ALA A 285 +TURN 130 130 GLY A 286 GLY A 286 +TURN 131 131 ASN A 287 ASN A 287 +TURN 132 132 ILE A 288 ILE A 288 +TURN 133 133 ASN A 289 ASN A 289 +TURN 134 134 GLU A 304 GLU A 304 +TURN 135 135 ARG A 305 ARG A 305 +TURN 136 136 THR A 306 THR A 306 +TURN 137 137 PRO A 307 PRO A 307 +TURN 138 138 HIS A 308 HIS A 308 +TURN 139 139 VAL A 309 VAL A 309 +TURN 140 140 PRO A 310 PRO A 310 +TURN 141 141 TYR A 311 TYR A 311 +TURN 142 142 ARG A 312 ARG A 312 +TURN 143 143 GLU A 313 GLU A 313 +TURN 144 144 SER A 314 SER A 314 +TURN 145 145 LEU A 320 LEU A 320 +TURN 146 146 GLN A 321 GLN A 321 +TURN 147 147 ASP A 322 ASP A 322 +TURN 148 148 SER A 323 SER A 323 +TURN 149 149 LEU A 324 LEU A 324 +TURN 150 150 GLY A 325 GLY A 325 +TURN 151 151 GLY A 326 GLY A 326 +TURN 152 152 ARG A 327 ARG A 327 +TURN 153 153 THR A 328 THR A 328 +TURN 154 154 ARG A 329 ARG A 329 +TURN 155 155 THR A 330 THR A 330 +TURN 156 156 SER A 331 SER A 331 +TURN 157 157 ILE A 332 ILE A 332 +TURN 158 158 ILE A 333 ILE A 333 +TURN 159 159 ALA A 334 ALA A 334 +TURN 160 160 THR A 335 THR A 335 +TURN 161 161 ILE A 336 ILE A 336 +TURN 162 162 SER A 337 SER A 337 +TURN 163 163 PRO A 338 PRO A 338 +TURN 164 164 ALA A 339 ALA A 339 +TURN 165 165 SER A 340 SER A 340 +TURN 166 166 LEU A 341 LEU A 341 +TURN 167 167 ASN A 342 ASN A 342 +TURN 168 168 LYS A 357 LYS A 357 +TURN 169 169 ASN A 358 ASN A 358 +TURN 170 170 ILE A 359 ILE A 359 +TURN 171 171 LEU A 360 LEU A 360 +TURN 172 172 ASN A 361 ASN A 361 +TURN 173 173 LYS A 362 LYS A 362 +SHEET 1 1 1 VAL A 22 VAL A 22 0 +SHEET 1 2 1 VAL A 23 VAL A 23 0 +SHEET 1 3 1 ARG A 24 ARG A 24 0 +SHEET 1 4 1 VAL A 41 VAL A 41 0 +SHEET 1 5 1 GLU A 42 GLU A 42 0 +SHEET 1 6 1 CYS A 43 CYS A 43 0 +SHEET 1 7 1 ASP A 44 ASP A 44 0 +SHEET 1 8 1 GLU A 49 GLU A 49 0 +SHEET 1 9 1 VAL A 50 VAL A 50 0 +SHEET 1 10 1 SER A 51 SER A 51 0 +SHEET 1 11 1 VAL A 52 VAL A 52 0 +SHEET 1 12 1 ARG A 53 ARG A 53 0 +SHEET 1 13 1 THR A 54 THR A 54 0 +SHEET 1 14 1 GLY A 55 GLY A 55 0 +SHEET 1 15 1 GLY A 56 GLY A 56 0 +SHEET 1 16 1 SER A 61 SER A 61 0 +SHEET 1 17 1 SER A 62 SER A 62 0 +SHEET 1 18 1 ARG A 63 ARG A 63 0 +SHEET 1 19 1 LYS A 64 LYS A 64 0 +SHEET 1 20 1 THR A 65 THR A 65 0 +SHEET 1 21 1 TYR A 66 TYR A 66 0 +SHEET 1 22 1 THR A 67 THR A 67 0 +SHEET 1 23 1 MET A 70 MET A 70 0 +SHEET 1 24 1 VAL A 71 VAL A 71 0 +SHEET 1 25 1 PHE A 72 PHE A 72 0 +SHEET 1 26 1 ASN A 98 ASN A 98 0 +SHEET 1 27 1 CYS A 99 CYS A 99 0 +SHEET 1 28 1 THR A 100 THR A 100 0 +SHEET 1 29 1 ILE A 101 ILE A 101 0 +SHEET 1 30 1 PHE A 102 PHE A 102 0 +SHEET 1 31 1 ALA A 103 ALA A 103 0 +SHEET 1 32 1 GLU A 153 GLU A 153 0 +SHEET 1 33 1 PHE A 154 PHE A 154 0 +SHEET 1 34 1 SER A 155 SER A 155 0 +SHEET 1 35 1 VAL A 156 VAL A 156 0 +SHEET 1 36 1 LYS A 157 LYS A 157 0 +SHEET 1 37 1 VAL A 158 VAL A 158 0 +SHEET 1 38 1 SER A 159 SER A 159 0 +SHEET 1 39 1 LEU A 160 LEU A 160 0 +SHEET 1 40 1 LEU A 161 LEU A 161 0 +SHEET 1 41 1 GLU A 162 GLU A 162 0 +SHEET 1 42 1 ILE A 163 ILE A 163 0 +SHEET 1 43 1 TYR A 164 TYR A 164 0 +SHEET 1 44 1 GLU A 167 GLU A 167 0 +SHEET 1 45 1 LEU A 168 LEU A 168 0 +SHEET 1 46 1 PHE A 169 PHE A 169 0 +SHEET 1 47 1 ASP A 170 ASP A 170 0 +SHEET 1 48 1 ARG A 181 ARG A 181 0 +SHEET 1 49 1 LEU A 182 LEU A 182 0 +SHEET 1 50 1 GLN A 183 GLN A 183 0 +SHEET 1 51 1 MET A 184 MET A 184 0 +SHEET 1 52 1 PHE A 185 PHE A 185 0 +SHEET 1 53 1 ASP A 186 ASP A 186 0 +SHEET 1 54 1 VAL A 194 VAL A 194 0 +SHEET 1 55 1 ILE A 195 ILE A 195 0 +SHEET 1 56 1 ILE A 196 ILE A 196 0 +SHEET 1 57 1 LYS A 197 LYS A 197 0 +SHEET 1 58 1 ILE A 202 ILE A 202 0 +SHEET 1 59 1 THR A 203 THR A 203 0 +SHEET 1 60 1 HIS A 236 HIS A 236 0 +SHEET 1 61 1 SER A 237 SER A 237 0 +SHEET 1 62 1 VAL A 238 VAL A 238 0 +SHEET 1 63 1 PHE A 239 PHE A 239 0 +SHEET 1 64 1 SER A 240 SER A 240 0 +SHEET 1 65 1 VAL A 241 VAL A 241 0 +SHEET 1 66 1 THR A 242 THR A 242 0 +SHEET 1 67 1 ILE A 243 ILE A 243 0 +SHEET 1 68 1 HIS A 244 HIS A 244 0 +SHEET 1 69 1 MET A 245 MET A 245 0 +SHEET 1 70 1 LYS A 246 LYS A 246 0 +SHEET 1 71 1 GLU A 247 GLU A 247 0 +SHEET 1 72 1 THR A 248 THR A 248 0 +SHEET 1 73 1 GLU A 254 GLU A 254 0 +SHEET 1 74 1 LEU A 255 LEU A 255 0 +SHEET 1 75 1 VAL A 256 VAL A 256 0 +SHEET 1 76 1 LYS A 257 LYS A 257 0 +SHEET 1 77 1 ILE A 258 ILE A 258 0 +SHEET 1 78 1 GLY A 259 GLY A 259 0 +SHEET 1 79 1 LYS A 260 LYS A 260 0 +SHEET 1 80 1 LEU A 261 LEU A 261 0 +SHEET 1 81 1 ASN A 262 ASN A 262 0 +SHEET 1 82 1 LEU A 263 LEU A 263 0 +SHEET 1 83 1 VAL A 264 VAL A 264 0 +SHEET 1 84 1 ASP A 265 ASP A 265 0 +CRYST1 160.950 79.718 69.513 90.00 96.88 90.00 C 1 2 1 8 +HETATM 1 CH3 ACE A 15 24.431 -17.877 -11.476 1.00 0.00 C +HETATM 2 C ACE A 15 24.674 -16.414 -11.124 1.00 0.00 C +HETATM 3 O ACE A 15 25.798 -15.931 -11.253 1.00 0.00 O +HETATM 4 H1 ACE A 15 25.311 -18.475 -11.239 1.00 0.00 H +HETATM 5 H2 ACE A 15 23.585 -18.282 -10.919 1.00 0.00 H +HETATM 6 H3 ACE A 15 24.223 -17.978 -12.542 1.00 0.00 H +ATOM 7 N GLY A 16 23.614 -15.724 -10.670 1.00 56.82 N +ATOM 8 CA GLY A 16 23.646 -14.323 -10.247 1.00 57.15 C +ATOM 9 C GLY A 16 24.213 -14.203 -8.825 1.00 56.24 C +ATOM 10 O GLY A 16 25.151 -14.910 -8.454 1.00 56.63 O +ATOM 11 H GLY A 16 22.728 -16.199 -10.583 1.00 56.82 H +ATOM 12 HA3 GLY A 16 22.635 -13.918 -10.293 1.00 57.15 H +ATOM 13 HA2 GLY A 16 24.256 -13.729 -10.929 1.00 57.15 H +ATOM 14 N LYS A 17 23.662 -13.267 -8.040 1.00 53.91 N +ATOM 15 CA LYS A 17 24.105 -13.003 -6.677 1.00 51.35 C +ATOM 16 C LYS A 17 22.888 -12.704 -5.798 1.00 48.72 C +ATOM 17 O LYS A 17 22.318 -11.618 -5.893 1.00 48.83 O +ATOM 18 CB LYS A 17 25.153 -11.868 -6.699 1.00 53.46 C +ATOM 19 CG LYS A 17 25.712 -11.461 -5.324 1.00 54.84 C +ATOM 20 CD LYS A 17 26.495 -12.582 -4.611 1.00 56.79 C +ATOM 21 CE LYS A 17 27.010 -12.193 -3.216 1.00 57.01 C +ATOM 22 NZ LYS A 17 28.016 -11.119 -3.266 1.00 59.10 N1+ +ATOM 23 H LYS A 17 22.912 -12.683 -8.386 1.00 53.91 H +ATOM 24 HA LYS A 17 24.578 -13.900 -6.274 1.00 51.35 H +ATOM 25 HB3 LYS A 17 24.714 -10.985 -7.167 1.00 53.46 H +ATOM 26 HB2 LYS A 17 25.987 -12.157 -7.341 1.00 53.46 H +ATOM 27 HG3 LYS A 17 24.896 -11.125 -4.688 1.00 54.84 H +ATOM 28 HG2 LYS A 17 26.353 -10.591 -5.464 1.00 54.84 H +ATOM 29 HD3 LYS A 17 27.325 -12.908 -5.240 1.00 56.79 H +ATOM 30 HD2 LYS A 17 25.855 -13.456 -4.490 1.00 56.79 H +ATOM 31 HE3 LYS A 17 27.459 -13.061 -2.732 1.00 57.01 H +ATOM 32 HE2 LYS A 17 26.180 -11.874 -2.586 1.00 57.01 H +ATOM 33 HZ1 LYS A 17 28.326 -10.902 -2.329 1.00 59.10 H +ATOM 34 HZ2 LYS A 17 28.805 -11.418 -3.822 1.00 59.10 H +ATOM 35 HZ3 LYS A 17 27.606 -10.296 -3.682 1.00 59.10 H +ATOM 36 N ASN A 18 22.534 -13.674 -4.941 1.00 45.87 N +ATOM 37 CA ASN A 18 21.461 -13.558 -3.950 1.00 44.12 C +ATOM 38 C ASN A 18 21.811 -12.503 -2.887 1.00 40.49 C +ATOM 39 O ASN A 18 22.990 -12.349 -2.557 1.00 38.53 O +ATOM 40 CB ASN A 18 21.221 -14.929 -3.273 1.00 45.88 C +ATOM 41 CG ASN A 18 20.663 -16.028 -4.189 1.00 48.93 C +ATOM 42 OD1 ASN A 18 20.711 -15.937 -5.414 1.00 50.57 O +ATOM 43 ND2 ASN A 18 20.140 -17.097 -3.585 1.00 49.83 N +ATOM 44 H ASN A 18 23.043 -14.546 -4.940 1.00 45.87 H +ATOM 45 HA ASN A 18 20.571 -13.264 -4.502 1.00 44.12 H +ATOM 46 HB3 ASN A 18 20.515 -14.801 -2.452 1.00 45.88 H +ATOM 47 HB2 ASN A 18 22.147 -15.292 -2.823 1.00 45.88 H +ATOM 48 HD22 ASN A 18 19.764 -17.854 -4.136 1.00 49.83 H +ATOM 49 HD21 ASN A 18 20.101 -17.148 -2.577 1.00 49.83 H +ATOM 50 N ILE A 19 20.785 -11.816 -2.354 1.00 37.01 N +ATOM 51 CA ILE A 19 20.936 -10.859 -1.254 1.00 33.92 C +ATOM 52 C ILE A 19 21.437 -11.568 0.018 1.00 32.91 C +ATOM 53 O ILE A 19 20.806 -12.523 0.471 1.00 32.02 O +ATOM 54 CB ILE A 19 19.627 -10.064 -0.954 1.00 34.31 C +ATOM 55 CG1 ILE A 19 19.307 -9.139 -2.156 1.00 33.64 C +ATOM 56 CG2 ILE A 19 19.667 -9.262 0.374 1.00 32.90 C +ATOM 57 CD1 ILE A 19 18.136 -8.165 -1.954 1.00 33.56 C +ATOM 58 H ILE A 19 19.841 -11.995 -2.674 1.00 37.01 H +ATOM 59 HA ILE A 19 21.695 -10.142 -1.565 1.00 33.92 H +ATOM 60 HB ILE A 19 18.810 -10.781 -0.877 1.00 34.31 H +ATOM 61 HG13 ILE A 19 19.108 -9.745 -3.041 1.00 33.64 H +ATOM 62 HG12 ILE A 19 20.194 -8.558 -2.400 1.00 33.64 H +ATOM 63 HG21 ILE A 19 18.744 -8.711 0.540 1.00 32.90 H +ATOM 64 HG22 ILE A 19 19.775 -9.903 1.249 1.00 32.90 H +ATOM 65 HG23 ILE A 19 20.487 -8.546 0.385 1.00 32.90 H +ATOM 66 HD11 ILE A 19 17.783 -7.782 -2.911 1.00 33.56 H +ATOM 67 HD12 ILE A 19 17.298 -8.645 -1.453 1.00 33.56 H +ATOM 68 HD13 ILE A 19 18.433 -7.305 -1.357 1.00 33.56 H +ATOM 69 N GLN A 20 22.581 -11.093 0.535 1.00 31.83 N +ATOM 70 CA GLN A 20 23.246 -11.666 1.700 1.00 31.76 C +ATOM 71 C GLN A 20 22.649 -11.100 2.987 1.00 29.83 C +ATOM 72 O GLN A 20 22.845 -9.923 3.283 1.00 30.30 O +ATOM 73 CB GLN A 20 24.758 -11.400 1.625 1.00 32.28 C +ATOM 74 CG GLN A 20 25.436 -12.188 0.492 1.00 35.88 C +ATOM 75 CD GLN A 20 26.959 -12.095 0.565 1.00 37.61 C +ATOM 76 OE1 GLN A 20 27.516 -11.013 0.728 1.00 40.61 O +ATOM 77 NE2 GLN A 20 27.641 -13.231 0.418 1.00 39.78 N +ATOM 78 H GLN A 20 23.027 -10.292 0.113 1.00 31.83 H +ATOM 79 HA GLN A 20 23.099 -12.747 1.693 1.00 31.76 H +ATOM 80 HB3 GLN A 20 25.214 -11.687 2.575 1.00 32.28 H +ATOM 81 HB2 GLN A 20 24.946 -10.332 1.506 1.00 32.28 H +ATOM 82 HG3 GLN A 20 25.101 -11.819 -0.477 1.00 35.88 H +ATOM 83 HG2 GLN A 20 25.137 -13.236 0.546 1.00 35.88 H +ATOM 84 HE22 GLN A 20 28.649 -13.230 0.470 1.00 39.78 H +ATOM 85 HE21 GLN A 20 27.153 -14.107 0.292 1.00 39.78 H +ATOM 86 N VAL A 21 21.934 -11.949 3.729 1.00 27.26 N +ATOM 87 CA VAL A 21 21.259 -11.549 4.953 1.00 26.53 C +ATOM 88 C VAL A 21 22.034 -12.104 6.151 1.00 27.22 C +ATOM 89 O VAL A 21 22.328 -13.298 6.190 1.00 28.15 O +ATOM 90 CB VAL A 21 19.814 -12.090 5.008 1.00 25.02 C +ATOM 91 CG1 VAL A 21 19.068 -11.635 6.274 1.00 25.05 C +ATOM 92 CG2 VAL A 21 19.017 -11.669 3.758 1.00 23.47 C +ATOM 93 H VAL A 21 21.845 -12.920 3.455 1.00 27.26 H +ATOM 94 HA VAL A 21 21.201 -10.464 5.023 1.00 26.53 H +ATOM 95 HB VAL A 21 19.847 -13.180 5.024 1.00 25.02 H +ATOM 96 HG11 VAL A 21 18.077 -12.072 6.286 1.00 25.05 H +ATOM 97 HG12 VAL A 21 19.552 -11.950 7.198 1.00 25.05 H +ATOM 98 HG13 VAL A 21 18.960 -10.550 6.308 1.00 25.05 H +ATOM 99 HG21 VAL A 21 17.985 -12.007 3.810 1.00 23.47 H +ATOM 100 HG22 VAL A 21 19.002 -10.586 3.641 1.00 23.47 H +ATOM 101 HG23 VAL A 21 19.438 -12.094 2.848 1.00 23.47 H +ATOM 102 N VAL A 22 22.328 -11.218 7.110 1.00 26.44 N +ATOM 103 CA VAL A 22 23.018 -11.556 8.348 1.00 27.25 C +ATOM 104 C VAL A 22 22.177 -11.059 9.531 1.00 25.59 C +ATOM 105 O VAL A 22 21.467 -10.064 9.391 1.00 22.16 O +ATOM 106 CB VAL A 22 24.448 -10.936 8.400 1.00 28.72 C +ATOM 107 CG1 VAL A 22 25.230 -11.232 7.107 1.00 32.98 C +ATOM 108 CG2 VAL A 22 24.532 -9.431 8.717 1.00 29.91 C +ATOM 109 H VAL A 22 22.039 -10.253 7.012 1.00 26.44 H +ATOM 110 HA VAL A 22 23.093 -12.636 8.430 1.00 27.25 H +ATOM 111 HB VAL A 22 24.979 -11.448 9.204 1.00 28.72 H +ATOM 112 HG11 VAL A 22 26.256 -10.888 7.188 1.00 32.98 H +ATOM 113 HG12 VAL A 22 25.247 -12.299 6.884 1.00 32.98 H +ATOM 114 HG13 VAL A 22 24.798 -10.723 6.246 1.00 32.98 H +ATOM 115 HG21 VAL A 22 25.564 -9.082 8.681 1.00 29.91 H +ATOM 116 HG22 VAL A 22 23.965 -8.856 7.986 1.00 29.91 H +ATOM 117 HG23 VAL A 22 24.156 -9.193 9.712 1.00 29.91 H +ATOM 118 N VAL A 23 22.269 -11.757 10.672 1.00 24.13 N +ATOM 119 CA VAL A 23 21.580 -11.373 11.905 1.00 23.21 C +ATOM 120 C VAL A 23 22.603 -10.887 12.939 1.00 24.05 C +ATOM 121 O VAL A 23 23.682 -11.468 13.034 1.00 25.40 O +ATOM 122 CB VAL A 23 20.755 -12.554 12.494 1.00 22.95 C +ATOM 123 CG1 VAL A 23 20.241 -12.363 13.940 1.00 24.02 C +ATOM 124 CG2 VAL A 23 19.558 -12.861 11.584 1.00 22.44 C +ATOM 125 H VAL A 23 22.869 -12.569 10.723 1.00 24.13 H +ATOM 126 HA VAL A 23 20.892 -10.560 11.698 1.00 23.21 H +ATOM 127 HB VAL A 23 21.392 -13.440 12.499 1.00 22.95 H +ATOM 128 HG11 VAL A 23 19.594 -13.190 14.235 1.00 24.02 H +ATOM 129 HG12 VAL A 23 21.051 -12.334 14.669 1.00 24.02 H +ATOM 130 HG13 VAL A 23 19.663 -11.444 14.038 1.00 24.02 H +ATOM 131 HG21 VAL A 23 19.017 -13.731 11.946 1.00 22.44 H +ATOM 132 HG22 VAL A 23 18.855 -12.029 11.559 1.00 22.44 H +ATOM 133 HG23 VAL A 23 19.868 -13.067 10.560 1.00 22.44 H +ATOM 134 N ARG A 24 22.228 -9.857 13.714 1.00 23.76 N +ATOM 135 CA ARG A 24 23.009 -9.381 14.849 1.00 24.07 C +ATOM 136 C ARG A 24 22.105 -9.252 16.077 1.00 23.91 C +ATOM 137 O ARG A 24 21.280 -8.343 16.138 1.00 23.91 O +ATOM 138 CB ARG A 24 23.730 -8.063 14.503 1.00 24.65 C +ATOM 139 CG ARG A 24 24.711 -7.627 15.607 1.00 24.28 C +ATOM 140 CD ARG A 24 25.349 -6.260 15.344 1.00 22.93 C +ATOM 141 NE ARG A 24 26.436 -5.996 16.300 1.00 21.81 N +ATOM 142 CZ ARG A 24 27.196 -4.891 16.374 1.00 24.11 C +ATOM 143 NH1 ARG A 24 26.979 -3.833 15.585 1.00 24.49 N +ATOM 144 NH2 ARG A 24 28.200 -4.844 17.256 1.00 25.73 N1+ +ATOM 145 H ARG A 24 21.323 -9.426 13.575 1.00 23.76 H +ATOM 146 HA ARG A 24 23.778 -10.111 15.093 1.00 24.07 H +ATOM 147 HB3 ARG A 24 23.004 -7.272 14.310 1.00 24.65 H +ATOM 148 HB2 ARG A 24 24.290 -8.193 13.576 1.00 24.65 H +ATOM 149 HG3 ARG A 24 25.460 -8.393 15.812 1.00 24.28 H +ATOM 150 HG2 ARG A 24 24.138 -7.528 16.530 1.00 24.28 H +ATOM 151 HD3 ARG A 24 24.600 -5.494 15.551 1.00 22.93 H +ATOM 152 HD2 ARG A 24 25.651 -6.135 14.304 1.00 22.93 H +ATOM 153 HE ARG A 24 26.586 -6.718 16.995 1.00 21.81 H +ATOM 154 HH12 ARG A 24 27.579 -3.019 15.648 1.00 24.49 H +ATOM 155 HH11 ARG A 24 26.195 -3.825 14.944 1.00 24.49 H +ATOM 156 HH22 ARG A 24 28.781 -4.020 17.314 1.00 25.73 H +ATOM 157 HH21 ARG A 24 28.395 -5.632 17.860 1.00 25.73 H +ATOM 158 N CYS A 25 22.320 -10.131 17.063 1.00 22.64 N +ATOM 159 CA CYS A 25 21.715 -10.009 18.383 1.00 24.93 C +ATOM 160 C CYS A 25 22.588 -9.082 19.242 1.00 26.45 C +ATOM 161 O CYS A 25 23.783 -9.344 19.369 1.00 27.13 O +ATOM 162 CB CYS A 25 21.520 -11.392 19.031 1.00 25.80 C +ATOM 163 SG CYS A 25 20.550 -11.265 20.560 1.00 30.42 S +ATOM 164 H CYS A 25 23.024 -10.851 16.953 1.00 22.64 H +ATOM 165 HA CYS A 25 20.730 -9.558 18.277 1.00 24.93 H +ATOM 166 HB3 CYS A 25 22.478 -11.867 19.248 1.00 25.80 H +ATOM 167 HB2 CYS A 25 20.986 -12.055 18.350 1.00 25.80 H +ATOM 168 HG CYS A 25 21.450 -10.556 21.249 1.00 30.42 H +ATOM 169 N ARG A 26 21.984 -8.031 19.822 1.00 25.64 N +ATOM 170 CA ARG A 26 22.656 -7.160 20.793 1.00 26.31 C +ATOM 171 C ARG A 26 22.728 -7.840 22.184 1.00 28.11 C +ATOM 172 O ARG A 26 21.927 -8.735 22.456 1.00 25.72 O +ATOM 173 CB ARG A 26 21.952 -5.782 20.834 1.00 26.30 C +ATOM 174 CG ARG A 26 20.507 -5.752 21.363 1.00 27.32 C +ATOM 175 CD ARG A 26 20.138 -4.352 21.882 1.00 28.22 C +ATOM 176 NE ARG A 26 18.758 -4.277 22.384 1.00 29.36 N +ATOM 177 CZ ARG A 26 18.256 -4.736 23.544 1.00 28.29 C +ATOM 178 NH1 ARG A 26 19.002 -5.395 24.439 1.00 33.40 N +ATOM 179 NH2 ARG A 26 16.966 -4.516 23.822 1.00 32.13 N1+ +ATOM 180 H ARG A 26 20.997 -7.868 19.671 1.00 25.64 H +ATOM 181 HA ARG A 26 23.671 -6.993 20.430 1.00 26.31 H +ATOM 182 HB3 ARG A 26 21.972 -5.339 19.838 1.00 26.30 H +ATOM 183 HB2 ARG A 26 22.541 -5.102 21.444 1.00 26.30 H +ATOM 184 HG3 ARG A 26 20.349 -6.488 22.150 1.00 27.32 H +ATOM 185 HG2 ARG A 26 19.835 -6.033 20.552 1.00 27.32 H +ATOM 186 HD3 ARG A 26 20.220 -3.632 21.067 1.00 28.22 H +ATOM 187 HD2 ARG A 26 20.837 -4.017 22.650 1.00 28.22 H +ATOM 188 HE ARG A 26 18.133 -3.743 21.793 1.00 29.36 H +ATOM 189 HH12 ARG A 26 18.610 -5.668 25.334 1.00 33.40 H +ATOM 190 HH11 ARG A 26 19.982 -5.572 24.262 1.00 33.40 H +ATOM 191 HH22 ARG A 26 16.568 -4.859 24.687 1.00 32.13 H +ATOM 192 HH21 ARG A 26 16.379 -4.009 23.175 1.00 32.13 H +ATOM 193 N PRO A 27 23.652 -7.395 23.064 1.00 31.04 N +ATOM 194 CA PRO A 27 23.677 -7.832 24.471 1.00 34.75 C +ATOM 195 C PRO A 27 22.548 -7.213 25.306 1.00 38.49 C +ATOM 196 O PRO A 27 21.915 -6.248 24.873 1.00 38.86 O +ATOM 197 CB PRO A 27 25.056 -7.353 24.962 1.00 34.27 C +ATOM 198 CG PRO A 27 25.342 -6.111 24.137 1.00 33.61 C +ATOM 199 CD PRO A 27 24.740 -6.460 22.783 1.00 32.04 C +ATOM 200 HA PRO A 27 23.596 -8.916 24.550 1.00 34.75 H +ATOM 201 HB3 PRO A 27 25.810 -8.110 24.748 1.00 34.27 H +ATOM 202 HB2 PRO A 27 25.101 -7.153 26.034 1.00 34.27 H +ATOM 203 HG3 PRO A 27 26.400 -5.854 24.084 1.00 33.61 H +ATOM 204 HG2 PRO A 27 24.810 -5.259 24.564 1.00 33.61 H +ATOM 205 HD2 PRO A 27 24.418 -5.557 22.278 1.00 32.04 H +ATOM 206 HD3 PRO A 27 25.468 -6.964 22.151 1.00 32.04 H +ATOM 207 N PHE A 28 22.361 -7.759 26.519 1.00 42.80 N +ATOM 208 CA PHE A 28 21.550 -7.130 27.558 1.00 45.58 C +ATOM 209 C PHE A 28 22.172 -5.810 28.030 1.00 48.44 C +ATOM 210 O PHE A 28 23.350 -5.792 28.395 1.00 50.16 O +ATOM 211 CB PHE A 28 21.358 -8.084 28.755 1.00 46.72 C +ATOM 212 CG PHE A 28 20.412 -9.250 28.530 1.00 46.51 C +ATOM 213 CD1 PHE A 28 20.782 -10.554 28.922 1.00 48.45 C +ATOM 214 CD2 PHE A 28 19.106 -9.029 28.045 1.00 45.93 C +ATOM 215 CE1 PHE A 28 19.877 -11.597 28.786 1.00 49.91 C +ATOM 216 CE2 PHE A 28 18.214 -10.080 27.926 1.00 45.72 C +ATOM 217 CZ PHE A 28 18.601 -11.357 28.293 1.00 47.71 C +ATOM 218 H PHE A 28 22.906 -8.560 26.800 1.00 42.80 H +ATOM 219 HA PHE A 28 20.582 -6.909 27.113 1.00 45.58 H +ATOM 220 HB3 PHE A 28 20.972 -7.535 29.615 1.00 46.72 H +ATOM 221 HB2 PHE A 28 22.331 -8.471 29.061 1.00 46.72 H +ATOM 222 HD1 PHE A 28 21.763 -10.747 29.330 1.00 48.45 H +ATOM 223 HD2 PHE A 28 18.780 -8.044 27.770 1.00 45.93 H +ATOM 224 HE1 PHE A 28 20.159 -12.596 29.085 1.00 49.91 H +ATOM 225 HE2 PHE A 28 17.217 -9.903 27.555 1.00 45.72 H +ATOM 226 HZ PHE A 28 17.891 -12.159 28.207 1.00 47.71 H +ATOM 227 N ASN A 29 21.356 -4.744 28.045 1.00 50.46 N +ATOM 228 CA ASN A 29 21.730 -3.436 28.584 1.00 53.78 C +ATOM 229 C ASN A 29 21.845 -3.467 30.123 1.00 55.58 C +ATOM 230 O ASN A 29 21.491 -4.460 30.761 1.00 55.96 O +ATOM 231 CB ASN A 29 20.788 -2.331 28.027 1.00 53.62 C +ATOM 232 CG ASN A 29 19.304 -2.428 28.409 1.00 54.79 C +ATOM 233 OD1 ASN A 29 18.962 -2.562 29.578 1.00 53.72 O +ATOM 234 ND2 ASN A 29 18.409 -2.325 27.424 1.00 53.06 N +ATOM 235 H ASN A 29 20.391 -4.853 27.754 1.00 50.46 H +ATOM 236 HA ASN A 29 22.729 -3.210 28.207 1.00 53.78 H +ATOM 237 HB3 ASN A 29 20.871 -2.323 26.939 1.00 53.62 H +ATOM 238 HB2 ASN A 29 21.142 -1.352 28.351 1.00 53.62 H +ATOM 239 HD22 ASN A 29 17.423 -2.390 27.631 1.00 53.06 H +ATOM 240 HD21 ASN A 29 18.707 -2.207 26.467 1.00 53.06 H +ATOM 241 N LEU A 30 22.341 -2.359 30.693 1.00 57.56 N +ATOM 242 CA LEU A 30 22.530 -2.164 32.133 1.00 59.64 C +ATOM 243 C LEU A 30 21.217 -2.299 32.935 1.00 60.88 C +ATOM 244 O LEU A 30 21.245 -2.847 34.034 1.00 62.21 O +ATOM 245 CB LEU A 30 23.193 -0.788 32.386 1.00 60.12 C +ATOM 246 CG LEU A 30 24.697 -0.689 32.028 1.00 60.89 C +ATOM 247 CD1 LEU A 30 25.005 -0.909 30.531 1.00 60.86 C +ATOM 248 CD2 LEU A 30 25.298 0.642 32.525 1.00 62.34 C +ATOM 249 H LEU A 30 22.613 -1.583 30.107 1.00 57.56 H +ATOM 250 HA LEU A 30 23.203 -2.946 32.490 1.00 59.64 H +ATOM 251 HB3 LEU A 30 23.099 -0.560 33.450 1.00 60.12 H +ATOM 252 HB2 LEU A 30 22.635 -0.005 31.869 1.00 60.12 H +ATOM 253 HG LEU A 30 25.206 -1.469 32.590 1.00 60.89 H +ATOM 254 HD11 LEU A 30 25.918 -0.401 30.221 1.00 60.86 H +ATOM 255 HD12 LEU A 30 25.141 -1.966 30.307 1.00 60.86 H +ATOM 256 HD13 LEU A 30 24.200 -0.535 29.898 1.00 60.86 H +ATOM 257 HD21 LEU A 30 26.157 0.462 33.173 1.00 62.34 H +ATOM 258 HD22 LEU A 30 25.636 1.279 31.708 1.00 62.34 H +ATOM 259 HD23 LEU A 30 24.580 1.227 33.101 1.00 62.34 H +ATOM 260 N ALA A 31 20.094 -1.847 32.350 1.00 61.49 N +ATOM 261 CA ALA A 31 18.746 -1.937 32.915 1.00 61.47 C +ATOM 262 C ALA A 31 18.064 -3.316 32.763 1.00 60.67 C +ATOM 263 O ALA A 31 16.956 -3.472 33.275 1.00 59.44 O +ATOM 264 CB ALA A 31 17.889 -0.813 32.311 1.00 63.13 C +ATOM 265 H ALA A 31 20.149 -1.452 31.421 1.00 61.49 H +ATOM 266 HA ALA A 31 18.815 -1.746 33.986 1.00 61.47 H +ATOM 267 HB1 ALA A 31 16.896 -0.782 32.762 1.00 63.13 H +ATOM 268 HB2 ALA A 31 18.348 0.162 32.477 1.00 63.13 H +ATOM 269 HB3 ALA A 31 17.755 -0.936 31.236 1.00 63.13 H +ATOM 270 N GLU A 32 18.716 -4.284 32.093 1.00 60.89 N +ATOM 271 CA GLU A 32 18.238 -5.659 31.908 1.00 61.52 C +ATOM 272 C GLU A 32 19.019 -6.665 32.769 1.00 61.89 C +ATOM 273 O GLU A 32 18.408 -7.600 33.286 1.00 62.53 O +ATOM 274 CB GLU A 32 18.311 -6.042 30.413 1.00 60.85 C +ATOM 275 CG GLU A 32 17.153 -5.444 29.581 1.00 60.97 C +ATOM 276 CD GLU A 32 17.285 -5.627 28.059 1.00 60.90 C +ATOM 277 OE1 GLU A 32 18.420 -5.548 27.545 1.00 59.14 O +ATOM 278 OE2 GLU A 32 16.237 -5.813 27.404 1.00 59.59 O1- +ATOM 279 H GLU A 32 19.606 -4.068 31.665 1.00 60.89 H +ATOM 280 HA GLU A 32 17.194 -5.739 32.219 1.00 61.52 H +ATOM 281 HB3 GLU A 32 18.307 -7.127 30.297 1.00 60.85 H +ATOM 282 HB2 GLU A 32 19.269 -5.707 30.016 1.00 60.85 H +ATOM 283 HG3 GLU A 32 17.065 -4.377 29.778 1.00 60.97 H +ATOM 284 HG2 GLU A 32 16.214 -5.886 29.918 1.00 60.97 H +ATOM 285 N ARG A 33 20.340 -6.462 32.926 1.00 62.13 N +ATOM 286 CA ARG A 33 21.209 -7.335 33.724 1.00 62.76 C +ATOM 287 C ARG A 33 20.979 -7.224 35.241 1.00 63.12 C +ATOM 288 O ARG A 33 21.171 -8.225 35.930 1.00 62.75 O +ATOM 289 CB ARG A 33 22.684 -7.061 33.394 1.00 62.27 C +ATOM 290 CG ARG A 33 23.081 -7.461 31.963 1.00 62.64 C +ATOM 291 CD ARG A 33 24.594 -7.388 31.686 1.00 63.34 C +ATOM 292 NE ARG A 33 25.108 -6.008 31.607 1.00 64.48 N +ATOM 293 CZ ARG A 33 25.614 -5.231 32.585 1.00 65.42 C +ATOM 294 NH1 ARG A 33 25.669 -5.606 33.872 1.00 65.97 N +ATOM 295 NH2 ARG A 33 26.099 -4.031 32.252 1.00 64.71 N1+ +ATOM 296 H ARG A 33 20.784 -5.681 32.463 1.00 62.13 H +ATOM 297 HA ARG A 33 20.991 -8.369 33.450 1.00 62.76 H +ATOM 298 HB3 ARG A 33 23.312 -7.627 34.084 1.00 62.27 H +ATOM 299 HB2 ARG A 33 22.902 -6.006 33.567 1.00 62.27 H +ATOM 300 HG3 ARG A 33 22.571 -6.784 31.279 1.00 62.64 H +ATOM 301 HG2 ARG A 33 22.712 -8.456 31.710 1.00 62.64 H +ATOM 302 HD3 ARG A 33 24.844 -7.946 30.784 1.00 63.34 H +ATOM 303 HD2 ARG A 33 25.130 -7.890 32.492 1.00 63.34 H +ATOM 304 HE ARG A 33 25.048 -5.606 30.681 1.00 64.48 H +ATOM 305 HH12 ARG A 33 26.068 -4.999 34.573 1.00 65.97 H +ATOM 306 HH11 ARG A 33 25.321 -6.515 34.144 1.00 65.97 H +ATOM 307 HH22 ARG A 33 26.501 -3.428 32.955 1.00 64.71 H +ATOM 308 HH21 ARG A 33 26.088 -3.724 31.290 1.00 64.71 H +ATOM 309 N LYS A 34 20.542 -6.049 35.732 1.00 63.45 N +ATOM 310 CA LYS A 34 20.125 -5.846 37.126 1.00 64.03 C +ATOM 311 C LYS A 34 18.891 -6.680 37.512 1.00 64.60 C +ATOM 312 O LYS A 34 18.813 -7.142 38.650 1.00 65.69 O +ATOM 313 CB LYS A 34 19.824 -4.358 37.376 1.00 63.62 C +ATOM 314 CG LYS A 34 21.065 -3.453 37.415 1.00 64.63 C +ATOM 315 CD LYS A 34 20.789 -2.005 37.873 1.00 64.91 C +ATOM 316 CE LYS A 34 19.717 -1.227 37.078 1.00 65.86 C +ATOM 317 NZ LYS A 34 18.341 -1.488 37.545 1.00 65.56 N1+ +ATOM 318 H LYS A 34 20.419 -5.265 35.107 1.00 63.45 H +ATOM 319 HA LYS A 34 20.950 -6.153 37.772 1.00 64.03 H +ATOM 320 HB3 LYS A 34 19.325 -4.259 38.343 1.00 63.62 H +ATOM 321 HB2 LYS A 34 19.117 -4.007 36.623 1.00 63.62 H +ATOM 322 HG3 LYS A 34 21.548 -3.445 36.441 1.00 64.63 H +ATOM 323 HG2 LYS A 34 21.798 -3.890 38.094 1.00 64.63 H +ATOM 324 HD3 LYS A 34 21.726 -1.452 37.797 1.00 64.91 H +ATOM 325 HD2 LYS A 34 20.549 -2.003 38.937 1.00 64.91 H +ATOM 326 HE3 LYS A 34 19.803 -1.439 36.014 1.00 65.86 H +ATOM 327 HE2 LYS A 34 19.894 -0.158 37.197 1.00 65.86 H +ATOM 328 HZ1 LYS A 34 18.263 -1.240 38.522 1.00 65.56 H +ATOM 329 HZ2 LYS A 34 17.690 -0.934 37.006 1.00 65.56 H +ATOM 330 HZ3 LYS A 34 18.123 -2.467 37.430 1.00 65.56 H +ATOM 331 N ALA A 35 17.971 -6.869 36.550 1.00 64.26 N +ATOM 332 CA ALA A 35 16.790 -7.719 36.680 1.00 64.31 C +ATOM 333 C ALA A 35 17.092 -9.217 36.489 1.00 64.22 C +ATOM 334 O ALA A 35 16.199 -10.028 36.731 1.00 63.88 O +ATOM 335 CB ALA A 35 15.740 -7.245 35.661 1.00 63.53 C +ATOM 336 H ALA A 35 18.120 -6.462 35.638 1.00 64.26 H +ATOM 337 HA ALA A 35 16.372 -7.591 37.681 1.00 64.31 H +ATOM 338 HB1 ALA A 35 14.813 -7.812 35.755 1.00 63.53 H +ATOM 339 HB2 ALA A 35 15.494 -6.194 35.812 1.00 63.53 H +ATOM 340 HB3 ALA A 35 16.093 -7.359 34.636 1.00 63.53 H +ATOM 341 N SER A 36 18.322 -9.555 36.050 1.00 64.97 N +ATOM 342 CA SER A 36 18.800 -10.899 35.709 1.00 64.87 C +ATOM 343 C SER A 36 17.929 -11.548 34.618 1.00 64.00 C +ATOM 344 O SER A 36 17.423 -12.656 34.806 1.00 64.70 O +ATOM 345 CB SER A 36 18.947 -11.771 36.979 1.00 65.13 C +ATOM 346 OG SER A 36 20.030 -11.309 37.760 1.00 65.33 O +ATOM 347 H SER A 36 18.995 -8.816 35.901 1.00 64.97 H +ATOM 348 HA SER A 36 19.789 -10.778 35.263 1.00 64.87 H +ATOM 349 HB3 SER A 36 19.168 -12.806 36.714 1.00 65.13 H +ATOM 350 HB2 SER A 36 18.037 -11.784 37.578 1.00 65.13 H +ATOM 351 HG SER A 36 19.806 -10.439 38.101 1.00 65.33 H +ATOM 352 N ALA A 37 17.737 -10.805 33.513 1.00 62.61 N +ATOM 353 CA ALA A 37 16.912 -11.194 32.371 1.00 60.97 C +ATOM 354 C ALA A 37 17.411 -12.488 31.710 1.00 59.83 C +ATOM 355 O ALA A 37 18.604 -12.606 31.429 1.00 59.91 O +ATOM 356 CB ALA A 37 16.888 -10.037 31.358 1.00 60.54 C +ATOM 357 H ALA A 37 18.169 -9.893 33.451 1.00 62.61 H +ATOM 358 HA ALA A 37 15.895 -11.351 32.736 1.00 60.97 H +ATOM 359 HB1 ALA A 37 16.288 -10.288 30.483 1.00 60.54 H +ATOM 360 HB2 ALA A 37 16.458 -9.138 31.800 1.00 60.54 H +ATOM 361 HB3 ALA A 37 17.892 -9.787 31.012 1.00 60.54 H +ATOM 362 N HIS A 38 16.481 -13.426 31.476 1.00 58.07 N +ATOM 363 CA HIS A 38 16.738 -14.670 30.753 1.00 56.37 C +ATOM 364 C HIS A 38 16.643 -14.400 29.245 1.00 53.14 C +ATOM 365 O HIS A 38 15.660 -13.812 28.788 1.00 52.97 O +ATOM 366 CB HIS A 38 15.751 -15.767 31.212 1.00 57.37 C +ATOM 367 CG HIS A 38 14.291 -15.485 30.947 1.00 58.33 C +ATOM 368 ND1 HIS A 38 13.585 -16.074 29.891 1.00 58.82 N +ATOM 369 CD2 HIS A 38 13.450 -14.624 31.621 1.00 58.28 C +ATOM 370 CE1 HIS A 38 12.377 -15.531 29.957 1.00 58.75 C +ATOM 371 NE2 HIS A 38 12.241 -14.664 30.957 1.00 57.35 N +ATOM 372 H HIS A 38 15.522 -13.252 31.738 1.00 58.07 H +ATOM 373 HA HIS A 38 17.746 -15.016 30.992 1.00 56.37 H +ATOM 374 HB3 HIS A 38 15.872 -15.941 32.282 1.00 57.37 H +ATOM 375 HB2 HIS A 38 16.010 -16.711 30.730 1.00 57.37 H +ATOM 376 HD2 HIS A 38 13.617 -13.990 32.479 1.00 58.28 H +ATOM 377 HE1 HIS A 38 11.582 -15.745 29.259 1.00 58.75 H +ATOM 378 HE2 HIS A 38 11.414 -14.125 31.176 1.00 57.35 H +ATOM 379 N SER A 39 17.675 -14.828 28.504 1.00 49.89 N +ATOM 380 CA SER A 39 17.704 -14.716 27.050 1.00 45.41 C +ATOM 381 C SER A 39 16.875 -15.843 26.426 1.00 41.77 C +ATOM 382 O SER A 39 17.040 -17.004 26.804 1.00 42.08 O +ATOM 383 CB SER A 39 19.161 -14.739 26.551 1.00 45.19 C +ATOM 384 OG SER A 39 19.209 -14.520 25.156 1.00 47.29 O +ATOM 385 H SER A 39 18.452 -15.303 28.940 1.00 49.89 H +ATOM 386 HA SER A 39 17.269 -13.757 26.762 1.00 45.41 H +ATOM 387 HB3 SER A 39 19.642 -15.690 26.781 1.00 45.19 H +ATOM 388 HB2 SER A 39 19.745 -13.958 27.038 1.00 45.19 H +ATOM 389 HG SER A 39 20.064 -14.807 24.823 1.00 47.29 H +ATOM 390 N ILE A 40 16.029 -15.469 25.458 1.00 37.57 N +ATOM 391 CA ILE A 40 15.319 -16.412 24.602 1.00 34.91 C +ATOM 392 C ILE A 40 16.072 -16.669 23.282 1.00 33.66 C +ATOM 393 O ILE A 40 15.690 -17.599 22.583 1.00 33.63 O +ATOM 394 CB ILE A 40 13.869 -15.941 24.296 1.00 35.48 C +ATOM 395 CG1 ILE A 40 13.760 -14.583 23.564 1.00 33.76 C +ATOM 396 CG2 ILE A 40 13.027 -15.957 25.585 1.00 34.54 C +ATOM 397 CD1 ILE A 40 12.395 -14.342 22.904 1.00 35.52 C +ATOM 398 H ILE A 40 15.953 -14.491 25.210 1.00 37.57 H +ATOM 399 HA ILE A 40 15.246 -17.381 25.101 1.00 34.91 H +ATOM 400 HB ILE A 40 13.424 -16.682 23.630 1.00 35.48 H +ATOM 401 HG13 ILE A 40 14.516 -14.505 22.786 1.00 33.76 H +ATOM 402 HG12 ILE A 40 13.969 -13.775 24.262 1.00 33.76 H +ATOM 403 HG21 ILE A 40 11.981 -15.719 25.397 1.00 34.54 H +ATOM 404 HG22 ILE A 40 13.053 -16.939 26.055 1.00 34.54 H +ATOM 405 HG23 ILE A 40 13.409 -15.238 26.309 1.00 34.54 H +ATOM 406 HD11 ILE A 40 12.030 -13.338 23.116 1.00 35.52 H +ATOM 407 HD12 ILE A 40 12.463 -14.437 21.821 1.00 35.52 H +ATOM 408 HD13 ILE A 40 11.639 -15.044 23.249 1.00 35.52 H +ATOM 409 N VAL A 41 17.127 -15.892 22.973 1.00 32.34 N +ATOM 410 CA VAL A 41 17.910 -16.023 21.744 1.00 33.13 C +ATOM 411 C VAL A 41 19.268 -16.693 22.034 1.00 33.37 C +ATOM 412 O VAL A 41 20.004 -16.236 22.908 1.00 33.03 O +ATOM 413 CB VAL A 41 18.170 -14.635 21.087 1.00 31.02 C +ATOM 414 CG1 VAL A 41 19.098 -14.683 19.855 1.00 30.01 C +ATOM 415 CG2 VAL A 41 16.850 -13.950 20.688 1.00 32.15 C +ATOM 416 H VAL A 41 17.427 -15.172 23.616 1.00 32.34 H +ATOM 417 HA VAL A 41 17.365 -16.627 21.017 1.00 33.13 H +ATOM 418 HB VAL A 41 18.658 -13.993 21.822 1.00 31.02 H +ATOM 419 HG11 VAL A 41 19.158 -13.711 19.368 1.00 30.01 H +ATOM 420 HG12 VAL A 41 20.120 -14.963 20.111 1.00 30.01 H +ATOM 421 HG13 VAL A 41 18.727 -15.398 19.122 1.00 30.01 H +ATOM 422 HG21 VAL A 41 17.034 -13.002 20.180 1.00 32.15 H +ATOM 423 HG22 VAL A 41 16.264 -14.575 20.016 1.00 32.15 H +ATOM 424 HG23 VAL A 41 16.235 -13.727 21.558 1.00 32.15 H +ATOM 425 N GLU A 42 19.589 -17.725 21.239 1.00 34.68 N +ATOM 426 CA GLU A 42 20.917 -18.330 21.142 1.00 37.62 C +ATOM 427 C GLU A 42 21.416 -18.169 19.704 1.00 37.62 C +ATOM 428 O GLU A 42 20.675 -18.465 18.768 1.00 37.32 O +ATOM 429 CB GLU A 42 20.870 -19.823 21.518 1.00 39.30 C +ATOM 430 CG GLU A 42 20.636 -20.073 23.023 1.00 44.83 C +ATOM 431 CD GLU A 42 20.549 -21.556 23.429 1.00 48.30 C +ATOM 432 OE1 GLU A 42 20.972 -22.431 22.640 1.00 49.42 O +ATOM 433 OE2 GLU A 42 20.044 -21.792 24.548 1.00 47.07 O1- +ATOM 434 H GLU A 42 18.920 -18.039 20.547 1.00 34.68 H +ATOM 435 HA GLU A 42 21.621 -17.826 21.807 1.00 37.62 H +ATOM 436 HB3 GLU A 42 21.808 -20.295 21.217 1.00 39.30 H +ATOM 437 HB2 GLU A 42 20.085 -20.318 20.944 1.00 39.30 H +ATOM 438 HG3 GLU A 42 19.726 -19.565 23.342 1.00 44.83 H +ATOM 439 HG2 GLU A 42 21.448 -19.620 23.592 1.00 44.83 H +ATOM 440 N CYS A 43 22.673 -17.727 19.570 1.00 37.12 N +ATOM 441 CA CYS A 43 23.362 -17.537 18.297 1.00 38.66 C +ATOM 442 C CYS A 43 24.501 -18.560 18.197 1.00 40.09 C +ATOM 443 O CYS A 43 25.208 -18.786 19.180 1.00 40.18 O +ATOM 444 CB CYS A 43 23.930 -16.109 18.189 1.00 37.97 C +ATOM 445 SG CYS A 43 22.581 -14.923 17.915 1.00 39.98 S +ATOM 446 H CYS A 43 23.223 -17.540 20.396 1.00 37.12 H +ATOM 447 HA CYS A 43 22.683 -17.703 17.458 1.00 38.66 H +ATOM 448 HB3 CYS A 43 24.633 -16.027 17.360 1.00 37.97 H +ATOM 449 HB2 CYS A 43 24.478 -15.833 19.091 1.00 37.97 H +ATOM 450 HG CYS A 43 22.271 -15.343 16.686 1.00 39.98 H +ATOM 451 N ASP A 44 24.675 -19.122 16.992 1.00 39.18 N +ATOM 452 CA ASP A 44 25.745 -20.054 16.646 1.00 39.68 C +ATOM 453 C ASP A 44 26.288 -19.598 15.274 1.00 37.75 C +ATOM 454 O ASP A 44 25.747 -20.029 14.256 1.00 34.98 O +ATOM 455 CB ASP A 44 25.243 -21.526 16.689 1.00 42.51 C +ATOM 456 CG ASP A 44 26.304 -22.640 16.552 1.00 45.22 C +ATOM 457 OD1 ASP A 44 27.392 -22.396 15.984 1.00 46.28 O +ATOM 458 OD2 ASP A 44 25.957 -23.782 16.927 1.00 48.98 O1- +ATOM 459 H ASP A 44 24.035 -18.897 16.240 1.00 39.18 H +ATOM 460 HA ASP A 44 26.544 -19.997 17.385 1.00 39.68 H +ATOM 461 HB3 ASP A 44 24.480 -21.676 15.923 1.00 42.51 H +ATOM 462 HB2 ASP A 44 24.713 -21.677 17.631 1.00 42.51 H +ATOM 463 N PRO A 45 27.326 -18.725 15.265 1.00 37.21 N +ATOM 464 CA PRO A 45 27.967 -18.229 14.028 1.00 38.23 C +ATOM 465 C PRO A 45 28.553 -19.293 13.082 1.00 39.60 C +ATOM 466 O PRO A 45 28.496 -19.092 11.869 1.00 38.37 O +ATOM 467 CB PRO A 45 29.075 -17.287 14.534 1.00 37.82 C +ATOM 468 CG PRO A 45 28.604 -16.837 15.904 1.00 36.47 C +ATOM 469 CD PRO A 45 27.909 -18.077 16.443 1.00 37.30 C +ATOM 470 HA PRO A 45 27.216 -17.646 13.490 1.00 38.23 H +ATOM 471 HB3 PRO A 45 29.255 -16.449 13.862 1.00 37.82 H +ATOM 472 HB2 PRO A 45 30.020 -17.823 14.645 1.00 37.82 H +ATOM 473 HG3 PRO A 45 27.875 -16.033 15.797 1.00 36.47 H +ATOM 474 HG2 PRO A 45 29.409 -16.478 16.545 1.00 36.47 H +ATOM 475 HD2 PRO A 45 28.630 -18.758 16.898 1.00 37.30 H +ATOM 476 HD3 PRO A 45 27.177 -17.794 17.199 1.00 37.30 H +ATOM 477 N VAL A 46 29.099 -20.388 13.643 1.00 40.68 N +ATOM 478 CA VAL A 46 29.722 -21.487 12.894 1.00 42.73 C +ATOM 479 C VAL A 46 28.687 -22.267 12.062 1.00 44.14 C +ATOM 480 O VAL A 46 28.940 -22.553 10.892 1.00 44.76 O +ATOM 481 CB VAL A 46 30.458 -22.486 13.837 1.00 45.34 C +ATOM 482 CG1 VAL A 46 31.100 -23.688 13.109 1.00 45.35 C +ATOM 483 CG2 VAL A 46 31.527 -21.776 14.687 1.00 45.25 C +ATOM 484 H VAL A 46 29.087 -20.492 14.648 1.00 40.68 H +ATOM 485 HA VAL A 46 30.452 -21.054 12.208 1.00 42.73 H +ATOM 486 HB VAL A 46 29.730 -22.898 14.537 1.00 45.34 H +ATOM 487 HG11 VAL A 46 31.679 -24.301 13.799 1.00 45.35 H +ATOM 488 HG12 VAL A 46 30.355 -24.347 12.661 1.00 45.35 H +ATOM 489 HG13 VAL A 46 31.773 -23.357 12.318 1.00 45.35 H +ATOM 490 HG21 VAL A 46 32.043 -22.479 15.342 1.00 45.25 H +ATOM 491 HG22 VAL A 46 32.277 -21.296 14.058 1.00 45.25 H +ATOM 492 HG23 VAL A 46 31.090 -21.009 15.327 1.00 45.25 H +ATOM 493 N ARG A 47 27.526 -22.541 12.678 1.00 43.50 N +ATOM 494 CA ARG A 47 26.360 -23.145 12.036 1.00 44.40 C +ATOM 495 C ARG A 47 25.573 -22.138 11.171 1.00 43.29 C +ATOM 496 O ARG A 47 24.765 -22.558 10.344 1.00 42.55 O +ATOM 497 CB ARG A 47 25.470 -23.732 13.148 1.00 46.46 C +ATOM 498 CG ARG A 47 24.634 -24.946 12.709 1.00 51.87 C +ATOM 499 CD ARG A 47 25.373 -26.293 12.807 1.00 55.57 C +ATOM 500 NE ARG A 47 25.573 -26.702 14.211 1.00 59.35 N +ATOM 501 CZ ARG A 47 26.228 -27.780 14.675 1.00 61.63 C +ATOM 502 NH1 ARG A 47 26.815 -28.666 13.855 1.00 62.28 N +ATOM 503 NH2 ARG A 47 26.297 -27.967 15.999 1.00 61.37 N1+ +ATOM 504 H ARG A 47 27.410 -22.283 13.650 1.00 43.50 H +ATOM 505 HA ARG A 47 26.716 -23.954 11.395 1.00 44.40 H +ATOM 506 HB3 ARG A 47 24.822 -22.955 13.557 1.00 46.46 H +ATOM 507 HB2 ARG A 47 26.096 -24.040 13.985 1.00 46.46 H +ATOM 508 HG3 ARG A 47 24.162 -24.818 11.735 1.00 51.87 H +ATOM 509 HG2 ARG A 47 23.812 -24.987 13.422 1.00 51.87 H +ATOM 510 HD3 ARG A 47 26.382 -26.156 12.417 1.00 55.57 H +ATOM 511 HD2 ARG A 47 24.903 -27.063 12.194 1.00 55.57 H +ATOM 512 HE ARG A 47 25.181 -26.066 14.893 1.00 59.35 H +ATOM 513 HH12 ARG A 47 27.304 -29.468 14.225 1.00 62.28 H +ATOM 514 HH11 ARG A 47 26.768 -28.530 12.856 1.00 62.28 H +ATOM 515 HH22 ARG A 47 26.780 -28.765 16.383 1.00 61.37 H +ATOM 516 HH21 ARG A 47 25.881 -27.292 16.627 1.00 61.37 H +ATOM 517 N LYS A 48 25.816 -20.833 11.401 1.00 42.41 N +ATOM 518 CA LYS A 48 25.125 -19.669 10.841 1.00 40.29 C +ATOM 519 C LYS A 48 23.639 -19.630 11.243 1.00 39.93 C +ATOM 520 O LYS A 48 22.806 -19.196 10.448 1.00 39.37 O +ATOM 521 CB LYS A 48 25.321 -19.575 9.313 1.00 41.78 C +ATOM 522 CG LYS A 48 26.783 -19.476 8.864 1.00 43.17 C +ATOM 523 CD LYS A 48 26.912 -19.576 7.334 1.00 45.52 C +ATOM 524 CE LYS A 48 28.298 -19.179 6.800 1.00 47.46 C +ATOM 525 NZ LYS A 48 29.365 -20.080 7.271 1.00 50.93 N1+ +ATOM 526 H LYS A 48 26.512 -20.608 12.099 1.00 42.41 H +ATOM 527 HA LYS A 48 25.585 -18.790 11.295 1.00 40.29 H +ATOM 528 HB3 LYS A 48 24.817 -18.679 8.955 1.00 41.78 H +ATOM 529 HB2 LYS A 48 24.841 -20.420 8.818 1.00 41.78 H +ATOM 530 HG3 LYS A 48 27.375 -20.263 9.331 1.00 43.17 H +ATOM 531 HG2 LYS A 48 27.198 -18.530 9.212 1.00 43.17 H +ATOM 532 HD3 LYS A 48 26.155 -18.950 6.864 1.00 45.52 H +ATOM 533 HD2 LYS A 48 26.677 -20.594 7.020 1.00 45.52 H +ATOM 534 HE3 LYS A 48 28.544 -18.162 7.107 1.00 47.46 H +ATOM 535 HE2 LYS A 48 28.291 -19.189 5.709 1.00 47.46 H +ATOM 536 HZ1 LYS A 48 30.254 -19.777 6.901 1.00 50.93 H +ATOM 537 HZ2 LYS A 48 29.397 -20.063 8.281 1.00 50.93 H +ATOM 538 HZ3 LYS A 48 29.173 -21.022 6.959 1.00 50.93 H +ATOM 539 N GLU A 49 23.340 -20.092 12.468 1.00 38.53 N +ATOM 540 CA GLU A 49 21.989 -20.229 12.994 1.00 39.11 C +ATOM 541 C GLU A 49 21.716 -19.262 14.143 1.00 37.38 C +ATOM 542 O GLU A 49 22.619 -18.913 14.903 1.00 35.68 O +ATOM 543 CB GLU A 49 21.744 -21.672 13.470 1.00 41.64 C +ATOM 544 CG GLU A 49 21.632 -22.677 12.306 1.00 47.78 C +ATOM 545 CD GLU A 49 21.267 -24.114 12.711 1.00 51.12 C +ATOM 546 OE1 GLU A 49 21.072 -24.382 13.918 1.00 50.60 O +ATOM 547 OE2 GLU A 49 21.203 -24.946 11.779 1.00 52.69 O1- +ATOM 548 H GLU A 49 24.088 -20.390 13.081 1.00 38.53 H +ATOM 549 HA GLU A 49 21.275 -20.012 12.205 1.00 39.11 H +ATOM 550 HB3 GLU A 49 20.830 -21.710 14.066 1.00 41.64 H +ATOM 551 HB2 GLU A 49 22.553 -21.979 14.136 1.00 41.64 H +ATOM 552 HG3 GLU A 49 22.569 -22.702 11.752 1.00 47.78 H +ATOM 553 HG2 GLU A 49 20.871 -22.325 11.608 1.00 47.78 H +ATOM 554 N VAL A 50 20.431 -18.915 14.258 1.00 35.62 N +ATOM 555 CA VAL A 50 19.838 -18.205 15.377 1.00 35.40 C +ATOM 556 C VAL A 50 18.571 -18.974 15.785 1.00 35.75 C +ATOM 557 O VAL A 50 17.700 -19.221 14.950 1.00 34.76 O +ATOM 558 CB VAL A 50 19.523 -16.727 15.021 1.00 35.70 C +ATOM 559 CG1 VAL A 50 18.625 -16.548 13.786 1.00 37.29 C +ATOM 560 CG2 VAL A 50 18.952 -15.935 16.210 1.00 33.58 C +ATOM 561 H VAL A 50 19.773 -19.247 13.564 1.00 35.62 H +ATOM 562 HA VAL A 50 20.536 -18.211 16.215 1.00 35.40 H +ATOM 563 HB VAL A 50 20.481 -16.267 14.772 1.00 35.70 H +ATOM 564 HG11 VAL A 50 18.651 -15.512 13.455 1.00 37.29 H +ATOM 565 HG12 VAL A 50 18.971 -17.152 12.949 1.00 37.29 H +ATOM 566 HG13 VAL A 50 17.586 -16.808 13.984 1.00 37.29 H +ATOM 567 HG21 VAL A 50 18.835 -14.883 15.954 1.00 33.58 H +ATOM 568 HG22 VAL A 50 17.976 -16.305 16.524 1.00 33.58 H +ATOM 569 HG23 VAL A 50 19.625 -15.992 17.065 1.00 33.58 H +ATOM 570 N SER A 51 18.531 -19.373 17.063 1.00 34.36 N +ATOM 571 CA SER A 51 17.468 -20.172 17.656 1.00 34.46 C +ATOM 572 C SER A 51 16.752 -19.323 18.711 1.00 35.79 C +ATOM 573 O SER A 51 17.421 -18.742 19.564 1.00 35.89 O +ATOM 574 CB SER A 51 18.094 -21.444 18.258 1.00 37.01 C +ATOM 575 OG SER A 51 17.089 -22.332 18.698 1.00 39.31 O +ATOM 576 H SER A 51 19.288 -19.117 17.685 1.00 34.36 H +ATOM 577 HA SER A 51 16.753 -20.474 16.893 1.00 34.46 H +ATOM 578 HB3 SER A 51 18.754 -21.205 19.092 1.00 37.01 H +ATOM 579 HB2 SER A 51 18.702 -21.958 17.512 1.00 37.01 H +ATOM 580 HG SER A 51 16.696 -22.752 17.929 1.00 39.31 H +ATOM 581 N VAL A 52 15.415 -19.273 18.632 1.00 34.84 N +ATOM 582 CA VAL A 52 14.570 -18.466 19.509 1.00 36.07 C +ATOM 583 C VAL A 52 13.629 -19.387 20.295 1.00 36.69 C +ATOM 584 O VAL A 52 12.938 -20.195 19.682 1.00 39.27 O +ATOM 585 CB VAL A 52 13.694 -17.470 18.700 1.00 35.47 C +ATOM 586 CG1 VAL A 52 12.754 -16.624 19.585 1.00 35.27 C +ATOM 587 CG2 VAL A 52 14.562 -16.535 17.847 1.00 35.83 C +ATOM 588 H VAL A 52 14.937 -19.779 17.897 1.00 34.84 H +ATOM 589 HA VAL A 52 15.179 -17.887 20.200 1.00 36.07 H +ATOM 590 HB VAL A 52 13.066 -18.031 18.006 1.00 35.47 H +ATOM 591 HG11 VAL A 52 12.254 -15.847 19.008 1.00 35.27 H +ATOM 592 HG12 VAL A 52 11.970 -17.226 20.044 1.00 35.27 H +ATOM 593 HG13 VAL A 52 13.310 -16.132 20.384 1.00 35.27 H +ATOM 594 HG21 VAL A 52 13.940 -15.795 17.347 1.00 35.83 H +ATOM 595 HG22 VAL A 52 15.292 -16.000 18.453 1.00 35.83 H +ATOM 596 HG23 VAL A 52 15.104 -17.079 17.073 1.00 35.83 H +ATOM 597 N ARG A 53 13.596 -19.219 21.626 1.00 38.55 N +ATOM 598 CA ARG A 53 12.708 -19.929 22.540 1.00 41.08 C +ATOM 599 C ARG A 53 11.301 -19.320 22.495 1.00 42.23 C +ATOM 600 O ARG A 53 11.147 -18.142 22.817 1.00 42.18 O +ATOM 601 CB ARG A 53 13.308 -19.884 23.957 1.00 42.63 C +ATOM 602 CG ARG A 53 12.695 -20.937 24.895 1.00 47.38 C +ATOM 603 CD ARG A 53 13.301 -20.956 26.312 1.00 50.43 C +ATOM 604 NE ARG A 53 12.954 -19.765 27.106 1.00 55.27 N +ATOM 605 CZ ARG A 53 11.773 -19.503 27.694 1.00 56.95 C +ATOM 606 NH1 ARG A 53 10.725 -20.334 27.608 1.00 59.72 N +ATOM 607 NH2 ARG A 53 11.635 -18.378 28.398 1.00 58.53 N1+ +ATOM 608 H ARG A 53 14.210 -18.533 22.048 1.00 38.55 H +ATOM 609 HA ARG A 53 12.663 -20.969 22.216 1.00 41.08 H +ATOM 610 HB3 ARG A 53 13.209 -18.887 24.384 1.00 42.63 H +ATOM 611 HB2 ARG A 53 14.378 -20.065 23.894 1.00 42.63 H +ATOM 612 HG3 ARG A 53 12.747 -21.932 24.454 1.00 47.38 H +ATOM 613 HG2 ARG A 53 11.632 -20.710 24.970 1.00 47.38 H +ATOM 614 HD3 ARG A 53 14.386 -20.910 26.218 1.00 50.43 H +ATOM 615 HD2 ARG A 53 13.092 -21.887 26.839 1.00 50.43 H +ATOM 616 HE ARG A 53 13.688 -19.077 27.192 1.00 55.27 H +ATOM 617 HH12 ARG A 53 9.863 -20.138 28.096 1.00 59.72 H +ATOM 618 HH11 ARG A 53 10.810 -21.196 27.087 1.00 59.72 H +ATOM 619 HH22 ARG A 53 10.759 -18.164 28.851 1.00 58.53 H +ATOM 620 HH21 ARG A 53 12.418 -17.748 28.518 1.00 58.53 H +ATOM 621 N THR A 54 10.315 -20.130 22.084 1.00 44.25 N +ATOM 622 CA THR A 54 8.952 -19.675 21.795 1.00 46.39 C +ATOM 623 C THR A 54 7.912 -20.111 22.851 1.00 48.51 C +ATOM 624 O THR A 54 6.730 -19.818 22.669 1.00 47.93 O +ATOM 625 CB THR A 54 8.506 -20.154 20.387 1.00 46.41 C +ATOM 626 OG1 THR A 54 8.198 -21.537 20.340 1.00 47.70 O +ATOM 627 CG2 THR A 54 9.533 -19.812 19.297 1.00 45.46 C +ATOM 628 H THR A 54 10.518 -21.093 21.852 1.00 44.25 H +ATOM 629 HA THR A 54 8.923 -18.586 21.777 1.00 46.39 H +ATOM 630 HB THR A 54 7.588 -19.621 20.132 1.00 46.41 H +ATOM 631 HG1 THR A 54 7.416 -21.688 20.879 1.00 47.70 H +ATOM 632 HG21 THR A 54 9.094 -19.880 18.307 1.00 45.46 H +ATOM 633 HG22 THR A 54 9.909 -18.794 19.410 1.00 45.46 H +ATOM 634 HG23 THR A 54 10.385 -20.489 19.326 1.00 45.46 H +ATOM 635 N GLY A 55 8.352 -20.762 23.938 1.00 50.52 N +ATOM 636 CA GLY A 55 7.480 -21.176 25.034 1.00 54.71 C +ATOM 637 C GLY A 55 8.156 -22.294 25.833 1.00 58.31 C +ATOM 638 O GLY A 55 9.194 -22.820 25.432 1.00 58.28 O +ATOM 639 H GLY A 55 9.332 -20.992 24.022 1.00 50.52 H +ATOM 640 HA3 GLY A 55 6.524 -21.542 24.657 1.00 54.71 H +ATOM 641 HA2 GLY A 55 7.282 -20.322 25.684 1.00 54.71 H +ATOM 642 N GLY A 56 7.548 -22.653 26.974 1.00 60.67 N +ATOM 643 CA GLY A 56 8.051 -23.681 27.884 1.00 63.02 C +ATOM 644 C GLY A 56 8.911 -23.040 28.982 1.00 64.97 C +ATOM 645 O GLY A 56 8.605 -21.952 29.470 1.00 66.30 O +ATOM 646 H GLY A 56 6.699 -22.182 27.251 1.00 60.67 H +ATOM 647 HA3 GLY A 56 8.609 -24.451 27.350 1.00 63.02 H +ATOM 648 HA2 GLY A 56 7.202 -24.178 28.355 1.00 63.02 H +ATOM 649 N LEU A 57 9.960 -23.767 29.392 1.00 65.39 N +ATOM 650 CA LEU A 57 10.880 -23.457 30.487 1.00 66.24 C +ATOM 651 C LEU A 57 12.337 -23.533 29.994 1.00 66.92 C +ATOM 652 O LEU A 57 12.604 -24.014 28.895 1.00 67.15 O +ATOM 653 CB LEU A 57 10.671 -24.493 31.629 1.00 65.98 C +ATOM 654 CG LEU A 57 9.336 -24.417 32.408 1.00 66.38 C +ATOM 655 CD1 LEU A 57 9.050 -23.014 32.978 1.00 66.32 C +ATOM 656 CD2 LEU A 57 8.135 -25.026 31.654 1.00 66.04 C +ATOM 657 H LEU A 57 10.144 -24.652 28.934 1.00 65.39 H +ATOM 658 HA LEU A 57 10.716 -22.442 30.850 1.00 66.24 H +ATOM 659 HB3 LEU A 57 11.462 -24.359 32.369 1.00 65.98 H +ATOM 660 HB2 LEU A 57 10.814 -25.505 31.246 1.00 65.98 H +ATOM 661 HG LEU A 57 9.490 -25.064 33.273 1.00 66.38 H +ATOM 662 HD11 LEU A 57 8.654 -23.084 33.991 1.00 66.32 H +ATOM 663 HD12 LEU A 57 9.951 -22.404 33.034 1.00 66.32 H +ATOM 664 HD13 LEU A 57 8.323 -22.467 32.379 1.00 66.32 H +ATOM 665 HD21 LEU A 57 7.600 -25.731 32.291 1.00 66.04 H +ATOM 666 HD22 LEU A 57 7.417 -24.270 31.337 1.00 66.04 H +ATOM 667 HD23 LEU A 57 8.444 -25.576 30.766 1.00 66.04 H +ATOM 668 N ALA A 58 13.282 -23.106 30.847 1.00 67.23 N +ATOM 669 CA ALA A 58 14.722 -23.288 30.626 1.00 66.48 C +ATOM 670 C ALA A 58 15.191 -24.760 30.712 1.00 65.87 C +ATOM 671 O ALA A 58 16.263 -25.069 30.194 1.00 66.21 O +ATOM 672 CB ALA A 58 15.487 -22.411 31.626 1.00 67.06 C +ATOM 673 H ALA A 58 13.015 -22.712 31.737 1.00 67.23 H +ATOM 674 HA ALA A 58 14.957 -22.932 29.621 1.00 66.48 H +ATOM 675 HB1 ALA A 58 16.565 -22.487 31.477 1.00 67.06 H +ATOM 676 HB2 ALA A 58 15.218 -21.360 31.512 1.00 67.06 H +ATOM 677 HB3 ALA A 58 15.274 -22.698 32.657 1.00 67.06 H +ATOM 678 N ASP A 59 14.380 -25.629 31.341 1.00 64.61 N +ATOM 679 CA ASP A 59 14.613 -27.069 31.489 1.00 62.91 C +ATOM 680 C ASP A 59 14.027 -27.872 30.301 1.00 61.47 C +ATOM 681 O ASP A 59 14.523 -28.958 30.004 1.00 60.79 O +ATOM 682 CB ASP A 59 14.013 -27.543 32.841 1.00 64.61 C +ATOM 683 CG ASP A 59 14.357 -28.965 33.326 1.00 65.60 C +ATOM 684 OD1 ASP A 59 13.610 -29.438 34.211 1.00 65.91 O +ATOM 685 OD2 ASP A 59 15.424 -29.494 32.945 1.00 67.03 O1- +ATOM 686 H ASP A 59 13.523 -25.285 31.747 1.00 64.61 H +ATOM 687 HA ASP A 59 15.691 -27.240 31.504 1.00 62.91 H +ATOM 688 HB3 ASP A 59 12.928 -27.426 32.808 1.00 64.61 H +ATOM 689 HB2 ASP A 59 14.339 -26.855 33.623 1.00 64.61 H +ATOM 690 N LYS A 60 12.988 -27.332 29.640 1.00 60.27 N +ATOM 691 CA LYS A 60 12.234 -27.994 28.574 1.00 58.55 C +ATOM 692 C LYS A 60 11.502 -26.919 27.763 1.00 57.58 C +ATOM 693 O LYS A 60 10.641 -26.249 28.329 1.00 58.16 O +ATOM 694 CB LYS A 60 11.246 -29.008 29.208 1.00 58.27 C +ATOM 695 CG LYS A 60 10.230 -29.648 28.237 1.00 57.51 C +ATOM 696 CD LYS A 60 9.083 -30.356 28.971 1.00 57.75 C +ATOM 697 CE LYS A 60 7.980 -30.820 28.007 1.00 57.66 C +ATOM 698 NZ LYS A 60 6.835 -31.403 28.728 1.00 59.13 N1+ +ATOM 699 H LYS A 60 12.654 -26.418 29.908 1.00 60.27 H +ATOM 700 HA LYS A 60 12.925 -28.524 27.916 1.00 58.55 H +ATOM 701 HB3 LYS A 60 10.685 -28.487 29.985 1.00 58.27 H +ATOM 702 HB2 LYS A 60 11.796 -29.797 29.723 1.00 58.27 H +ATOM 703 HG3 LYS A 60 10.746 -30.354 27.585 1.00 57.51 H +ATOM 704 HG2 LYS A 60 9.787 -28.901 27.578 1.00 57.51 H +ATOM 705 HD3 LYS A 60 8.663 -29.680 29.719 1.00 57.75 H +ATOM 706 HD2 LYS A 60 9.484 -31.210 29.519 1.00 57.75 H +ATOM 707 HE3 LYS A 60 8.374 -31.558 27.308 1.00 57.66 H +ATOM 708 HE2 LYS A 60 7.615 -29.979 27.416 1.00 57.66 H +ATOM 709 HZ1 LYS A 60 6.441 -30.714 29.352 1.00 59.13 H +ATOM 710 HZ2 LYS A 60 6.132 -31.697 28.064 1.00 59.13 H +ATOM 711 HZ3 LYS A 60 7.144 -32.202 29.263 1.00 59.13 H +ATOM 712 N SER A 61 11.804 -26.800 26.461 1.00 55.59 N +ATOM 713 CA SER A 61 11.184 -25.804 25.584 1.00 52.94 C +ATOM 714 C SER A 61 11.201 -26.196 24.105 1.00 51.62 C +ATOM 715 O SER A 61 12.091 -26.917 23.654 1.00 50.85 O +ATOM 716 CB SER A 61 11.836 -24.420 25.787 1.00 53.73 C +ATOM 717 OG SER A 61 13.243 -24.448 25.640 1.00 53.69 O +ATOM 718 H SER A 61 12.502 -27.395 26.037 1.00 55.59 H +ATOM 719 HA SER A 61 10.130 -25.722 25.859 1.00 52.94 H +ATOM 720 HB3 SER A 61 11.550 -23.993 26.742 1.00 53.73 H +ATOM 721 HB2 SER A 61 11.464 -23.725 25.037 1.00 53.73 H +ATOM 722 HG SER A 61 13.613 -24.916 26.393 1.00 53.69 H +ATOM 723 N SER A 62 10.226 -25.619 23.385 1.00 49.47 N +ATOM 724 CA SER A 62 10.166 -25.547 21.930 1.00 48.07 C +ATOM 725 C SER A 62 10.924 -24.301 21.439 1.00 46.24 C +ATOM 726 O SER A 62 10.928 -23.273 22.124 1.00 45.55 O +ATOM 727 CB SER A 62 8.681 -25.529 21.509 1.00 47.76 C +ATOM 728 OG SER A 62 8.012 -24.350 21.921 1.00 48.25 O +ATOM 729 H SER A 62 9.546 -25.042 23.859 1.00 49.47 H +ATOM 730 HA SER A 62 10.634 -26.439 21.509 1.00 48.07 H +ATOM 731 HB3 SER A 62 8.157 -26.394 21.918 1.00 47.76 H +ATOM 732 HB2 SER A 62 8.601 -25.603 20.423 1.00 47.76 H +ATOM 733 HG SER A 62 8.378 -23.607 21.434 1.00 48.25 H +ATOM 734 N ARG A 63 11.545 -24.421 20.255 1.00 44.90 N +ATOM 735 CA ARG A 63 12.338 -23.359 19.639 1.00 44.08 C +ATOM 736 C ARG A 63 12.109 -23.317 18.121 1.00 42.93 C +ATOM 737 O ARG A 63 11.867 -24.360 17.511 1.00 42.40 O +ATOM 738 CB ARG A 63 13.844 -23.546 19.956 1.00 45.10 C +ATOM 739 CG ARG A 63 14.193 -23.757 21.448 1.00 45.50 C +ATOM 740 CD ARG A 63 15.702 -23.796 21.744 1.00 47.24 C +ATOM 741 NE ARG A 63 16.331 -22.470 21.625 1.00 48.56 N +ATOM 742 CZ ARG A 63 16.618 -21.599 22.607 1.00 50.82 C +ATOM 743 NH1 ARG A 63 17.148 -20.416 22.281 1.00 50.08 N +ATOM 744 NH2 ARG A 63 16.394 -21.879 23.899 1.00 53.19 N1+ +ATOM 745 H ARG A 63 11.485 -25.284 19.733 1.00 44.90 H +ATOM 746 HA ARG A 63 11.999 -22.409 20.047 1.00 44.08 H +ATOM 747 HB3 ARG A 63 14.386 -22.681 19.572 1.00 45.10 H +ATOM 748 HB2 ARG A 63 14.222 -24.405 19.400 1.00 45.10 H +ATOM 749 HG3 ARG A 63 13.721 -24.643 21.872 1.00 45.50 H +ATOM 750 HG2 ARG A 63 13.765 -22.912 21.986 1.00 45.50 H +ATOM 751 HD3 ARG A 63 16.183 -24.375 20.955 1.00 47.24 H +ATOM 752 HD2 ARG A 63 15.931 -24.323 22.671 1.00 47.24 H +ATOM 753 HE ARG A 63 16.567 -22.205 20.675 1.00 48.56 H +ATOM 754 HH12 ARG A 63 17.389 -19.747 22.998 1.00 50.08 H +ATOM 755 HH11 ARG A 63 17.317 -20.176 21.313 1.00 50.08 H +ATOM 756 HH22 ARG A 63 16.697 -21.240 24.619 1.00 53.19 H +ATOM 757 HH21 ARG A 63 16.017 -22.779 24.158 1.00 53.19 H +ATOM 758 N LYS A 64 12.243 -22.113 17.542 1.00 42.57 N +ATOM 759 CA LYS A 64 12.290 -21.874 16.099 1.00 41.26 C +ATOM 760 C LYS A 64 13.727 -21.515 15.707 1.00 38.78 C +ATOM 761 O LYS A 64 14.285 -20.579 16.277 1.00 38.88 O +ATOM 762 CB LYS A 64 11.341 -20.719 15.719 1.00 43.63 C +ATOM 763 CG LYS A 64 9.853 -21.103 15.742 1.00 47.59 C +ATOM 764 CD LYS A 64 8.963 -19.947 15.245 1.00 49.93 C +ATOM 765 CE LYS A 64 7.452 -20.233 15.277 1.00 51.92 C +ATOM 766 NZ LYS A 64 6.896 -20.212 16.643 1.00 52.03 N1+ +ATOM 767 H LYS A 64 12.452 -21.312 18.124 1.00 42.57 H +ATOM 768 HA LYS A 64 11.987 -22.768 15.550 1.00 41.26 H +ATOM 769 HB3 LYS A 64 11.573 -20.396 14.702 1.00 43.63 H +ATOM 770 HB2 LYS A 64 11.521 -19.851 16.356 1.00 43.63 H +ATOM 771 HG3 LYS A 64 9.567 -21.418 16.744 1.00 47.59 H +ATOM 772 HG2 LYS A 64 9.698 -21.971 15.100 1.00 47.59 H +ATOM 773 HD3 LYS A 64 9.240 -19.718 14.216 1.00 49.93 H +ATOM 774 HD2 LYS A 64 9.182 -19.042 15.811 1.00 49.93 H +ATOM 775 HE3 LYS A 64 7.235 -21.193 14.807 1.00 51.92 H +ATOM 776 HE2 LYS A 64 6.929 -19.471 14.698 1.00 51.92 H +ATOM 777 HZ1 LYS A 64 7.349 -20.921 17.203 1.00 52.03 H +ATOM 778 HZ2 LYS A 64 7.054 -19.304 17.057 1.00 52.03 H +ATOM 779 HZ3 LYS A 64 5.904 -20.396 16.605 1.00 52.03 H +ATOM 780 N THR A 65 14.279 -22.251 14.731 1.00 38.63 N +ATOM 781 CA THR A 65 15.624 -22.045 14.195 1.00 37.37 C +ATOM 782 C THR A 65 15.543 -21.489 12.763 1.00 37.22 C +ATOM 783 O THR A 65 14.638 -21.840 12.004 1.00 36.21 O +ATOM 784 CB THR A 65 16.422 -23.376 14.149 1.00 38.99 C +ATOM 785 OG1 THR A 65 15.835 -24.338 13.291 1.00 41.01 O +ATOM 786 CG2 THR A 65 16.615 -24.005 15.536 1.00 37.71 C +ATOM 787 H THR A 65 13.750 -22.996 14.299 1.00 38.63 H +ATOM 788 HA THR A 65 16.176 -21.339 14.813 1.00 37.37 H +ATOM 789 HB THR A 65 17.416 -23.169 13.748 1.00 38.99 H +ATOM 790 HG1 THR A 65 15.820 -23.986 12.397 1.00 41.01 H +ATOM 791 HG21 THR A 65 17.197 -24.926 15.470 1.00 37.71 H +ATOM 792 HG22 THR A 65 17.158 -23.326 16.189 1.00 37.71 H +ATOM 793 HG23 THR A 65 15.664 -24.247 16.012 1.00 37.71 H +ATOM 794 N TYR A 66 16.520 -20.633 12.437 1.00 35.89 N +ATOM 795 CA TYR A 66 16.673 -19.986 11.139 1.00 35.61 C +ATOM 796 C TYR A 66 18.160 -19.982 10.792 1.00 34.68 C +ATOM 797 O TYR A 66 18.961 -19.578 11.634 1.00 34.69 O +ATOM 798 CB TYR A 66 16.185 -18.525 11.219 1.00 35.24 C +ATOM 799 CG TYR A 66 14.757 -18.318 11.670 1.00 35.81 C +ATOM 800 CD1 TYR A 66 14.474 -18.140 13.042 1.00 36.83 C +ATOM 801 CD2 TYR A 66 13.711 -18.298 10.726 1.00 36.87 C +ATOM 802 CE1 TYR A 66 13.147 -17.964 13.471 1.00 37.60 C +ATOM 803 CE2 TYR A 66 12.385 -18.118 11.157 1.00 38.67 C +ATOM 804 CZ TYR A 66 12.101 -17.957 12.529 1.00 38.55 C +ATOM 805 OH TYR A 66 10.815 -17.800 12.953 1.00 40.55 O +ATOM 806 H TYR A 66 17.215 -20.385 13.128 1.00 35.89 H +ATOM 807 HA TYR A 66 16.119 -20.521 10.365 1.00 35.61 H +ATOM 808 HB3 TYR A 66 16.315 -18.038 10.252 1.00 35.24 H +ATOM 809 HB2 TYR A 66 16.813 -17.985 11.926 1.00 35.24 H +ATOM 810 HD1 TYR A 66 15.272 -18.152 13.770 1.00 36.83 H +ATOM 811 HD2 TYR A 66 13.922 -18.428 9.675 1.00 36.87 H +ATOM 812 HE1 TYR A 66 12.933 -17.841 14.523 1.00 37.60 H +ATOM 813 HE2 TYR A 66 11.590 -18.115 10.428 1.00 38.67 H +ATOM 814 HH TYR A 66 10.173 -17.850 12.234 1.00 40.55 H +ATOM 815 N THR A 67 18.492 -20.370 9.553 1.00 34.56 N +ATOM 816 CA THR A 67 19.838 -20.225 9.001 1.00 35.90 C +ATOM 817 C THR A 67 19.908 -18.928 8.175 1.00 34.33 C +ATOM 818 O THR A 67 18.936 -18.573 7.507 1.00 36.54 O +ATOM 819 CB THR A 67 20.212 -21.422 8.088 1.00 35.84 C +ATOM 820 OG1 THR A 67 20.182 -22.608 8.859 1.00 40.38 O +ATOM 821 CG2 THR A 67 21.604 -21.340 7.430 1.00 38.08 C +ATOM 822 H THR A 67 17.781 -20.696 8.915 1.00 34.56 H +ATOM 823 HA THR A 67 20.568 -20.176 9.809 1.00 35.90 H +ATOM 824 HB THR A 67 19.461 -21.532 7.303 1.00 35.84 H +ATOM 825 HG1 THR A 67 20.919 -22.602 9.475 1.00 40.38 H +ATOM 826 HG21 THR A 67 21.846 -22.267 6.910 1.00 38.08 H +ATOM 827 HG22 THR A 67 21.661 -20.541 6.690 1.00 38.08 H +ATOM 828 HG23 THR A 67 22.384 -21.164 8.173 1.00 38.08 H +ATOM 829 N PHE A 68 21.066 -18.259 8.238 1.00 33.30 N +ATOM 830 CA PHE A 68 21.389 -17.033 7.511 1.00 34.46 C +ATOM 831 C PHE A 68 22.759 -17.169 6.829 1.00 35.45 C +ATOM 832 O PHE A 68 23.421 -18.194 6.989 1.00 35.78 O +ATOM 833 CB PHE A 68 21.330 -15.843 8.491 1.00 32.88 C +ATOM 834 CG PHE A 68 19.921 -15.483 8.914 1.00 32.39 C +ATOM 835 CD1 PHE A 68 19.367 -16.013 10.098 1.00 30.02 C +ATOM 836 CD2 PHE A 68 19.095 -14.754 8.036 1.00 32.12 C +ATOM 837 CE1 PHE A 68 18.043 -15.746 10.414 1.00 32.75 C +ATOM 838 CE2 PHE A 68 17.775 -14.503 8.376 1.00 32.46 C +ATOM 839 CZ PHE A 68 17.250 -14.992 9.562 1.00 30.39 C +ATOM 840 H PHE A 68 21.812 -18.624 8.818 1.00 33.30 H +ATOM 841 HA PHE A 68 20.670 -16.864 6.708 1.00 34.46 H +ATOM 842 HB3 PHE A 68 21.772 -14.953 8.047 1.00 32.88 H +ATOM 843 HB2 PHE A 68 21.927 -16.056 9.378 1.00 32.88 H +ATOM 844 HD1 PHE A 68 19.971 -16.617 10.760 1.00 30.02 H +ATOM 845 HD2 PHE A 68 19.488 -14.390 7.099 1.00 32.12 H +ATOM 846 HE1 PHE A 68 17.621 -16.109 11.333 1.00 32.75 H +ATOM 847 HE2 PHE A 68 17.161 -13.925 7.710 1.00 32.46 H +ATOM 848 HZ PHE A 68 16.224 -14.788 9.826 1.00 30.39 H +ATOM 849 N ASP A 69 23.163 -16.140 6.066 1.00 35.34 N +ATOM 850 CA ASP A 69 24.493 -16.049 5.450 1.00 36.28 C +ATOM 851 C ASP A 69 25.610 -15.856 6.493 1.00 36.61 C +ATOM 852 O ASP A 69 26.680 -16.434 6.315 1.00 37.28 O +ATOM 853 CB ASP A 69 24.591 -14.990 4.326 1.00 36.93 C +ATOM 854 CG ASP A 69 23.641 -15.265 3.149 1.00 38.87 C +ATOM 855 OD1 ASP A 69 22.434 -14.959 3.276 1.00 40.13 O +ATOM 856 OD2 ASP A 69 24.112 -15.913 2.188 1.00 42.22 O1- +ATOM 857 H ASP A 69 22.567 -15.331 5.942 1.00 35.34 H +ATOM 858 HA ASP A 69 24.684 -17.016 4.980 1.00 36.28 H +ATOM 859 HB3 ASP A 69 25.615 -14.931 3.951 1.00 36.93 H +ATOM 860 HB2 ASP A 69 24.363 -14.000 4.722 1.00 36.93 H +ATOM 861 N MET A 70 25.328 -15.109 7.573 1.00 36.59 N +ATOM 862 CA MET A 70 26.141 -15.024 8.791 1.00 35.56 C +ATOM 863 C MET A 70 25.221 -14.753 9.990 1.00 34.74 C +ATOM 864 O MET A 70 24.092 -14.298 9.811 1.00 31.88 O +ATOM 865 CB MET A 70 27.245 -13.939 8.688 1.00 39.47 C +ATOM 866 CG MET A 70 28.322 -14.212 7.626 1.00 45.06 C +ATOM 867 SD MET A 70 29.760 -13.111 7.657 1.00 51.52 S +ATOM 868 CE MET A 70 29.062 -11.670 6.820 1.00 51.68 C +ATOM 869 H MET A 70 24.422 -14.665 7.634 1.00 36.59 H +ATOM 870 HA MET A 70 26.610 -15.994 8.966 1.00 35.56 H +ATOM 871 HB3 MET A 70 27.748 -13.844 9.652 1.00 39.47 H +ATOM 872 HB2 MET A 70 26.797 -12.965 8.505 1.00 39.47 H +ATOM 873 HG3 MET A 70 27.894 -14.157 6.626 1.00 45.06 H +ATOM 874 HG2 MET A 70 28.697 -15.228 7.752 1.00 45.06 H +ATOM 875 HE1 MET A 70 29.856 -10.977 6.548 1.00 51.68 H +ATOM 876 HE2 MET A 70 28.535 -11.960 5.911 1.00 51.68 H +ATOM 877 HE3 MET A 70 28.369 -11.165 7.488 1.00 51.68 H +ATOM 878 N VAL A 71 25.721 -15.024 11.204 1.00 32.66 N +ATOM 879 CA VAL A 71 25.039 -14.676 12.450 1.00 31.78 C +ATOM 880 C VAL A 71 26.083 -14.187 13.464 1.00 32.81 C +ATOM 881 O VAL A 71 27.161 -14.770 13.568 1.00 31.61 O +ATOM 882 CB VAL A 71 24.218 -15.858 13.050 1.00 31.25 C +ATOM 883 CG1 VAL A 71 23.634 -15.563 14.447 1.00 33.70 C +ATOM 884 CG2 VAL A 71 23.070 -16.276 12.115 1.00 33.69 C +ATOM 885 H VAL A 71 26.654 -15.397 11.301 1.00 32.66 H +ATOM 886 HA VAL A 71 24.354 -13.848 12.264 1.00 31.78 H +ATOM 887 HB VAL A 71 24.876 -16.723 13.154 1.00 31.25 H +ATOM 888 HG11 VAL A 71 22.986 -16.367 14.791 1.00 33.70 H +ATOM 889 HG12 VAL A 71 24.415 -15.453 15.197 1.00 33.70 H +ATOM 890 HG13 VAL A 71 23.042 -14.647 14.442 1.00 33.70 H +ATOM 891 HG21 VAL A 71 22.454 -17.056 12.556 1.00 33.69 H +ATOM 892 HG22 VAL A 71 22.414 -15.436 11.887 1.00 33.69 H +ATOM 893 HG23 VAL A 71 23.449 -16.666 11.172 1.00 33.69 H +ATOM 894 N PHE A 72 25.719 -13.119 14.185 1.00 31.41 N +ATOM 895 CA PHE A 72 26.526 -12.450 15.196 1.00 30.44 C +ATOM 896 C PHE A 72 25.753 -12.437 16.520 1.00 33.41 C +ATOM 897 O PHE A 72 24.587 -12.040 16.544 1.00 34.20 O +ATOM 898 CB PHE A 72 26.847 -11.021 14.712 1.00 31.40 C +ATOM 899 CG PHE A 72 27.760 -10.979 13.499 1.00 31.93 C +ATOM 900 CD1 PHE A 72 29.136 -11.266 13.630 1.00 29.89 C +ATOM 901 CD2 PHE A 72 27.205 -10.842 12.208 1.00 33.00 C +ATOM 902 CE1 PHE A 72 29.929 -11.384 12.496 1.00 31.75 C +ATOM 903 CE2 PHE A 72 28.014 -10.967 11.089 1.00 32.57 C +ATOM 904 CZ PHE A 72 29.364 -11.249 11.234 1.00 33.90 C +ATOM 905 H PHE A 72 24.816 -12.695 14.010 1.00 31.41 H +ATOM 906 HA PHE A 72 27.465 -12.985 15.353 1.00 30.44 H +ATOM 907 HB3 PHE A 72 27.306 -10.456 15.517 1.00 31.40 H +ATOM 908 HB2 PHE A 72 25.931 -10.482 14.472 1.00 31.40 H +ATOM 909 HD1 PHE A 72 29.570 -11.420 14.606 1.00 29.89 H +ATOM 910 HD2 PHE A 72 26.147 -10.667 12.084 1.00 33.00 H +ATOM 911 HE1 PHE A 72 30.981 -11.610 12.593 1.00 31.75 H +ATOM 912 HE2 PHE A 72 27.585 -10.874 10.101 1.00 32.57 H +ATOM 913 HZ PHE A 72 29.965 -11.388 10.350 1.00 33.90 H +ATOM 914 N GLY A 73 26.425 -12.873 17.595 1.00 33.64 N +ATOM 915 CA GLY A 73 25.866 -12.923 18.944 1.00 32.52 C +ATOM 916 C GLY A 73 26.119 -11.609 19.694 1.00 32.30 C +ATOM 917 O GLY A 73 26.727 -10.675 19.171 1.00 31.71 O +ATOM 918 H GLY A 73 27.381 -13.180 17.486 1.00 33.64 H +ATOM 919 HA3 GLY A 73 26.341 -13.742 19.485 1.00 32.52 H +ATOM 920 HA2 GLY A 73 24.796 -13.133 18.922 1.00 32.52 H +ATOM 921 N ALA A 74 25.654 -11.570 20.953 1.00 32.62 N +ATOM 922 CA ALA A 74 25.782 -10.462 21.907 1.00 32.76 C +ATOM 923 C ALA A 74 27.219 -9.977 22.186 1.00 33.54 C +ATOM 924 O ALA A 74 27.400 -8.803 22.505 1.00 34.23 O +ATOM 925 CB ALA A 74 25.111 -10.902 23.215 1.00 33.34 C +ATOM 926 H ALA A 74 25.162 -12.377 21.306 1.00 32.62 H +ATOM 927 HA ALA A 74 25.233 -9.608 21.511 1.00 32.76 H +ATOM 928 HB1 ALA A 74 25.340 -10.228 24.037 1.00 33.34 H +ATOM 929 HB2 ALA A 74 24.026 -10.938 23.104 1.00 33.34 H +ATOM 930 HB3 ALA A 74 25.445 -11.895 23.519 1.00 33.34 H +ATOM 931 N SER A 75 28.206 -10.877 22.054 1.00 34.01 N +ATOM 932 CA SER A 75 29.630 -10.609 22.262 1.00 34.43 C +ATOM 933 C SER A 75 30.325 -9.871 21.098 1.00 34.89 C +ATOM 934 O SER A 75 31.456 -9.423 21.286 1.00 35.01 O +ATOM 935 CB SER A 75 30.322 -11.951 22.582 1.00 34.37 C +ATOM 936 OG SER A 75 30.361 -12.814 21.460 1.00 36.98 O +ATOM 937 H SER A 75 27.980 -11.824 21.783 1.00 34.01 H +ATOM 938 HA SER A 75 29.725 -9.972 23.144 1.00 34.43 H +ATOM 939 HB3 SER A 75 29.817 -12.458 23.405 1.00 34.37 H +ATOM 940 HB2 SER A 75 31.348 -11.775 22.912 1.00 34.37 H +ATOM 941 HG SER A 75 31.027 -12.491 20.847 1.00 36.98 H +ATOM 942 N THR A 76 29.667 -9.780 19.928 1.00 34.17 N +ATOM 943 CA THR A 76 30.229 -9.228 18.694 1.00 32.21 C +ATOM 944 C THR A 76 30.534 -7.723 18.814 1.00 32.29 C +ATOM 945 O THR A 76 29.636 -6.940 19.122 1.00 33.66 O +ATOM 946 CB THR A 76 29.264 -9.433 17.497 1.00 32.67 C +ATOM 947 OG1 THR A 76 29.038 -10.820 17.342 1.00 34.27 O +ATOM 948 CG2 THR A 76 29.752 -8.888 16.145 1.00 30.68 C +ATOM 949 H THR A 76 28.727 -10.146 19.861 1.00 34.17 H +ATOM 950 HA THR A 76 31.157 -9.765 18.486 1.00 32.21 H +ATOM 951 HB THR A 76 28.303 -8.970 17.723 1.00 32.67 H +ATOM 952 HG1 THR A 76 28.499 -11.118 18.079 1.00 34.27 H +ATOM 953 HG21 THR A 76 28.994 -8.998 15.372 1.00 30.68 H +ATOM 954 HG22 THR A 76 29.980 -7.827 16.190 1.00 30.68 H +ATOM 955 HG23 THR A 76 30.641 -9.419 15.811 1.00 30.68 H +ATOM 956 N LYS A 77 31.793 -7.357 18.541 1.00 29.27 N +ATOM 957 CA LYS A 77 32.267 -5.976 18.504 1.00 30.93 C +ATOM 958 C LYS A 77 32.053 -5.354 17.115 1.00 29.85 C +ATOM 959 O LYS A 77 31.833 -6.067 16.137 1.00 28.59 O +ATOM 960 CB LYS A 77 33.761 -5.957 18.893 1.00 30.84 C +ATOM 961 CG LYS A 77 34.063 -6.449 20.324 1.00 33.75 C +ATOM 962 CD LYS A 77 33.336 -5.696 21.455 1.00 39.24 C +ATOM 963 CE LYS A 77 33.618 -4.182 21.480 1.00 41.33 C +ATOM 964 NZ LYS A 77 32.957 -3.518 22.617 1.00 40.00 N1+ +ATOM 965 H LYS A 77 32.469 -8.065 18.279 1.00 29.27 H +ATOM 966 HA LYS A 77 31.702 -5.374 19.217 1.00 30.93 H +ATOM 967 HB3 LYS A 77 34.155 -4.946 18.786 1.00 30.84 H +ATOM 968 HB2 LYS A 77 34.328 -6.566 18.189 1.00 30.84 H +ATOM 969 HG3 LYS A 77 35.138 -6.386 20.493 1.00 33.75 H +ATOM 970 HG2 LYS A 77 33.822 -7.511 20.396 1.00 33.75 H +ATOM 971 HD3 LYS A 77 33.645 -6.137 22.405 1.00 39.24 H +ATOM 972 HD2 LYS A 77 32.263 -5.882 21.388 1.00 39.24 H +ATOM 973 HE3 LYS A 77 33.267 -3.708 20.563 1.00 41.33 H +ATOM 974 HE2 LYS A 77 34.692 -3.999 21.546 1.00 41.33 H +ATOM 975 HZ1 LYS A 77 33.292 -3.915 23.483 1.00 40.00 H +ATOM 976 HZ2 LYS A 77 33.164 -2.530 22.600 1.00 40.00 H +ATOM 977 HZ3 LYS A 77 31.957 -3.651 22.553 1.00 40.00 H +ATOM 978 N GLN A 78 32.143 -4.017 17.053 1.00 28.05 N +ATOM 979 CA GLN A 78 32.015 -3.236 15.820 1.00 27.78 C +ATOM 980 C GLN A 78 33.085 -3.566 14.763 1.00 28.95 C +ATOM 981 O GLN A 78 32.777 -3.556 13.572 1.00 25.92 O +ATOM 982 CB GLN A 78 32.124 -1.743 16.156 1.00 27.45 C +ATOM 983 CG GLN A 78 31.092 -1.171 17.144 1.00 25.90 C +ATOM 984 CD GLN A 78 29.726 -0.917 16.518 1.00 24.67 C +ATOM 985 OE1 GLN A 78 29.121 -1.813 15.941 1.00 25.98 O +ATOM 986 NE2 GLN A 78 29.217 0.305 16.656 1.00 22.88 N +ATOM 987 H GLN A 78 32.325 -3.488 17.893 1.00 28.05 H +ATOM 988 HA GLN A 78 31.040 -3.449 15.380 1.00 27.78 H +ATOM 989 HB3 GLN A 78 32.078 -1.186 15.221 1.00 27.45 H +ATOM 990 HB2 GLN A 78 33.113 -1.556 16.570 1.00 27.45 H +ATOM 991 HG3 GLN A 78 31.474 -0.219 17.501 1.00 25.90 H +ATOM 992 HG2 GLN A 78 30.980 -1.802 18.026 1.00 25.90 H +ATOM 993 HE22 GLN A 78 28.300 0.518 16.278 1.00 22.88 H +ATOM 994 HE21 GLN A 78 29.726 1.032 17.144 1.00 22.88 H +ATOM 995 N ILE A 79 34.312 -3.860 15.227 1.00 27.36 N +ATOM 996 CA ILE A 79 35.437 -4.293 14.400 1.00 29.06 C +ATOM 997 C ILE A 79 35.202 -5.674 13.749 1.00 27.29 C +ATOM 998 O ILE A 79 35.612 -5.864 12.606 1.00 27.78 O +ATOM 999 CB ILE A 79 36.767 -4.300 15.218 1.00 30.11 C +ATOM 1000 CG1 ILE A 79 38.034 -4.597 14.384 1.00 32.36 C +ATOM 1001 CG2 ILE A 79 36.739 -5.239 16.442 1.00 27.95 C +ATOM 1002 CD1 ILE A 79 38.249 -3.654 13.192 1.00 34.09 C +ATOM 1003 H ILE A 79 34.481 -3.839 16.222 1.00 27.36 H +ATOM 1004 HA ILE A 79 35.528 -3.560 13.597 1.00 29.06 H +ATOM 1005 HB ILE A 79 36.887 -3.288 15.609 1.00 30.11 H +ATOM 1006 HG13 ILE A 79 38.019 -5.628 14.037 1.00 32.36 H +ATOM 1007 HG12 ILE A 79 38.909 -4.524 15.030 1.00 32.36 H +ATOM 1008 HG21 ILE A 79 37.631 -5.104 17.055 1.00 27.95 H +ATOM 1009 HG22 ILE A 79 35.881 -5.043 17.081 1.00 27.95 H +ATOM 1010 HG23 ILE A 79 36.709 -6.287 16.149 1.00 27.95 H +ATOM 1011 HD11 ILE A 79 39.256 -3.766 12.789 1.00 34.09 H +ATOM 1012 HD12 ILE A 79 37.549 -3.863 12.383 1.00 34.09 H +ATOM 1013 HD13 ILE A 79 38.125 -2.612 13.483 1.00 34.09 H +ATOM 1014 N ASP A 80 34.496 -6.576 14.456 1.00 28.59 N +ATOM 1015 CA ASP A 80 34.096 -7.901 13.971 1.00 27.29 C +ATOM 1016 C ASP A 80 33.113 -7.801 12.795 1.00 29.89 C +ATOM 1017 O ASP A 80 33.333 -8.469 11.786 1.00 27.87 O +ATOM 1018 CB ASP A 80 33.499 -8.817 15.069 1.00 28.62 C +ATOM 1019 CG ASP A 80 34.316 -9.001 16.360 1.00 31.56 C +ATOM 1020 OD1 ASP A 80 33.704 -9.485 17.337 1.00 29.84 O +ATOM 1021 OD2 ASP A 80 35.545 -8.768 16.344 1.00 31.94 O1- +ATOM 1022 H ASP A 80 34.181 -6.339 15.385 1.00 28.59 H +ATOM 1023 HA ASP A 80 34.999 -8.385 13.593 1.00 27.29 H +ATOM 1024 HB3 ASP A 80 33.320 -9.811 14.655 1.00 28.62 H +ATOM 1025 HB2 ASP A 80 32.531 -8.417 15.362 1.00 28.62 H +ATOM 1026 N VAL A 81 32.088 -6.936 12.927 1.00 26.47 N +ATOM 1027 CA VAL A 81 31.121 -6.618 11.870 1.00 27.06 C +ATOM 1028 C VAL A 81 31.795 -5.975 10.643 1.00 27.68 C +ATOM 1029 O VAL A 81 31.490 -6.368 9.518 1.00 27.78 O +ATOM 1030 CB VAL A 81 29.992 -5.665 12.372 1.00 26.45 C +ATOM 1031 CG1 VAL A 81 29.049 -5.125 11.271 1.00 26.19 C +ATOM 1032 CG2 VAL A 81 29.156 -6.336 13.473 1.00 24.32 C +ATOM 1033 H VAL A 81 31.979 -6.430 13.796 1.00 26.47 H +ATOM 1034 HA VAL A 81 30.666 -7.557 11.547 1.00 27.06 H +ATOM 1035 HB VAL A 81 30.461 -4.793 12.830 1.00 26.45 H +ATOM 1036 HG11 VAL A 81 28.219 -4.569 11.705 1.00 26.19 H +ATOM 1037 HG12 VAL A 81 29.553 -4.438 10.591 1.00 26.19 H +ATOM 1038 HG13 VAL A 81 28.625 -5.937 10.679 1.00 26.19 H +ATOM 1039 HG21 VAL A 81 28.342 -5.691 13.801 1.00 24.32 H +ATOM 1040 HG22 VAL A 81 28.719 -7.274 13.129 1.00 24.32 H +ATOM 1041 HG23 VAL A 81 29.766 -6.549 14.348 1.00 24.32 H +ATOM 1042 N TYR A 82 32.711 -5.020 10.877 1.00 31.58 N +ATOM 1043 CA TYR A 82 33.408 -4.314 9.808 1.00 34.08 C +ATOM 1044 C TYR A 82 34.322 -5.230 8.971 1.00 34.35 C +ATOM 1045 O TYR A 82 34.248 -5.177 7.746 1.00 35.44 O +ATOM 1046 CB TYR A 82 34.152 -3.082 10.357 1.00 37.56 C +ATOM 1047 CG TYR A 82 34.718 -2.221 9.244 1.00 40.86 C +ATOM 1048 CD1 TYR A 82 36.027 -2.444 8.767 1.00 42.74 C +ATOM 1049 CD2 TYR A 82 33.891 -1.271 8.611 1.00 41.86 C +ATOM 1050 CE1 TYR A 82 36.479 -1.771 7.618 1.00 44.29 C +ATOM 1051 CE2 TYR A 82 34.356 -0.578 7.479 1.00 43.80 C +ATOM 1052 CZ TYR A 82 35.638 -0.849 6.968 1.00 45.95 C +ATOM 1053 OH TYR A 82 36.059 -0.227 5.834 1.00 47.94 O +ATOM 1054 H TYR A 82 32.915 -4.733 11.826 1.00 31.58 H +ATOM 1055 HA TYR A 82 32.635 -3.937 9.137 1.00 34.08 H +ATOM 1056 HB3 TYR A 82 34.951 -3.382 11.038 1.00 37.56 H +ATOM 1057 HB2 TYR A 82 33.465 -2.472 10.945 1.00 37.56 H +ATOM 1058 HD1 TYR A 82 36.662 -3.177 9.242 1.00 42.74 H +ATOM 1059 HD2 TYR A 82 32.887 -1.096 8.969 1.00 41.86 H +ATOM 1060 HE1 TYR A 82 37.464 -1.978 7.225 1.00 44.29 H +ATOM 1061 HE2 TYR A 82 33.716 0.140 6.990 1.00 43.80 H +ATOM 1062 HH TYR A 82 35.398 0.358 5.457 1.00 47.94 H +ATOM 1063 N ARG A 83 35.144 -6.056 9.637 1.00 33.61 N +ATOM 1064 CA ARG A 83 36.062 -7.003 8.998 1.00 33.79 C +ATOM 1065 C ARG A 83 35.344 -8.068 8.154 1.00 32.60 C +ATOM 1066 O ARG A 83 35.787 -8.337 7.039 1.00 31.20 O +ATOM 1067 CB ARG A 83 36.916 -7.697 10.076 1.00 33.24 C +ATOM 1068 CG ARG A 83 38.028 -6.810 10.662 1.00 34.93 C +ATOM 1069 CD ARG A 83 38.706 -7.420 11.905 1.00 36.32 C +ATOM 1070 NE ARG A 83 39.373 -8.706 11.627 1.00 35.56 N +ATOM 1071 CZ ARG A 83 40.584 -8.918 11.080 1.00 37.72 C +ATOM 1072 NH1 ARG A 83 41.398 -7.911 10.726 1.00 36.80 N +ATOM 1073 NH2 ARG A 83 40.987 -10.179 10.880 1.00 38.76 N1+ +ATOM 1074 H ARG A 83 35.147 -6.047 10.650 1.00 33.61 H +ATOM 1075 HA ARG A 83 36.721 -6.447 8.327 1.00 33.79 H +ATOM 1076 HB3 ARG A 83 37.394 -8.576 9.641 1.00 33.24 H +ATOM 1077 HB2 ARG A 83 36.269 -8.073 10.871 1.00 33.24 H +ATOM 1078 HG3 ARG A 83 37.666 -5.809 10.897 1.00 34.93 H +ATOM 1079 HG2 ARG A 83 38.775 -6.665 9.880 1.00 34.93 H +ATOM 1080 HD3 ARG A 83 37.937 -7.639 12.647 1.00 36.32 H +ATOM 1081 HD2 ARG A 83 39.382 -6.707 12.377 1.00 36.32 H +ATOM 1082 HE ARG A 83 38.815 -9.520 11.845 1.00 35.56 H +ATOM 1083 HH12 ARG A 83 42.302 -8.097 10.317 1.00 36.80 H +ATOM 1084 HH11 ARG A 83 41.108 -6.955 10.874 1.00 36.80 H +ATOM 1085 HH22 ARG A 83 41.891 -10.369 10.471 1.00 38.76 H +ATOM 1086 HH21 ARG A 83 40.394 -10.953 11.141 1.00 38.76 H +ATOM 1087 N SER A 84 34.278 -8.663 8.710 1.00 29.89 N +ATOM 1088 CA SER A 84 33.582 -9.798 8.109 1.00 33.65 C +ATOM 1089 C SER A 84 32.568 -9.419 7.016 1.00 31.73 C +ATOM 1090 O SER A 84 32.480 -10.167 6.042 1.00 32.56 O +ATOM 1091 CB SER A 84 32.952 -10.655 9.221 1.00 33.28 C +ATOM 1092 OG SER A 84 31.922 -9.959 9.888 1.00 42.99 O +ATOM 1093 H SER A 84 33.966 -8.380 9.629 1.00 29.89 H +ATOM 1094 HA SER A 84 34.335 -10.429 7.630 1.00 33.65 H +ATOM 1095 HB3 SER A 84 33.706 -10.959 9.949 1.00 33.28 H +ATOM 1096 HB2 SER A 84 32.531 -11.570 8.802 1.00 33.28 H +ATOM 1097 HG SER A 84 32.322 -9.382 10.548 1.00 42.99 H +ATOM 1098 N VAL A 85 31.824 -8.306 7.184 1.00 32.27 N +ATOM 1099 CA VAL A 85 30.730 -7.941 6.274 1.00 30.87 C +ATOM 1100 C VAL A 85 31.093 -6.724 5.402 1.00 30.01 C +ATOM 1101 O VAL A 85 30.891 -6.804 4.192 1.00 32.23 O +ATOM 1102 CB VAL A 85 29.327 -7.758 6.969 1.00 32.16 C +ATOM 1103 CG1 VAL A 85 29.183 -8.501 8.313 1.00 32.40 C +ATOM 1104 CG2 VAL A 85 28.748 -6.334 7.115 1.00 32.73 C +ATOM 1105 H VAL A 85 31.936 -7.737 8.012 1.00 32.27 H +ATOM 1106 HA VAL A 85 30.580 -8.754 5.561 1.00 30.87 H +ATOM 1107 HB VAL A 85 28.630 -8.267 6.301 1.00 32.16 H +ATOM 1108 HG11 VAL A 85 28.132 -8.636 8.573 1.00 32.40 H +ATOM 1109 HG12 VAL A 85 29.644 -9.484 8.296 1.00 32.40 H +ATOM 1110 HG13 VAL A 85 29.642 -7.955 9.132 1.00 32.40 H +ATOM 1111 HG21 VAL A 85 27.754 -6.367 7.561 1.00 32.73 H +ATOM 1112 HG22 VAL A 85 29.368 -5.726 7.770 1.00 32.73 H +ATOM 1113 HG23 VAL A 85 28.641 -5.821 6.159 1.00 32.73 H +ATOM 1114 N VAL A 86 31.615 -5.632 5.994 1.00 28.37 N +ATOM 1115 CA VAL A 86 31.777 -4.360 5.277 1.00 30.45 C +ATOM 1116 C VAL A 86 33.036 -4.309 4.402 1.00 32.51 C +ATOM 1117 O VAL A 86 32.955 -3.773 3.301 1.00 30.96 O +ATOM 1118 CB VAL A 86 31.848 -3.126 6.215 1.00 29.71 C +ATOM 1119 CG1 VAL A 86 31.919 -1.776 5.462 1.00 30.36 C +ATOM 1120 CG2 VAL A 86 30.674 -3.082 7.193 1.00 30.48 C +ATOM 1121 H VAL A 86 31.796 -5.626 6.988 1.00 28.37 H +ATOM 1122 HA VAL A 86 30.912 -4.223 4.625 1.00 30.45 H +ATOM 1123 HB VAL A 86 32.753 -3.199 6.818 1.00 29.71 H +ATOM 1124 HG11 VAL A 86 31.834 -0.938 6.151 1.00 30.36 H +ATOM 1125 HG12 VAL A 86 32.862 -1.638 4.933 1.00 30.36 H +ATOM 1126 HG13 VAL A 86 31.109 -1.683 4.738 1.00 30.36 H +ATOM 1127 HG21 VAL A 86 30.776 -2.198 7.812 1.00 30.48 H +ATOM 1128 HG22 VAL A 86 29.715 -3.038 6.676 1.00 30.48 H +ATOM 1129 HG23 VAL A 86 30.669 -3.938 7.865 1.00 30.48 H +ATOM 1130 N CYS A 87 34.171 -4.829 4.898 1.00 33.65 N +ATOM 1131 CA CYS A 87 35.466 -4.747 4.221 1.00 34.56 C +ATOM 1132 C CYS A 87 35.499 -5.428 2.826 1.00 33.22 C +ATOM 1133 O CYS A 87 35.979 -4.778 1.898 1.00 32.37 O +ATOM 1134 CB CYS A 87 36.637 -5.135 5.153 1.00 37.83 C +ATOM 1135 SG CYS A 87 38.257 -4.723 4.441 1.00 49.64 S +ATOM 1136 H CYS A 87 34.171 -5.234 5.826 1.00 33.65 H +ATOM 1137 HA CYS A 87 35.602 -3.681 4.026 1.00 34.56 H +ATOM 1138 HB3 CYS A 87 36.620 -6.192 5.414 1.00 37.83 H +ATOM 1139 HB2 CYS A 87 36.552 -4.586 6.092 1.00 37.83 H +ATOM 1140 HG CYS A 87 38.187 -5.585 3.422 1.00 49.64 H +ATOM 1141 N PRO A 88 34.877 -6.623 2.651 1.00 32.21 N +ATOM 1142 CA PRO A 88 34.634 -7.211 1.317 1.00 33.69 C +ATOM 1143 C PRO A 88 33.717 -6.386 0.393 1.00 34.06 C +ATOM 1144 O PRO A 88 34.009 -6.288 -0.798 1.00 33.78 O +ATOM 1145 CB PRO A 88 34.022 -8.593 1.617 1.00 33.34 C +ATOM 1146 CG PRO A 88 34.480 -8.924 3.025 1.00 30.72 C +ATOM 1147 CD PRO A 88 34.482 -7.563 3.702 1.00 31.11 C +ATOM 1148 HA PRO A 88 35.606 -7.343 0.836 1.00 33.69 H +ATOM 1149 HB3 PRO A 88 34.328 -9.352 0.896 1.00 33.34 H +ATOM 1150 HB2 PRO A 88 32.931 -8.550 1.603 1.00 33.34 H +ATOM 1151 HG3 PRO A 88 35.497 -9.317 2.995 1.00 30.72 H +ATOM 1152 HG2 PRO A 88 33.849 -9.657 3.529 1.00 30.72 H +ATOM 1153 HD2 PRO A 88 33.478 -7.319 4.039 1.00 31.11 H +ATOM 1154 HD3 PRO A 88 35.141 -7.565 4.566 1.00 31.11 H +ATOM 1155 N ILE A 89 32.637 -5.810 0.955 1.00 33.67 N +ATOM 1156 CA ILE A 89 31.678 -4.963 0.237 1.00 32.79 C +ATOM 1157 C ILE A 89 32.318 -3.647 -0.250 1.00 33.05 C +ATOM 1158 O ILE A 89 32.088 -3.270 -1.398 1.00 33.90 O +ATOM 1159 CB ILE A 89 30.408 -4.655 1.095 1.00 34.37 C +ATOM 1160 CG1 ILE A 89 29.592 -5.944 1.343 1.00 34.88 C +ATOM 1161 CG2 ILE A 89 29.476 -3.569 0.514 1.00 31.66 C +ATOM 1162 CD1 ILE A 89 28.557 -5.817 2.473 1.00 40.21 C +ATOM 1163 H ILE A 89 32.465 -5.932 1.943 1.00 33.67 H +ATOM 1164 HA ILE A 89 31.357 -5.514 -0.649 1.00 32.79 H +ATOM 1165 HB ILE A 89 30.747 -4.296 2.066 1.00 34.37 H +ATOM 1166 HG13 ILE A 89 30.254 -6.776 1.582 1.00 34.88 H +ATOM 1167 HG12 ILE A 89 29.083 -6.232 0.423 1.00 34.88 H +ATOM 1168 HG21 ILE A 89 28.588 -3.427 1.130 1.00 31.66 H +ATOM 1169 HG22 ILE A 89 29.954 -2.592 0.442 1.00 31.66 H +ATOM 1170 HG23 ILE A 89 29.140 -3.861 -0.479 1.00 31.66 H +ATOM 1171 HD11 ILE A 89 28.344 -6.790 2.915 1.00 40.21 H +ATOM 1172 HD12 ILE A 89 28.909 -5.164 3.271 1.00 40.21 H +ATOM 1173 HD13 ILE A 89 27.615 -5.412 2.109 1.00 40.21 H +ATOM 1174 N LEU A 90 33.136 -3.007 0.606 1.00 34.40 N +ATOM 1175 CA LEU A 90 33.893 -1.797 0.292 1.00 36.12 C +ATOM 1176 C LEU A 90 34.934 -2.024 -0.812 1.00 36.86 C +ATOM 1177 O LEU A 90 35.085 -1.142 -1.647 1.00 35.34 O +ATOM 1178 CB LEU A 90 34.528 -1.192 1.569 1.00 35.83 C +ATOM 1179 CG LEU A 90 35.307 0.134 1.353 1.00 37.20 C +ATOM 1180 CD1 LEU A 90 34.436 1.251 0.742 1.00 39.93 C +ATOM 1181 CD2 LEU A 90 36.004 0.598 2.643 1.00 37.31 C +ATOM 1182 H LEU A 90 33.258 -3.378 1.541 1.00 34.40 H +ATOM 1183 HA LEU A 90 33.165 -1.083 -0.095 1.00 36.12 H +ATOM 1184 HB3 LEU A 90 35.196 -1.934 2.010 1.00 35.83 H +ATOM 1185 HB2 LEU A 90 33.744 -1.024 2.310 1.00 35.83 H +ATOM 1186 HG LEU A 90 36.119 -0.063 0.652 1.00 37.20 H +ATOM 1187 HD11 LEU A 90 34.560 2.196 1.266 1.00 39.93 H +ATOM 1188 HD12 LEU A 90 34.701 1.426 -0.301 1.00 39.93 H +ATOM 1189 HD13 LEU A 90 33.373 1.013 0.776 1.00 39.93 H +ATOM 1190 HD21 LEU A 90 36.930 1.130 2.418 1.00 37.31 H +ATOM 1191 HD22 LEU A 90 35.375 1.265 3.234 1.00 37.31 H +ATOM 1192 HD23 LEU A 90 36.270 -0.252 3.270 1.00 37.31 H +ATOM 1193 N ASP A 91 35.598 -3.193 -0.840 1.00 36.65 N +ATOM 1194 CA ASP A 91 36.536 -3.564 -1.910 1.00 39.50 C +ATOM 1195 C ASP A 91 35.874 -3.637 -3.290 1.00 39.38 C +ATOM 1196 O ASP A 91 36.474 -3.162 -4.251 1.00 39.21 O +ATOM 1197 CB ASP A 91 37.327 -4.862 -1.621 1.00 39.23 C +ATOM 1198 CG ASP A 91 38.243 -4.809 -0.389 1.00 42.38 C +ATOM 1199 OD1 ASP A 91 38.630 -3.692 0.019 1.00 41.38 O +ATOM 1200 OD2 ASP A 91 38.656 -5.900 0.061 1.00 43.09 O1- +ATOM 1201 H ASP A 91 35.449 -3.878 -0.112 1.00 36.65 H +ATOM 1202 HA ASP A 91 37.255 -2.745 -1.986 1.00 39.50 H +ATOM 1203 HB3 ASP A 91 37.948 -5.118 -2.481 1.00 39.23 H +ATOM 1204 HB2 ASP A 91 36.626 -5.687 -1.482 1.00 39.23 H +ATOM 1205 N GLU A 92 34.636 -4.153 -3.357 1.00 38.83 N +ATOM 1206 CA GLU A 92 33.822 -4.130 -4.570 1.00 39.48 C +ATOM 1207 C GLU A 92 33.406 -2.704 -4.992 1.00 38.74 C +ATOM 1208 O GLU A 92 33.427 -2.412 -6.187 1.00 36.80 O +ATOM 1209 CB GLU A 92 32.677 -5.155 -4.437 1.00 41.28 C +ATOM 1210 CG GLU A 92 31.664 -5.155 -5.606 1.00 42.07 C +ATOM 1211 CD GLU A 92 30.783 -6.408 -5.738 1.00 44.04 C +ATOM 1212 OE1 GLU A 92 31.165 -7.481 -5.219 1.00 41.66 O +ATOM 1213 OE2 GLU A 92 29.716 -6.276 -6.378 1.00 43.65 O1- +ATOM 1214 H GLU A 92 34.199 -4.522 -2.524 1.00 38.83 H +ATOM 1215 HA GLU A 92 34.456 -4.501 -5.378 1.00 39.48 H +ATOM 1216 HB3 GLU A 92 32.142 -5.003 -3.499 1.00 41.28 H +ATOM 1217 HB2 GLU A 92 33.151 -6.134 -4.349 1.00 41.28 H +ATOM 1218 HG3 GLU A 92 32.197 -5.039 -6.550 1.00 42.07 H +ATOM 1219 HG2 GLU A 92 31.013 -4.287 -5.499 1.00 42.07 H +ATOM 1220 N VAL A 93 33.139 -1.814 -4.019 1.00 37.58 N +ATOM 1221 CA VAL A 93 32.923 -0.380 -4.251 1.00 39.39 C +ATOM 1222 C VAL A 93 34.175 0.314 -4.837 1.00 39.94 C +ATOM 1223 O VAL A 93 34.025 1.084 -5.783 1.00 38.57 O +ATOM 1224 CB VAL A 93 32.449 0.365 -2.966 1.00 39.78 C +ATOM 1225 CG1 VAL A 93 32.354 1.898 -3.088 1.00 38.88 C +ATOM 1226 CG2 VAL A 93 31.106 -0.188 -2.478 1.00 39.30 C +ATOM 1227 H VAL A 93 33.145 -2.116 -3.054 1.00 37.58 H +ATOM 1228 HA VAL A 93 32.130 -0.298 -4.994 1.00 39.39 H +ATOM 1229 HB VAL A 93 33.162 0.174 -2.172 1.00 39.78 H +ATOM 1230 HG11 VAL A 93 31.929 2.340 -2.186 1.00 38.88 H +ATOM 1231 HG12 VAL A 93 33.328 2.363 -3.237 1.00 38.88 H +ATOM 1232 HG13 VAL A 93 31.716 2.176 -3.922 1.00 38.88 H +ATOM 1233 HG21 VAL A 93 30.928 0.081 -1.439 1.00 39.30 H +ATOM 1234 HG22 VAL A 93 30.281 0.183 -3.087 1.00 39.30 H +ATOM 1235 HG23 VAL A 93 31.073 -1.272 -2.519 1.00 39.30 H +ATOM 1236 N ILE A 94 35.381 -0.018 -4.332 1.00 39.41 N +ATOM 1237 CA ILE A 94 36.664 0.464 -4.868 1.00 41.12 C +ATOM 1238 C ILE A 94 36.959 -0.065 -6.295 1.00 42.53 C +ATOM 1239 O ILE A 94 37.577 0.656 -7.077 1.00 42.63 O +ATOM 1240 CB ILE A 94 37.881 0.141 -3.934 1.00 41.77 C +ATOM 1241 CG1 ILE A 94 37.738 0.693 -2.491 1.00 41.96 C +ATOM 1242 CG2 ILE A 94 39.247 0.594 -4.501 1.00 41.60 C +ATOM 1243 CD1 ILE A 94 37.118 2.090 -2.355 1.00 42.93 C +ATOM 1244 H ILE A 94 35.433 -0.655 -3.548 1.00 39.41 H +ATOM 1245 HA ILE A 94 36.581 1.547 -4.959 1.00 41.12 H +ATOM 1246 HB ILE A 94 37.938 -0.944 -3.835 1.00 41.77 H +ATOM 1247 HG13 ILE A 94 38.703 0.678 -1.982 1.00 41.96 H +ATOM 1248 HG12 ILE A 94 37.141 0.003 -1.907 1.00 41.96 H +ATOM 1249 HG21 ILE A 94 40.053 0.409 -3.791 1.00 41.60 H +ATOM 1250 HG22 ILE A 94 39.524 0.059 -5.409 1.00 41.60 H +ATOM 1251 HG23 ILE A 94 39.249 1.660 -4.727 1.00 41.60 H +ATOM 1252 HD11 ILE A 94 37.408 2.554 -1.412 1.00 42.93 H +ATOM 1253 HD12 ILE A 94 37.428 2.758 -3.160 1.00 42.93 H +ATOM 1254 HD13 ILE A 94 36.031 2.027 -2.368 1.00 42.93 H +ATOM 1255 N MET A 95 36.451 -1.262 -6.647 1.00 42.42 N +ATOM 1256 CA MET A 95 36.461 -1.797 -8.018 1.00 44.90 C +ATOM 1257 C MET A 95 35.496 -1.076 -8.985 1.00 45.13 C +ATOM 1258 O MET A 95 35.525 -1.380 -10.177 1.00 44.37 O +ATOM 1259 CB MET A 95 36.185 -3.314 -8.011 1.00 46.53 C +ATOM 1260 CG MET A 95 37.313 -4.150 -7.394 1.00 50.85 C +ATOM 1261 SD MET A 95 36.937 -5.920 -7.288 1.00 55.62 S +ATOM 1262 CE MET A 95 37.130 -6.386 -9.029 1.00 55.21 C +ATOM 1263 H MET A 95 35.964 -1.817 -5.956 1.00 42.42 H +ATOM 1264 HA MET A 95 37.461 -1.646 -8.428 1.00 44.90 H +ATOM 1265 HB3 MET A 95 36.038 -3.661 -9.034 1.00 46.53 H +ATOM 1266 HB2 MET A 95 35.251 -3.531 -7.499 1.00 46.53 H +ATOM 1267 HG3 MET A 95 37.548 -3.798 -6.393 1.00 50.85 H +ATOM 1268 HG2 MET A 95 38.227 -4.026 -7.975 1.00 50.85 H +ATOM 1269 HE1 MET A 95 36.999 -7.462 -9.143 1.00 55.21 H +ATOM 1270 HE2 MET A 95 36.388 -5.885 -9.650 1.00 55.21 H +ATOM 1271 HE3 MET A 95 38.124 -6.120 -9.389 1.00 55.21 H +ATOM 1272 N GLY A 96 34.701 -0.117 -8.485 1.00 43.95 N +ATOM 1273 CA GLY A 96 33.850 0.740 -9.300 1.00 42.59 C +ATOM 1274 C GLY A 96 32.426 0.183 -9.428 1.00 42.57 C +ATOM 1275 O GLY A 96 31.765 0.478 -10.423 1.00 41.48 O +ATOM 1276 H GLY A 96 34.728 0.080 -7.494 1.00 43.95 H +ATOM 1277 HA3 GLY A 96 34.283 0.899 -10.288 1.00 42.59 H +ATOM 1278 HA2 GLY A 96 33.806 1.714 -8.817 1.00 42.59 H +ATOM 1279 N TYR A 97 31.959 -0.616 -8.453 1.00 41.65 N +ATOM 1280 CA TYR A 97 30.594 -1.150 -8.403 1.00 41.71 C +ATOM 1281 C TYR A 97 29.727 -0.365 -7.413 1.00 38.76 C +ATOM 1282 O TYR A 97 30.233 0.370 -6.562 1.00 37.69 O +ATOM 1283 CB TYR A 97 30.624 -2.643 -8.016 1.00 45.44 C +ATOM 1284 CG TYR A 97 31.041 -3.583 -9.133 1.00 52.18 C +ATOM 1285 CD1 TYR A 97 32.369 -3.594 -9.610 1.00 54.66 C +ATOM 1286 CD2 TYR A 97 30.085 -4.446 -9.708 1.00 53.53 C +ATOM 1287 CE1 TYR A 97 32.728 -4.436 -10.680 1.00 57.85 C +ATOM 1288 CE2 TYR A 97 30.447 -5.296 -10.769 1.00 57.11 C +ATOM 1289 CZ TYR A 97 31.765 -5.284 -11.263 1.00 58.28 C +ATOM 1290 OH TYR A 97 32.105 -6.094 -12.307 1.00 60.52 O +ATOM 1291 H TYR A 97 32.551 -0.842 -7.666 1.00 41.65 H +ATOM 1292 HA TYR A 97 30.123 -1.070 -9.385 1.00 41.71 H +ATOM 1293 HB3 TYR A 97 29.632 -2.965 -7.695 1.00 45.44 H +ATOM 1294 HB2 TYR A 97 31.253 -2.798 -7.149 1.00 45.44 H +ATOM 1295 HD1 TYR A 97 33.115 -2.953 -9.166 1.00 54.66 H +ATOM 1296 HD2 TYR A 97 29.068 -4.456 -9.345 1.00 53.53 H +ATOM 1297 HE1 TYR A 97 33.744 -4.428 -11.046 1.00 57.85 H +ATOM 1298 HE2 TYR A 97 29.708 -5.950 -11.210 1.00 57.11 H +ATOM 1299 HH TYR A 97 33.026 -6.009 -12.564 1.00 60.52 H +ATOM 1300 N ASN A 98 28.411 -0.575 -7.554 1.00 36.08 N +ATOM 1301 CA ASN A 98 27.384 -0.057 -6.660 1.00 33.17 C +ATOM 1302 C ASN A 98 27.034 -1.142 -5.638 1.00 29.96 C +ATOM 1303 O ASN A 98 26.784 -2.287 -6.022 1.00 27.65 O +ATOM 1304 CB ASN A 98 26.144 0.359 -7.479 1.00 34.52 C +ATOM 1305 CG ASN A 98 26.423 1.507 -8.460 1.00 37.68 C +ATOM 1306 OD1 ASN A 98 27.249 2.378 -8.202 1.00 37.20 O +ATOM 1307 ND2 ASN A 98 25.727 1.517 -9.596 1.00 36.60 N +ATOM 1308 H ASN A 98 28.085 -1.200 -8.278 1.00 36.08 H +ATOM 1309 HA ASN A 98 27.764 0.825 -6.148 1.00 33.17 H +ATOM 1310 HB3 ASN A 98 25.353 0.691 -6.805 1.00 34.52 H +ATOM 1311 HB2 ASN A 98 25.747 -0.499 -8.024 1.00 34.52 H +ATOM 1312 HD22 ASN A 98 25.873 2.254 -10.270 1.00 36.60 H +ATOM 1313 HD21 ASN A 98 25.081 0.767 -9.813 1.00 36.60 H +ATOM 1314 N CYS A 99 27.016 -0.749 -4.358 1.00 28.42 N +ATOM 1315 CA CYS A 99 26.696 -1.611 -3.225 1.00 26.99 C +ATOM 1316 C CYS A 99 25.673 -0.908 -2.318 1.00 24.43 C +ATOM 1317 O CYS A 99 25.582 0.320 -2.325 1.00 23.39 O +ATOM 1318 CB CYS A 99 27.955 -1.985 -2.425 1.00 26.76 C +ATOM 1319 SG CYS A 99 29.011 -3.136 -3.354 1.00 30.41 S +ATOM 1320 H CYS A 99 27.243 0.211 -4.130 1.00 28.42 H +ATOM 1321 HA CYS A 99 26.241 -2.526 -3.591 1.00 26.99 H +ATOM 1322 HB3 CYS A 99 27.680 -2.458 -1.483 1.00 26.76 H +ATOM 1323 HB2 CYS A 99 28.525 -1.090 -2.189 1.00 26.76 H +ATOM 1324 HG CYS A 99 30.010 -3.165 -2.466 1.00 30.41 H +ATOM 1325 N THR A 100 24.921 -1.703 -1.543 1.00 23.88 N +ATOM 1326 CA THR A 100 23.961 -1.219 -0.553 1.00 23.96 C +ATOM 1327 C THR A 100 23.948 -2.173 0.649 1.00 24.20 C +ATOM 1328 O THR A 100 24.034 -3.385 0.467 1.00 24.93 O +ATOM 1329 CB THR A 100 22.521 -1.117 -1.133 1.00 21.66 C +ATOM 1330 OG1 THR A 100 22.493 -0.090 -2.101 1.00 23.67 O +ATOM 1331 CG2 THR A 100 21.398 -0.804 -0.122 1.00 20.28 C +ATOM 1332 H THR A 100 25.014 -2.708 -1.619 1.00 23.88 H +ATOM 1333 HA THR A 100 24.284 -0.238 -0.213 1.00 23.96 H +ATOM 1334 HB THR A 100 22.274 -2.046 -1.648 1.00 21.66 H +ATOM 1335 HG1 THR A 100 21.640 -0.127 -2.550 1.00 23.67 H +ATOM 1336 HG21 THR A 100 20.452 -0.608 -0.628 1.00 20.28 H +ATOM 1337 HG22 THR A 100 21.223 -1.636 0.560 1.00 20.28 H +ATOM 1338 HG23 THR A 100 21.637 0.074 0.478 1.00 20.28 H +ATOM 1339 N ILE A 101 23.827 -1.612 1.859 1.00 23.51 N +ATOM 1340 CA ILE A 101 23.663 -2.377 3.089 1.00 21.26 C +ATOM 1341 C ILE A 101 22.478 -1.766 3.854 1.00 20.88 C +ATOM 1342 O ILE A 101 22.540 -0.599 4.238 1.00 21.37 O +ATOM 1343 CB ILE A 101 24.924 -2.353 4.005 1.00 21.03 C +ATOM 1344 CG1 ILE A 101 26.227 -2.696 3.242 1.00 21.50 C +ATOM 1345 CG2 ILE A 101 24.751 -3.311 5.208 1.00 19.72 C +ATOM 1346 CD1 ILE A 101 27.506 -2.553 4.084 1.00 22.58 C +ATOM 1347 H ILE A 101 23.786 -0.604 1.949 1.00 23.51 H +ATOM 1348 HA ILE A 101 23.433 -3.418 2.864 1.00 21.26 H +ATOM 1349 HB ILE A 101 25.049 -1.341 4.391 1.00 21.03 H +ATOM 1350 HG13 ILE A 101 26.338 -2.050 2.372 1.00 21.50 H +ATOM 1351 HG12 ILE A 101 26.162 -3.711 2.852 1.00 21.50 H +ATOM 1352 HG21 ILE A 101 25.608 -3.268 5.879 1.00 19.72 H +ATOM 1353 HG22 ILE A 101 23.874 -3.074 5.811 1.00 19.72 H +ATOM 1354 HG23 ILE A 101 24.646 -4.344 4.877 1.00 19.72 H +ATOM 1355 HD11 ILE A 101 28.371 -2.365 3.448 1.00 22.58 H +ATOM 1356 HD12 ILE A 101 27.433 -1.726 4.791 1.00 22.58 H +ATOM 1357 HD13 ILE A 101 27.708 -3.461 4.651 1.00 22.58 H +ATOM 1358 N PHE A 102 21.428 -2.574 4.056 1.00 20.90 N +ATOM 1359 CA PHE A 102 20.280 -2.239 4.896 1.00 21.42 C +ATOM 1360 C PHE A 102 20.543 -2.625 6.359 1.00 22.24 C +ATOM 1361 O PHE A 102 21.201 -3.632 6.615 1.00 22.50 O +ATOM 1362 CB PHE A 102 19.023 -2.974 4.390 1.00 21.24 C +ATOM 1363 CG PHE A 102 18.434 -2.482 3.079 1.00 24.65 C +ATOM 1364 CD1 PHE A 102 17.545 -1.388 3.071 1.00 24.59 C +ATOM 1365 CD2 PHE A 102 18.848 -3.032 1.847 1.00 23.12 C +ATOM 1366 CE1 PHE A 102 17.011 -0.931 1.874 1.00 27.89 C +ATOM 1367 CE2 PHE A 102 18.315 -2.550 0.657 1.00 26.02 C +ATOM 1368 CZ PHE A 102 17.391 -1.513 0.671 1.00 25.24 C +ATOM 1369 H PHE A 102 21.449 -3.517 3.690 1.00 20.90 H +ATOM 1370 HA PHE A 102 20.086 -1.169 4.849 1.00 21.42 H +ATOM 1371 HB3 PHE A 102 18.231 -2.908 5.138 1.00 21.24 H +ATOM 1372 HB2 PHE A 102 19.243 -4.035 4.295 1.00 21.24 H +ATOM 1373 HD1 PHE A 102 17.263 -0.913 3.999 1.00 24.59 H +ATOM 1374 HD2 PHE A 102 19.564 -3.840 1.828 1.00 23.12 H +ATOM 1375 HE1 PHE A 102 16.305 -0.114 1.877 1.00 27.89 H +ATOM 1376 HE2 PHE A 102 18.617 -2.981 -0.285 1.00 26.02 H +ATOM 1377 HZ PHE A 102 16.978 -1.148 -0.258 1.00 25.24 H +ATOM 1378 N ALA A 103 19.945 -1.860 7.281 1.00 19.47 N +ATOM 1379 CA ALA A 103 19.755 -2.227 8.677 1.00 20.05 C +ATOM 1380 C ALA A 103 18.246 -2.264 8.921 1.00 19.29 C +ATOM 1381 O ALA A 103 17.575 -1.250 8.726 1.00 18.27 O +ATOM 1382 CB ALA A 103 20.464 -1.237 9.610 1.00 18.35 C +ATOM 1383 H ALA A 103 19.478 -1.012 6.990 1.00 19.47 H +ATOM 1384 HA ALA A 103 20.173 -3.213 8.870 1.00 20.05 H +ATOM 1385 HB1 ALA A 103 20.191 -1.415 10.649 1.00 18.35 H +ATOM 1386 HB2 ALA A 103 21.543 -1.363 9.545 1.00 18.35 H +ATOM 1387 HB3 ALA A 103 20.232 -0.200 9.375 1.00 18.35 H +ATOM 1388 N TYR A 104 17.754 -3.448 9.308 1.00 17.95 N +ATOM 1389 CA TYR A 104 16.345 -3.736 9.559 1.00 19.33 C +ATOM 1390 C TYR A 104 16.200 -4.308 10.975 1.00 20.55 C +ATOM 1391 O TYR A 104 17.114 -4.974 11.451 1.00 22.06 O +ATOM 1392 CB TYR A 104 15.845 -4.732 8.486 1.00 18.75 C +ATOM 1393 CG TYR A 104 14.369 -5.088 8.581 1.00 19.21 C +ATOM 1394 CD1 TYR A 104 13.953 -6.183 9.364 1.00 21.30 C +ATOM 1395 CD2 TYR A 104 13.402 -4.303 7.921 1.00 20.16 C +ATOM 1396 CE1 TYR A 104 12.582 -6.462 9.515 1.00 21.55 C +ATOM 1397 CE2 TYR A 104 12.031 -4.588 8.061 1.00 20.84 C +ATOM 1398 CZ TYR A 104 11.621 -5.671 8.861 1.00 22.27 C +ATOM 1399 OH TYR A 104 10.296 -5.965 8.993 1.00 22.91 O +ATOM 1400 H TYR A 104 18.392 -4.217 9.471 1.00 17.95 H +ATOM 1401 HA TYR A 104 15.759 -2.819 9.496 1.00 19.33 H +ATOM 1402 HB3 TYR A 104 16.428 -5.655 8.536 1.00 18.75 H +ATOM 1403 HB2 TYR A 104 16.032 -4.326 7.491 1.00 18.75 H +ATOM 1404 HD1 TYR A 104 14.685 -6.793 9.871 1.00 21.30 H +ATOM 1405 HD2 TYR A 104 13.708 -3.467 7.319 1.00 20.16 H +ATOM 1406 HE1 TYR A 104 12.267 -7.288 10.129 1.00 21.55 H +ATOM 1407 HE2 TYR A 104 11.300 -3.979 7.551 1.00 20.84 H +ATOM 1408 HH TYR A 104 9.725 -5.398 8.471 1.00 22.91 H +ATOM 1409 N GLY A 105 15.040 -4.081 11.605 1.00 19.26 N +ATOM 1410 CA GLY A 105 14.725 -4.644 12.911 1.00 21.52 C +ATOM 1411 C GLY A 105 13.948 -3.638 13.755 1.00 20.28 C +ATOM 1412 O GLY A 105 13.716 -2.494 13.358 1.00 18.68 O +ATOM 1413 H GLY A 105 14.335 -3.496 11.171 1.00 19.26 H +ATOM 1414 HA3 GLY A 105 15.626 -4.913 13.463 1.00 21.52 H +ATOM 1415 HA2 GLY A 105 14.135 -5.550 12.776 1.00 21.52 H +ATOM 1416 N GLN A 106 13.532 -4.107 14.940 1.00 21.44 N +ATOM 1417 CA GLN A 106 12.794 -3.351 15.948 1.00 20.84 C +ATOM 1418 C GLN A 106 13.602 -2.165 16.513 1.00 21.07 C +ATOM 1419 O GLN A 106 14.830 -2.189 16.500 1.00 21.08 O +ATOM 1420 CB GLN A 106 12.285 -4.341 17.023 1.00 22.65 C +ATOM 1421 CG GLN A 106 11.686 -3.716 18.302 1.00 25.55 C +ATOM 1422 CD GLN A 106 11.212 -4.756 19.314 1.00 28.83 C +ATOM 1423 OE1 GLN A 106 11.800 -5.827 19.446 1.00 30.01 O +ATOM 1424 NE2 GLN A 106 10.160 -4.423 20.062 1.00 30.80 N +ATOM 1425 H GLN A 106 13.737 -5.069 15.184 1.00 21.44 H +ATOM 1426 HA GLN A 106 11.921 -2.955 15.433 1.00 20.84 H +ATOM 1427 HB3 GLN A 106 13.097 -5.003 17.309 1.00 22.65 H +ATOM 1428 HB2 GLN A 106 11.533 -4.986 16.564 1.00 22.65 H +ATOM 1429 HG3 GLN A 106 10.860 -3.055 18.037 1.00 25.55 H +ATOM 1430 HG2 GLN A 106 12.430 -3.114 18.820 1.00 25.55 H +ATOM 1431 HE22 GLN A 106 9.782 -5.072 20.738 1.00 30.80 H +ATOM 1432 HE21 GLN A 106 9.710 -3.527 19.937 1.00 30.80 H +ATOM 1433 N THR A 107 12.892 -1.140 17.001 1.00 22.00 N +ATOM 1434 CA THR A 107 13.447 0.056 17.620 1.00 22.73 C +ATOM 1435 C THR A 107 14.171 -0.302 18.923 1.00 24.87 C +ATOM 1436 O THR A 107 13.597 -0.965 19.788 1.00 22.44 O +ATOM 1437 CB THR A 107 12.342 1.100 17.933 1.00 22.42 C +ATOM 1438 OG1 THR A 107 11.751 1.514 16.718 1.00 21.89 O +ATOM 1439 CG2 THR A 107 12.816 2.371 18.664 1.00 22.99 C +ATOM 1440 H THR A 107 11.882 -1.188 16.966 1.00 22.00 H +ATOM 1441 HA THR A 107 14.161 0.483 16.918 1.00 22.73 H +ATOM 1442 HB THR A 107 11.556 0.631 18.527 1.00 22.42 H +ATOM 1443 HG1 THR A 107 10.878 1.871 16.912 1.00 21.89 H +ATOM 1444 HG21 THR A 107 12.005 3.093 18.758 1.00 22.99 H +ATOM 1445 HG22 THR A 107 13.164 2.156 19.675 1.00 22.99 H +ATOM 1446 HG23 THR A 107 13.633 2.857 18.128 1.00 22.99 H +ATOM 1447 N GLY A 108 15.426 0.146 19.009 1.00 25.38 N +ATOM 1448 CA GLY A 108 16.298 -0.095 20.144 1.00 25.41 C +ATOM 1449 C GLY A 108 17.017 -1.451 20.065 1.00 23.92 C +ATOM 1450 O GLY A 108 17.517 -1.888 21.099 1.00 21.87 O +ATOM 1451 H GLY A 108 15.804 0.707 18.251 1.00 25.38 H +ATOM 1452 HA3 GLY A 108 15.743 -0.023 21.081 1.00 25.41 H +ATOM 1453 HA2 GLY A 108 17.032 0.707 20.154 1.00 25.41 H +ATOM 1454 N THR A 109 17.076 -2.123 18.898 1.00 21.42 N +ATOM 1455 CA THR A 109 17.781 -3.405 18.737 1.00 22.55 C +ATOM 1456 C THR A 109 19.199 -3.267 18.150 1.00 24.86 C +ATOM 1457 O THR A 109 19.950 -4.237 18.261 1.00 23.18 O +ATOM 1458 CB THR A 109 16.997 -4.425 17.881 1.00 25.44 C +ATOM 1459 OG1 THR A 109 16.842 -4.014 16.541 1.00 25.10 O +ATOM 1460 CG2 THR A 109 15.633 -4.772 18.479 1.00 23.33 C +ATOM 1461 H THR A 109 16.676 -1.715 18.062 1.00 21.42 H +ATOM 1462 HA THR A 109 17.907 -3.876 19.711 1.00 22.55 H +ATOM 1463 HB THR A 109 17.569 -5.351 17.845 1.00 25.44 H +ATOM 1464 HG1 THR A 109 16.186 -3.307 16.514 1.00 25.10 H +ATOM 1465 HG21 THR A 109 15.155 -5.552 17.892 1.00 23.33 H +ATOM 1466 HG22 THR A 109 15.742 -5.149 19.493 1.00 23.33 H +ATOM 1467 HG23 THR A 109 14.966 -3.911 18.523 1.00 23.33 H +ATOM 1468 N GLY A 110 19.571 -2.092 17.614 1.00 22.69 N +ATOM 1469 CA GLY A 110 20.961 -1.794 17.276 1.00 22.97 C +ATOM 1470 C GLY A 110 21.173 -1.403 15.813 1.00 23.46 C +ATOM 1471 O GLY A 110 22.295 -1.577 15.341 1.00 22.88 O +ATOM 1472 H GLY A 110 18.894 -1.346 17.498 1.00 22.69 H +ATOM 1473 HA3 GLY A 110 21.636 -2.620 17.506 1.00 22.97 H +ATOM 1474 HA2 GLY A 110 21.290 -0.967 17.897 1.00 22.97 H +ATOM 1475 N LYS A 111 20.159 -0.894 15.085 1.00 19.23 N +ATOM 1476 CA LYS A 111 20.320 -0.437 13.696 1.00 20.76 C +ATOM 1477 C LYS A 111 21.287 0.753 13.576 1.00 20.44 C +ATOM 1478 O LYS A 111 22.252 0.649 12.821 1.00 21.60 O +ATOM 1479 CB LYS A 111 18.975 -0.072 13.046 1.00 18.15 C +ATOM 1480 CG LYS A 111 17.980 -1.229 12.902 1.00 21.24 C +ATOM 1481 CD LYS A 111 16.680 -0.802 12.193 1.00 20.68 C +ATOM 1482 CE LYS A 111 15.860 0.293 12.895 1.00 18.44 C +ATOM 1483 NZ LYS A 111 15.512 -0.068 14.276 1.00 18.27 N1+ +ATOM 1484 H LYS A 111 19.254 -0.729 15.516 1.00 19.23 H +ATOM 1485 HA LYS A 111 20.746 -1.266 13.128 1.00 20.76 H +ATOM 1486 HB3 LYS A 111 19.175 0.306 12.045 1.00 18.15 H +ATOM 1487 HB2 LYS A 111 18.514 0.747 13.593 1.00 18.15 H +ATOM 1488 HG3 LYS A 111 17.754 -1.645 13.883 1.00 21.24 H +ATOM 1489 HG2 LYS A 111 18.443 -2.037 12.336 1.00 21.24 H +ATOM 1490 HD3 LYS A 111 16.047 -1.674 12.051 1.00 20.68 H +ATOM 1491 HD2 LYS A 111 16.922 -0.454 11.189 1.00 20.68 H +ATOM 1492 HE3 LYS A 111 14.929 0.454 12.353 1.00 18.44 H +ATOM 1493 HE2 LYS A 111 16.395 1.242 12.901 1.00 18.44 H +ATOM 1494 HZ1 LYS A 111 16.356 -0.186 14.826 1.00 18.27 H +ATOM 1495 HZ2 LYS A 111 14.963 0.677 14.684 1.00 18.27 H +ATOM 1496 HZ3 LYS A 111 14.983 -0.929 14.281 1.00 18.27 H +ATOM 1497 N THR A 112 21.037 1.827 14.348 1.00 20.23 N +ATOM 1498 CA THR A 112 21.883 3.023 14.425 1.00 21.91 C +ATOM 1499 C THR A 112 23.283 2.719 14.991 1.00 21.96 C +ATOM 1500 O THR A 112 24.266 3.230 14.460 1.00 20.36 O +ATOM 1501 CB THR A 112 21.250 4.137 15.307 1.00 23.15 C +ATOM 1502 OG1 THR A 112 19.962 4.458 14.824 1.00 24.85 O +ATOM 1503 CG2 THR A 112 22.054 5.448 15.386 1.00 22.97 C +ATOM 1504 H THR A 112 20.204 1.838 14.930 1.00 20.23 H +ATOM 1505 HA THR A 112 22.007 3.408 13.411 1.00 21.91 H +ATOM 1506 HB THR A 112 21.113 3.767 16.322 1.00 23.15 H +ATOM 1507 HG1 THR A 112 19.384 3.697 14.974 1.00 24.85 H +ATOM 1508 HG21 THR A 112 21.507 6.208 15.946 1.00 22.97 H +ATOM 1509 HG22 THR A 112 23.015 5.318 15.883 1.00 22.97 H +ATOM 1510 HG23 THR A 112 22.242 5.845 14.389 1.00 22.97 H +ATOM 1511 N PHE A 113 23.354 1.861 16.023 1.00 22.76 N +ATOM 1512 CA PHE A 113 24.592 1.384 16.635 1.00 23.80 C +ATOM 1513 C PHE A 113 25.478 0.622 15.637 1.00 21.95 C +ATOM 1514 O PHE A 113 26.684 0.843 15.619 1.00 22.14 O +ATOM 1515 CB PHE A 113 24.269 0.536 17.883 1.00 23.71 C +ATOM 1516 CG PHE A 113 25.481 0.078 18.677 1.00 26.76 C +ATOM 1517 CD1 PHE A 113 26.063 0.946 19.624 1.00 27.02 C +ATOM 1518 CD2 PHE A 113 26.141 -1.129 18.359 1.00 26.47 C +ATOM 1519 CE1 PHE A 113 27.228 0.578 20.283 1.00 27.82 C +ATOM 1520 CE2 PHE A 113 27.308 -1.475 19.024 1.00 29.17 C +ATOM 1521 CZ PHE A 113 27.843 -0.632 19.988 1.00 28.08 C +ATOM 1522 H PHE A 113 22.490 1.526 16.442 1.00 22.76 H +ATOM 1523 HA PHE A 113 25.145 2.267 16.963 1.00 23.80 H +ATOM 1524 HB3 PHE A 113 23.679 -0.338 17.603 1.00 23.71 H +ATOM 1525 HB2 PHE A 113 23.637 1.118 18.554 1.00 23.71 H +ATOM 1526 HD1 PHE A 113 25.601 1.897 19.842 1.00 27.02 H +ATOM 1527 HD2 PHE A 113 25.737 -1.787 17.604 1.00 26.47 H +ATOM 1528 HE1 PHE A 113 27.658 1.237 21.023 1.00 27.82 H +ATOM 1529 HE2 PHE A 113 27.800 -2.408 18.796 1.00 29.17 H +ATOM 1530 HZ PHE A 113 28.744 -0.921 20.505 1.00 28.08 H +ATOM 1531 N THR A 114 24.870 -0.227 14.795 1.00 21.64 N +ATOM 1532 CA THR A 114 25.576 -0.934 13.733 1.00 22.49 C +ATOM 1533 C THR A 114 26.054 0.029 12.631 1.00 24.03 C +ATOM 1534 O THR A 114 27.251 0.055 12.356 1.00 20.85 O +ATOM 1535 CB THR A 114 24.714 -2.051 13.092 1.00 24.26 C +ATOM 1536 OG1 THR A 114 24.377 -3.012 14.073 1.00 21.97 O +ATOM 1537 CG2 THR A 114 25.388 -2.795 11.930 1.00 22.94 C +ATOM 1538 H THR A 114 23.869 -0.367 14.852 1.00 21.64 H +ATOM 1539 HA THR A 114 26.462 -1.396 14.170 1.00 22.49 H +ATOM 1540 HB THR A 114 23.774 -1.629 12.732 1.00 24.26 H +ATOM 1541 HG1 THR A 114 23.727 -2.617 14.666 1.00 21.97 H +ATOM 1542 HG21 THR A 114 24.766 -3.619 11.597 1.00 22.94 H +ATOM 1543 HG22 THR A 114 25.531 -2.149 11.065 1.00 22.94 H +ATOM 1544 HG23 THR A 114 26.358 -3.198 12.221 1.00 22.94 H +ATOM 1545 N MET A 115 25.125 0.805 12.046 1.00 23.61 N +ATOM 1546 CA MET A 115 25.385 1.675 10.898 1.00 25.56 C +ATOM 1547 C MET A 115 26.330 2.850 11.186 1.00 25.01 C +ATOM 1548 O MET A 115 27.101 3.210 10.302 1.00 22.73 O +ATOM 1549 CB MET A 115 24.050 2.181 10.296 1.00 28.20 C +ATOM 1550 CG MET A 115 23.882 1.813 8.819 1.00 36.97 C +ATOM 1551 SD MET A 115 23.787 0.024 8.540 1.00 41.03 S +ATOM 1552 CE MET A 115 24.716 -0.077 7.001 1.00 40.29 C +ATOM 1553 H MET A 115 24.161 0.751 12.351 1.00 23.61 H +ATOM 1554 HA MET A 115 25.889 1.049 10.161 1.00 25.56 H +ATOM 1555 HB3 MET A 115 23.960 3.262 10.401 1.00 28.20 H +ATOM 1556 HB2 MET A 115 23.194 1.784 10.837 1.00 28.20 H +ATOM 1557 HG3 MET A 115 24.714 2.230 8.252 1.00 36.97 H +ATOM 1558 HG2 MET A 115 22.978 2.270 8.415 1.00 36.97 H +ATOM 1559 HE1 MET A 115 24.860 -1.119 6.736 1.00 40.29 H +ATOM 1560 HE2 MET A 115 24.180 0.428 6.199 1.00 40.29 H +ATOM 1561 HE3 MET A 115 25.697 0.381 7.124 1.00 40.29 H +ATOM 1562 N GLU A 116 26.241 3.432 12.389 1.00 24.06 N +ATOM 1563 CA GLU A 116 26.899 4.688 12.749 1.00 25.23 C +ATOM 1564 C GLU A 116 27.826 4.525 13.943 1.00 25.96 C +ATOM 1565 O GLU A 116 28.910 5.108 13.950 1.00 25.46 O +ATOM 1566 CB GLU A 116 25.842 5.731 13.139 1.00 25.27 C +ATOM 1567 CG GLU A 116 24.681 5.814 12.145 1.00 28.22 C +ATOM 1568 CD GLU A 116 23.925 7.134 12.194 1.00 28.85 C +ATOM 1569 OE1 GLU A 116 23.921 7.810 13.248 1.00 30.85 O +ATOM 1570 OE2 GLU A 116 23.365 7.458 11.130 1.00 32.46 O1- +ATOM 1571 H GLU A 116 25.565 3.083 13.058 1.00 24.06 H +ATOM 1572 HA GLU A 116 27.482 5.077 11.912 1.00 25.23 H +ATOM 1573 HB3 GLU A 116 26.339 6.696 13.227 1.00 25.27 H +ATOM 1574 HB2 GLU A 116 25.435 5.536 14.133 1.00 25.27 H +ATOM 1575 HG3 GLU A 116 23.969 5.011 12.337 1.00 28.22 H +ATOM 1576 HG2 GLU A 116 25.051 5.652 11.135 1.00 28.22 H +ATOM 1577 N GLY A 117 27.354 3.768 14.944 1.00 24.48 N +ATOM 1578 CA GLY A 117 27.987 3.678 16.245 1.00 25.32 C +ATOM 1579 C GLY A 117 27.735 4.949 17.053 1.00 27.26 C +ATOM 1580 O GLY A 117 26.839 5.745 16.765 1.00 27.39 O +ATOM 1581 H GLY A 117 26.444 3.337 14.849 1.00 24.48 H +ATOM 1582 HA3 GLY A 117 29.054 3.530 16.112 1.00 25.32 H +ATOM 1583 HA2 GLY A 117 27.601 2.831 16.808 1.00 25.32 H +ATOM 1584 N GLU A 118 28.550 5.102 18.096 1.00 28.11 N +ATOM 1585 CA GLU A 118 28.487 6.196 19.053 1.00 28.54 C +ATOM 1586 C GLU A 118 29.873 6.386 19.675 1.00 29.30 C +ATOM 1587 O GLU A 118 30.763 5.558 19.483 1.00 27.87 O +ATOM 1588 CB GLU A 118 27.388 5.893 20.096 1.00 31.14 C +ATOM 1589 CG GLU A 118 27.600 4.600 20.918 1.00 32.60 C +ATOM 1590 CD GLU A 118 26.412 4.280 21.833 1.00 34.85 C +ATOM 1591 OE1 GLU A 118 25.272 4.234 21.316 1.00 33.99 O +ATOM 1592 OE2 GLU A 118 26.658 4.072 23.040 1.00 36.88 O1- +ATOM 1593 H GLU A 118 29.272 4.415 18.270 1.00 28.11 H +ATOM 1594 HA GLU A 118 28.238 7.120 18.528 1.00 28.54 H +ATOM 1595 HB3 GLU A 118 26.429 5.861 19.577 1.00 31.14 H +ATOM 1596 HB2 GLU A 118 27.307 6.731 20.788 1.00 31.14 H +ATOM 1597 HG3 GLU A 118 28.514 4.679 21.509 1.00 32.60 H +ATOM 1598 HG2 GLU A 118 27.741 3.746 20.254 1.00 32.60 H +ATOM 1599 N ARG A 119 30.028 7.492 20.411 1.00 28.64 N +ATOM 1600 CA ARG A 119 31.229 7.764 21.190 1.00 31.10 C +ATOM 1601 C ARG A 119 31.181 7.022 22.530 1.00 30.49 C +ATOM 1602 O ARG A 119 30.154 7.060 23.212 1.00 30.81 O +ATOM 1603 CB ARG A 119 31.395 9.287 21.404 1.00 31.76 C +ATOM 1604 CG ARG A 119 31.425 10.139 20.114 1.00 32.25 C +ATOM 1605 CD ARG A 119 32.334 9.605 18.990 1.00 35.36 C +ATOM 1606 NE ARG A 119 33.708 9.358 19.453 1.00 36.57 N +ATOM 1607 CZ ARG A 119 34.644 10.249 19.821 1.00 34.93 C +ATOM 1608 NH1 ARG A 119 34.510 11.570 19.649 1.00 36.05 N +ATOM 1609 NH2 ARG A 119 35.750 9.786 20.404 1.00 36.63 N1+ +ATOM 1610 H ARG A 119 29.262 8.140 20.519 1.00 28.64 H +ATOM 1611 HA ARG A 119 32.092 7.396 20.634 1.00 31.10 H +ATOM 1612 HB3 ARG A 119 32.321 9.460 21.955 1.00 31.76 H +ATOM 1613 HB2 ARG A 119 30.610 9.670 22.054 1.00 31.76 H +ATOM 1614 HG3 ARG A 119 31.628 11.190 20.323 1.00 32.25 H +ATOM 1615 HG2 ARG A 119 30.407 10.127 19.723 1.00 32.25 H +ATOM 1616 HD3 ARG A 119 32.416 10.358 18.212 1.00 35.36 H +ATOM 1617 HD2 ARG A 119 31.894 8.735 18.510 1.00 35.36 H +ATOM 1618 HE ARG A 119 33.910 8.387 19.662 1.00 36.57 H +ATOM 1619 HH12 ARG A 119 35.227 12.208 19.963 1.00 36.05 H +ATOM 1620 HH11 ARG A 119 33.688 11.937 19.185 1.00 36.05 H +ATOM 1621 HH22 ARG A 119 36.471 10.409 20.742 1.00 36.63 H +ATOM 1622 HH21 ARG A 119 35.849 8.793 20.574 1.00 36.63 H +ATOM 1623 N SER A 120 32.322 6.419 22.899 1.00 32.22 N +ATOM 1624 CA SER A 120 32.587 5.871 24.228 1.00 32.57 C +ATOM 1625 C SER A 120 32.531 7.002 25.279 1.00 32.68 C +ATOM 1626 O SER A 120 33.111 8.060 25.020 1.00 31.36 O +ATOM 1627 CB SER A 120 33.986 5.226 24.243 1.00 32.71 C +ATOM 1628 OG SER A 120 33.976 3.966 23.608 1.00 34.94 O +ATOM 1629 H SER A 120 33.108 6.418 22.259 1.00 32.22 H +ATOM 1630 HA SER A 120 31.849 5.097 24.407 1.00 32.57 H +ATOM 1631 HB3 SER A 120 34.331 5.067 25.266 1.00 32.71 H +ATOM 1632 HB2 SER A 120 34.717 5.867 23.761 1.00 32.71 H +ATOM 1633 HG SER A 120 33.912 4.110 22.657 1.00 34.94 H +ATOM 1634 N PRO A 121 31.827 6.786 26.416 1.00 34.84 N +ATOM 1635 CA PRO A 121 31.739 7.769 27.517 1.00 37.38 C +ATOM 1636 C PRO A 121 33.075 8.361 28.004 1.00 39.81 C +ATOM 1637 O PRO A 121 34.088 7.662 28.018 1.00 39.38 O +ATOM 1638 CB PRO A 121 31.059 6.978 28.647 1.00 38.04 C +ATOM 1639 CG PRO A 121 30.200 5.954 27.933 1.00 38.85 C +ATOM 1640 CD PRO A 121 31.046 5.584 26.725 1.00 35.74 C +ATOM 1641 HA PRO A 121 31.078 8.569 27.179 1.00 37.38 H +ATOM 1642 HB3 PRO A 121 30.475 7.613 29.313 1.00 38.04 H +ATOM 1643 HB2 PRO A 121 31.801 6.457 29.255 1.00 38.04 H +ATOM 1644 HG3 PRO A 121 29.278 6.431 27.598 1.00 38.85 H +ATOM 1645 HG2 PRO A 121 29.932 5.099 28.554 1.00 38.85 H +ATOM 1646 HD2 PRO A 121 31.729 4.767 26.962 1.00 35.74 H +ATOM 1647 HD3 PRO A 121 30.387 5.270 25.915 1.00 35.74 H +ATOM 1648 N ASN A 122 33.023 9.640 28.414 1.00 41.25 N +ATOM 1649 CA ASN A 122 34.096 10.377 29.097 1.00 43.22 C +ATOM 1650 C ASN A 122 35.334 10.693 28.223 1.00 44.35 C +ATOM 1651 O ASN A 122 36.402 10.950 28.778 1.00 44.32 O +ATOM 1652 CB ASN A 122 34.481 9.651 30.421 1.00 42.57 C +ATOM 1653 CG ASN A 122 35.081 10.549 31.509 1.00 44.13 C +ATOM 1654 OD1 ASN A 122 34.754 11.729 31.616 1.00 43.28 O +ATOM 1655 ND2 ASN A 122 35.964 9.982 32.334 1.00 42.61 N +ATOM 1656 H ASN A 122 32.146 10.134 28.344 1.00 41.25 H +ATOM 1657 HA ASN A 122 33.708 11.369 29.330 1.00 43.22 H +ATOM 1658 HB3 ASN A 122 35.141 8.804 30.221 1.00 42.57 H +ATOM 1659 HB2 ASN A 122 33.580 9.230 30.870 1.00 42.57 H +ATOM 1660 HD22 ASN A 122 36.390 10.528 33.068 1.00 42.61 H +ATOM 1661 HD21 ASN A 122 36.221 9.012 32.222 1.00 42.61 H +ATOM 1662 N GLU A 123 35.182 10.689 26.884 1.00 44.87 N +ATOM 1663 CA GLU A 123 36.237 10.983 25.900 1.00 45.91 C +ATOM 1664 C GLU A 123 37.492 10.091 26.054 1.00 45.85 C +ATOM 1665 O GLU A 123 38.608 10.613 26.022 1.00 45.69 O +ATOM 1666 CB GLU A 123 36.618 12.488 25.904 1.00 46.51 C +ATOM 1667 CG GLU A 123 35.465 13.470 25.625 1.00 49.83 C +ATOM 1668 CD GLU A 123 35.978 14.909 25.460 1.00 51.36 C +ATOM 1669 OE1 GLU A 123 36.522 15.450 26.449 1.00 52.20 O +ATOM 1670 OE2 GLU A 123 35.824 15.447 24.341 1.00 52.40 O1- +ATOM 1671 H GLU A 123 34.277 10.463 26.499 1.00 44.87 H +ATOM 1672 HA GLU A 123 35.817 10.750 24.921 1.00 45.91 H +ATOM 1673 HB3 GLU A 123 37.388 12.660 25.149 1.00 46.51 H +ATOM 1674 HB2 GLU A 123 37.082 12.744 26.858 1.00 46.51 H +ATOM 1675 HG3 GLU A 123 34.742 13.446 26.442 1.00 49.83 H +ATOM 1676 HG2 GLU A 123 34.926 13.158 24.729 1.00 49.83 H +ATOM 1677 N GLU A 124 37.301 8.770 26.239 1.00 45.90 N +ATOM 1678 CA GLU A 124 38.400 7.801 26.356 1.00 46.68 C +ATOM 1679 C GLU A 124 39.345 7.778 25.144 1.00 46.72 C +ATOM 1680 O GLU A 124 40.561 7.776 25.328 1.00 46.68 O +ATOM 1681 CB GLU A 124 37.866 6.373 26.591 1.00 48.60 C +ATOM 1682 CG GLU A 124 37.466 6.069 28.046 1.00 51.23 C +ATOM 1683 CD GLU A 124 37.313 4.561 28.298 1.00 52.35 C +ATOM 1684 OE1 GLU A 124 38.315 3.834 28.112 1.00 52.94 O +ATOM 1685 OE2 GLU A 124 36.197 4.153 28.687 1.00 53.19 O1- +ATOM 1686 H GLU A 124 36.364 8.397 26.284 1.00 45.90 H +ATOM 1687 HA GLU A 124 39.004 8.092 27.218 1.00 46.68 H +ATOM 1688 HB3 GLU A 124 38.611 5.649 26.254 1.00 48.60 H +ATOM 1689 HB2 GLU A 124 36.994 6.206 25.958 1.00 48.60 H +ATOM 1690 HG3 GLU A 124 36.548 6.602 28.299 1.00 51.23 H +ATOM 1691 HG2 GLU A 124 38.231 6.442 28.728 1.00 51.23 H +ATOM 1692 N TYR A 125 38.753 7.747 23.944 1.00 44.20 N +ATOM 1693 CA TYR A 125 39.460 7.603 22.678 1.00 43.39 C +ATOM 1694 C TYR A 125 39.227 8.852 21.824 1.00 43.25 C +ATOM 1695 O TYR A 125 38.278 9.603 22.054 1.00 43.62 O +ATOM 1696 CB TYR A 125 38.926 6.355 21.932 1.00 43.13 C +ATOM 1697 CG TYR A 125 38.839 5.088 22.766 1.00 42.67 C +ATOM 1698 CD1 TYR A 125 37.653 4.810 23.472 1.00 41.89 C +ATOM 1699 CD2 TYR A 125 39.932 4.203 22.861 1.00 42.68 C +ATOM 1700 CE1 TYR A 125 37.562 3.675 24.298 1.00 41.87 C +ATOM 1701 CE2 TYR A 125 39.838 3.056 23.677 1.00 40.06 C +ATOM 1702 CZ TYR A 125 38.658 2.799 24.404 1.00 41.85 C +ATOM 1703 OH TYR A 125 38.576 1.706 25.216 1.00 42.69 O +ATOM 1704 H TYR A 125 37.745 7.806 23.885 1.00 44.20 H +ATOM 1705 HA TYR A 125 40.534 7.488 22.833 1.00 43.39 H +ATOM 1706 HB3 TYR A 125 39.537 6.153 21.052 1.00 43.13 H +ATOM 1707 HB2 TYR A 125 37.923 6.559 21.551 1.00 43.13 H +ATOM 1708 HD1 TYR A 125 36.819 5.489 23.400 1.00 41.89 H +ATOM 1709 HD2 TYR A 125 40.845 4.406 22.320 1.00 42.68 H +ATOM 1710 HE1 TYR A 125 36.654 3.487 24.852 1.00 41.87 H +ATOM 1711 HE2 TYR A 125 40.679 2.383 23.755 1.00 40.06 H +ATOM 1712 HH TYR A 125 37.807 1.727 25.790 1.00 42.69 H +ATOM 1713 N THR A 126 40.058 8.987 20.785 1.00 42.92 N +ATOM 1714 CA THR A 126 39.752 9.778 19.596 1.00 43.57 C +ATOM 1715 C THR A 126 38.758 8.984 18.710 1.00 42.84 C +ATOM 1716 O THR A 126 38.630 7.772 18.894 1.00 42.17 O +ATOM 1717 CB THR A 126 41.062 10.065 18.818 1.00 44.90 C +ATOM 1718 OG1 THR A 126 41.562 8.932 18.130 1.00 44.67 O +ATOM 1719 CG2 THR A 126 42.184 10.664 19.681 1.00 45.17 C +ATOM 1720 H THR A 126 40.829 8.343 20.678 1.00 42.92 H +ATOM 1721 HA THR A 126 39.292 10.725 19.888 1.00 43.57 H +ATOM 1722 HB THR A 126 40.825 10.817 18.067 1.00 44.90 H +ATOM 1723 HG1 THR A 126 41.244 8.977 17.222 1.00 44.67 H +ATOM 1724 HG21 THR A 126 43.038 10.945 19.066 1.00 45.17 H +ATOM 1725 HG22 THR A 126 41.843 11.560 20.200 1.00 45.17 H +ATOM 1726 HG23 THR A 126 42.542 9.958 20.431 1.00 45.17 H +ATOM 1727 N TRP A 127 38.039 9.657 17.792 1.00 42.95 N +ATOM 1728 CA TRP A 127 36.971 9.026 16.996 1.00 43.84 C +ATOM 1729 C TRP A 127 37.456 7.869 16.094 1.00 44.40 C +ATOM 1730 O TRP A 127 36.702 6.923 15.878 1.00 42.80 O +ATOM 1731 CB TRP A 127 36.197 10.097 16.200 1.00 42.89 C +ATOM 1732 CG TRP A 127 36.894 10.708 15.021 1.00 42.66 C +ATOM 1733 CD1 TRP A 127 37.614 11.851 15.050 1.00 44.16 C +ATOM 1734 CD2 TRP A 127 37.031 10.178 13.662 1.00 43.10 C +ATOM 1735 NE1 TRP A 127 38.178 12.071 13.812 1.00 43.55 N +ATOM 1736 CE2 TRP A 127 37.867 11.064 12.923 1.00 43.27 C +ATOM 1737 CE3 TRP A 127 36.565 9.027 12.981 1.00 45.46 C +ATOM 1738 CZ2 TRP A 127 38.235 10.813 11.592 1.00 43.09 C +ATOM 1739 CZ3 TRP A 127 36.904 8.778 11.635 1.00 44.80 C +ATOM 1740 CH2 TRP A 127 37.743 9.669 10.939 1.00 45.11 C +ATOM 1741 H TRP A 127 38.188 10.645 17.651 1.00 42.95 H +ATOM 1742 HA TRP A 127 36.268 8.596 17.711 1.00 43.84 H +ATOM 1743 HB3 TRP A 127 35.868 10.893 16.870 1.00 42.89 H +ATOM 1744 HB2 TRP A 127 35.281 9.650 15.819 1.00 42.89 H +ATOM 1745 HD1 TRP A 127 37.737 12.476 15.923 1.00 44.16 H +ATOM 1746 HE1 TRP A 127 38.799 12.846 13.626 1.00 43.55 H +ATOM 1747 HE3 TRP A 127 35.955 8.308 13.504 1.00 45.46 H +ATOM 1748 HZ2 TRP A 127 38.917 11.486 11.102 1.00 43.09 H +ATOM 1749 HZ3 TRP A 127 36.531 7.891 11.144 1.00 44.80 H +ATOM 1750 HH2 TRP A 127 38.019 9.469 9.914 1.00 45.11 H +ATOM 1751 N GLU A 128 38.710 7.954 15.617 1.00 45.51 N +ATOM 1752 CA GLU A 128 39.398 6.942 14.814 1.00 46.17 C +ATOM 1753 C GLU A 128 39.657 5.634 15.581 1.00 44.95 C +ATOM 1754 O GLU A 128 39.607 4.565 14.975 1.00 45.02 O +ATOM 1755 CB GLU A 128 40.754 7.490 14.311 1.00 48.66 C +ATOM 1756 CG GLU A 128 40.691 8.813 13.515 1.00 52.56 C +ATOM 1757 CD GLU A 128 40.914 10.115 14.309 1.00 55.33 C +ATOM 1758 OE1 GLU A 128 41.225 11.131 13.651 1.00 56.74 O +ATOM 1759 OE2 GLU A 128 40.761 10.106 15.547 1.00 55.59 O1- +ATOM 1760 H GLU A 128 39.257 8.784 15.818 1.00 45.51 H +ATOM 1761 HA GLU A 128 38.770 6.715 13.950 1.00 46.17 H +ATOM 1762 HB3 GLU A 128 41.195 6.739 13.655 1.00 48.66 H +ATOM 1763 HB2 GLU A 128 41.461 7.575 15.139 1.00 48.66 H +ATOM 1764 HG3 GLU A 128 39.740 8.874 12.989 1.00 52.56 H +ATOM 1765 HG2 GLU A 128 41.447 8.756 12.734 1.00 52.56 H +ATOM 1766 N GLU A 129 39.943 5.757 16.887 1.00 42.89 N +ATOM 1767 CA GLU A 129 40.312 4.658 17.778 1.00 42.13 C +ATOM 1768 C GLU A 129 39.141 4.139 18.624 1.00 41.35 C +ATOM 1769 O GLU A 129 39.318 3.133 19.310 1.00 39.97 O +ATOM 1770 CB GLU A 129 41.457 5.134 18.691 1.00 46.76 C +ATOM 1771 CG GLU A 129 42.753 5.444 17.913 1.00 51.38 C +ATOM 1772 CD GLU A 129 43.966 5.784 18.793 1.00 54.75 C +ATOM 1773 OE1 GLU A 129 43.773 6.200 19.958 1.00 56.39 O +ATOM 1774 OE2 GLU A 129 45.091 5.619 18.272 1.00 57.50 O1- +ATOM 1775 H GLU A 129 39.949 6.677 17.305 1.00 42.89 H +ATOM 1776 HA GLU A 129 40.674 3.811 17.193 1.00 42.13 H +ATOM 1777 HB3 GLU A 129 41.666 4.380 19.453 1.00 46.76 H +ATOM 1778 HB2 GLU A 129 41.137 6.028 19.228 1.00 46.76 H +ATOM 1779 HG3 GLU A 129 42.591 6.284 17.235 1.00 51.38 H +ATOM 1780 HG2 GLU A 129 43.004 4.588 17.285 1.00 51.38 H +ATOM 1781 N ASP A 130 37.984 4.823 18.578 1.00 38.84 N +ATOM 1782 CA ASP A 130 36.802 4.514 19.376 1.00 36.35 C +ATOM 1783 C ASP A 130 36.222 3.145 18.943 1.00 34.79 C +ATOM 1784 O ASP A 130 35.811 3.019 17.788 1.00 33.59 O +ATOM 1785 CB ASP A 130 35.758 5.649 19.243 1.00 37.00 C +ATOM 1786 CG ASP A 130 34.789 5.722 20.430 1.00 37.96 C +ATOM 1787 OD1 ASP A 130 34.764 6.790 21.075 1.00 37.28 O +ATOM 1788 OD2 ASP A 130 34.098 4.718 20.702 1.00 37.20 O1- +ATOM 1789 H ASP A 130 37.922 5.642 17.989 1.00 38.84 H +ATOM 1790 HA ASP A 130 37.147 4.505 20.408 1.00 36.35 H +ATOM 1791 HB3 ASP A 130 35.182 5.546 18.322 1.00 37.00 H +ATOM 1792 HB2 ASP A 130 36.271 6.606 19.133 1.00 37.00 H +ATOM 1793 N PRO A 131 36.208 2.142 19.855 1.00 34.64 N +ATOM 1794 CA PRO A 131 35.711 0.793 19.533 1.00 33.09 C +ATOM 1795 C PRO A 131 34.185 0.699 19.343 1.00 30.37 C +ATOM 1796 O PRO A 131 33.726 -0.330 18.848 1.00 29.21 O +ATOM 1797 CB PRO A 131 36.193 -0.058 20.716 1.00 34.60 C +ATOM 1798 CG PRO A 131 36.187 0.905 21.890 1.00 35.14 C +ATOM 1799 CD PRO A 131 36.628 2.219 21.257 1.00 34.51 C +ATOM 1800 HA PRO A 131 36.185 0.431 18.620 1.00 33.09 H +ATOM 1801 HB3 PRO A 131 37.212 -0.398 20.526 1.00 34.60 H +ATOM 1802 HB2 PRO A 131 35.583 -0.944 20.902 1.00 34.60 H +ATOM 1803 HG3 PRO A 131 36.825 0.591 22.717 1.00 35.14 H +ATOM 1804 HG2 PRO A 131 35.170 1.008 22.272 1.00 35.14 H +ATOM 1805 HD2 PRO A 131 36.175 3.059 21.783 1.00 34.51 H +ATOM 1806 HD3 PRO A 131 37.712 2.319 21.304 1.00 34.51 H +ATOM 1807 N LEU A 132 33.441 1.758 19.712 1.00 28.68 N +ATOM 1808 CA LEU A 132 31.997 1.874 19.520 1.00 26.61 C +ATOM 1809 C LEU A 132 31.618 2.564 18.198 1.00 26.87 C +ATOM 1810 O LEU A 132 30.422 2.668 17.942 1.00 24.37 O +ATOM 1811 CB LEU A 132 31.344 2.590 20.725 1.00 25.86 C +ATOM 1812 CG LEU A 132 31.572 1.931 22.100 1.00 27.89 C +ATOM 1813 CD1 LEU A 132 30.827 2.718 23.197 1.00 26.82 C +ATOM 1814 CD2 LEU A 132 31.207 0.435 22.132 1.00 27.95 C +ATOM 1815 H LEU A 132 33.891 2.572 20.114 1.00 28.68 H +ATOM 1816 HA LEU A 132 31.566 0.875 19.463 1.00 26.61 H +ATOM 1817 HB3 LEU A 132 30.268 2.660 20.559 1.00 25.86 H +ATOM 1818 HB2 LEU A 132 31.700 3.616 20.775 1.00 25.86 H +ATOM 1819 HG LEU A 132 32.636 2.006 22.323 1.00 27.89 H +ATOM 1820 HD11 LEU A 132 31.444 2.814 24.090 1.00 26.82 H +ATOM 1821 HD12 LEU A 132 30.565 3.725 22.871 1.00 26.82 H +ATOM 1822 HD13 LEU A 132 29.898 2.232 23.493 1.00 26.82 H +ATOM 1823 HD21 LEU A 132 30.730 0.145 23.068 1.00 27.95 H +ATOM 1824 HD22 LEU A 132 30.523 0.168 21.329 1.00 27.95 H +ATOM 1825 HD23 LEU A 132 32.101 -0.180 22.023 1.00 27.95 H +ATOM 1826 N ALA A 133 32.596 2.973 17.363 1.00 25.36 N +ATOM 1827 CA ALA A 133 32.378 3.463 15.994 1.00 25.95 C +ATOM 1828 C ALA A 133 31.762 2.377 15.100 1.00 25.66 C +ATOM 1829 O ALA A 133 32.189 1.231 15.192 1.00 23.39 O +ATOM 1830 CB ALA A 133 33.726 3.923 15.414 1.00 22.78 C +ATOM 1831 H ALA A 133 33.561 2.871 17.646 1.00 25.36 H +ATOM 1832 HA ALA A 133 31.692 4.309 16.039 1.00 25.95 H +ATOM 1833 HB1 ALA A 133 33.595 4.415 14.451 1.00 22.78 H +ATOM 1834 HB2 ALA A 133 34.219 4.632 16.078 1.00 22.78 H +ATOM 1835 HB3 ALA A 133 34.410 3.086 15.268 1.00 22.78 H +ATOM 1836 N GLY A 134 30.772 2.739 14.272 1.00 26.37 N +ATOM 1837 CA GLY A 134 30.015 1.791 13.452 1.00 24.19 C +ATOM 1838 C GLY A 134 30.543 1.771 12.017 1.00 26.33 C +ATOM 1839 O GLY A 134 31.680 2.159 11.749 1.00 25.05 O +ATOM 1840 H GLY A 134 30.473 3.705 14.241 1.00 26.37 H +ATOM 1841 HA3 GLY A 134 28.964 2.069 13.447 1.00 24.19 H +ATOM 1842 HA2 GLY A 134 30.057 0.780 13.858 1.00 24.19 H +ATOM 1843 N ILE A 135 29.699 1.273 11.101 1.00 26.17 N +ATOM 1844 CA ILE A 135 30.011 1.047 9.689 1.00 26.40 C +ATOM 1845 C ILE A 135 30.429 2.323 8.931 1.00 27.39 C +ATOM 1846 O ILE A 135 31.471 2.289 8.285 1.00 28.26 O +ATOM 1847 CB ILE A 135 28.844 0.323 8.946 1.00 27.45 C +ATOM 1848 CG1 ILE A 135 28.660 -1.103 9.526 1.00 25.10 C +ATOM 1849 CG2 ILE A 135 28.981 0.289 7.405 1.00 27.06 C +ATOM 1850 CD1 ILE A 135 27.487 -1.903 8.948 1.00 23.56 C +ATOM 1851 H ILE A 135 28.779 0.972 11.397 1.00 26.17 H +ATOM 1852 HA ILE A 135 30.875 0.378 9.673 1.00 26.40 H +ATOM 1853 HB ILE A 135 27.927 0.871 9.160 1.00 27.45 H +ATOM 1854 HG13 ILE A 135 28.518 -1.050 10.599 1.00 25.10 H +ATOM 1855 HG12 ILE A 135 29.574 -1.677 9.424 1.00 25.10 H +ATOM 1856 HG21 ILE A 135 28.166 -0.257 6.934 1.00 27.06 H +ATOM 1857 HG22 ILE A 135 28.956 1.286 6.967 1.00 27.06 H +ATOM 1858 HG23 ILE A 135 29.913 -0.180 7.099 1.00 27.06 H +ATOM 1859 HD11 ILE A 135 27.298 -2.788 9.554 1.00 23.56 H +ATOM 1860 HD12 ILE A 135 26.573 -1.310 8.931 1.00 23.56 H +ATOM 1861 HD13 ILE A 135 27.690 -2.249 7.934 1.00 23.56 H +ATOM 1862 N ILE A 136 29.640 3.407 9.040 1.00 28.24 N +ATOM 1863 CA ILE A 136 29.866 4.696 8.376 1.00 28.10 C +ATOM 1864 C ILE A 136 31.250 5.328 8.672 1.00 28.82 C +ATOM 1865 O ILE A 136 32.006 5.476 7.714 1.00 28.49 O +ATOM 1866 CB ILE A 136 28.701 5.708 8.631 1.00 28.83 C +ATOM 1867 CG1 ILE A 136 27.423 5.289 7.869 1.00 30.10 C +ATOM 1868 CG2 ILE A 136 29.016 7.183 8.289 1.00 28.01 C +ATOM 1869 CD1 ILE A 136 26.135 5.923 8.408 1.00 29.54 C +ATOM 1870 H ILE A 136 28.792 3.343 9.593 1.00 28.24 H +ATOM 1871 HA ILE A 136 29.860 4.476 7.306 1.00 28.10 H +ATOM 1872 HB ILE A 136 28.461 5.661 9.692 1.00 28.83 H +ATOM 1873 HG13 ILE A 136 27.302 4.206 7.888 1.00 30.10 H +ATOM 1874 HG12 ILE A 136 27.528 5.562 6.821 1.00 30.10 H +ATOM 1875 HG21 ILE A 136 28.143 7.818 8.431 1.00 28.01 H +ATOM 1876 HG22 ILE A 136 29.802 7.596 8.919 1.00 28.01 H +ATOM 1877 HG23 ILE A 136 29.321 7.288 7.248 1.00 28.01 H +ATOM 1878 HD11 ILE A 136 25.308 5.213 8.387 1.00 29.54 H +ATOM 1879 HD12 ILE A 136 26.259 6.255 9.435 1.00 29.54 H +ATOM 1880 HD13 ILE A 136 25.844 6.792 7.820 1.00 29.54 H +ATOM 1881 N PRO A 137 31.603 5.656 9.942 1.00 27.97 N +ATOM 1882 CA PRO A 137 32.911 6.275 10.241 1.00 29.98 C +ATOM 1883 C PRO A 137 34.133 5.409 9.883 1.00 31.46 C +ATOM 1884 O PRO A 137 35.117 5.961 9.390 1.00 32.74 O +ATOM 1885 CB PRO A 137 32.846 6.600 11.740 1.00 30.07 C +ATOM 1886 CG PRO A 137 31.811 5.638 12.296 1.00 28.98 C +ATOM 1887 CD PRO A 137 30.800 5.538 11.161 1.00 26.54 C +ATOM 1888 HA PRO A 137 32.997 7.210 9.682 1.00 29.98 H +ATOM 1889 HB3 PRO A 137 32.496 7.625 11.863 1.00 30.07 H +ATOM 1890 HB2 PRO A 137 33.805 6.521 12.255 1.00 30.07 H +ATOM 1891 HG3 PRO A 137 31.376 5.966 13.240 1.00 28.98 H +ATOM 1892 HG2 PRO A 137 32.272 4.665 12.462 1.00 28.98 H +ATOM 1893 HD2 PRO A 137 30.222 4.619 11.236 1.00 26.54 H +ATOM 1894 HD3 PRO A 137 30.110 6.380 11.208 1.00 26.54 H +ATOM 1895 N ARG A 138 34.026 4.081 10.075 1.00 32.19 N +ATOM 1896 CA ARG A 138 35.033 3.106 9.651 1.00 31.81 C +ATOM 1897 C ARG A 138 35.192 3.034 8.126 1.00 34.98 C +ATOM 1898 O ARG A 138 36.327 2.939 7.670 1.00 35.97 O +ATOM 1899 CB ARG A 138 34.697 1.708 10.196 1.00 31.32 C +ATOM 1900 CG ARG A 138 34.800 1.593 11.720 1.00 28.44 C +ATOM 1901 CD ARG A 138 34.463 0.174 12.202 1.00 28.17 C +ATOM 1902 NE ARG A 138 34.462 0.097 13.668 1.00 28.21 N +ATOM 1903 CZ ARG A 138 35.517 0.038 14.500 1.00 30.29 C +ATOM 1904 NH1 ARG A 138 36.782 -0.044 14.061 1.00 28.82 N +ATOM 1905 NH2 ARG A 138 35.296 0.079 15.817 1.00 28.61 N1+ +ATOM 1906 H ARG A 138 33.182 3.702 10.484 1.00 32.19 H +ATOM 1907 HA ARG A 138 35.996 3.413 10.065 1.00 31.81 H +ATOM 1908 HB3 ARG A 138 35.386 0.980 9.766 1.00 31.32 H +ATOM 1909 HB2 ARG A 138 33.698 1.414 9.869 1.00 31.32 H +ATOM 1910 HG3 ARG A 138 34.194 2.342 12.232 1.00 28.44 H +ATOM 1911 HG2 ARG A 138 35.832 1.823 11.987 1.00 28.44 H +ATOM 1912 HD3 ARG A 138 35.213 -0.527 11.835 1.00 28.17 H +ATOM 1913 HD2 ARG A 138 33.508 -0.163 11.797 1.00 28.17 H +ATOM 1914 HE ARG A 138 33.552 0.234 14.093 1.00 28.21 H +ATOM 1915 HH12 ARG A 138 37.554 -0.059 14.711 1.00 28.82 H +ATOM 1916 HH11 ARG A 138 36.969 -0.061 13.069 1.00 28.82 H +ATOM 1917 HH22 ARG A 138 36.067 0.069 16.468 1.00 28.61 H +ATOM 1918 HH21 ARG A 138 34.354 0.176 16.172 1.00 28.61 H +ATOM 1919 N THR A 139 34.079 3.101 7.371 1.00 35.78 N +ATOM 1920 CA THR A 139 34.073 3.106 5.906 1.00 36.79 C +ATOM 1921 C THR A 139 34.789 4.343 5.345 1.00 37.82 C +ATOM 1922 O THR A 139 35.692 4.162 4.533 1.00 35.78 O +ATOM 1923 CB THR A 139 32.640 3.040 5.305 1.00 37.62 C +ATOM 1924 OG1 THR A 139 32.080 1.775 5.587 1.00 35.78 O +ATOM 1925 CG2 THR A 139 32.523 3.258 3.785 1.00 37.13 C +ATOM 1926 H THR A 139 33.175 3.173 7.821 1.00 35.78 H +ATOM 1927 HA THR A 139 34.623 2.223 5.574 1.00 36.79 H +ATOM 1928 HB THR A 139 32.004 3.777 5.795 1.00 37.62 H +ATOM 1929 HG1 THR A 139 31.906 1.732 6.534 1.00 35.78 H +ATOM 1930 HG21 THR A 139 31.495 3.118 3.457 1.00 37.13 H +ATOM 1931 HG22 THR A 139 32.797 4.272 3.494 1.00 37.13 H +ATOM 1932 HG23 THR A 139 33.152 2.561 3.232 1.00 37.13 H +ATOM 1933 N LEU A 140 34.419 5.551 5.813 1.00 39.09 N +ATOM 1934 CA LEU A 140 35.057 6.808 5.409 1.00 40.74 C +ATOM 1935 C LEU A 140 36.559 6.833 5.729 1.00 42.29 C +ATOM 1936 O LEU A 140 37.342 7.149 4.836 1.00 42.16 O +ATOM 1937 CB LEU A 140 34.361 8.037 6.044 1.00 40.56 C +ATOM 1938 CG LEU A 140 33.082 8.569 5.359 1.00 42.13 C +ATOM 1939 CD1 LEU A 140 33.229 8.796 3.845 1.00 41.68 C +ATOM 1940 CD2 LEU A 140 31.831 7.757 5.698 1.00 45.74 C +ATOM 1941 H LEU A 140 33.673 5.622 6.493 1.00 39.09 H +ATOM 1942 HA LEU A 140 34.978 6.865 4.325 1.00 40.74 H +ATOM 1943 HB3 LEU A 140 35.068 8.864 6.014 1.00 40.56 H +ATOM 1944 HB2 LEU A 140 34.175 7.859 7.104 1.00 40.56 H +ATOM 1945 HG LEU A 140 32.912 9.556 5.794 1.00 42.13 H +ATOM 1946 HD11 LEU A 140 32.799 9.753 3.551 1.00 41.68 H +ATOM 1947 HD12 LEU A 140 34.270 8.814 3.524 1.00 41.68 H +ATOM 1948 HD13 LEU A 140 32.718 8.017 3.282 1.00 41.68 H +ATOM 1949 HD21 LEU A 140 30.960 8.173 5.198 1.00 45.74 H +ATOM 1950 HD22 LEU A 140 31.923 6.716 5.390 1.00 45.74 H +ATOM 1951 HD23 LEU A 140 31.633 7.798 6.767 1.00 45.74 H +ATOM 1952 N HIS A 141 36.933 6.455 6.965 1.00 42.88 N +ATOM 1953 CA HIS A 141 38.323 6.362 7.417 1.00 44.87 C +ATOM 1954 C HIS A 141 39.172 5.410 6.556 1.00 44.22 C +ATOM 1955 O HIS A 141 40.252 5.805 6.121 1.00 43.81 O +ATOM 1956 CB HIS A 141 38.364 5.966 8.907 1.00 46.81 C +ATOM 1957 CG HIS A 141 39.755 5.914 9.494 1.00 50.62 C +ATOM 1958 ND1 HIS A 141 40.556 4.783 9.456 1.00 52.14 N +ATOM 1959 CD2 HIS A 141 40.506 6.879 10.125 1.00 51.05 C +ATOM 1960 CE1 HIS A 141 41.724 5.111 10.016 1.00 52.04 C +ATOM 1961 NE2 HIS A 141 41.765 6.367 10.446 1.00 50.72 N +ATOM 1962 H HIS A 141 36.226 6.201 7.644 1.00 42.88 H +ATOM 1963 HA HIS A 141 38.755 7.360 7.325 1.00 44.87 H +ATOM 1964 HB3 HIS A 141 37.884 4.998 9.058 1.00 46.81 H +ATOM 1965 HB2 HIS A 141 37.789 6.684 9.490 1.00 46.81 H +ATOM 1966 HD1 HIS A 141 40.324 3.889 9.047 1.00 52.14 H +ATOM 1967 HD2 HIS A 141 40.244 7.900 10.357 1.00 51.05 H +ATOM 1968 HE1 HIS A 141 42.555 4.426 10.104 1.00 52.04 H +ATOM 1969 N GLN A 142 38.652 4.194 6.318 1.00 43.78 N +ATOM 1970 CA GLN A 142 39.307 3.161 5.521 1.00 44.19 C +ATOM 1971 C GLN A 142 39.404 3.486 4.024 1.00 44.75 C +ATOM 1972 O GLN A 142 40.373 3.054 3.409 1.00 45.21 O +ATOM 1973 CB GLN A 142 38.637 1.795 5.758 1.00 45.44 C +ATOM 1974 CG GLN A 142 38.894 1.197 7.158 1.00 48.56 C +ATOM 1975 CD GLN A 142 40.296 0.608 7.316 1.00 50.10 C +ATOM 1976 OE1 GLN A 142 41.260 1.338 7.532 1.00 49.63 O +ATOM 1977 NE2 GLN A 142 40.413 -0.718 7.226 1.00 51.81 N +ATOM 1978 H GLN A 142 37.752 3.947 6.709 1.00 43.78 H +ATOM 1979 HA GLN A 142 40.332 3.100 5.881 1.00 44.19 H +ATOM 1980 HB3 GLN A 142 38.957 1.074 5.003 1.00 45.44 H +ATOM 1981 HB2 GLN A 142 37.565 1.911 5.604 1.00 45.44 H +ATOM 1982 HG3 GLN A 142 38.165 0.419 7.366 1.00 48.56 H +ATOM 1983 HG2 GLN A 142 38.747 1.951 7.932 1.00 48.56 H +ATOM 1984 HE22 GLN A 142 41.319 -1.150 7.330 1.00 51.81 H +ATOM 1985 HE21 GLN A 142 39.604 -1.294 7.044 1.00 51.81 H +ATOM 1986 N ILE A 143 38.466 4.278 3.470 1.00 43.60 N +ATOM 1987 CA ILE A 143 38.564 4.817 2.108 1.00 43.61 C +ATOM 1988 C ILE A 143 39.809 5.711 1.944 1.00 45.62 C +ATOM 1989 O ILE A 143 40.591 5.468 1.028 1.00 44.70 O +ATOM 1990 CB ILE A 143 37.278 5.581 1.658 1.00 42.40 C +ATOM 1991 CG1 ILE A 143 36.127 4.588 1.384 1.00 40.31 C +ATOM 1992 CG2 ILE A 143 37.458 6.515 0.436 1.00 40.71 C +ATOM 1993 CD1 ILE A 143 34.728 5.228 1.419 1.00 38.90 C +ATOM 1994 H ILE A 143 37.676 4.585 4.022 1.00 43.60 H +ATOM 1995 HA ILE A 143 38.693 3.965 1.437 1.00 43.61 H +ATOM 1996 HB ILE A 143 36.963 6.210 2.489 1.00 42.40 H +ATOM 1997 HG13 ILE A 143 36.150 3.777 2.110 1.00 40.31 H +ATOM 1998 HG12 ILE A 143 36.285 4.097 0.424 1.00 40.31 H +ATOM 1999 HG21 ILE A 143 36.514 6.960 0.128 1.00 40.71 H +ATOM 2000 HG22 ILE A 143 38.128 7.350 0.646 1.00 40.71 H +ATOM 2001 HG23 ILE A 143 37.857 5.972 -0.421 1.00 40.71 H +ATOM 2002 HD11 ILE A 143 33.951 4.471 1.317 1.00 38.90 H +ATOM 2003 HD12 ILE A 143 34.555 5.750 2.359 1.00 38.90 H +ATOM 2004 HD13 ILE A 143 34.584 5.944 0.612 1.00 38.90 H +ATOM 2005 N PHE A 144 40.008 6.663 2.874 1.00 46.96 N +ATOM 2006 CA PHE A 144 41.208 7.504 2.934 1.00 49.07 C +ATOM 2007 C PHE A 144 42.489 6.763 3.345 1.00 50.61 C +ATOM 2008 O PHE A 144 43.560 7.331 3.162 1.00 51.54 O +ATOM 2009 CB PHE A 144 40.983 8.717 3.858 1.00 48.69 C +ATOM 2010 CG PHE A 144 39.969 9.712 3.337 1.00 49.25 C +ATOM 2011 CD1 PHE A 144 40.245 10.472 2.182 1.00 49.30 C +ATOM 2012 CD2 PHE A 144 38.703 9.816 3.944 1.00 48.10 C +ATOM 2013 CE1 PHE A 144 39.263 11.287 1.639 1.00 48.65 C +ATOM 2014 CE2 PHE A 144 37.731 10.627 3.383 1.00 49.28 C +ATOM 2015 CZ PHE A 144 38.011 11.351 2.233 1.00 49.42 C +ATOM 2016 H PHE A 144 39.328 6.796 3.610 1.00 46.96 H +ATOM 2017 HA PHE A 144 41.395 7.879 1.926 1.00 49.07 H +ATOM 2018 HB3 PHE A 144 41.917 9.259 4.012 1.00 48.69 H +ATOM 2019 HB2 PHE A 144 40.673 8.365 4.841 1.00 48.69 H +ATOM 2020 HD1 PHE A 144 41.215 10.416 1.714 1.00 49.30 H +ATOM 2021 HD2 PHE A 144 38.487 9.269 4.847 1.00 48.10 H +ATOM 2022 HE1 PHE A 144 39.468 11.865 0.749 1.00 48.65 H +ATOM 2023 HE2 PHE A 144 36.755 10.688 3.840 1.00 49.28 H +ATOM 2024 HZ PHE A 144 37.248 11.968 1.796 1.00 49.42 H +ATOM 2025 N GLU A 145 42.386 5.537 3.881 1.00 51.76 N +ATOM 2026 CA GLU A 145 43.545 4.720 4.230 1.00 53.26 C +ATOM 2027 C GLU A 145 44.002 3.875 3.030 1.00 53.56 C +ATOM 2028 O GLU A 145 45.191 3.859 2.727 1.00 53.41 O +ATOM 2029 CB GLU A 145 43.215 3.852 5.466 1.00 54.78 C +ATOM 2030 CG GLU A 145 44.400 3.059 6.056 1.00 58.42 C +ATOM 2031 CD GLU A 145 45.499 3.967 6.626 1.00 60.55 C +ATOM 2032 OE1 GLU A 145 46.488 4.204 5.899 1.00 61.57 O +ATOM 2033 OE2 GLU A 145 45.330 4.414 7.783 1.00 60.12 O1- +ATOM 2034 H GLU A 145 41.475 5.128 4.038 1.00 51.76 H +ATOM 2035 HA GLU A 145 44.368 5.384 4.500 1.00 53.26 H +ATOM 2036 HB3 GLU A 145 42.444 3.132 5.197 1.00 54.78 H +ATOM 2037 HB2 GLU A 145 42.774 4.476 6.246 1.00 54.78 H +ATOM 2038 HG3 GLU A 145 44.823 2.387 5.308 1.00 58.42 H +ATOM 2039 HG2 GLU A 145 44.033 2.412 6.854 1.00 58.42 H +ATOM 2040 N LYS A 146 43.050 3.195 2.371 1.00 52.91 N +ATOM 2041 CA LYS A 146 43.314 2.210 1.323 1.00 53.75 C +ATOM 2042 C LYS A 146 43.578 2.834 -0.060 1.00 54.11 C +ATOM 2043 O LYS A 146 44.247 2.187 -0.861 1.00 53.73 O +ATOM 2044 CB LYS A 146 42.151 1.191 1.273 1.00 54.00 C +ATOM 2045 CG LYS A 146 41.928 0.435 2.607 1.00 56.01 C +ATOM 2046 CD LYS A 146 42.075 -1.090 2.530 1.00 56.78 C +ATOM 2047 CE LYS A 146 40.922 -1.777 1.782 1.00 56.67 C +ATOM 2048 NZ LYS A 146 41.048 -3.243 1.840 1.00 56.24 N1+ +ATOM 2049 H LYS A 146 42.087 3.267 2.676 1.00 52.91 H +ATOM 2050 HA LYS A 146 44.217 1.659 1.597 1.00 53.75 H +ATOM 2051 HB3 LYS A 146 42.335 0.476 0.470 1.00 54.00 H +ATOM 2052 HB2 LYS A 146 41.227 1.705 0.999 1.00 54.00 H +ATOM 2053 HG3 LYS A 146 40.933 0.655 2.988 1.00 56.01 H +ATOM 2054 HG2 LYS A 146 42.617 0.799 3.370 1.00 56.01 H +ATOM 2055 HD3 LYS A 146 42.144 -1.481 3.547 1.00 56.78 H +ATOM 2056 HD2 LYS A 146 43.025 -1.332 2.050 1.00 56.78 H +ATOM 2057 HE3 LYS A 146 40.897 -1.466 0.737 1.00 56.67 H +ATOM 2058 HE2 LYS A 146 39.963 -1.500 2.222 1.00 56.67 H +ATOM 2059 HZ1 LYS A 146 40.276 -3.650 1.322 1.00 56.24 H +ATOM 2060 HZ2 LYS A 146 41.918 -3.530 1.417 1.00 56.24 H +ATOM 2061 HZ3 LYS A 146 41.011 -3.557 2.799 1.00 56.24 H +ATOM 2062 N LEU A 147 43.076 4.056 -0.325 1.00 53.89 N +ATOM 2063 CA LEU A 147 43.275 4.755 -1.603 1.00 54.30 C +ATOM 2064 C LEU A 147 44.414 5.781 -1.547 1.00 56.38 C +ATOM 2065 O LEU A 147 45.034 5.990 -2.588 1.00 57.15 O +ATOM 2066 CB LEU A 147 41.971 5.437 -2.073 1.00 52.68 C +ATOM 2067 CG LEU A 147 41.046 4.548 -2.925 1.00 51.66 C +ATOM 2068 CD1 LEU A 147 40.693 3.211 -2.254 1.00 49.87 C +ATOM 2069 CD2 LEU A 147 39.783 5.332 -3.314 1.00 48.79 C +ATOM 2070 H LEU A 147 42.510 4.528 0.368 1.00 53.89 H +ATOM 2071 HA LEU A 147 43.561 4.039 -2.376 1.00 54.30 H +ATOM 2072 HB3 LEU A 147 42.221 6.286 -2.709 1.00 52.68 H +ATOM 2073 HB2 LEU A 147 41.439 5.869 -1.230 1.00 52.68 H +ATOM 2074 HG LEU A 147 41.570 4.305 -3.852 1.00 51.66 H +ATOM 2075 HD11 LEU A 147 39.750 2.815 -2.616 1.00 49.87 H +ATOM 2076 HD12 LEU A 147 41.453 2.456 -2.460 1.00 49.87 H +ATOM 2077 HD13 LEU A 147 40.603 3.313 -1.172 1.00 49.87 H +ATOM 2078 HD21 LEU A 147 38.968 4.674 -3.612 1.00 48.79 H +ATOM 2079 HD22 LEU A 147 39.422 5.954 -2.494 1.00 48.79 H +ATOM 2080 HD23 LEU A 147 39.994 5.992 -4.153 1.00 48.79 H +ATOM 2081 N THR A 148 44.691 6.386 -0.376 1.00 57.67 N +ATOM 2082 CA THR A 148 45.844 7.284 -0.198 1.00 58.54 C +ATOM 2083 C THR A 148 47.175 6.508 -0.107 1.00 60.02 C +ATOM 2084 O THR A 148 48.210 7.060 -0.480 1.00 59.77 O +ATOM 2085 CB THR A 148 45.720 8.185 1.059 1.00 58.20 C +ATOM 2086 OG1 THR A 148 44.516 8.922 0.985 1.00 58.85 O +ATOM 2087 CG2 THR A 148 46.851 9.207 1.278 1.00 58.05 C +ATOM 2088 H THR A 148 44.149 6.173 0.448 1.00 57.67 H +ATOM 2089 HA THR A 148 45.907 7.938 -1.072 1.00 58.54 H +ATOM 2090 HB THR A 148 45.682 7.548 1.941 1.00 58.20 H +ATOM 2091 HG1 THR A 148 43.790 8.324 1.177 1.00 58.85 H +ATOM 2092 HG21 THR A 148 46.613 9.880 2.103 1.00 58.05 H +ATOM 2093 HG22 THR A 148 47.795 8.724 1.531 1.00 58.05 H +ATOM 2094 HG23 THR A 148 47.012 9.816 0.388 1.00 58.05 H +ATOM 2095 N ASP A 149 47.112 5.233 0.325 1.00 61.81 N +ATOM 2096 CA ASP A 149 48.198 4.247 0.267 1.00 63.39 C +ATOM 2097 C ASP A 149 48.673 4.050 -1.186 1.00 64.18 C +ATOM 2098 O ASP A 149 49.865 4.188 -1.460 1.00 64.37 O +ATOM 2099 CB ASP A 149 47.769 2.947 1.010 1.00 64.12 C +ATOM 2100 CG ASP A 149 48.717 1.730 1.096 1.00 65.61 C +ATOM 2101 OD1 ASP A 149 49.522 1.479 0.172 1.00 66.85 O +ATOM 2102 OD2 ASP A 149 48.519 0.960 2.061 1.00 67.42 O1- +ATOM 2103 H ASP A 149 46.223 4.871 0.640 1.00 61.81 H +ATOM 2104 HA ASP A 149 49.037 4.671 0.822 1.00 63.39 H +ATOM 2105 HB3 ASP A 149 46.823 2.598 0.592 1.00 64.12 H +ATOM 2106 HB2 ASP A 149 47.534 3.237 2.034 1.00 64.12 H +ATOM 2107 N ASN A 150 47.713 3.798 -2.088 1.00 64.99 N +ATOM 2108 CA ASN A 150 47.926 3.705 -3.532 1.00 65.74 C +ATOM 2109 C ASN A 150 48.150 5.098 -4.151 1.00 65.03 C +ATOM 2110 O ASN A 150 47.802 6.117 -3.553 1.00 65.91 O +ATOM 2111 CB ASN A 150 46.702 3.004 -4.171 1.00 67.17 C +ATOM 2112 CG ASN A 150 46.561 1.530 -3.764 1.00 68.38 C +ATOM 2113 OD1 ASN A 150 46.375 1.213 -2.592 1.00 69.69 O +ATOM 2114 ND2 ASN A 150 46.630 0.615 -4.732 1.00 69.67 N +ATOM 2115 H ASN A 150 46.759 3.697 -1.773 1.00 64.99 H +ATOM 2116 HA ASN A 150 48.813 3.088 -3.689 1.00 65.74 H +ATOM 2117 HB3 ASN A 150 46.770 3.053 -5.259 1.00 67.17 H +ATOM 2118 HB2 ASN A 150 45.784 3.528 -3.899 1.00 67.17 H +ATOM 2119 HD22 ASN A 150 46.538 -0.364 -4.502 1.00 69.67 H +ATOM 2120 HD21 ASN A 150 46.765 0.888 -5.694 1.00 69.67 H +ATOM 2121 N GLY A 151 48.679 5.108 -5.385 1.00 64.36 N +ATOM 2122 CA GLY A 151 48.858 6.310 -6.205 1.00 63.41 C +ATOM 2123 C GLY A 151 47.542 6.803 -6.838 1.00 62.81 C +ATOM 2124 O GLY A 151 47.594 7.619 -7.756 1.00 63.61 O +ATOM 2125 H GLY A 151 48.945 4.231 -5.810 1.00 64.36 H +ATOM 2126 HA3 GLY A 151 49.567 6.082 -7.001 1.00 63.41 H +ATOM 2127 HA2 GLY A 151 49.297 7.114 -5.611 1.00 63.41 H +ATOM 2128 N THR A 152 46.379 6.304 -6.380 1.00 60.95 N +ATOM 2129 CA THR A 152 45.049 6.654 -6.871 1.00 59.02 C +ATOM 2130 C THR A 152 44.722 8.134 -6.610 1.00 58.13 C +ATOM 2131 O THR A 152 44.837 8.591 -5.473 1.00 57.82 O +ATOM 2132 CB THR A 152 43.938 5.798 -6.196 1.00 59.09 C +ATOM 2133 OG1 THR A 152 44.261 4.424 -6.291 1.00 59.39 O +ATOM 2134 CG2 THR A 152 42.539 5.969 -6.819 1.00 57.71 C +ATOM 2135 H THR A 152 46.406 5.680 -5.588 1.00 60.95 H +ATOM 2136 HA THR A 152 45.039 6.473 -7.946 1.00 59.02 H +ATOM 2137 HB THR A 152 43.879 6.041 -5.134 1.00 59.09 H +ATOM 2138 HG1 THR A 152 45.064 4.263 -5.791 1.00 59.39 H +ATOM 2139 HG21 THR A 152 41.792 5.397 -6.269 1.00 57.71 H +ATOM 2140 HG22 THR A 152 42.214 7.007 -6.821 1.00 57.71 H +ATOM 2141 HG23 THR A 152 42.521 5.627 -7.854 1.00 57.71 H +ATOM 2142 N GLU A 153 44.316 8.840 -7.674 1.00 56.97 N +ATOM 2143 CA GLU A 153 43.813 10.207 -7.618 1.00 56.69 C +ATOM 2144 C GLU A 153 42.294 10.144 -7.433 1.00 55.11 C +ATOM 2145 O GLU A 153 41.599 9.811 -8.389 1.00 55.09 O +ATOM 2146 CB GLU A 153 44.273 10.944 -8.896 1.00 57.96 C +ATOM 2147 CG GLU A 153 43.615 12.319 -9.151 1.00 60.39 C +ATOM 2148 CD GLU A 153 44.224 13.071 -10.343 1.00 61.93 C +ATOM 2149 OE1 GLU A 153 45.468 13.196 -10.383 1.00 62.34 O +ATOM 2150 OE2 GLU A 153 43.432 13.531 -11.195 1.00 61.46 O1- +ATOM 2151 H GLU A 153 44.278 8.398 -8.583 1.00 56.97 H +ATOM 2152 HA GLU A 153 44.244 10.734 -6.764 1.00 56.69 H +ATOM 2153 HB3 GLU A 153 44.125 10.311 -9.770 1.00 57.96 H +ATOM 2154 HB2 GLU A 153 45.354 11.070 -8.816 1.00 57.96 H +ATOM 2155 HG3 GLU A 153 43.725 12.947 -8.266 1.00 60.39 H +ATOM 2156 HG2 GLU A 153 42.542 12.200 -9.310 1.00 60.39 H +ATOM 2157 N PHE A 154 41.811 10.402 -6.207 1.00 52.70 N +ATOM 2158 CA PHE A 154 40.409 10.189 -5.850 1.00 49.80 C +ATOM 2159 C PHE A 154 39.805 11.395 -5.124 1.00 49.14 C +ATOM 2160 O PHE A 154 40.516 12.198 -4.520 1.00 48.93 O +ATOM 2161 CB PHE A 154 40.270 8.882 -5.029 1.00 48.80 C +ATOM 2162 CG PHE A 154 40.753 8.928 -3.589 1.00 49.66 C +ATOM 2163 CD1 PHE A 154 39.834 9.060 -2.527 1.00 48.25 C +ATOM 2164 CD2 PHE A 154 42.134 8.956 -3.307 1.00 48.95 C +ATOM 2165 CE1 PHE A 154 40.296 9.160 -1.222 1.00 49.33 C +ATOM 2166 CE2 PHE A 154 42.577 9.068 -1.999 1.00 50.09 C +ATOM 2167 CZ PHE A 154 41.661 9.160 -0.961 1.00 50.47 C +ATOM 2168 H PHE A 154 42.428 10.684 -5.459 1.00 52.70 H +ATOM 2169 HA PHE A 154 39.842 10.079 -6.770 1.00 49.80 H +ATOM 2170 HB3 PHE A 154 40.788 8.074 -5.539 1.00 48.80 H +ATOM 2171 HB2 PHE A 154 39.223 8.577 -5.016 1.00 48.80 H +ATOM 2172 HD1 PHE A 154 38.772 9.071 -2.725 1.00 48.25 H +ATOM 2173 HD2 PHE A 154 42.849 8.884 -4.108 1.00 48.95 H +ATOM 2174 HE1 PHE A 154 39.591 9.236 -0.407 1.00 49.33 H +ATOM 2175 HE2 PHE A 154 43.637 9.076 -1.788 1.00 50.09 H +ATOM 2176 HZ PHE A 154 42.016 9.234 0.053 1.00 50.47 H +ATOM 2177 N SER A 155 38.469 11.445 -5.189 1.00 45.90 N +ATOM 2178 CA SER A 155 37.605 12.383 -4.490 1.00 45.47 C +ATOM 2179 C SER A 155 36.435 11.587 -3.901 1.00 43.55 C +ATOM 2180 O SER A 155 35.952 10.651 -4.539 1.00 43.15 O +ATOM 2181 CB SER A 155 37.138 13.465 -5.485 1.00 43.93 C +ATOM 2182 OG SER A 155 36.300 14.422 -4.866 1.00 46.92 O +ATOM 2183 H SER A 155 37.983 10.724 -5.708 1.00 45.90 H +ATOM 2184 HA SER A 155 38.153 12.855 -3.672 1.00 45.47 H +ATOM 2185 HB3 SER A 155 36.597 13.016 -6.319 1.00 43.93 H +ATOM 2186 HB2 SER A 155 37.999 13.985 -5.908 1.00 43.93 H +ATOM 2187 HG SER A 155 36.085 15.101 -5.511 1.00 46.92 H +ATOM 2188 N VAL A 156 36.000 11.984 -2.698 1.00 42.99 N +ATOM 2189 CA VAL A 156 34.894 11.360 -1.981 1.00 40.85 C +ATOM 2190 C VAL A 156 33.810 12.424 -1.770 1.00 40.89 C +ATOM 2191 O VAL A 156 34.131 13.524 -1.330 1.00 42.32 O +ATOM 2192 CB VAL A 156 35.356 10.843 -0.588 1.00 40.60 C +ATOM 2193 CG1 VAL A 156 34.222 10.235 0.260 1.00 41.68 C +ATOM 2194 CG2 VAL A 156 36.494 9.818 -0.715 1.00 41.72 C +ATOM 2195 H VAL A 156 36.427 12.779 -2.245 1.00 42.99 H +ATOM 2196 HA VAL A 156 34.477 10.525 -2.544 1.00 40.85 H +ATOM 2197 HB VAL A 156 35.761 11.686 -0.030 1.00 40.60 H +ATOM 2198 HG11 VAL A 156 34.606 9.830 1.197 1.00 41.68 H +ATOM 2199 HG12 VAL A 156 33.457 10.965 0.524 1.00 41.68 H +ATOM 2200 HG13 VAL A 156 33.741 9.420 -0.281 1.00 41.68 H +ATOM 2201 HG21 VAL A 156 36.798 9.446 0.263 1.00 41.72 H +ATOM 2202 HG22 VAL A 156 36.191 8.963 -1.320 1.00 41.72 H +ATOM 2203 HG23 VAL A 156 37.379 10.259 -1.174 1.00 41.72 H +ATOM 2204 N LYS A 157 32.554 12.066 -2.066 1.00 39.19 N +ATOM 2205 CA LYS A 157 31.364 12.855 -1.753 1.00 37.21 C +ATOM 2206 C LYS A 157 30.448 12.020 -0.860 1.00 35.33 C +ATOM 2207 O LYS A 157 30.394 10.804 -1.033 1.00 33.52 O +ATOM 2208 CB LYS A 157 30.613 13.221 -3.044 1.00 38.54 C +ATOM 2209 CG LYS A 157 31.374 14.195 -3.957 1.00 42.32 C +ATOM 2210 CD LYS A 157 30.564 14.651 -5.183 1.00 44.23 C +ATOM 2211 CE LYS A 157 30.042 13.484 -6.041 1.00 46.31 C +ATOM 2212 NZ LYS A 157 29.441 13.952 -7.301 1.00 48.40 N1+ +ATOM 2213 H LYS A 157 32.378 11.139 -2.432 1.00 39.19 H +ATOM 2214 HA LYS A 157 31.636 13.767 -1.224 1.00 37.21 H +ATOM 2215 HB3 LYS A 157 29.661 13.684 -2.780 1.00 38.54 H +ATOM 2216 HB2 LYS A 157 30.368 12.305 -3.585 1.00 38.54 H +ATOM 2217 HG3 LYS A 157 32.302 13.731 -4.294 1.00 42.32 H +ATOM 2218 HG2 LYS A 157 31.669 15.073 -3.380 1.00 42.32 H +ATOM 2219 HD3 LYS A 157 31.199 15.299 -5.788 1.00 44.23 H +ATOM 2220 HD2 LYS A 157 29.731 15.273 -4.854 1.00 44.23 H +ATOM 2221 HE3 LYS A 157 29.285 12.913 -5.502 1.00 46.31 H +ATOM 2222 HE2 LYS A 157 30.858 12.801 -6.269 1.00 46.31 H +ATOM 2223 HZ1 LYS A 157 28.645 14.539 -7.074 1.00 48.40 H +ATOM 2224 HZ2 LYS A 157 30.113 14.485 -7.834 1.00 48.40 H +ATOM 2225 HZ3 LYS A 157 29.111 13.167 -7.844 1.00 48.40 H +ATOM 2226 N VAL A 158 29.719 12.691 0.042 1.00 34.70 N +ATOM 2227 CA VAL A 158 28.712 12.071 0.897 1.00 32.77 C +ATOM 2228 C VAL A 158 27.419 12.897 0.905 1.00 33.04 C +ATOM 2229 O VAL A 158 27.466 14.124 0.841 1.00 33.91 O +ATOM 2230 CB VAL A 158 29.195 11.895 2.364 1.00 32.67 C +ATOM 2231 CG1 VAL A 158 30.320 10.856 2.474 1.00 31.61 C +ATOM 2232 CG2 VAL A 158 29.590 13.197 3.086 1.00 33.84 C +ATOM 2233 H VAL A 158 29.828 13.693 0.139 1.00 34.70 H +ATOM 2234 HA VAL A 158 28.463 11.094 0.490 1.00 32.77 H +ATOM 2235 HB VAL A 158 28.360 11.477 2.929 1.00 32.67 H +ATOM 2236 HG11 VAL A 158 30.587 10.678 3.516 1.00 31.61 H +ATOM 2237 HG12 VAL A 158 30.008 9.902 2.052 1.00 31.61 H +ATOM 2238 HG13 VAL A 158 31.220 11.177 1.950 1.00 31.61 H +ATOM 2239 HG21 VAL A 158 29.920 12.976 4.100 1.00 33.84 H +ATOM 2240 HG22 VAL A 158 30.411 13.704 2.579 1.00 33.84 H +ATOM 2241 HG23 VAL A 158 28.763 13.901 3.163 1.00 33.84 H +ATOM 2242 N SER A 159 26.288 12.188 1.014 1.00 31.10 N +ATOM 2243 CA SER A 159 24.956 12.763 1.155 1.00 29.81 C +ATOM 2244 C SER A 159 24.130 11.910 2.125 1.00 27.90 C +ATOM 2245 O SER A 159 24.349 10.703 2.221 1.00 26.67 O +ATOM 2246 CB SER A 159 24.300 12.933 -0.234 1.00 29.49 C +ATOM 2247 OG SER A 159 23.938 11.706 -0.832 1.00 33.07 O +ATOM 2248 H SER A 159 26.335 11.178 1.066 1.00 31.10 H +ATOM 2249 HA SER A 159 25.060 13.752 1.604 1.00 29.81 H +ATOM 2250 HB3 SER A 159 24.963 13.476 -0.908 1.00 29.49 H +ATOM 2251 HB2 SER A 159 23.394 13.532 -0.143 1.00 29.49 H +ATOM 2252 HG SER A 159 23.162 11.357 -0.379 1.00 33.07 H +ATOM 2253 N LEU A 160 23.191 12.566 2.816 1.00 28.07 N +ATOM 2254 CA LEU A 160 22.306 11.969 3.803 1.00 24.85 C +ATOM 2255 C LEU A 160 20.880 12.425 3.496 1.00 24.84 C +ATOM 2256 O LEU A 160 20.458 13.495 3.937 1.00 25.97 O +ATOM 2257 CB LEU A 160 22.785 12.377 5.208 1.00 25.10 C +ATOM 2258 CG LEU A 160 22.040 11.742 6.395 1.00 24.01 C +ATOM 2259 CD1 LEU A 160 22.077 10.203 6.383 1.00 23.66 C +ATOM 2260 CD2 LEU A 160 22.594 12.318 7.710 1.00 27.15 C +ATOM 2261 H LEU A 160 23.064 13.561 2.656 1.00 28.07 H +ATOM 2262 HA LEU A 160 22.339 10.883 3.723 1.00 24.85 H +ATOM 2263 HB3 LEU A 160 22.694 13.460 5.286 1.00 25.10 H +ATOM 2264 HB2 LEU A 160 23.844 12.138 5.308 1.00 25.10 H +ATOM 2265 HG LEU A 160 20.996 12.036 6.322 1.00 24.01 H +ATOM 2266 HD11 LEU A 160 22.331 9.789 7.359 1.00 23.66 H +ATOM 2267 HD12 LEU A 160 21.107 9.795 6.098 1.00 23.66 H +ATOM 2268 HD13 LEU A 160 22.809 9.823 5.676 1.00 23.66 H +ATOM 2269 HD21 LEU A 160 21.872 12.248 8.522 1.00 27.15 H +ATOM 2270 HD22 LEU A 160 23.491 11.786 8.013 1.00 27.15 H +ATOM 2271 HD23 LEU A 160 22.870 13.368 7.611 1.00 27.15 H +ATOM 2272 N LEU A 161 20.178 11.585 2.725 1.00 23.65 N +ATOM 2273 CA LEU A 161 18.763 11.735 2.419 1.00 23.59 C +ATOM 2274 C LEU A 161 17.957 10.936 3.440 1.00 21.28 C +ATOM 2275 O LEU A 161 18.292 9.777 3.681 1.00 20.76 O +ATOM 2276 CB LEU A 161 18.505 11.202 0.998 1.00 25.98 C +ATOM 2277 CG LEU A 161 17.033 11.282 0.536 1.00 27.94 C +ATOM 2278 CD1 LEU A 161 16.530 12.740 0.453 1.00 26.95 C +ATOM 2279 CD2 LEU A 161 16.840 10.505 -0.775 1.00 28.87 C +ATOM 2280 H LEU A 161 20.608 10.725 2.416 1.00 23.65 H +ATOM 2281 HA LEU A 161 18.486 12.789 2.464 1.00 23.59 H +ATOM 2282 HB3 LEU A 161 18.833 10.162 0.949 1.00 25.98 H +ATOM 2283 HB2 LEU A 161 19.133 11.741 0.294 1.00 25.98 H +ATOM 2284 HG LEU A 161 16.399 10.772 1.262 1.00 27.94 H +ATOM 2285 HD11 LEU A 161 16.005 12.957 -0.476 1.00 26.95 H +ATOM 2286 HD12 LEU A 161 15.837 12.952 1.268 1.00 26.95 H +ATOM 2287 HD13 LEU A 161 17.345 13.459 0.529 1.00 26.95 H +ATOM 2288 HD21 LEU A 161 16.277 11.069 -1.518 1.00 28.87 H +ATOM 2289 HD22 LEU A 161 17.790 10.223 -1.229 1.00 28.87 H +ATOM 2290 HD23 LEU A 161 16.295 9.582 -0.586 1.00 28.87 H +ATOM 2291 N GLU A 162 16.897 11.549 3.986 1.00 21.39 N +ATOM 2292 CA GLU A 162 16.019 10.906 4.960 1.00 22.91 C +ATOM 2293 C GLU A 162 14.555 11.099 4.593 1.00 21.99 C +ATOM 2294 O GLU A 162 14.198 12.121 4.018 1.00 22.20 O +ATOM 2295 CB GLU A 162 16.314 11.413 6.378 1.00 20.42 C +ATOM 2296 CG GLU A 162 17.813 11.301 6.698 1.00 26.15 C +ATOM 2297 CD GLU A 162 18.207 11.221 8.163 1.00 25.20 C +ATOM 2298 OE1 GLU A 162 19.430 11.100 8.351 1.00 25.08 O +ATOM 2299 OE2 GLU A 162 17.346 11.279 9.067 1.00 25.71 O1- +ATOM 2300 H GLU A 162 16.682 12.509 3.746 1.00 21.39 H +ATOM 2301 HA GLU A 162 16.202 9.834 4.931 1.00 22.91 H +ATOM 2302 HB3 GLU A 162 15.718 10.829 7.081 1.00 20.42 H +ATOM 2303 HB2 GLU A 162 15.992 12.449 6.483 1.00 20.42 H +ATOM 2304 HG3 GLU A 162 18.343 12.141 6.245 1.00 26.15 H +ATOM 2305 HG2 GLU A 162 18.219 10.404 6.234 1.00 26.15 H +ATOM 2306 N ILE A 163 13.748 10.087 4.932 1.00 19.55 N +ATOM 2307 CA ILE A 163 12.349 9.985 4.552 1.00 20.11 C +ATOM 2308 C ILE A 163 11.533 9.827 5.840 1.00 19.59 C +ATOM 2309 O ILE A 163 11.668 8.809 6.516 1.00 19.30 O +ATOM 2310 CB ILE A 163 12.078 8.749 3.638 1.00 21.56 C +ATOM 2311 CG1 ILE A 163 13.127 8.643 2.505 1.00 20.64 C +ATOM 2312 CG2 ILE A 163 10.636 8.778 3.078 1.00 20.03 C +ATOM 2313 CD1 ILE A 163 12.921 7.468 1.546 1.00 22.06 C +ATOM 2314 H ILE A 163 14.131 9.298 5.439 1.00 19.55 H +ATOM 2315 HA ILE A 163 12.029 10.877 4.019 1.00 20.11 H +ATOM 2316 HB ILE A 163 12.171 7.837 4.228 1.00 21.56 H +ATOM 2317 HG13 ILE A 163 14.128 8.540 2.925 1.00 20.64 H +ATOM 2318 HG12 ILE A 163 13.142 9.570 1.940 1.00 20.64 H +ATOM 2319 HG21 ILE A 163 10.416 7.893 2.482 1.00 20.03 H +ATOM 2320 HG22 ILE A 163 9.887 8.806 3.870 1.00 20.03 H +ATOM 2321 HG23 ILE A 163 10.476 9.651 2.444 1.00 20.03 H +ATOM 2322 HD11 ILE A 163 13.870 7.141 1.119 1.00 22.06 H +ATOM 2323 HD12 ILE A 163 12.479 6.616 2.060 1.00 22.06 H +ATOM 2324 HD13 ILE A 163 12.267 7.746 0.721 1.00 22.06 H +ATOM 2325 N TYR A 164 10.696 10.828 6.140 1.00 19.64 N +ATOM 2326 CA TYR A 164 9.721 10.786 7.225 1.00 22.59 C +ATOM 2327 C TYR A 164 8.374 11.223 6.644 1.00 21.43 C +ATOM 2328 O TYR A 164 8.281 12.327 6.108 1.00 23.00 O +ATOM 2329 CB TYR A 164 10.197 11.657 8.411 1.00 18.51 C +ATOM 2330 CG TYR A 164 9.213 11.791 9.564 1.00 20.90 C +ATOM 2331 CD1 TYR A 164 8.145 12.713 9.489 1.00 20.72 C +ATOM 2332 CD2 TYR A 164 9.358 10.989 10.715 1.00 20.94 C +ATOM 2333 CE1 TYR A 164 7.207 12.802 10.533 1.00 23.50 C +ATOM 2334 CE2 TYR A 164 8.437 11.104 11.775 1.00 24.08 C +ATOM 2335 CZ TYR A 164 7.352 11.996 11.676 1.00 23.90 C +ATOM 2336 OH TYR A 164 6.450 12.096 12.694 1.00 25.55 O +ATOM 2337 H TYR A 164 10.647 11.636 5.533 1.00 19.64 H +ATOM 2338 HA TYR A 164 9.611 9.763 7.592 1.00 22.59 H +ATOM 2339 HB3 TYR A 164 10.442 12.660 8.073 1.00 18.51 H +ATOM 2340 HB2 TYR A 164 11.132 11.247 8.795 1.00 18.51 H +ATOM 2341 HD1 TYR A 164 8.033 13.346 8.622 1.00 20.72 H +ATOM 2342 HD2 TYR A 164 10.175 10.287 10.793 1.00 20.94 H +ATOM 2343 HE1 TYR A 164 6.385 13.499 10.459 1.00 23.50 H +ATOM 2344 HE2 TYR A 164 8.559 10.504 12.663 1.00 24.08 H +ATOM 2345 HH TYR A 164 6.727 11.613 13.480 1.00 25.55 H +ATOM 2346 N ASN A 165 7.362 10.345 6.766 1.00 22.76 N +ATOM 2347 CA ASN A 165 5.983 10.536 6.297 1.00 27.93 C +ATOM 2348 C ASN A 165 5.897 10.807 4.774 1.00 25.77 C +ATOM 2349 O ASN A 165 5.116 11.654 4.343 1.00 25.97 O +ATOM 2350 CB ASN A 165 5.284 11.629 7.154 1.00 30.06 C +ATOM 2351 CG ASN A 165 3.753 11.598 7.077 1.00 37.45 C +ATOM 2352 OD1 ASN A 165 3.134 10.551 7.252 1.00 40.14 O +ATOM 2353 ND2 ASN A 165 3.138 12.753 6.813 1.00 39.66 N +ATOM 2354 H ASN A 165 7.538 9.465 7.237 1.00 22.76 H +ATOM 2355 HA ASN A 165 5.457 9.591 6.434 1.00 27.93 H +ATOM 2356 HB3 ASN A 165 5.663 12.622 6.904 1.00 30.06 H +ATOM 2357 HB2 ASN A 165 5.531 11.470 8.204 1.00 30.06 H +ATOM 2358 HD22 ASN A 165 2.132 12.785 6.747 1.00 39.66 H +ATOM 2359 HD21 ASN A 165 3.673 13.595 6.653 1.00 39.66 H +ATOM 2360 N GLU A 166 6.738 10.110 3.987 1.00 25.78 N +ATOM 2361 CA GLU A 166 6.918 10.284 2.536 1.00 27.67 C +ATOM 2362 C GLU A 166 7.451 11.664 2.104 1.00 27.00 C +ATOM 2363 O GLU A 166 7.320 12.014 0.930 1.00 28.61 O +ATOM 2364 CB GLU A 166 5.646 9.878 1.740 1.00 29.56 C +ATOM 2365 CG GLU A 166 5.176 8.430 1.952 1.00 29.68 C +ATOM 2366 CD GLU A 166 6.246 7.410 1.559 1.00 30.08 C +ATOM 2367 OE1 GLU A 166 6.974 6.970 2.473 1.00 27.75 O +ATOM 2368 OE2 GLU A 166 6.325 7.090 0.354 1.00 28.15 O1- +ATOM 2369 H GLU A 166 7.338 9.418 4.415 1.00 25.78 H +ATOM 2370 HA GLU A 166 7.729 9.609 2.263 1.00 27.67 H +ATOM 2371 HB3 GLU A 166 5.813 10.018 0.670 1.00 29.56 H +ATOM 2372 HB2 GLU A 166 4.824 10.550 1.986 1.00 29.56 H +ATOM 2373 HG3 GLU A 166 4.275 8.248 1.365 1.00 29.68 H +ATOM 2374 HG2 GLU A 166 4.885 8.283 2.991 1.00 29.68 H +ATOM 2375 N GLU A 167 8.070 12.407 3.035 1.00 26.94 N +ATOM 2376 CA GLU A 167 8.728 13.677 2.757 1.00 27.18 C +ATOM 2377 C GLU A 167 10.241 13.479 2.866 1.00 28.13 C +ATOM 2378 O GLU A 167 10.716 12.938 3.864 1.00 24.51 O +ATOM 2379 CB GLU A 167 8.249 14.772 3.724 1.00 31.62 C +ATOM 2380 CG GLU A 167 6.712 14.884 3.845 1.00 40.49 C +ATOM 2381 CD GLU A 167 6.180 16.204 4.427 1.00 46.73 C +ATOM 2382 OE1 GLU A 167 6.986 17.113 4.729 1.00 51.21 O +ATOM 2383 OE2 GLU A 167 4.938 16.298 4.528 1.00 50.72 O1- +ATOM 2384 H GLU A 167 8.134 12.074 3.987 1.00 26.94 H +ATOM 2385 HA GLU A 167 8.488 14.013 1.748 1.00 27.18 H +ATOM 2386 HB3 GLU A 167 8.678 15.715 3.380 1.00 31.62 H +ATOM 2387 HB2 GLU A 167 8.656 14.599 4.718 1.00 31.62 H +ATOM 2388 HG3 GLU A 167 6.353 14.073 4.480 1.00 40.49 H +ATOM 2389 HG2 GLU A 167 6.248 14.724 2.872 1.00 40.49 H +ATOM 2390 N LEU A 168 10.955 13.934 1.830 1.00 25.62 N +ATOM 2391 CA LEU A 168 12.407 13.871 1.716 1.00 26.26 C +ATOM 2392 C LEU A 168 13.048 15.068 2.427 1.00 27.12 C +ATOM 2393 O LEU A 168 12.573 16.189 2.263 1.00 27.76 O +ATOM 2394 CB LEU A 168 12.789 13.886 0.225 1.00 26.24 C +ATOM 2395 CG LEU A 168 12.244 12.705 -0.602 1.00 27.75 C +ATOM 2396 CD1 LEU A 168 12.632 12.868 -2.083 1.00 26.99 C +ATOM 2397 CD2 LEU A 168 12.667 11.338 -0.037 1.00 24.52 C +ATOM 2398 H LEU A 168 10.475 14.361 1.048 1.00 25.62 H +ATOM 2399 HA LEU A 168 12.758 12.946 2.169 1.00 26.26 H +ATOM 2400 HB3 LEU A 168 13.875 13.911 0.133 1.00 26.24 H +ATOM 2401 HB2 LEU A 168 12.424 14.812 -0.220 1.00 26.24 H +ATOM 2402 HG LEU A 168 11.154 12.740 -0.564 1.00 27.75 H +ATOM 2403 HD11 LEU A 168 11.737 12.916 -2.701 1.00 26.99 H +ATOM 2404 HD12 LEU A 168 13.192 13.786 -2.264 1.00 26.99 H +ATOM 2405 HD13 LEU A 168 13.246 12.046 -2.452 1.00 26.99 H +ATOM 2406 HD21 LEU A 168 12.868 10.606 -0.817 1.00 24.52 H +ATOM 2407 HD22 LEU A 168 13.567 11.414 0.574 1.00 24.52 H +ATOM 2408 HD23 LEU A 168 11.870 10.926 0.583 1.00 24.52 H +ATOM 2409 N PHE A 169 14.124 14.803 3.177 1.00 27.59 N +ATOM 2410 CA PHE A 169 14.868 15.787 3.954 1.00 28.06 C +ATOM 2411 C PHE A 169 16.367 15.569 3.752 1.00 27.91 C +ATOM 2412 O PHE A 169 16.814 14.435 3.584 1.00 26.56 O +ATOM 2413 CB PHE A 169 14.509 15.657 5.448 1.00 27.08 C +ATOM 2414 CG PHE A 169 13.043 15.882 5.762 1.00 29.27 C +ATOM 2415 CD1 PHE A 169 12.213 14.804 6.134 1.00 26.75 C +ATOM 2416 CD2 PHE A 169 12.467 17.153 5.562 1.00 29.59 C +ATOM 2417 CE1 PHE A 169 10.861 15.027 6.356 1.00 29.38 C +ATOM 2418 CE2 PHE A 169 11.120 17.359 5.817 1.00 29.78 C +ATOM 2419 CZ PHE A 169 10.322 16.299 6.219 1.00 29.34 C +ATOM 2420 H PHE A 169 14.431 13.843 3.280 1.00 27.59 H +ATOM 2421 HA PHE A 169 14.627 16.796 3.611 1.00 28.06 H +ATOM 2422 HB3 PHE A 169 15.077 16.395 6.017 1.00 27.08 H +ATOM 2423 HB2 PHE A 169 14.812 14.681 5.832 1.00 27.08 H +ATOM 2424 HD1 PHE A 169 12.619 13.808 6.238 1.00 26.75 H +ATOM 2425 HD2 PHE A 169 13.070 17.964 5.186 1.00 29.59 H +ATOM 2426 HE1 PHE A 169 10.213 14.210 6.626 1.00 29.38 H +ATOM 2427 HE2 PHE A 169 10.688 18.340 5.677 1.00 29.78 H +ATOM 2428 HZ PHE A 169 9.269 16.457 6.400 1.00 29.34 H +ATOM 2429 N ASP A 170 17.109 16.680 3.802 1.00 28.99 N +ATOM 2430 CA ASP A 170 18.554 16.738 3.668 1.00 31.65 C +ATOM 2431 C ASP A 170 19.115 17.011 5.069 1.00 31.23 C +ATOM 2432 O ASP A 170 18.846 18.070 5.634 1.00 33.73 O +ATOM 2433 CB ASP A 170 18.923 17.840 2.652 1.00 32.63 C +ATOM 2434 CG ASP A 170 20.381 17.900 2.188 1.00 36.16 C +ATOM 2435 OD1 ASP A 170 21.291 17.440 2.913 1.00 37.04 O +ATOM 2436 OD2 ASP A 170 20.576 18.543 1.139 1.00 37.99 O1- +ATOM 2437 H ASP A 170 16.659 17.570 3.984 1.00 28.99 H +ATOM 2438 HA ASP A 170 18.941 15.785 3.299 1.00 31.65 H +ATOM 2439 HB3 ASP A 170 18.651 18.819 3.054 1.00 32.63 H +ATOM 2440 HB2 ASP A 170 18.289 17.729 1.774 1.00 32.63 H +ATOM 2441 N LEU A 171 19.872 16.041 5.600 1.00 32.05 N +ATOM 2442 CA LEU A 171 20.402 16.076 6.962 1.00 33.78 C +ATOM 2443 C LEU A 171 21.898 16.424 7.024 1.00 36.20 C +ATOM 2444 O LEU A 171 22.421 16.452 8.135 1.00 37.78 O +ATOM 2445 CB LEU A 171 20.058 14.747 7.678 1.00 31.15 C +ATOM 2446 CG LEU A 171 18.695 14.759 8.402 1.00 31.77 C +ATOM 2447 CD1 LEU A 171 18.679 15.685 9.621 1.00 29.95 C +ATOM 2448 CD2 LEU A 171 17.497 14.983 7.464 1.00 27.08 C +ATOM 2449 H LEU A 171 20.055 15.200 5.068 1.00 32.05 H +ATOM 2450 HA LEU A 171 19.925 16.881 7.523 1.00 33.78 H +ATOM 2451 HB3 LEU A 171 20.814 14.496 8.422 1.00 31.15 H +ATOM 2452 HB2 LEU A 171 20.079 13.929 6.960 1.00 31.15 H +ATOM 2453 HG LEU A 171 18.586 13.765 8.822 1.00 31.77 H +ATOM 2454 HD11 LEU A 171 18.104 15.244 10.434 1.00 29.95 H +ATOM 2455 HD12 LEU A 171 19.685 15.874 9.993 1.00 29.95 H +ATOM 2456 HD13 LEU A 171 18.226 16.642 9.385 1.00 29.95 H +ATOM 2457 HD21 LEU A 171 16.625 14.435 7.814 1.00 27.08 H +ATOM 2458 HD22 LEU A 171 17.217 16.034 7.401 1.00 27.08 H +ATOM 2459 HD23 LEU A 171 17.703 14.632 6.453 1.00 27.08 H +ATOM 2460 N LEU A 172 22.550 16.751 5.892 1.00 38.78 N +ATOM 2461 CA LEU A 172 23.935 17.241 5.883 1.00 42.77 C +ATOM 2462 C LEU A 172 24.066 18.716 5.474 1.00 44.63 C +ATOM 2463 O LEU A 172 25.080 19.299 5.852 1.00 46.83 O +ATOM 2464 CB LEU A 172 24.832 16.352 4.992 1.00 39.05 C +ATOM 2465 CG LEU A 172 25.307 15.037 5.645 1.00 37.98 C +ATOM 2466 CD1 LEU A 172 26.123 14.192 4.643 1.00 35.12 C +ATOM 2467 CD2 LEU A 172 26.075 15.258 6.962 1.00 35.36 C +ATOM 2468 H LEU A 172 22.069 16.724 5.002 1.00 38.78 H +ATOM 2469 HA LEU A 172 24.344 17.220 6.893 1.00 42.77 H +ATOM 2470 HB3 LEU A 172 25.727 16.901 4.703 1.00 39.05 H +ATOM 2471 HB2 LEU A 172 24.313 16.142 4.059 1.00 39.05 H +ATOM 2472 HG LEU A 172 24.424 14.469 5.913 1.00 37.98 H +ATOM 2473 HD11 LEU A 172 25.708 13.191 4.535 1.00 35.12 H +ATOM 2474 HD12 LEU A 172 26.142 14.639 3.649 1.00 35.12 H +ATOM 2475 HD13 LEU A 172 27.162 14.073 4.950 1.00 35.12 H +ATOM 2476 HD21 LEU A 172 26.871 14.529 7.105 1.00 35.36 H +ATOM 2477 HD22 LEU A 172 26.525 16.250 7.011 1.00 35.36 H +ATOM 2478 HD23 LEU A 172 25.406 15.157 7.815 1.00 35.36 H +ATOM 2479 N ASN A 173 23.092 19.302 4.748 1.00 48.64 N +ATOM 2480 CA ASN A 173 23.133 20.692 4.261 1.00 51.22 C +ATOM 2481 C ASN A 173 23.265 21.701 5.426 1.00 53.10 C +ATOM 2482 O ASN A 173 22.304 21.851 6.180 1.00 51.10 O +ATOM 2483 CB ASN A 173 21.855 20.967 3.432 1.00 53.38 C +ATOM 2484 CG ASN A 173 21.805 22.326 2.717 1.00 55.13 C +ATOM 2485 OD1 ASN A 173 22.729 23.131 2.801 1.00 57.22 O +ATOM 2486 ND2 ASN A 173 20.729 22.571 1.970 1.00 54.72 N +ATOM 2487 H ASN A 173 22.302 18.749 4.439 1.00 48.64 H +ATOM 2488 HA ASN A 173 23.978 20.739 3.576 1.00 51.22 H +ATOM 2489 HB3 ASN A 173 20.953 20.828 4.030 1.00 53.38 H +ATOM 2490 HB2 ASN A 173 21.824 20.230 2.638 1.00 53.38 H +ATOM 2491 HD22 ASN A 173 20.662 23.429 1.441 1.00 54.72 H +ATOM 2492 HD21 ASN A 173 20.003 21.875 1.876 1.00 54.72 H +ATOM 2493 N PRO A 174 24.427 22.381 5.556 1.00 55.43 N +ATOM 2494 CA PRO A 174 24.622 23.370 6.626 1.00 55.93 C +ATOM 2495 C PRO A 174 23.961 24.738 6.347 1.00 56.43 C +ATOM 2496 O PRO A 174 23.924 25.563 7.259 1.00 57.87 O +ATOM 2497 CB PRO A 174 26.151 23.476 6.701 1.00 56.37 C +ATOM 2498 CG PRO A 174 26.603 23.310 5.258 1.00 57.18 C +ATOM 2499 CD PRO A 174 25.612 22.296 4.692 1.00 55.65 C +ATOM 2500 HA PRO A 174 24.239 22.998 7.578 1.00 55.93 H +ATOM 2501 HB3 PRO A 174 26.540 22.654 7.305 1.00 56.37 H +ATOM 2502 HB2 PRO A 174 26.509 24.405 7.147 1.00 56.37 H +ATOM 2503 HG3 PRO A 174 27.642 22.996 5.162 1.00 57.18 H +ATOM 2504 HG2 PRO A 174 26.492 24.260 4.733 1.00 57.18 H +ATOM 2505 HD2 PRO A 174 25.383 22.520 3.649 1.00 55.65 H +ATOM 2506 HD3 PRO A 174 26.043 21.298 4.737 1.00 55.65 H +ATOM 2507 N SER A 175 23.478 24.962 5.110 1.00 56.90 N +ATOM 2508 CA SER A 175 22.917 26.234 4.655 1.00 57.82 C +ATOM 2509 C SER A 175 21.427 26.351 5.007 1.00 58.21 C +ATOM 2510 O SER A 175 21.030 27.361 5.587 1.00 59.23 O +ATOM 2511 CB SER A 175 23.116 26.386 3.132 1.00 58.15 C +ATOM 2512 OG SER A 175 24.487 26.344 2.795 1.00 58.20 O +ATOM 2513 H SER A 175 23.525 24.227 4.417 1.00 56.90 H +ATOM 2514 HA SER A 175 23.447 27.053 5.146 1.00 57.82 H +ATOM 2515 HB3 SER A 175 22.720 27.346 2.798 1.00 58.15 H +ATOM 2516 HB2 SER A 175 22.582 25.622 2.569 1.00 58.15 H +ATOM 2517 HG SER A 175 24.795 25.438 2.878 1.00 58.20 H +ATOM 2518 N SER A 176 20.641 25.321 4.652 1.00 58.11 N +ATOM 2519 CA SER A 176 19.201 25.264 4.893 1.00 57.43 C +ATOM 2520 C SER A 176 18.903 24.357 6.097 1.00 57.06 C +ATOM 2521 O SER A 176 19.651 23.416 6.358 1.00 56.98 O +ATOM 2522 CB SER A 176 18.519 24.749 3.613 1.00 58.25 C +ATOM 2523 OG SER A 176 17.116 24.806 3.721 1.00 59.33 O +ATOM 2524 H SER A 176 21.050 24.514 4.205 1.00 58.11 H +ATOM 2525 HA SER A 176 18.816 26.263 5.106 1.00 57.43 H +ATOM 2526 HB3 SER A 176 18.800 23.716 3.414 1.00 58.25 H +ATOM 2527 HB2 SER A 176 18.821 25.342 2.748 1.00 58.25 H +ATOM 2528 HG SER A 176 16.809 25.690 3.498 1.00 59.33 H +ATOM 2529 N ASP A 177 17.790 24.649 6.786 1.00 56.57 N +ATOM 2530 CA ASP A 177 17.235 23.873 7.901 1.00 57.04 C +ATOM 2531 C ASP A 177 16.579 22.562 7.423 1.00 55.49 C +ATOM 2532 O ASP A 177 16.300 22.407 6.233 1.00 54.80 O +ATOM 2533 CB ASP A 177 16.266 24.712 8.788 1.00 59.67 C +ATOM 2534 CG ASP A 177 15.378 25.748 8.070 1.00 62.71 C +ATOM 2535 OD1 ASP A 177 14.852 25.430 6.979 1.00 63.65 O +ATOM 2536 OD2 ASP A 177 15.145 26.810 8.686 1.00 64.94 O1- +ATOM 2537 H ASP A 177 17.208 25.413 6.470 1.00 56.57 H +ATOM 2538 HA ASP A 177 18.079 23.589 8.533 1.00 57.04 H +ATOM 2539 HB3 ASP A 177 16.863 25.222 9.546 1.00 59.67 H +ATOM 2540 HB2 ASP A 177 15.595 24.060 9.350 1.00 59.67 H +ATOM 2541 N VAL A 178 16.343 21.634 8.367 1.00 53.79 N +ATOM 2542 CA VAL A 178 15.723 20.332 8.095 1.00 52.83 C +ATOM 2543 C VAL A 178 14.278 20.406 7.574 1.00 52.35 C +ATOM 2544 O VAL A 178 13.897 19.522 6.816 1.00 53.10 O +ATOM 2545 CB VAL A 178 15.698 19.406 9.336 1.00 52.72 C +ATOM 2546 CG1 VAL A 178 17.108 19.092 9.820 1.00 52.31 C +ATOM 2547 CG2 VAL A 178 14.819 19.901 10.498 1.00 53.46 C +ATOM 2548 H VAL A 178 16.580 21.823 9.330 1.00 53.79 H +ATOM 2549 HA VAL A 178 16.325 19.847 7.324 1.00 52.83 H +ATOM 2550 HB VAL A 178 15.286 18.445 9.020 1.00 52.72 H +ATOM 2551 HG11 VAL A 178 17.080 18.289 10.550 1.00 52.31 H +ATOM 2552 HG12 VAL A 178 17.740 18.772 8.992 1.00 52.31 H +ATOM 2553 HG13 VAL A 178 17.567 19.958 10.294 1.00 52.31 H +ATOM 2554 HG21 VAL A 178 14.971 19.292 11.385 1.00 53.46 H +ATOM 2555 HG22 VAL A 178 15.050 20.931 10.768 1.00 53.46 H +ATOM 2556 HG23 VAL A 178 13.760 19.839 10.251 1.00 53.46 H +ATOM 2557 N SER A 179 13.519 21.448 7.957 1.00 51.84 N +ATOM 2558 CA SER A 179 12.134 21.677 7.532 1.00 50.53 C +ATOM 2559 C SER A 179 11.957 21.927 6.020 1.00 49.55 C +ATOM 2560 O SER A 179 10.836 21.802 5.527 1.00 48.64 O +ATOM 2561 CB SER A 179 11.533 22.809 8.390 1.00 50.49 C +ATOM 2562 OG SER A 179 12.186 24.046 8.186 1.00 49.66 O +ATOM 2563 H SER A 179 13.912 22.160 8.556 1.00 51.84 H +ATOM 2564 HA SER A 179 11.578 20.766 7.760 1.00 50.53 H +ATOM 2565 HB3 SER A 179 11.590 22.553 9.447 1.00 50.49 H +ATOM 2566 HB2 SER A 179 10.474 22.936 8.160 1.00 50.49 H +ATOM 2567 HG SER A 179 12.054 24.334 7.279 1.00 49.66 H +ATOM 2568 N GLU A 180 13.058 22.246 5.319 1.00 49.36 N +ATOM 2569 CA GLU A 180 13.113 22.473 3.882 1.00 49.04 C +ATOM 2570 C GLU A 180 13.111 21.123 3.140 1.00 48.31 C +ATOM 2571 O GLU A 180 14.169 20.533 2.924 1.00 48.45 O +ATOM 2572 CB GLU A 180 14.378 23.308 3.597 1.00 51.29 C +ATOM 2573 CG GLU A 180 14.324 24.086 2.267 1.00 55.71 C +ATOM 2574 CD GLU A 180 13.886 25.541 2.488 1.00 58.55 C +ATOM 2575 OE1 GLU A 180 12.722 25.737 2.906 1.00 58.48 O +ATOM 2576 OE2 GLU A 180 14.726 26.437 2.249 1.00 58.81 O1- +ATOM 2577 H GLU A 180 13.940 22.333 5.806 1.00 49.36 H +ATOM 2578 HA GLU A 180 12.232 23.049 3.590 1.00 49.04 H +ATOM 2579 HB3 GLU A 180 15.264 22.673 3.589 1.00 51.29 H +ATOM 2580 HB2 GLU A 180 14.559 23.996 4.426 1.00 51.29 H +ATOM 2581 HG3 GLU A 180 13.648 23.606 1.558 1.00 55.71 H +ATOM 2582 HG2 GLU A 180 15.307 24.066 1.794 1.00 55.71 H +ATOM 2583 N ARG A 181 11.908 20.641 2.795 1.00 46.01 N +ATOM 2584 CA ARG A 181 11.706 19.364 2.113 1.00 46.71 C +ATOM 2585 C ARG A 181 12.213 19.394 0.656 1.00 45.19 C +ATOM 2586 O ARG A 181 12.084 20.415 -0.022 1.00 45.10 O +ATOM 2587 CB ARG A 181 10.220 18.964 2.224 1.00 48.88 C +ATOM 2588 CG ARG A 181 9.244 19.850 1.418 1.00 53.95 C +ATOM 2589 CD ARG A 181 7.754 19.627 1.735 1.00 58.90 C +ATOM 2590 NE ARG A 181 7.311 18.229 1.586 1.00 62.40 N +ATOM 2591 CZ ARG A 181 7.171 17.509 0.457 1.00 63.28 C +ATOM 2592 NH1 ARG A 181 7.504 17.984 -0.753 1.00 64.77 N +ATOM 2593 NH2 ARG A 181 6.678 16.268 0.547 1.00 63.18 N1+ +ATOM 2594 H ARG A 181 11.077 21.165 3.030 1.00 46.01 H +ATOM 2595 HA ARG A 181 12.289 18.630 2.669 1.00 46.71 H +ATOM 2596 HB3 ARG A 181 9.929 18.968 3.275 1.00 48.88 H +ATOM 2597 HB2 ARG A 181 10.117 17.929 1.894 1.00 48.88 H +ATOM 2598 HG3 ARG A 181 9.426 19.814 0.344 1.00 53.95 H +ATOM 2599 HG2 ARG A 181 9.457 20.880 1.705 1.00 53.95 H +ATOM 2600 HD3 ARG A 181 7.165 20.192 1.013 1.00 58.90 H +ATOM 2601 HD2 ARG A 181 7.489 20.033 2.712 1.00 58.90 H +ATOM 2602 HE ARG A 181 7.090 17.776 2.466 1.00 62.40 H +ATOM 2603 HH12 ARG A 181 7.380 17.423 -1.583 1.00 64.77 H +ATOM 2604 HH11 ARG A 181 7.879 18.918 -0.836 1.00 64.77 H +ATOM 2605 HH22 ARG A 181 6.537 15.704 -0.278 1.00 63.18 H +ATOM 2606 HH21 ARG A 181 6.397 15.901 1.447 1.00 63.18 H +ATOM 2607 N LEU A 182 12.770 18.259 0.209 1.00 41.92 N +ATOM 2608 CA LEU A 182 13.299 18.066 -1.143 1.00 39.89 C +ATOM 2609 C LEU A 182 12.213 17.500 -2.073 1.00 38.35 C +ATOM 2610 O LEU A 182 11.207 16.974 -1.598 1.00 38.67 O +ATOM 2611 CB LEU A 182 14.511 17.107 -1.092 1.00 40.08 C +ATOM 2612 CG LEU A 182 15.627 17.483 -0.091 1.00 39.80 C +ATOM 2613 CD1 LEU A 182 16.759 16.436 -0.147 1.00 39.86 C +ATOM 2614 CD2 LEU A 182 16.149 18.923 -0.282 1.00 39.90 C +ATOM 2615 H LEU A 182 12.827 17.461 0.829 1.00 41.92 H +ATOM 2616 HA LEU A 182 13.623 19.025 -1.551 1.00 39.89 H +ATOM 2617 HB3 LEU A 182 14.946 17.033 -2.090 1.00 40.08 H +ATOM 2618 HB2 LEU A 182 14.167 16.103 -0.852 1.00 40.08 H +ATOM 2619 HG LEU A 182 15.209 17.425 0.915 1.00 39.80 H +ATOM 2620 HD11 LEU A 182 16.928 15.991 0.834 1.00 39.86 H +ATOM 2621 HD12 LEU A 182 16.529 15.616 -0.827 1.00 39.86 H +ATOM 2622 HD13 LEU A 182 17.704 16.860 -0.480 1.00 39.86 H +ATOM 2623 HD21 LEU A 182 17.227 18.999 -0.141 1.00 39.90 H +ATOM 2624 HD22 LEU A 182 15.931 19.308 -1.278 1.00 39.90 H +ATOM 2625 HD23 LEU A 182 15.688 19.597 0.441 1.00 39.90 H +ATOM 2626 N GLN A 183 12.449 17.604 -3.387 1.00 36.55 N +ATOM 2627 CA GLN A 183 11.569 17.071 -4.429 1.00 36.23 C +ATOM 2628 C GLN A 183 12.327 15.986 -5.198 1.00 33.70 C +ATOM 2629 O GLN A 183 13.508 16.181 -5.482 1.00 32.46 O +ATOM 2630 CB GLN A 183 11.155 18.217 -5.375 1.00 40.21 C +ATOM 2631 CG GLN A 183 10.294 19.294 -4.686 1.00 46.32 C +ATOM 2632 CD GLN A 183 10.070 20.524 -5.567 1.00 51.85 C +ATOM 2633 OE1 GLN A 183 9.771 20.409 -6.753 1.00 53.00 O +ATOM 2634 NE2 GLN A 183 10.189 21.717 -4.981 1.00 54.16 N +ATOM 2635 H GLN A 183 13.312 18.021 -3.708 1.00 36.55 H +ATOM 2636 HA GLN A 183 10.668 16.627 -4.002 1.00 36.23 H +ATOM 2637 HB3 GLN A 183 10.599 17.807 -6.220 1.00 40.21 H +ATOM 2638 HB2 GLN A 183 12.049 18.680 -5.798 1.00 40.21 H +ATOM 2639 HG3 GLN A 183 10.767 19.618 -3.758 1.00 46.32 H +ATOM 2640 HG2 GLN A 183 9.325 18.877 -4.409 1.00 46.32 H +ATOM 2641 HE22 GLN A 183 10.020 22.560 -5.510 1.00 54.16 H +ATOM 2642 HE21 GLN A 183 10.426 21.786 -4.002 1.00 54.16 H +ATOM 2643 N MET A 184 11.634 14.890 -5.554 1.00 32.15 N +ATOM 2644 CA MET A 184 12.185 13.854 -6.428 1.00 35.07 C +ATOM 2645 C MET A 184 11.328 13.685 -7.684 1.00 35.72 C +ATOM 2646 O MET A 184 10.109 13.860 -7.649 1.00 34.61 O +ATOM 2647 CB MET A 184 12.407 12.522 -5.682 1.00 34.84 C +ATOM 2648 CG MET A 184 11.141 11.723 -5.318 1.00 38.74 C +ATOM 2649 SD MET A 184 11.469 10.099 -4.586 1.00 41.75 S +ATOM 2650 CE MET A 184 12.019 9.209 -6.055 1.00 40.67 C +ATOM 2651 H MET A 184 10.658 14.802 -5.315 1.00 32.15 H +ATOM 2652 HA MET A 184 13.162 14.185 -6.768 1.00 35.07 H +ATOM 2653 HB3 MET A 184 12.998 12.711 -4.787 1.00 34.84 H +ATOM 2654 HB2 MET A 184 13.047 11.899 -6.306 1.00 34.84 H +ATOM 2655 HG3 MET A 184 10.513 11.553 -6.192 1.00 38.74 H +ATOM 2656 HG2 MET A 184 10.539 12.299 -4.616 1.00 38.74 H +ATOM 2657 HE1 MET A 184 12.197 8.162 -5.816 1.00 40.67 H +ATOM 2658 HE2 MET A 184 11.275 9.266 -6.846 1.00 40.67 H +ATOM 2659 HE3 MET A 184 12.946 9.641 -6.425 1.00 40.67 H +ATOM 2660 N PHE A 185 12.027 13.326 -8.765 1.00 38.29 N +ATOM 2661 CA PHE A 185 11.511 13.112 -10.109 1.00 42.79 C +ATOM 2662 C PHE A 185 12.190 11.854 -10.660 1.00 44.70 C +ATOM 2663 O PHE A 185 13.246 11.458 -10.169 1.00 44.77 O +ATOM 2664 CB PHE A 185 11.885 14.325 -10.993 1.00 43.13 C +ATOM 2665 CG PHE A 185 11.475 15.680 -10.444 1.00 43.75 C +ATOM 2666 CD1 PHE A 185 12.364 16.403 -9.619 1.00 43.96 C +ATOM 2667 CD2 PHE A 185 10.152 16.142 -10.600 1.00 44.55 C +ATOM 2668 CE1 PHE A 185 11.950 17.586 -9.023 1.00 44.32 C +ATOM 2669 CE2 PHE A 185 9.760 17.332 -10.002 1.00 45.42 C +ATOM 2670 CZ PHE A 185 10.658 18.052 -9.225 1.00 45.48 C +ATOM 2671 H PHE A 185 13.027 13.195 -8.672 1.00 38.29 H +ATOM 2672 HA PHE A 185 10.429 12.968 -10.092 1.00 42.79 H +ATOM 2673 HB3 PHE A 185 11.422 14.208 -11.975 1.00 43.13 H +ATOM 2674 HB2 PHE A 185 12.962 14.343 -11.174 1.00 43.13 H +ATOM 2675 HD1 PHE A 185 13.365 16.035 -9.441 1.00 43.96 H +ATOM 2676 HD2 PHE A 185 9.442 15.574 -11.185 1.00 44.55 H +ATOM 2677 HE1 PHE A 185 12.632 18.143 -8.397 1.00 44.32 H +ATOM 2678 HE2 PHE A 185 8.752 17.694 -10.134 1.00 45.42 H +ATOM 2679 HZ PHE A 185 10.344 18.976 -8.766 1.00 45.48 H +ATOM 2680 N ASP A 186 11.608 11.273 -11.714 1.00 49.80 N +ATOM 2681 CA ASP A 186 12.247 10.204 -12.488 1.00 53.56 C +ATOM 2682 C ASP A 186 13.375 10.786 -13.350 1.00 53.93 C +ATOM 2683 O ASP A 186 13.199 11.856 -13.933 1.00 53.64 O +ATOM 2684 CB ASP A 186 11.238 9.432 -13.367 1.00 56.42 C +ATOM 2685 CG ASP A 186 10.033 8.857 -12.608 1.00 58.79 C +ATOM 2686 OD1 ASP A 186 9.009 8.610 -13.280 1.00 61.00 O +ATOM 2687 OD2 ASP A 186 10.179 8.532 -11.406 1.00 60.88 O1- +ATOM 2688 H ASP A 186 10.743 11.638 -12.085 1.00 49.80 H +ATOM 2689 HA ASP A 186 12.695 9.493 -11.790 1.00 53.56 H +ATOM 2690 HB3 ASP A 186 11.742 8.602 -13.863 1.00 56.42 H +ATOM 2691 HB2 ASP A 186 10.860 10.092 -14.151 1.00 56.42 H +ATOM 2692 N ASP A 187 14.506 10.066 -13.412 1.00 55.24 N +ATOM 2693 CA ASP A 187 15.660 10.426 -14.235 1.00 58.13 C +ATOM 2694 C ASP A 187 15.295 10.136 -15.712 1.00 59.52 C +ATOM 2695 O ASP A 187 14.926 8.996 -15.999 1.00 59.93 O +ATOM 2696 CB ASP A 187 16.911 9.644 -13.752 1.00 58.39 C +ATOM 2697 CG ASP A 187 18.283 10.085 -14.307 1.00 59.33 C +ATOM 2698 OD1 ASP A 187 18.375 10.537 -15.470 1.00 60.74 O +ATOM 2699 OD2 ASP A 187 19.271 9.846 -13.580 1.00 60.02 O1- +ATOM 2700 H ASP A 187 14.570 9.185 -12.921 1.00 55.24 H +ATOM 2701 HA ASP A 187 15.863 11.477 -14.052 1.00 58.13 H +ATOM 2702 HB3 ASP A 187 16.784 8.582 -13.960 1.00 58.39 H +ATOM 2703 HB2 ASP A 187 16.948 9.704 -12.663 1.00 58.39 H +ATOM 2704 N PRO A 188 15.387 11.151 -16.613 1.00 60.65 N +ATOM 2705 CA PRO A 188 15.169 10.977 -18.066 1.00 62.13 C +ATOM 2706 C PRO A 188 15.918 9.815 -18.748 1.00 63.15 C +ATOM 2707 O PRO A 188 15.374 9.233 -19.685 1.00 63.29 O +ATOM 2708 CB PRO A 188 15.589 12.328 -18.669 1.00 62.23 C +ATOM 2709 CG PRO A 188 15.324 13.330 -17.563 1.00 61.55 C +ATOM 2710 CD PRO A 188 15.690 12.553 -16.309 1.00 60.85 C +ATOM 2711 HA PRO A 188 14.096 10.835 -18.208 1.00 62.13 H +ATOM 2712 HB3 PRO A 188 15.044 12.568 -19.582 1.00 62.23 H +ATOM 2713 HB2 PRO A 188 16.654 12.331 -18.909 1.00 62.23 H +ATOM 2714 HG3 PRO A 188 14.260 13.571 -17.542 1.00 61.55 H +ATOM 2715 HG2 PRO A 188 15.879 14.262 -17.675 1.00 61.55 H +ATOM 2716 HD2 PRO A 188 16.757 12.650 -16.110 1.00 60.85 H +ATOM 2717 HD3 PRO A 188 15.132 12.945 -15.459 1.00 60.85 H +ATOM 2718 N ARG A 189 17.128 9.495 -18.256 1.00 64.44 N +ATOM 2719 CA ARG A 189 17.941 8.367 -18.704 1.00 65.37 C +ATOM 2720 C ARG A 189 17.538 7.090 -17.948 1.00 66.47 C +ATOM 2721 O ARG A 189 16.638 6.387 -18.409 1.00 66.61 O +ATOM 2722 CB ARG A 189 19.440 8.703 -18.541 1.00 65.44 C +ATOM 2723 CG ARG A 189 19.894 9.938 -19.326 1.00 66.51 C +ATOM 2724 CD ARG A 189 21.406 10.165 -19.175 1.00 66.86 C +ATOM 2725 NE ARG A 189 21.821 11.485 -19.674 1.00 66.26 N +ATOM 2726 CZ ARG A 189 21.719 12.656 -19.015 1.00 66.65 C +ATOM 2727 NH1 ARG A 189 21.194 12.743 -17.781 1.00 66.57 N +ATOM 2728 NH2 ARG A 189 22.156 13.771 -19.612 1.00 65.04 N1+ +ATOM 2729 H ARG A 189 17.492 10.010 -17.464 1.00 64.44 H +ATOM 2730 HA ARG A 189 17.758 8.189 -19.766 1.00 65.37 H +ATOM 2731 HB3 ARG A 189 20.039 7.845 -18.853 1.00 65.44 H +ATOM 2732 HB2 ARG A 189 19.674 8.874 -17.489 1.00 65.44 H +ATOM 2733 HG3 ARG A 189 19.318 10.832 -19.082 1.00 66.51 H +ATOM 2734 HG2 ARG A 189 19.686 9.721 -20.375 1.00 66.51 H +ATOM 2735 HD3 ARG A 189 21.914 9.469 -19.843 1.00 66.86 H +ATOM 2736 HD2 ARG A 189 21.777 9.943 -18.174 1.00 66.86 H +ATOM 2737 HE ARG A 189 22.187 11.498 -20.615 1.00 66.26 H +ATOM 2738 HH12 ARG A 189 21.130 13.631 -17.306 1.00 66.57 H +ATOM 2739 HH11 ARG A 189 20.850 11.912 -17.318 1.00 66.57 H +ATOM 2740 HH22 ARG A 189 22.091 14.662 -19.141 1.00 65.04 H +ATOM 2741 HH21 ARG A 189 22.555 13.734 -20.539 1.00 65.04 H +ATOM 2742 N ASN A 190 18.237 6.806 -16.833 1.00 66.58 N +ATOM 2743 CA ASN A 190 18.134 5.599 -16.007 1.00 66.84 C +ATOM 2744 C ASN A 190 16.696 5.336 -15.546 1.00 66.83 C +ATOM 2745 O ASN A 190 16.134 6.142 -14.806 1.00 66.79 O +ATOM 2746 CB ASN A 190 19.070 5.736 -14.780 1.00 67.44 C +ATOM 2747 CG ASN A 190 20.569 5.739 -15.104 1.00 68.51 C +ATOM 2748 OD1 ASN A 190 20.992 5.373 -16.199 1.00 68.94 O +ATOM 2749 ND2 ASN A 190 21.388 6.142 -14.130 1.00 68.38 N +ATOM 2750 H ASN A 190 18.941 7.465 -16.533 1.00 66.58 H +ATOM 2751 HA ASN A 190 18.479 4.775 -16.636 1.00 66.84 H +ATOM 2752 HB3 ASN A 190 18.901 4.901 -14.098 1.00 67.44 H +ATOM 2753 HB2 ASN A 190 18.825 6.643 -14.224 1.00 67.44 H +ATOM 2754 HD22 ASN A 190 22.385 6.160 -14.286 1.00 68.38 H +ATOM 2755 HD21 ASN A 190 21.018 6.451 -13.243 1.00 68.38 H +ATOM 2756 N LYS A 191 16.145 4.198 -15.991 1.00 66.99 N +ATOM 2757 CA LYS A 191 14.784 3.760 -15.671 1.00 67.22 C +ATOM 2758 C LYS A 191 14.638 3.258 -14.222 1.00 66.45 C +ATOM 2759 O LYS A 191 13.533 3.302 -13.683 1.00 65.12 O +ATOM 2760 CB LYS A 191 14.349 2.676 -16.675 1.00 68.00 C +ATOM 2761 CG LYS A 191 14.388 3.157 -18.140 1.00 69.16 C +ATOM 2762 CD LYS A 191 13.687 2.212 -19.128 1.00 69.10 C +ATOM 2763 CE LYS A 191 12.152 2.257 -19.017 1.00 69.33 C +ATOM 2764 NZ LYS A 191 11.504 1.395 -20.020 1.00 70.64 N1+ +ATOM 2765 H LYS A 191 16.671 3.600 -16.611 1.00 66.99 H +ATOM 2766 HA LYS A 191 14.117 4.617 -15.785 1.00 67.22 H +ATOM 2767 HB3 LYS A 191 13.336 2.365 -16.419 1.00 68.00 H +ATOM 2768 HB2 LYS A 191 14.973 1.788 -16.570 1.00 68.00 H +ATOM 2769 HG3 LYS A 191 15.427 3.272 -18.450 1.00 69.16 H +ATOM 2770 HG2 LYS A 191 13.946 4.152 -18.216 1.00 69.16 H +ATOM 2771 HD3 LYS A 191 14.042 1.193 -18.961 1.00 69.10 H +ATOM 2772 HD2 LYS A 191 13.995 2.476 -20.140 1.00 69.10 H +ATOM 2773 HE3 LYS A 191 11.795 3.278 -19.160 1.00 69.33 H +ATOM 2774 HE2 LYS A 191 11.820 1.937 -18.030 1.00 69.33 H +ATOM 2775 HZ1 LYS A 191 11.795 0.438 -19.884 1.00 70.64 H +ATOM 2776 HZ2 LYS A 191 10.500 1.457 -19.921 1.00 70.64 H +ATOM 2777 HZ3 LYS A 191 11.768 1.698 -20.947 1.00 70.64 H +ATOM 2778 N ARG A 192 15.758 2.817 -13.624 1.00 66.07 N +ATOM 2779 CA ARG A 192 15.870 2.398 -12.226 1.00 65.07 C +ATOM 2780 C ARG A 192 16.387 3.527 -11.313 1.00 63.80 C +ATOM 2781 O ARG A 192 16.500 3.310 -10.106 1.00 64.94 O +ATOM 2782 CB ARG A 192 16.781 1.154 -12.141 1.00 65.08 C +ATOM 2783 CG ARG A 192 16.354 0.029 -13.106 1.00 65.38 C +ATOM 2784 CD ARG A 192 17.045 -1.325 -12.868 1.00 64.94 C +ATOM 2785 NE ARG A 192 16.612 -1.982 -11.621 1.00 63.91 N +ATOM 2786 CZ ARG A 192 15.437 -2.598 -11.387 1.00 65.68 C +ATOM 2787 NH1 ARG A 192 14.472 -2.687 -12.315 1.00 64.31 N +ATOM 2788 NH2 ARG A 192 15.218 -3.147 -10.188 1.00 65.10 N1+ +ATOM 2789 H ARG A 192 16.619 2.820 -14.150 1.00 66.07 H +ATOM 2790 HA ARG A 192 14.884 2.117 -11.857 1.00 65.07 H +ATOM 2791 HB3 ARG A 192 16.782 0.784 -11.115 1.00 65.08 H +ATOM 2792 HB2 ARG A 192 17.813 1.432 -12.363 1.00 65.08 H +ATOM 2793 HG3 ARG A 192 16.453 0.313 -14.153 1.00 65.38 H +ATOM 2794 HG2 ARG A 192 15.282 -0.096 -12.947 1.00 65.38 H +ATOM 2795 HD3 ARG A 192 18.107 -1.133 -12.717 1.00 64.94 H +ATOM 2796 HD2 ARG A 192 16.986 -1.979 -13.739 1.00 64.94 H +ATOM 2797 HE ARG A 192 17.285 -1.929 -10.868 1.00 63.91 H +ATOM 2798 HH12 ARG A 192 13.592 -3.134 -12.099 1.00 64.31 H +ATOM 2799 HH11 ARG A 192 14.604 -2.267 -13.223 1.00 64.31 H +ATOM 2800 HH22 ARG A 192 14.344 -3.614 -9.984 1.00 65.10 H +ATOM 2801 HH21 ARG A 192 15.898 -3.059 -9.446 1.00 65.10 H +ATOM 2802 N GLY A 193 16.702 4.693 -11.905 1.00 61.68 N +ATOM 2803 CA GLY A 193 17.254 5.858 -11.229 1.00 57.85 C +ATOM 2804 C GLY A 193 16.195 6.959 -11.119 1.00 54.40 C +ATOM 2805 O GLY A 193 15.203 6.988 -11.851 1.00 54.74 O +ATOM 2806 H GLY A 193 16.527 4.797 -12.895 1.00 61.68 H +ATOM 2807 HA3 GLY A 193 18.090 6.238 -11.817 1.00 57.85 H +ATOM 2808 HA2 GLY A 193 17.645 5.607 -10.242 1.00 57.85 H +ATOM 2809 N VAL A 194 16.460 7.887 -10.193 1.00 51.20 N +ATOM 2810 CA VAL A 194 15.654 9.067 -9.903 1.00 47.88 C +ATOM 2811 C VAL A 194 16.595 10.258 -9.641 1.00 45.73 C +ATOM 2812 O VAL A 194 17.732 10.067 -9.208 1.00 44.54 O +ATOM 2813 CB VAL A 194 14.747 8.844 -8.654 1.00 48.42 C +ATOM 2814 CG1 VAL A 194 13.683 7.760 -8.910 1.00 48.70 C +ATOM 2815 CG2 VAL A 194 15.511 8.570 -7.342 1.00 48.70 C +ATOM 2816 H VAL A 194 17.309 7.814 -9.651 1.00 51.20 H +ATOM 2817 HA VAL A 194 15.032 9.315 -10.764 1.00 47.88 H +ATOM 2818 HB VAL A 194 14.191 9.765 -8.486 1.00 48.42 H +ATOM 2819 HG11 VAL A 194 12.988 7.675 -8.078 1.00 48.70 H +ATOM 2820 HG12 VAL A 194 13.096 7.988 -9.801 1.00 48.70 H +ATOM 2821 HG13 VAL A 194 14.133 6.777 -9.049 1.00 48.70 H +ATOM 2822 HG21 VAL A 194 14.826 8.324 -6.533 1.00 48.70 H +ATOM 2823 HG22 VAL A 194 16.195 7.727 -7.446 1.00 48.70 H +ATOM 2824 HG23 VAL A 194 16.091 9.432 -7.015 1.00 48.70 H +ATOM 2825 N ILE A 195 16.084 11.468 -9.901 1.00 44.00 N +ATOM 2826 CA ILE A 195 16.733 12.741 -9.594 1.00 42.15 C +ATOM 2827 C ILE A 195 16.114 13.287 -8.303 1.00 39.98 C +ATOM 2828 O ILE A 195 14.891 13.378 -8.232 1.00 40.39 O +ATOM 2829 CB ILE A 195 16.504 13.768 -10.746 1.00 42.60 C +ATOM 2830 CG1 ILE A 195 17.329 13.348 -11.983 1.00 44.09 C +ATOM 2831 CG2 ILE A 195 16.803 15.243 -10.378 1.00 43.47 C +ATOM 2832 CD1 ILE A 195 16.950 14.086 -13.272 1.00 45.10 C +ATOM 2833 H ILE A 195 15.130 11.535 -10.231 1.00 44.00 H +ATOM 2834 HA ILE A 195 17.807 12.603 -9.450 1.00 42.15 H +ATOM 2835 HB ILE A 195 15.450 13.718 -11.028 1.00 42.60 H +ATOM 2836 HG13 ILE A 195 17.219 12.279 -12.164 1.00 44.09 H +ATOM 2837 HG12 ILE A 195 18.390 13.501 -11.781 1.00 44.09 H +ATOM 2838 HG21 ILE A 195 16.663 15.907 -11.231 1.00 43.47 H +ATOM 2839 HG22 ILE A 195 16.142 15.624 -9.599 1.00 43.47 H +ATOM 2840 HG23 ILE A 195 17.831 15.362 -10.034 1.00 43.47 H +ATOM 2841 HD11 ILE A 195 17.393 13.586 -14.133 1.00 45.10 H +ATOM 2842 HD12 ILE A 195 15.869 14.112 -13.415 1.00 45.10 H +ATOM 2843 HD13 ILE A 195 17.320 15.111 -13.274 1.00 45.10 H +ATOM 2844 N ILE A 196 16.960 13.663 -7.333 1.00 39.35 N +ATOM 2845 CA ILE A 196 16.533 14.278 -6.076 1.00 38.26 C +ATOM 2846 C ILE A 196 17.091 15.711 -6.063 1.00 39.38 C +ATOM 2847 O ILE A 196 18.280 15.916 -5.810 1.00 41.32 O +ATOM 2848 CB ILE A 196 17.032 13.494 -4.827 1.00 37.13 C +ATOM 2849 CG1 ILE A 196 16.555 12.020 -4.838 1.00 37.59 C +ATOM 2850 CG2 ILE A 196 16.604 14.156 -3.495 1.00 36.34 C +ATOM 2851 CD1 ILE A 196 17.502 11.069 -4.096 1.00 38.64 C +ATOM 2852 H ILE A 196 17.957 13.568 -7.465 1.00 39.35 H +ATOM 2853 HA ILE A 196 15.445 14.330 -6.013 1.00 38.26 H +ATOM 2854 HB ILE A 196 18.123 13.484 -4.855 1.00 37.13 H +ATOM 2855 HG13 ILE A 196 16.473 11.644 -5.856 1.00 37.59 H +ATOM 2856 HG12 ILE A 196 15.547 11.943 -4.428 1.00 37.59 H +ATOM 2857 HG21 ILE A 196 17.029 13.633 -2.639 1.00 36.34 H +ATOM 2858 HG22 ILE A 196 16.914 15.197 -3.420 1.00 36.34 H +ATOM 2859 HG23 ILE A 196 15.519 14.141 -3.383 1.00 36.34 H +ATOM 2860 HD11 ILE A 196 16.967 10.192 -3.730 1.00 38.64 H +ATOM 2861 HD12 ILE A 196 18.293 10.717 -4.759 1.00 38.64 H +ATOM 2862 HD13 ILE A 196 17.981 11.552 -3.245 1.00 38.64 H +ATOM 2863 N LYS A 197 16.206 16.669 -6.375 1.00 38.14 N +ATOM 2864 CA LYS A 197 16.483 18.101 -6.405 1.00 37.79 C +ATOM 2865 C LYS A 197 16.796 18.642 -5.000 1.00 36.85 C +ATOM 2866 O LYS A 197 15.981 18.483 -4.091 1.00 35.36 O +ATOM 2867 CB LYS A 197 15.276 18.827 -7.042 1.00 37.13 C +ATOM 2868 CG LYS A 197 15.433 20.356 -7.147 1.00 39.41 C +ATOM 2869 CD LYS A 197 14.198 21.047 -7.739 1.00 41.69 C +ATOM 2870 CE LYS A 197 14.383 22.571 -7.820 1.00 44.71 C +ATOM 2871 NZ LYS A 197 13.187 23.240 -8.360 1.00 46.18 N1+ +ATOM 2872 H LYS A 197 15.243 16.408 -6.536 1.00 38.14 H +ATOM 2873 HA LYS A 197 17.350 18.254 -7.051 1.00 37.79 H +ATOM 2874 HB3 LYS A 197 14.377 18.605 -6.466 1.00 37.13 H +ATOM 2875 HB2 LYS A 197 15.103 18.421 -8.040 1.00 37.13 H +ATOM 2876 HG3 LYS A 197 16.309 20.586 -7.755 1.00 39.41 H +ATOM 2877 HG2 LYS A 197 15.622 20.788 -6.164 1.00 39.41 H +ATOM 2878 HD3 LYS A 197 13.326 20.807 -7.128 1.00 41.69 H +ATOM 2879 HD2 LYS A 197 13.999 20.639 -8.732 1.00 41.69 H +ATOM 2880 HE3 LYS A 197 15.236 22.815 -8.455 1.00 44.71 H +ATOM 2881 HE2 LYS A 197 14.591 22.979 -6.831 1.00 44.71 H +ATOM 2882 HZ1 LYS A 197 12.394 23.046 -7.765 1.00 46.18 H +ATOM 2883 HZ2 LYS A 197 13.344 24.237 -8.397 1.00 46.18 H +ATOM 2884 HZ3 LYS A 197 12.998 22.895 -9.291 1.00 46.18 H +ATOM 2885 N GLY A 198 17.950 19.316 -4.887 1.00 38.11 N +ATOM 2886 CA GLY A 198 18.369 20.028 -3.683 1.00 39.85 C +ATOM 2887 C GLY A 198 19.177 19.157 -2.710 1.00 40.71 C +ATOM 2888 O GLY A 198 19.602 19.689 -1.687 1.00 41.56 O +ATOM 2889 H GLY A 198 18.561 19.387 -5.688 1.00 38.11 H +ATOM 2890 HA3 GLY A 198 17.508 20.447 -3.159 1.00 39.85 H +ATOM 2891 HA2 GLY A 198 18.990 20.872 -3.984 1.00 39.85 H +ATOM 2892 N LEU A 199 19.406 17.860 -3.002 1.00 40.46 N +ATOM 2893 CA LEU A 199 20.236 16.974 -2.181 1.00 40.03 C +ATOM 2894 C LEU A 199 21.720 17.357 -2.291 1.00 41.70 C +ATOM 2895 O LEU A 199 22.331 17.127 -3.336 1.00 41.24 O +ATOM 2896 CB LEU A 199 19.980 15.500 -2.569 1.00 37.82 C +ATOM 2897 CG LEU A 199 20.751 14.454 -1.727 1.00 36.34 C +ATOM 2898 CD1 LEU A 199 20.402 14.545 -0.229 1.00 35.93 C +ATOM 2899 CD2 LEU A 199 20.538 13.032 -2.280 1.00 35.17 C +ATOM 2900 H LEU A 199 19.042 17.467 -3.858 1.00 40.46 H +ATOM 2901 HA LEU A 199 19.922 17.100 -1.144 1.00 40.03 H +ATOM 2902 HB3 LEU A 199 20.215 15.363 -3.626 1.00 37.82 H +ATOM 2903 HB2 LEU A 199 18.917 15.298 -2.467 1.00 37.82 H +ATOM 2904 HG LEU A 199 21.819 14.653 -1.826 1.00 36.34 H +ATOM 2905 HD11 LEU A 199 20.575 13.602 0.290 1.00 35.93 H +ATOM 2906 HD12 LEU A 199 21.018 15.297 0.260 1.00 35.93 H +ATOM 2907 HD13 LEU A 199 19.361 14.826 -0.071 1.00 35.93 H +ATOM 2908 HD21 LEU A 199 21.481 12.487 -2.325 1.00 35.17 H +ATOM 2909 HD22 LEU A 199 19.850 12.452 -1.670 1.00 35.17 H +ATOM 2910 HD23 LEU A 199 20.127 13.046 -3.290 1.00 35.17 H +ATOM 2911 N GLU A 200 22.260 17.926 -1.202 1.00 42.28 N +ATOM 2912 CA GLU A 200 23.662 18.300 -1.065 1.00 45.64 C +ATOM 2913 C GLU A 200 24.586 17.084 -1.041 1.00 45.00 C +ATOM 2914 O GLU A 200 24.344 16.134 -0.298 1.00 43.55 O +ATOM 2915 CB GLU A 200 23.881 19.147 0.208 1.00 49.57 C +ATOM 2916 CG GLU A 200 23.403 20.605 0.081 1.00 57.01 C +ATOM 2917 CD GLU A 200 24.177 21.431 -0.956 1.00 60.33 C +ATOM 2918 OE1 GLU A 200 25.428 21.389 -0.918 1.00 62.11 O +ATOM 2919 OE2 GLU A 200 23.506 22.099 -1.773 1.00 62.56 O1- +ATOM 2920 H GLU A 200 21.673 18.114 -0.396 1.00 42.28 H +ATOM 2921 HA GLU A 200 23.922 18.895 -1.943 1.00 45.64 H +ATOM 2922 HB3 GLU A 200 24.932 19.133 0.505 1.00 49.57 H +ATOM 2923 HB2 GLU A 200 23.357 18.684 1.045 1.00 49.57 H +ATOM 2924 HG3 GLU A 200 23.558 21.094 1.039 1.00 57.01 H +ATOM 2925 HG2 GLU A 200 22.331 20.635 -0.120 1.00 57.01 H +ATOM 2926 N GLU A 201 25.655 17.189 -1.835 1.00 45.79 N +ATOM 2927 CA GLU A 201 26.770 16.261 -1.858 1.00 46.72 C +ATOM 2928 C GLU A 201 27.987 17.028 -1.341 1.00 46.76 C +ATOM 2929 O GLU A 201 28.514 17.885 -2.050 1.00 47.10 O +ATOM 2930 CB GLU A 201 26.981 15.751 -3.293 1.00 48.30 C +ATOM 2931 CG GLU A 201 25.827 14.857 -3.797 1.00 53.27 C +ATOM 2932 CD GLU A 201 26.003 14.333 -5.231 1.00 56.17 C +ATOM 2933 OE1 GLU A 201 25.324 13.334 -5.553 1.00 57.27 O +ATOM 2934 OE2 GLU A 201 26.803 14.919 -5.994 1.00 58.06 O1- +ATOM 2935 H GLU A 201 25.767 18.019 -2.401 1.00 45.79 H +ATOM 2936 HA GLU A 201 26.586 15.402 -1.213 1.00 46.72 H +ATOM 2937 HB3 GLU A 201 27.913 15.188 -3.337 1.00 48.30 H +ATOM 2938 HB2 GLU A 201 27.107 16.605 -3.962 1.00 48.30 H +ATOM 2939 HG3 GLU A 201 24.884 15.404 -3.759 1.00 53.27 H +ATOM 2940 HG2 GLU A 201 25.715 14.006 -3.124 1.00 53.27 H +ATOM 2941 N ILE A 202 28.387 16.724 -0.098 1.00 46.40 N +ATOM 2942 CA ILE A 202 29.537 17.339 0.553 1.00 46.13 C +ATOM 2943 C ILE A 202 30.800 16.547 0.202 1.00 45.18 C +ATOM 2944 O ILE A 202 30.892 15.369 0.548 1.00 45.33 O +ATOM 2945 CB ILE A 202 29.374 17.399 2.100 1.00 45.98 C +ATOM 2946 CG1 ILE A 202 28.192 18.330 2.456 1.00 47.32 C +ATOM 2947 CG2 ILE A 202 30.658 17.856 2.835 1.00 45.32 C +ATOM 2948 CD1 ILE A 202 27.916 18.466 3.957 1.00 48.95 C +ATOM 2949 H ILE A 202 27.912 15.995 0.419 1.00 46.40 H +ATOM 2950 HA ILE A 202 29.652 18.364 0.192 1.00 46.13 H +ATOM 2951 HB ILE A 202 29.126 16.398 2.460 1.00 45.98 H +ATOM 2952 HG13 ILE A 202 27.279 17.981 1.970 1.00 47.32 H +ATOM 2953 HG12 ILE A 202 28.382 19.324 2.049 1.00 47.32 H +ATOM 2954 HG21 ILE A 202 30.512 17.895 3.913 1.00 45.32 H +ATOM 2955 HG22 ILE A 202 31.500 17.184 2.676 1.00 45.32 H +ATOM 2956 HG23 ILE A 202 30.965 18.850 2.509 1.00 45.32 H +ATOM 2957 HD11 ILE A 202 26.907 18.840 4.115 1.00 48.95 H +ATOM 2958 HD12 ILE A 202 28.011 17.511 4.474 1.00 48.95 H +ATOM 2959 HD13 ILE A 202 28.597 19.176 4.426 1.00 48.95 H +ATOM 2960 N THR A 203 31.755 17.231 -0.447 1.00 44.53 N +ATOM 2961 CA THR A 203 33.084 16.702 -0.726 1.00 44.04 C +ATOM 2962 C THR A 203 33.895 16.557 0.574 1.00 43.54 C +ATOM 2963 O THR A 203 34.031 17.525 1.323 1.00 43.23 O +ATOM 2964 CB THR A 203 33.879 17.615 -1.695 1.00 44.86 C +ATOM 2965 OG1 THR A 203 33.165 17.718 -2.911 1.00 43.73 O +ATOM 2966 CG2 THR A 203 35.301 17.121 -2.028 1.00 44.45 C +ATOM 2967 H THR A 203 31.594 18.191 -0.714 1.00 44.53 H +ATOM 2968 HA THR A 203 32.958 15.728 -1.197 1.00 44.04 H +ATOM 2969 HB THR A 203 33.948 18.621 -1.278 1.00 44.86 H +ATOM 2970 HG1 THR A 203 33.191 16.868 -3.355 1.00 43.73 H +ATOM 2971 HG21 THR A 203 35.766 17.749 -2.788 1.00 44.45 H +ATOM 2972 HG22 THR A 203 35.957 17.141 -1.157 1.00 44.45 H +ATOM 2973 HG23 THR A 203 35.287 16.098 -2.407 1.00 44.45 H +ATOM 2974 N VAL A 204 34.418 15.345 0.788 1.00 44.30 N +ATOM 2975 CA VAL A 204 35.281 14.998 1.904 1.00 45.77 C +ATOM 2976 C VAL A 204 36.712 14.913 1.337 1.00 46.96 C +ATOM 2977 O VAL A 204 36.987 14.072 0.480 1.00 47.51 O +ATOM 2978 CB VAL A 204 34.901 13.628 2.533 1.00 44.79 C +ATOM 2979 CG1 VAL A 204 35.601 13.429 3.888 1.00 45.00 C +ATOM 2980 CG2 VAL A 204 33.382 13.431 2.688 1.00 44.50 C +ATOM 2981 H VAL A 204 34.268 14.612 0.105 1.00 44.30 H +ATOM 2982 HA VAL A 204 35.229 15.762 2.681 1.00 45.77 H +ATOM 2983 HB VAL A 204 35.224 12.820 1.880 1.00 44.79 H +ATOM 2984 HG11 VAL A 204 35.324 12.471 4.321 1.00 45.00 H +ATOM 2985 HG12 VAL A 204 36.685 13.444 3.790 1.00 45.00 H +ATOM 2986 HG13 VAL A 204 35.324 14.207 4.601 1.00 45.00 H +ATOM 2987 HG21 VAL A 204 33.152 12.516 3.236 1.00 44.50 H +ATOM 2988 HG22 VAL A 204 32.926 14.261 3.218 1.00 44.50 H +ATOM 2989 HG23 VAL A 204 32.889 13.352 1.719 1.00 44.50 H +ATOM 2990 N HIS A 205 37.575 15.836 1.781 1.00 48.27 N +ATOM 2991 CA HIS A 205 38.931 16.026 1.262 1.00 50.42 C +ATOM 2992 C HIS A 205 39.951 15.083 1.921 1.00 50.78 C +ATOM 2993 O HIS A 205 40.913 14.695 1.260 1.00 50.81 O +ATOM 2994 CB HIS A 205 39.346 17.499 1.461 1.00 50.66 C +ATOM 2995 CG HIS A 205 38.441 18.496 0.772 1.00 50.85 C +ATOM 2996 ND1 HIS A 205 37.443 19.173 1.453 1.00 51.12 N1+ +ATOM 2997 CD2 HIS A 205 38.419 18.960 -0.530 1.00 50.79 C +ATOM 2998 CE1 HIS A 205 36.831 19.966 0.580 1.00 50.20 C +ATOM 2999 NE2 HIS A 205 37.383 19.876 -0.628 1.00 50.46 N +ATOM 3000 H HIS A 205 37.269 16.496 2.488 1.00 48.27 H +ATOM 3001 HA HIS A 205 38.931 15.817 0.190 1.00 50.42 H +ATOM 3002 HB3 HIS A 205 40.355 17.653 1.078 1.00 50.66 H +ATOM 3003 HB2 HIS A 205 39.386 17.740 2.524 1.00 50.66 H +ATOM 3004 HD1 HIS A 205 37.198 19.056 2.434 1.00 51.12 H +ATOM 3005 HD2 HIS A 205 39.029 18.715 -1.387 1.00 50.79 H +ATOM 3006 HE1 HIS A 205 35.993 20.603 0.824 1.00 50.20 H +ATOM 3007 HE2 HIS A 205 37.102 20.383 -1.456 1.00 50.46 H +ATOM 3008 N ASN A 206 39.723 14.732 3.196 1.00 51.18 N +ATOM 3009 CA ASN A 206 40.587 13.867 4.002 1.00 51.18 C +ATOM 3010 C ASN A 206 39.800 13.298 5.192 1.00 51.21 C +ATOM 3011 O ASN A 206 38.724 13.802 5.521 1.00 51.46 O +ATOM 3012 CB ASN A 206 41.888 14.608 4.425 1.00 50.68 C +ATOM 3013 CG ASN A 206 41.676 15.927 5.184 1.00 52.37 C +ATOM 3014 OD1 ASN A 206 41.149 15.935 6.292 1.00 53.55 O +ATOM 3015 ND2 ASN A 206 42.102 17.048 4.600 1.00 52.82 N +ATOM 3016 H ASN A 206 38.896 15.074 3.667 1.00 51.18 H +ATOM 3017 HA ASN A 206 40.870 13.027 3.366 1.00 51.18 H +ATOM 3018 HB3 ASN A 206 42.489 14.809 3.538 1.00 50.68 H +ATOM 3019 HB2 ASN A 206 42.503 13.956 5.047 1.00 50.68 H +ATOM 3020 HD22 ASN A 206 41.990 17.933 5.072 1.00 52.82 H +ATOM 3021 HD21 ASN A 206 42.546 17.020 3.693 1.00 52.82 H +ATOM 3022 N LYS A 207 40.377 12.268 5.835 1.00 52.18 N +ATOM 3023 CA LYS A 207 39.844 11.647 7.051 1.00 53.37 C +ATOM 3024 C LYS A 207 39.692 12.620 8.237 1.00 53.82 C +ATOM 3025 O LYS A 207 38.712 12.501 8.964 1.00 53.82 O +ATOM 3026 CB LYS A 207 40.661 10.397 7.432 1.00 55.31 C +ATOM 3027 CG LYS A 207 42.174 10.642 7.607 1.00 56.90 C +ATOM 3028 CD LYS A 207 42.791 9.989 8.851 1.00 58.37 C +ATOM 3029 CE LYS A 207 42.207 10.523 10.171 1.00 58.94 C +ATOM 3030 NZ LYS A 207 43.150 10.352 11.287 1.00 60.33 N1+ +ATOM 3031 H LYS A 207 41.258 11.904 5.502 1.00 52.18 H +ATOM 3032 HA LYS A 207 38.849 11.290 6.798 1.00 53.37 H +ATOM 3033 HB3 LYS A 207 40.517 9.625 6.679 1.00 55.31 H +ATOM 3034 HB2 LYS A 207 40.234 9.970 8.340 1.00 55.31 H +ATOM 3035 HG3 LYS A 207 42.401 11.707 7.630 1.00 56.90 H +ATOM 3036 HG2 LYS A 207 42.690 10.265 6.723 1.00 56.90 H +ATOM 3037 HD3 LYS A 207 43.870 10.153 8.813 1.00 58.37 H +ATOM 3038 HD2 LYS A 207 42.651 8.907 8.799 1.00 58.37 H +ATOM 3039 HE3 LYS A 207 41.268 10.025 10.414 1.00 58.94 H +ATOM 3040 HE2 LYS A 207 41.982 11.584 10.088 1.00 58.94 H +ATOM 3041 HZ1 LYS A 207 43.986 10.889 11.103 1.00 60.33 H +ATOM 3042 HZ2 LYS A 207 42.716 10.697 12.135 1.00 60.33 H +ATOM 3043 HZ3 LYS A 207 43.382 9.375 11.397 1.00 60.33 H +ATOM 3044 N ASP A 208 40.598 13.605 8.367 1.00 53.64 N +ATOM 3045 CA ASP A 208 40.578 14.669 9.385 1.00 54.33 C +ATOM 3046 C ASP A 208 39.460 15.724 9.194 1.00 53.71 C +ATOM 3047 O ASP A 208 39.445 16.713 9.926 1.00 54.95 O +ATOM 3048 CB ASP A 208 41.962 15.346 9.585 1.00 56.35 C +ATOM 3049 CG ASP A 208 43.135 14.361 9.717 1.00 58.62 C +ATOM 3050 OD1 ASP A 208 43.298 13.818 10.832 1.00 59.21 O +ATOM 3051 OD2 ASP A 208 43.750 14.043 8.674 1.00 60.63 O1- +ATOM 3052 H ASP A 208 41.367 13.656 7.713 1.00 53.64 H +ATOM 3053 HA ASP A 208 40.341 14.177 10.331 1.00 54.33 H +ATOM 3054 HB3 ASP A 208 41.945 15.959 10.488 1.00 56.35 H +ATOM 3055 HB2 ASP A 208 42.172 16.024 8.757 1.00 56.35 H +ATOM 3056 N GLU A 209 38.540 15.490 8.244 1.00 52.25 N +ATOM 3057 CA GLU A 209 37.350 16.296 7.978 1.00 50.66 C +ATOM 3058 C GLU A 209 36.059 15.451 8.073 1.00 48.60 C +ATOM 3059 O GLU A 209 34.976 16.033 8.133 1.00 47.52 O +ATOM 3060 CB GLU A 209 37.525 16.928 6.584 1.00 52.62 C +ATOM 3061 CG GLU A 209 36.485 18.011 6.222 1.00 55.80 C +ATOM 3062 CD GLU A 209 36.679 18.541 4.802 1.00 58.39 C +ATOM 3063 OE1 GLU A 209 36.692 17.701 3.880 1.00 60.18 O +ATOM 3064 OE2 GLU A 209 36.806 19.774 4.639 1.00 60.45 O1- +ATOM 3065 H GLU A 209 38.660 14.682 7.649 1.00 52.25 H +ATOM 3066 HA GLU A 209 37.265 17.096 8.715 1.00 50.66 H +ATOM 3067 HB3 GLU A 209 37.498 16.128 5.842 1.00 52.62 H +ATOM 3068 HB2 GLU A 209 38.523 17.363 6.509 1.00 52.62 H +ATOM 3069 HG3 GLU A 209 36.537 18.827 6.945 1.00 55.80 H +ATOM 3070 HG2 GLU A 209 35.470 17.620 6.273 1.00 55.80 H +ATOM 3071 N VAL A 210 36.179 14.107 8.111 1.00 46.40 N +ATOM 3072 CA VAL A 210 35.064 13.157 8.216 1.00 44.14 C +ATOM 3073 C VAL A 210 34.184 13.402 9.451 1.00 43.51 C +ATOM 3074 O VAL A 210 32.966 13.475 9.303 1.00 42.39 O +ATOM 3075 CB VAL A 210 35.563 11.677 8.236 1.00 44.48 C +ATOM 3076 CG1 VAL A 210 34.548 10.607 8.703 1.00 42.85 C +ATOM 3077 CG2 VAL A 210 36.103 11.282 6.855 1.00 42.99 C +ATOM 3078 H VAL A 210 37.100 13.694 8.085 1.00 46.40 H +ATOM 3079 HA VAL A 210 34.438 13.300 7.333 1.00 44.14 H +ATOM 3080 HB VAL A 210 36.393 11.620 8.937 1.00 44.48 H +ATOM 3081 HG11 VAL A 210 34.965 9.606 8.597 1.00 42.85 H +ATOM 3082 HG12 VAL A 210 34.286 10.715 9.756 1.00 42.85 H +ATOM 3083 HG13 VAL A 210 33.629 10.648 8.118 1.00 42.85 H +ATOM 3084 HG21 VAL A 210 36.648 10.339 6.899 1.00 42.99 H +ATOM 3085 HG22 VAL A 210 35.287 11.165 6.144 1.00 42.99 H +ATOM 3086 HG23 VAL A 210 36.777 12.038 6.453 1.00 42.99 H +ATOM 3087 N TYR A 211 34.816 13.545 10.629 1.00 42.45 N +ATOM 3088 CA TYR A 211 34.116 13.676 11.904 1.00 41.99 C +ATOM 3089 C TYR A 211 33.244 14.937 12.017 1.00 43.14 C +ATOM 3090 O TYR A 211 32.134 14.827 12.533 1.00 42.53 O +ATOM 3091 CB TYR A 211 35.115 13.564 13.065 1.00 40.52 C +ATOM 3092 CG TYR A 211 34.451 13.378 14.414 1.00 39.40 C +ATOM 3093 CD1 TYR A 211 33.783 12.168 14.683 1.00 39.03 C +ATOM 3094 CD2 TYR A 211 34.452 14.409 15.376 1.00 39.70 C +ATOM 3095 CE1 TYR A 211 33.083 12.003 15.887 1.00 37.82 C +ATOM 3096 CE2 TYR A 211 33.743 14.243 16.582 1.00 39.48 C +ATOM 3097 CZ TYR A 211 33.032 13.052 16.824 1.00 38.29 C +ATOM 3098 OH TYR A 211 32.279 12.914 17.953 1.00 39.27 O +ATOM 3099 H TYR A 211 35.824 13.494 10.668 1.00 42.45 H +ATOM 3100 HA TYR A 211 33.441 12.820 11.965 1.00 41.99 H +ATOM 3101 HB3 TYR A 211 35.794 14.418 13.086 1.00 40.52 H +ATOM 3102 HB2 TYR A 211 35.730 12.685 12.894 1.00 40.52 H +ATOM 3103 HD1 TYR A 211 33.791 11.368 13.957 1.00 39.03 H +ATOM 3104 HD2 TYR A 211 34.960 15.341 15.179 1.00 39.70 H +ATOM 3105 HE1 TYR A 211 32.574 11.072 16.069 1.00 37.82 H +ATOM 3106 HE2 TYR A 211 33.720 15.047 17.304 1.00 39.48 H +ATOM 3107 HH TYR A 211 32.066 13.751 18.382 1.00 39.27 H +ATOM 3108 N GLN A 212 33.723 16.076 11.484 1.00 43.75 N +ATOM 3109 CA GLN A 212 32.967 17.331 11.390 1.00 43.56 C +ATOM 3110 C GLN A 212 31.652 17.219 10.604 1.00 41.95 C +ATOM 3111 O GLN A 212 30.649 17.793 11.026 1.00 41.64 O +ATOM 3112 CB GLN A 212 33.842 18.445 10.781 1.00 46.00 C +ATOM 3113 CG GLN A 212 34.710 19.183 11.809 1.00 48.97 C +ATOM 3114 CD GLN A 212 35.341 20.426 11.181 1.00 50.63 C +ATOM 3115 OE1 GLN A 212 36.243 20.316 10.355 1.00 50.62 O +ATOM 3116 NE2 GLN A 212 34.862 21.612 11.560 1.00 51.22 N +ATOM 3117 H GLN A 212 34.640 16.078 11.061 1.00 43.75 H +ATOM 3118 HA GLN A 212 32.696 17.617 12.407 1.00 43.56 H +ATOM 3119 HB3 GLN A 212 33.199 19.188 10.303 1.00 46.00 H +ATOM 3120 HB2 GLN A 212 34.464 18.044 9.979 1.00 46.00 H +ATOM 3121 HG3 GLN A 212 35.495 18.526 12.185 1.00 48.97 H +ATOM 3122 HG2 GLN A 212 34.109 19.478 12.671 1.00 48.97 H +ATOM 3123 HE22 GLN A 212 35.249 22.458 11.168 1.00 51.22 H +ATOM 3124 HE21 GLN A 212 34.119 21.673 12.241 1.00 51.22 H +ATOM 3125 N ILE A 213 31.687 16.476 9.487 1.00 40.96 N +ATOM 3126 CA ILE A 213 30.529 16.230 8.629 1.00 40.40 C +ATOM 3127 C ILE A 213 29.480 15.340 9.326 1.00 38.82 C +ATOM 3128 O ILE A 213 28.289 15.636 9.231 1.00 38.70 O +ATOM 3129 CB ILE A 213 30.957 15.608 7.268 1.00 41.38 C +ATOM 3130 CG1 ILE A 213 31.837 16.609 6.480 1.00 41.39 C +ATOM 3131 CG2 ILE A 213 29.782 15.120 6.391 1.00 41.81 C +ATOM 3132 CD1 ILE A 213 32.608 15.980 5.316 1.00 43.68 C +ATOM 3133 H ILE A 213 32.552 16.034 9.207 1.00 40.96 H +ATOM 3134 HA ILE A 213 30.056 17.193 8.425 1.00 40.40 H +ATOM 3135 HB ILE A 213 31.577 14.737 7.480 1.00 41.38 H +ATOM 3136 HG13 ILE A 213 32.570 17.079 7.135 1.00 41.39 H +ATOM 3137 HG12 ILE A 213 31.216 17.426 6.109 1.00 41.39 H +ATOM 3138 HG21 ILE A 213 30.126 14.797 5.412 1.00 41.81 H +ATOM 3139 HG22 ILE A 213 29.266 14.267 6.831 1.00 41.81 H +ATOM 3140 HG23 ILE A 213 29.053 15.914 6.230 1.00 41.81 H +ATOM 3141 HD11 ILE A 213 33.407 16.639 4.973 1.00 43.68 H +ATOM 3142 HD12 ILE A 213 33.065 15.033 5.605 1.00 43.68 H +ATOM 3143 HD13 ILE A 213 31.949 15.797 4.470 1.00 43.68 H +ATOM 3144 N LEU A 214 29.945 14.313 10.058 1.00 37.14 N +ATOM 3145 CA LEU A 214 29.104 13.416 10.852 1.00 36.39 C +ATOM 3146 C LEU A 214 28.479 14.105 12.081 1.00 36.96 C +ATOM 3147 O LEU A 214 27.314 13.834 12.371 1.00 36.52 O +ATOM 3148 CB LEU A 214 29.912 12.164 11.257 1.00 34.22 C +ATOM 3149 CG LEU A 214 30.410 11.292 10.082 1.00 34.05 C +ATOM 3150 CD1 LEU A 214 31.178 10.063 10.600 1.00 33.97 C +ATOM 3151 CD2 LEU A 214 29.303 10.894 9.091 1.00 31.89 C +ATOM 3152 H LEU A 214 30.941 14.140 10.094 1.00 37.14 H +ATOM 3153 HA LEU A 214 28.269 13.107 10.222 1.00 36.39 H +ATOM 3154 HB3 LEU A 214 29.294 11.542 11.899 1.00 34.22 H +ATOM 3155 HB2 LEU A 214 30.763 12.466 11.870 1.00 34.22 H +ATOM 3156 HG LEU A 214 31.126 11.880 9.516 1.00 34.05 H +ATOM 3157 HD11 LEU A 214 31.949 9.759 9.893 1.00 33.97 H +ATOM 3158 HD12 LEU A 214 31.673 10.271 11.547 1.00 33.97 H +ATOM 3159 HD13 LEU A 214 30.517 9.209 10.755 1.00 33.97 H +ATOM 3160 HD21 LEU A 214 29.456 9.893 8.693 1.00 31.89 H +ATOM 3161 HD22 LEU A 214 28.316 10.916 9.549 1.00 31.89 H +ATOM 3162 HD23 LEU A 214 29.286 11.573 8.238 1.00 31.89 H +ATOM 3163 N GLU A 215 29.221 15.016 12.741 1.00 36.83 N +ATOM 3164 CA GLU A 215 28.717 15.886 13.811 1.00 37.19 C +ATOM 3165 C GLU A 215 27.581 16.810 13.352 1.00 35.62 C +ATOM 3166 O GLU A 215 26.598 16.939 14.080 1.00 34.59 O +ATOM 3167 CB GLU A 215 29.846 16.745 14.410 1.00 38.50 C +ATOM 3168 CG GLU A 215 30.763 16.002 15.394 1.00 40.59 C +ATOM 3169 CD GLU A 215 31.796 16.959 16.002 1.00 43.18 C +ATOM 3170 OE1 GLU A 215 32.668 17.433 15.241 1.00 43.05 O +ATOM 3171 OE2 GLU A 215 31.698 17.203 17.225 1.00 42.79 O1- +ATOM 3172 H GLU A 215 30.184 15.164 12.467 1.00 36.83 H +ATOM 3173 HA GLU A 215 28.313 15.245 14.597 1.00 37.19 H +ATOM 3174 HB3 GLU A 215 29.426 17.616 14.918 1.00 38.50 H +ATOM 3175 HB2 GLU A 215 30.451 17.147 13.597 1.00 38.50 H +ATOM 3176 HG3 GLU A 215 31.280 15.179 14.902 1.00 40.59 H +ATOM 3177 HG2 GLU A 215 30.163 15.548 16.184 1.00 40.59 H +ATOM 3178 N LYS A 216 27.722 17.402 12.152 1.00 34.60 N +ATOM 3179 CA LYS A 216 26.673 18.182 11.491 1.00 35.20 C +ATOM 3180 C LYS A 216 25.416 17.356 11.182 1.00 33.65 C +ATOM 3181 O LYS A 216 24.317 17.870 11.373 1.00 33.67 O +ATOM 3182 CB LYS A 216 27.231 18.877 10.226 1.00 37.19 C +ATOM 3183 CG LYS A 216 27.593 20.356 10.444 1.00 41.61 C +ATOM 3184 CD LYS A 216 26.351 21.265 10.575 1.00 45.71 C +ATOM 3185 CE LYS A 216 26.675 22.749 10.822 1.00 48.01 C +ATOM 3186 NZ LYS A 216 27.247 22.987 12.161 1.00 49.53 N1+ +ATOM 3187 H LYS A 216 28.573 17.260 11.625 1.00 34.60 H +ATOM 3188 HA LYS A 216 26.375 18.944 12.212 1.00 35.20 H +ATOM 3189 HB3 LYS A 216 26.504 18.839 9.412 1.00 37.19 H +ATOM 3190 HB2 LYS A 216 28.097 18.331 9.849 1.00 37.19 H +ATOM 3191 HG3 LYS A 216 28.196 20.697 9.602 1.00 41.61 H +ATOM 3192 HG2 LYS A 216 28.229 20.439 11.325 1.00 41.61 H +ATOM 3193 HD3 LYS A 216 25.684 20.900 11.358 1.00 45.71 H +ATOM 3194 HD2 LYS A 216 25.772 21.194 9.652 1.00 45.71 H +ATOM 3195 HE3 LYS A 216 25.762 23.341 10.737 1.00 48.01 H +ATOM 3196 HE2 LYS A 216 27.363 23.120 10.062 1.00 48.01 H +ATOM 3197 HZ1 LYS A 216 28.109 22.470 12.256 1.00 49.53 H +ATOM 3198 HZ2 LYS A 216 27.434 23.973 12.278 1.00 49.53 H +ATOM 3199 HZ3 LYS A 216 26.594 22.683 12.868 1.00 49.53 H +ATOM 3200 N GLY A 217 25.605 16.088 10.778 1.00 33.75 N +ATOM 3201 CA GLY A 217 24.547 15.106 10.549 1.00 32.24 C +ATOM 3202 C GLY A 217 23.714 14.869 11.815 1.00 30.95 C +ATOM 3203 O GLY A 217 22.497 15.046 11.788 1.00 30.94 O +ATOM 3204 H GLY A 217 26.553 15.763 10.645 1.00 33.75 H +ATOM 3205 HA3 GLY A 217 25.004 14.166 10.240 1.00 32.24 H +ATOM 3206 HA2 GLY A 217 23.908 15.430 9.735 1.00 32.24 H +ATOM 3207 N ALA A 218 24.390 14.516 12.921 1.00 31.76 N +ATOM 3208 CA ALA A 218 23.798 14.267 14.237 1.00 30.06 C +ATOM 3209 C ALA A 218 23.133 15.502 14.875 1.00 30.68 C +ATOM 3210 O ALA A 218 22.100 15.352 15.529 1.00 28.25 O +ATOM 3211 CB ALA A 218 24.881 13.694 15.163 1.00 30.77 C +ATOM 3212 H ALA A 218 25.394 14.401 12.862 1.00 31.76 H +ATOM 3213 HA ALA A 218 23.026 13.507 14.110 1.00 30.06 H +ATOM 3214 HB1 ALA A 218 24.487 13.496 16.160 1.00 30.77 H +ATOM 3215 HB2 ALA A 218 25.266 12.752 14.774 1.00 30.77 H +ATOM 3216 HB3 ALA A 218 25.725 14.378 15.267 1.00 30.77 H +ATOM 3217 N ALA A 219 23.713 16.694 14.654 1.00 30.08 N +ATOM 3218 CA ALA A 219 23.179 17.977 15.111 1.00 31.41 C +ATOM 3219 C ALA A 219 21.873 18.360 14.401 1.00 31.60 C +ATOM 3220 O ALA A 219 20.940 18.801 15.070 1.00 31.54 O +ATOM 3221 CB ALA A 219 24.238 19.073 14.927 1.00 34.27 C +ATOM 3222 H ALA A 219 24.578 16.734 14.129 1.00 30.08 H +ATOM 3223 HA ALA A 219 22.967 17.890 16.178 1.00 31.41 H +ATOM 3224 HB1 ALA A 219 23.867 20.042 15.264 1.00 34.27 H +ATOM 3225 HB2 ALA A 219 25.135 18.850 15.505 1.00 34.27 H +ATOM 3226 HB3 ALA A 219 24.533 19.176 13.883 1.00 34.27 H +ATOM 3227 N LYS A 220 21.809 18.143 13.075 1.00 32.32 N +ATOM 3228 CA LYS A 220 20.595 18.345 12.285 1.00 32.64 C +ATOM 3229 C LYS A 220 19.482 17.338 12.624 1.00 30.46 C +ATOM 3230 O LYS A 220 18.320 17.736 12.611 1.00 31.31 O +ATOM 3231 CB LYS A 220 20.920 18.360 10.780 1.00 35.19 C +ATOM 3232 CG LYS A 220 21.672 19.626 10.319 1.00 41.44 C +ATOM 3233 CD LYS A 220 21.510 19.893 8.816 1.00 45.82 C +ATOM 3234 CE LYS A 220 20.213 20.659 8.510 1.00 46.78 C +ATOM 3235 NZ LYS A 220 19.777 20.499 7.115 1.00 49.70 N1+ +ATOM 3236 H LYS A 220 22.615 17.785 12.580 1.00 32.32 H +ATOM 3237 HA LYS A 220 20.203 19.330 12.545 1.00 32.64 H +ATOM 3238 HB3 LYS A 220 19.977 18.318 10.235 1.00 35.19 H +ATOM 3239 HB2 LYS A 220 21.471 17.464 10.492 1.00 35.19 H +ATOM 3240 HG3 LYS A 220 22.730 19.537 10.549 1.00 41.44 H +ATOM 3241 HG2 LYS A 220 21.329 20.497 10.878 1.00 41.44 H +ATOM 3242 HD3 LYS A 220 21.528 18.946 8.280 1.00 45.82 H +ATOM 3243 HD2 LYS A 220 22.371 20.456 8.456 1.00 45.82 H +ATOM 3244 HE3 LYS A 220 20.345 21.720 8.724 1.00 46.78 H +ATOM 3245 HE2 LYS A 220 19.409 20.315 9.148 1.00 46.78 H +ATOM 3246 HZ1 LYS A 220 20.506 20.849 6.506 1.00 49.70 H +ATOM 3247 HZ2 LYS A 220 19.595 19.527 6.900 1.00 49.70 H +ATOM 3248 HZ3 LYS A 220 18.939 21.039 6.955 1.00 49.70 H +ATOM 3249 N ARG A 221 19.833 16.090 12.988 1.00 29.75 N +ATOM 3250 CA ARG A 221 18.874 15.095 13.486 1.00 28.19 C +ATOM 3251 C ARG A 221 18.180 15.489 14.797 1.00 27.11 C +ATOM 3252 O ARG A 221 17.042 15.071 14.998 1.00 26.10 O +ATOM 3253 CB ARG A 221 19.540 13.730 13.697 1.00 30.31 C +ATOM 3254 CG ARG A 221 19.927 13.005 12.406 1.00 30.67 C +ATOM 3255 CD ARG A 221 19.353 11.585 12.409 1.00 34.41 C +ATOM 3256 NE ARG A 221 19.885 10.797 11.306 1.00 31.18 N +ATOM 3257 CZ ARG A 221 21.010 10.074 11.293 1.00 30.15 C +ATOM 3258 NH1 ARG A 221 21.803 9.984 12.368 1.00 26.01 N +ATOM 3259 NH2 ARG A 221 21.325 9.427 10.169 1.00 29.12 N1+ +ATOM 3260 H ARG A 221 20.805 15.811 12.963 1.00 29.75 H +ATOM 3261 HA ARG A 221 18.085 14.982 12.742 1.00 28.19 H +ATOM 3262 HB3 ARG A 221 18.846 13.096 14.253 1.00 30.31 H +ATOM 3263 HB2 ARG A 221 20.414 13.819 14.341 1.00 30.31 H +ATOM 3264 HG3 ARG A 221 21.000 13.015 12.220 1.00 30.67 H +ATOM 3265 HG2 ARG A 221 19.474 13.541 11.571 1.00 30.67 H +ATOM 3266 HD3 ARG A 221 18.287 11.652 12.185 1.00 34.41 H +ATOM 3267 HD2 ARG A 221 19.428 11.083 13.374 1.00 34.41 H +ATOM 3268 HE ARG A 221 19.373 10.871 10.431 1.00 31.18 H +ATOM 3269 HH12 ARG A 221 22.601 9.356 12.361 1.00 26.01 H +ATOM 3270 HH11 ARG A 221 21.562 10.468 13.219 1.00 26.01 H +ATOM 3271 HH22 ARG A 221 22.124 8.802 10.158 1.00 29.12 H +ATOM 3272 HH21 ARG A 221 20.746 9.532 9.345 1.00 29.12 H +ATOM 3273 N THR A 222 18.853 16.278 15.650 1.00 25.90 N +ATOM 3274 CA THR A 222 18.279 16.788 16.895 1.00 26.98 C +ATOM 3275 C THR A 222 17.165 17.823 16.633 1.00 24.38 C +ATOM 3276 O THR A 222 16.139 17.783 17.313 1.00 25.97 O +ATOM 3277 CB THR A 222 19.360 17.426 17.804 1.00 27.34 C +ATOM 3278 OG1 THR A 222 20.358 16.460 18.081 1.00 28.70 O +ATOM 3279 CG2 THR A 222 18.845 17.969 19.149 1.00 29.13 C +ATOM 3280 H THR A 222 19.787 16.585 15.420 1.00 25.90 H +ATOM 3281 HA THR A 222 17.835 15.947 17.433 1.00 26.98 H +ATOM 3282 HB THR A 222 19.845 18.247 17.278 1.00 27.34 H +ATOM 3283 HG1 THR A 222 20.778 16.198 17.257 1.00 28.70 H +ATOM 3284 HG21 THR A 222 19.672 18.309 19.774 1.00 29.13 H +ATOM 3285 HG22 THR A 222 18.177 18.821 19.018 1.00 29.13 H +ATOM 3286 HG23 THR A 222 18.304 17.202 19.703 1.00 29.13 H +ATOM 3287 N THR A 223 17.357 18.681 15.615 1.00 26.05 N +ATOM 3288 CA THR A 223 16.345 19.631 15.145 1.00 28.52 C +ATOM 3289 C THR A 223 15.186 18.937 14.394 1.00 27.17 C +ATOM 3290 O THR A 223 14.052 19.396 14.510 1.00 27.18 O +ATOM 3291 CB THR A 223 16.954 20.753 14.254 1.00 30.32 C +ATOM 3292 OG1 THR A 223 17.185 20.375 12.911 1.00 39.33 O +ATOM 3293 CG2 THR A 223 18.227 21.389 14.832 1.00 30.64 C +ATOM 3294 H THR A 223 18.222 18.652 15.094 1.00 26.05 H +ATOM 3295 HA THR A 223 15.915 20.115 16.024 1.00 28.52 H +ATOM 3296 HB THR A 223 16.208 21.548 14.198 1.00 30.32 H +ATOM 3297 HG1 THR A 223 17.773 19.613 12.896 1.00 39.33 H +ATOM 3298 HG21 THR A 223 18.547 22.240 14.229 1.00 30.64 H +ATOM 3299 HG22 THR A 223 18.057 21.750 15.847 1.00 30.64 H +ATOM 3300 HG23 THR A 223 19.055 20.682 14.863 1.00 30.64 H +ATOM 3301 N ALA A 224 15.468 17.821 13.696 1.00 25.91 N +ATOM 3302 CA ALA A 224 14.459 16.977 13.053 1.00 24.46 C +ATOM 3303 C ALA A 224 13.585 16.233 14.076 1.00 23.90 C +ATOM 3304 O ALA A 224 12.376 16.155 13.878 1.00 20.38 O +ATOM 3305 CB ALA A 224 15.144 15.998 12.089 1.00 24.41 C +ATOM 3306 H ALA A 224 16.426 17.505 13.626 1.00 25.91 H +ATOM 3307 HA ALA A 224 13.802 17.620 12.466 1.00 24.46 H +ATOM 3308 HB1 ALA A 224 14.407 15.437 11.516 1.00 24.41 H +ATOM 3309 HB2 ALA A 224 15.777 16.522 11.374 1.00 24.41 H +ATOM 3310 HB3 ALA A 224 15.764 15.276 12.618 1.00 24.41 H +ATOM 3311 N ALA A 225 14.198 15.758 15.174 1.00 24.13 N +ATOM 3312 CA ALA A 225 13.517 15.140 16.311 1.00 25.95 C +ATOM 3313 C ALA A 225 12.609 16.104 17.090 1.00 25.57 C +ATOM 3314 O ALA A 225 11.577 15.664 17.597 1.00 26.74 O +ATOM 3315 CB ALA A 225 14.558 14.488 17.233 1.00 23.02 C +ATOM 3316 H ALA A 225 15.204 15.839 15.252 1.00 24.13 H +ATOM 3317 HA ALA A 225 12.867 14.358 15.926 1.00 25.95 H +ATOM 3318 HB1 ALA A 225 14.085 14.009 18.091 1.00 23.02 H +ATOM 3319 HB2 ALA A 225 15.121 13.720 16.701 1.00 23.02 H +ATOM 3320 HB3 ALA A 225 15.273 15.218 17.614 1.00 23.02 H +ATOM 3321 N THR A 226 12.980 17.394 17.136 1.00 25.99 N +ATOM 3322 CA THR A 226 12.169 18.458 17.729 1.00 26.54 C +ATOM 3323 C THR A 226 10.896 18.746 16.904 1.00 25.91 C +ATOM 3324 O THR A 226 9.824 18.897 17.491 1.00 26.81 O +ATOM 3325 CB THR A 226 12.980 19.776 17.866 1.00 27.83 C +ATOM 3326 OG1 THR A 226 14.105 19.547 18.692 1.00 29.02 O +ATOM 3327 CG2 THR A 226 12.208 20.975 18.450 1.00 30.31 C +ATOM 3328 H THR A 226 13.843 17.678 16.696 1.00 25.99 H +ATOM 3329 HA THR A 226 11.861 18.136 18.726 1.00 26.54 H +ATOM 3330 HB THR A 226 13.365 20.071 16.891 1.00 27.83 H +ATOM 3331 HG1 THR A 226 14.675 18.896 18.271 1.00 29.02 H +ATOM 3332 HG21 THR A 226 12.874 21.822 18.620 1.00 30.31 H +ATOM 3333 HG22 THR A 226 11.422 21.321 17.778 1.00 30.31 H +ATOM 3334 HG23 THR A 226 11.747 20.720 19.404 1.00 30.31 H +ATOM 3335 N LEU A 227 11.039 18.796 15.569 1.00 26.53 N +ATOM 3336 CA LEU A 227 9.971 19.157 14.634 1.00 26.89 C +ATOM 3337 C LEU A 227 8.993 18.011 14.324 1.00 26.84 C +ATOM 3338 O LEU A 227 7.818 18.293 14.092 1.00 27.26 O +ATOM 3339 CB LEU A 227 10.609 19.683 13.327 1.00 28.85 C +ATOM 3340 CG LEU A 227 11.323 21.046 13.476 1.00 34.29 C +ATOM 3341 CD1 LEU A 227 12.190 21.352 12.239 1.00 36.73 C +ATOM 3342 CD2 LEU A 227 10.335 22.189 13.799 1.00 33.59 C +ATOM 3343 H LEU A 227 11.951 18.646 15.160 1.00 26.53 H +ATOM 3344 HA LEU A 227 9.381 19.956 15.084 1.00 26.89 H +ATOM 3345 HB3 LEU A 227 9.850 19.773 12.547 1.00 28.85 H +ATOM 3346 HB2 LEU A 227 11.318 18.937 12.962 1.00 28.85 H +ATOM 3347 HG LEU A 227 12.007 20.981 14.322 1.00 34.29 H +ATOM 3348 HD11 LEU A 227 12.043 22.359 11.849 1.00 36.73 H +ATOM 3349 HD12 LEU A 227 13.248 21.261 12.485 1.00 36.73 H +ATOM 3350 HD13 LEU A 227 11.980 20.664 11.421 1.00 36.73 H +ATOM 3351 HD21 LEU A 227 10.441 23.048 13.137 1.00 33.59 H +ATOM 3352 HD22 LEU A 227 9.296 21.866 13.724 1.00 33.59 H +ATOM 3353 HD23 LEU A 227 10.488 22.551 14.816 1.00 33.59 H +ATOM 3354 N MET A 228 9.485 16.762 14.295 1.00 25.26 N +ATOM 3355 CA MET A 228 8.739 15.587 13.838 1.00 24.70 C +ATOM 3356 C MET A 228 8.686 14.531 14.949 1.00 23.35 C +ATOM 3357 O MET A 228 9.711 14.233 15.564 1.00 20.92 O +ATOM 3358 CB MET A 228 9.408 15.055 12.555 1.00 24.08 C +ATOM 3359 CG MET A 228 9.168 15.961 11.334 1.00 24.87 C +ATOM 3360 SD MET A 228 10.164 15.579 9.869 1.00 24.76 S +ATOM 3361 CE MET A 228 11.710 16.421 10.296 1.00 26.75 C +ATOM 3362 H MET A 228 10.463 16.606 14.503 1.00 25.26 H +ATOM 3363 HA MET A 228 7.710 15.854 13.592 1.00 24.70 H +ATOM 3364 HB3 MET A 228 9.025 14.062 12.329 1.00 24.08 H +ATOM 3365 HB2 MET A 228 10.476 14.923 12.717 1.00 24.08 H +ATOM 3366 HG3 MET A 228 9.346 17.007 11.584 1.00 24.87 H +ATOM 3367 HG2 MET A 228 8.119 15.895 11.046 1.00 24.87 H +ATOM 3368 HE1 MET A 228 12.441 16.291 9.498 1.00 26.75 H +ATOM 3369 HE2 MET A 228 11.541 17.488 10.443 1.00 26.75 H +ATOM 3370 HE3 MET A 228 12.121 16.003 11.213 1.00 26.75 H +ATOM 3371 N ASN A 229 7.472 14.008 15.196 1.00 23.78 N +ATOM 3372 CA ASN A 229 7.145 13.104 16.305 1.00 26.25 C +ATOM 3373 C ASN A 229 7.753 11.712 16.102 1.00 24.54 C +ATOM 3374 O ASN A 229 7.451 11.061 15.101 1.00 24.23 O +ATOM 3375 CB ASN A 229 5.610 12.979 16.458 1.00 28.76 C +ATOM 3376 CG ASN A 229 4.848 14.258 16.830 1.00 36.20 C +ATOM 3377 OD1 ASN A 229 3.625 14.278 16.730 1.00 39.05 O +ATOM 3378 ND2 ASN A 229 5.529 15.321 17.270 1.00 36.12 N +ATOM 3379 H ASN A 229 6.691 14.297 14.625 1.00 23.78 H +ATOM 3380 HA ASN A 229 7.558 13.541 17.217 1.00 26.25 H +ATOM 3381 HB3 ASN A 229 5.383 12.247 17.236 1.00 28.76 H +ATOM 3382 HB2 ASN A 229 5.175 12.586 15.537 1.00 28.76 H +ATOM 3383 HD22 ASN A 229 5.033 16.163 17.521 1.00 36.12 H +ATOM 3384 HD21 ASN A 229 6.537 15.300 17.359 1.00 36.12 H +ATOM 3385 N ALA A 230 8.584 11.290 17.072 1.00 23.31 N +ATOM 3386 CA ALA A 230 9.316 10.019 17.096 1.00 22.45 C +ATOM 3387 C ALA A 230 10.159 9.809 15.823 1.00 22.19 C +ATOM 3388 O ALA A 230 10.096 8.743 15.212 1.00 21.45 O +ATOM 3389 CB ALA A 230 8.342 8.859 17.379 1.00 23.18 C +ATOM 3390 H ALA A 230 8.781 11.910 17.844 1.00 23.31 H +ATOM 3391 HA ALA A 230 10.017 10.078 17.928 1.00 22.45 H +ATOM 3392 HB1 ALA A 230 8.873 7.917 17.512 1.00 23.18 H +ATOM 3393 HB2 ALA A 230 7.773 9.040 18.292 1.00 23.18 H +ATOM 3394 HB3 ALA A 230 7.629 8.729 16.567 1.00 23.18 H +ATOM 3395 N TYR A 231 10.893 10.865 15.427 1.00 20.58 N +ATOM 3396 CA TYR A 231 11.648 10.941 14.177 1.00 23.09 C +ATOM 3397 C TYR A 231 12.699 9.831 14.038 1.00 23.15 C +ATOM 3398 O TYR A 231 12.776 9.221 12.977 1.00 21.50 O +ATOM 3399 CB TYR A 231 12.298 12.330 14.036 1.00 21.56 C +ATOM 3400 CG TYR A 231 13.026 12.550 12.723 1.00 22.51 C +ATOM 3401 CD1 TYR A 231 14.422 12.360 12.636 1.00 22.41 C +ATOM 3402 CD2 TYR A 231 12.293 12.898 11.571 1.00 22.80 C +ATOM 3403 CE1 TYR A 231 15.072 12.484 11.394 1.00 26.33 C +ATOM 3404 CE2 TYR A 231 12.946 13.045 10.336 1.00 22.49 C +ATOM 3405 CZ TYR A 231 14.330 12.820 10.244 1.00 23.24 C +ATOM 3406 OH TYR A 231 14.942 12.918 9.032 1.00 25.69 O +ATOM 3407 H TYR A 231 10.889 11.702 15.996 1.00 20.58 H +ATOM 3408 HA TYR A 231 10.930 10.820 13.365 1.00 23.09 H +ATOM 3409 HB3 TYR A 231 13.004 12.479 14.852 1.00 21.56 H +ATOM 3410 HB2 TYR A 231 11.542 13.108 14.131 1.00 21.56 H +ATOM 3411 HD1 TYR A 231 14.993 12.090 13.512 1.00 22.41 H +ATOM 3412 HD2 TYR A 231 11.225 13.034 11.626 1.00 22.80 H +ATOM 3413 HE1 TYR A 231 16.136 12.318 11.326 1.00 26.33 H +ATOM 3414 HE2 TYR A 231 12.381 13.310 9.454 1.00 22.49 H +ATOM 3415 HH TYR A 231 15.826 12.530 9.037 1.00 25.69 H +ATOM 3416 N SER A 232 13.458 9.578 15.115 1.00 22.12 N +ATOM 3417 CA SER A 232 14.523 8.577 15.172 1.00 21.84 C +ATOM 3418 C SER A 232 14.069 7.130 14.895 1.00 21.72 C +ATOM 3419 O SER A 232 14.886 6.351 14.409 1.00 22.45 O +ATOM 3420 CB SER A 232 15.255 8.712 16.523 1.00 21.64 C +ATOM 3421 OG SER A 232 14.455 8.291 17.612 1.00 26.16 O +ATOM 3422 H SER A 232 13.306 10.103 15.965 1.00 22.12 H +ATOM 3423 HA SER A 232 15.235 8.841 14.386 1.00 21.84 H +ATOM 3424 HB3 SER A 232 15.571 9.743 16.688 1.00 21.64 H +ATOM 3425 HB2 SER A 232 16.164 8.108 16.515 1.00 21.64 H +ATOM 3426 HG SER A 232 14.425 7.331 17.616 1.00 26.16 H +ATOM 3427 N SER A 233 12.798 6.807 15.193 1.00 20.41 N +ATOM 3428 CA SER A 233 12.223 5.475 15.018 1.00 20.63 C +ATOM 3429 C SER A 233 11.335 5.334 13.770 1.00 19.00 C +ATOM 3430 O SER A 233 11.184 4.210 13.297 1.00 19.49 O +ATOM 3431 CB SER A 233 11.483 5.075 16.311 1.00 24.24 C +ATOM 3432 OG SER A 233 10.309 5.832 16.529 1.00 29.04 O +ATOM 3433 H SER A 233 12.181 7.506 15.583 1.00 20.41 H +ATOM 3434 HA SER A 233 13.034 4.762 14.890 1.00 20.63 H +ATOM 3435 HB3 SER A 233 12.140 5.172 17.176 1.00 24.24 H +ATOM 3436 HB2 SER A 233 11.190 4.028 16.256 1.00 24.24 H +ATOM 3437 HG SER A 233 9.885 5.511 17.328 1.00 29.04 H +ATOM 3438 N ARG A 234 10.761 6.437 13.263 1.00 18.33 N +ATOM 3439 CA ARG A 234 9.834 6.423 12.126 1.00 22.18 C +ATOM 3440 C ARG A 234 10.484 6.846 10.803 1.00 22.21 C +ATOM 3441 O ARG A 234 9.923 6.518 9.757 1.00 20.94 O +ATOM 3442 CB ARG A 234 8.635 7.335 12.426 1.00 23.89 C +ATOM 3443 CG ARG A 234 7.771 6.850 13.597 1.00 25.44 C +ATOM 3444 CD ARG A 234 6.533 7.735 13.784 1.00 31.15 C +ATOM 3445 NE ARG A 234 5.779 7.372 14.993 1.00 38.50 N +ATOM 3446 CZ ARG A 234 4.777 8.070 15.560 1.00 41.33 C +ATOM 3447 NH1 ARG A 234 4.323 9.221 15.039 1.00 40.07 N +ATOM 3448 NH2 ARG A 234 4.217 7.600 16.681 1.00 42.46 N1+ +ATOM 3449 H ARG A 234 10.909 7.329 13.714 1.00 18.33 H +ATOM 3450 HA ARG A 234 9.444 5.415 11.969 1.00 22.18 H +ATOM 3451 HB3 ARG A 234 8.000 7.413 11.542 1.00 23.89 H +ATOM 3452 HB2 ARG A 234 8.997 8.342 12.632 1.00 23.89 H +ATOM 3453 HG3 ARG A 234 8.335 6.741 14.524 1.00 25.44 H +ATOM 3454 HG2 ARG A 234 7.434 5.847 13.328 1.00 25.44 H +ATOM 3455 HD3 ARG A 234 5.845 7.536 12.961 1.00 31.15 H +ATOM 3456 HD2 ARG A 234 6.785 8.794 13.732 1.00 31.15 H +ATOM 3457 HE ARG A 234 6.063 6.507 15.431 1.00 38.50 H +ATOM 3458 HH12 ARG A 234 3.570 9.728 15.479 1.00 40.07 H +ATOM 3459 HH11 ARG A 234 4.741 9.588 14.196 1.00 40.07 H +ATOM 3460 HH22 ARG A 234 3.464 8.103 17.128 1.00 42.46 H +ATOM 3461 HH21 ARG A 234 4.542 6.736 17.091 1.00 42.46 H +ATOM 3462 N SER A 235 11.627 7.550 10.843 1.00 19.99 N +ATOM 3463 CA SER A 235 12.362 7.927 9.638 1.00 19.86 C +ATOM 3464 C SER A 235 13.190 6.754 9.090 1.00 19.77 C +ATOM 3465 O SER A 235 13.654 5.908 9.854 1.00 20.24 O +ATOM 3466 CB SER A 235 13.218 9.191 9.887 1.00 21.58 C +ATOM 3467 OG SER A 235 14.389 8.940 10.641 1.00 21.88 O +ATOM 3468 H SER A 235 12.049 7.797 11.728 1.00 19.99 H +ATOM 3469 HA SER A 235 11.616 8.202 8.894 1.00 19.86 H +ATOM 3470 HB3 SER A 235 12.630 9.964 10.381 1.00 21.58 H +ATOM 3471 HB2 SER A 235 13.532 9.613 8.932 1.00 21.58 H +ATOM 3472 HG SER A 235 14.132 8.796 11.556 1.00 21.88 H +ATOM 3473 N HIS A 236 13.385 6.775 7.767 1.00 18.17 N +ATOM 3474 CA HIS A 236 14.415 6.021 7.061 1.00 19.29 C +ATOM 3475 C HIS A 236 15.540 7.008 6.739 1.00 18.44 C +ATOM 3476 O HIS A 236 15.240 8.154 6.412 1.00 20.59 O +ATOM 3477 CB HIS A 236 13.838 5.446 5.751 1.00 18.44 C +ATOM 3478 CG HIS A 236 12.567 4.658 5.915 1.00 20.86 C +ATOM 3479 ND1 HIS A 236 12.567 3.288 6.186 1.00 20.53 N +ATOM 3480 CD2 HIS A 236 11.262 5.099 5.848 1.00 19.38 C +ATOM 3481 CE1 HIS A 236 11.289 2.955 6.262 1.00 18.42 C +ATOM 3482 NE2 HIS A 236 10.470 3.991 6.085 1.00 19.60 N +ATOM 3483 H HIS A 236 12.937 7.503 7.225 1.00 18.17 H +ATOM 3484 HA HIS A 236 14.788 5.205 7.682 1.00 19.29 H +ATOM 3485 HB3 HIS A 236 14.579 4.798 5.281 1.00 18.44 H +ATOM 3486 HB2 HIS A 236 13.643 6.244 5.034 1.00 18.44 H +ATOM 3487 HD2 HIS A 236 10.849 6.082 5.670 1.00 19.38 H +ATOM 3488 HE1 HIS A 236 10.952 1.951 6.463 1.00 18.42 H +ATOM 3489 HE2 HIS A 236 9.458 3.974 6.127 1.00 19.60 H +ATOM 3490 N SER A 237 16.795 6.553 6.800 1.00 20.58 N +ATOM 3491 CA SER A 237 17.963 7.337 6.407 1.00 21.26 C +ATOM 3492 C SER A 237 18.805 6.538 5.412 1.00 21.57 C +ATOM 3493 O SER A 237 18.957 5.331 5.575 1.00 20.33 O +ATOM 3494 CB SER A 237 18.746 7.785 7.658 1.00 24.54 C +ATOM 3495 OG SER A 237 19.438 6.740 8.306 1.00 26.90 O +ATOM 3496 H SER A 237 16.979 5.608 7.117 1.00 20.58 H +ATOM 3497 HA SER A 237 17.636 8.238 5.889 1.00 21.26 H +ATOM 3498 HB3 SER A 237 18.080 8.263 8.376 1.00 24.54 H +ATOM 3499 HB2 SER A 237 19.489 8.527 7.370 1.00 24.54 H +ATOM 3500 HG SER A 237 20.153 6.437 7.740 1.00 26.90 H +ATOM 3501 N VAL A 238 19.332 7.242 4.403 1.00 22.05 N +ATOM 3502 CA VAL A 238 20.194 6.705 3.361 1.00 22.38 C +ATOM 3503 C VAL A 238 21.449 7.588 3.345 1.00 23.09 C +ATOM 3504 O VAL A 238 21.437 8.661 2.740 1.00 25.68 O +ATOM 3505 CB VAL A 238 19.505 6.745 1.960 1.00 21.69 C +ATOM 3506 CG1 VAL A 238 20.417 6.244 0.817 1.00 20.82 C +ATOM 3507 CG2 VAL A 238 18.179 5.960 1.947 1.00 20.75 C +ATOM 3508 H VAL A 238 19.125 8.231 4.327 1.00 22.05 H +ATOM 3509 HA VAL A 238 20.492 5.678 3.581 1.00 22.38 H +ATOM 3510 HB VAL A 238 19.240 7.777 1.727 1.00 21.69 H +ATOM 3511 HG11 VAL A 238 19.878 6.212 -0.131 1.00 20.82 H +ATOM 3512 HG12 VAL A 238 21.283 6.888 0.664 1.00 20.82 H +ATOM 3513 HG13 VAL A 238 20.787 5.239 1.019 1.00 20.82 H +ATOM 3514 HG21 VAL A 238 17.729 5.956 0.953 1.00 20.75 H +ATOM 3515 HG22 VAL A 238 18.326 4.924 2.248 1.00 20.75 H +ATOM 3516 HG23 VAL A 238 17.448 6.400 2.625 1.00 20.75 H +ATOM 3517 N PHE A 239 22.506 7.123 4.030 1.00 25.74 N +ATOM 3518 CA PHE A 239 23.827 7.740 3.977 1.00 25.50 C +ATOM 3519 C PHE A 239 24.558 7.114 2.787 1.00 27.21 C +ATOM 3520 O PHE A 239 24.990 5.967 2.888 1.00 25.60 O +ATOM 3521 CB PHE A 239 24.578 7.511 5.311 1.00 24.56 C +ATOM 3522 CG PHE A 239 25.854 8.329 5.462 1.00 23.56 C +ATOM 3523 CD1 PHE A 239 27.025 7.986 4.751 1.00 24.94 C +ATOM 3524 CD2 PHE A 239 25.838 9.529 6.207 1.00 23.03 C +ATOM 3525 CE1 PHE A 239 28.138 8.812 4.803 1.00 25.28 C +ATOM 3526 CE2 PHE A 239 26.973 10.326 6.270 1.00 24.84 C +ATOM 3527 CZ PHE A 239 28.118 9.970 5.570 1.00 24.20 C +ATOM 3528 H PHE A 239 22.445 6.239 4.520 1.00 25.74 H +ATOM 3529 HA PHE A 239 23.731 8.815 3.829 1.00 25.50 H +ATOM 3530 HB3 PHE A 239 24.830 6.458 5.432 1.00 24.56 H +ATOM 3531 HB2 PHE A 239 23.920 7.740 6.149 1.00 24.56 H +ATOM 3532 HD1 PHE A 239 27.060 7.091 4.149 1.00 24.94 H +ATOM 3533 HD2 PHE A 239 24.948 9.833 6.737 1.00 23.03 H +ATOM 3534 HE1 PHE A 239 29.017 8.553 4.233 1.00 25.28 H +ATOM 3535 HE2 PHE A 239 26.959 11.237 6.851 1.00 24.84 H +ATOM 3536 HZ PHE A 239 28.992 10.604 5.608 1.00 24.20 H +ATOM 3537 N SER A 240 24.678 7.865 1.684 1.00 28.35 N +ATOM 3538 CA SER A 240 25.437 7.427 0.520 1.00 31.42 C +ATOM 3539 C SER A 240 26.833 8.061 0.527 1.00 32.07 C +ATOM 3540 O SER A 240 26.976 9.215 0.929 1.00 32.25 O +ATOM 3541 CB SER A 240 24.635 7.678 -0.772 1.00 34.03 C +ATOM 3542 OG SER A 240 24.801 8.961 -1.338 1.00 40.12 O +ATOM 3543 H SER A 240 24.334 8.817 1.676 1.00 28.35 H +ATOM 3544 HA SER A 240 25.557 6.350 0.576 1.00 31.42 H +ATOM 3545 HB3 SER A 240 23.573 7.482 -0.617 1.00 34.03 H +ATOM 3546 HB2 SER A 240 24.974 6.957 -1.515 1.00 34.03 H +ATOM 3547 HG SER A 240 24.336 9.607 -0.796 1.00 40.12 H +ATOM 3548 N VAL A 241 27.817 7.288 0.052 1.00 33.55 N +ATOM 3549 CA VAL A 241 29.173 7.736 -0.231 1.00 34.45 C +ATOM 3550 C VAL A 241 29.516 7.325 -1.670 1.00 34.62 C +ATOM 3551 O VAL A 241 29.385 6.151 -2.006 1.00 35.51 O +ATOM 3552 CB VAL A 241 30.218 7.168 0.778 1.00 34.83 C +ATOM 3553 CG1 VAL A 241 30.239 5.637 0.921 1.00 38.79 C +ATOM 3554 CG2 VAL A 241 31.645 7.669 0.487 1.00 35.64 C +ATOM 3555 H VAL A 241 27.608 6.336 -0.224 1.00 33.55 H +ATOM 3556 HA VAL A 241 29.205 8.822 -0.168 1.00 34.45 H +ATOM 3557 HB VAL A 241 29.942 7.557 1.759 1.00 34.83 H +ATOM 3558 HG11 VAL A 241 30.890 5.333 1.741 1.00 38.79 H +ATOM 3559 HG12 VAL A 241 29.247 5.242 1.140 1.00 38.79 H +ATOM 3560 HG13 VAL A 241 30.619 5.155 0.020 1.00 38.79 H +ATOM 3561 HG21 VAL A 241 32.356 7.285 1.217 1.00 35.64 H +ATOM 3562 HG22 VAL A 241 32.007 7.357 -0.493 1.00 35.64 H +ATOM 3563 HG23 VAL A 241 31.682 8.757 0.528 1.00 35.64 H +ATOM 3564 N THR A 242 29.937 8.305 -2.483 1.00 35.79 N +ATOM 3565 CA THR A 242 30.386 8.109 -3.859 1.00 37.70 C +ATOM 3566 C THR A 242 31.881 8.444 -3.934 1.00 37.87 C +ATOM 3567 O THR A 242 32.287 9.492 -3.432 1.00 37.49 O +ATOM 3568 CB THR A 242 29.638 9.035 -4.853 1.00 37.97 C +ATOM 3569 OG1 THR A 242 28.251 8.772 -4.771 1.00 39.56 O +ATOM 3570 CG2 THR A 242 30.056 8.873 -6.329 1.00 37.97 C +ATOM 3571 H THR A 242 30.018 9.247 -2.121 1.00 35.79 H +ATOM 3572 HA THR A 242 30.233 7.075 -4.163 1.00 37.70 H +ATOM 3573 HB THR A 242 29.780 10.077 -4.562 1.00 37.97 H +ATOM 3574 HG1 THR A 242 27.942 9.076 -3.910 1.00 39.56 H +ATOM 3575 HG21 THR A 242 29.443 9.500 -6.978 1.00 37.97 H +ATOM 3576 HG22 THR A 242 31.093 9.162 -6.497 1.00 37.97 H +ATOM 3577 HG23 THR A 242 29.940 7.842 -6.663 1.00 37.97 H +ATOM 3578 N ILE A 243 32.662 7.550 -4.557 1.00 39.49 N +ATOM 3579 CA ILE A 243 34.109 7.678 -4.676 1.00 41.33 C +ATOM 3580 C ILE A 243 34.449 7.701 -6.177 1.00 42.69 C +ATOM 3581 O ILE A 243 34.334 6.678 -6.850 1.00 41.59 O +ATOM 3582 CB ILE A 243 34.876 6.490 -4.019 1.00 42.17 C +ATOM 3583 CG1 ILE A 243 34.339 6.106 -2.620 1.00 40.50 C +ATOM 3584 CG2 ILE A 243 36.390 6.787 -3.930 1.00 40.47 C +ATOM 3585 CD1 ILE A 243 34.920 4.783 -2.110 1.00 41.65 C +ATOM 3586 H ILE A 243 32.248 6.725 -4.976 1.00 39.49 H +ATOM 3587 HA ILE A 243 34.458 8.602 -4.216 1.00 41.33 H +ATOM 3588 HB ILE A 243 34.752 5.605 -4.645 1.00 42.17 H +ATOM 3589 HG13 ILE A 243 33.255 5.995 -2.632 1.00 40.50 H +ATOM 3590 HG12 ILE A 243 34.550 6.905 -1.908 1.00 40.50 H +ATOM 3591 HG21 ILE A 243 36.951 5.895 -3.657 1.00 40.47 H +ATOM 3592 HG22 ILE A 243 36.803 7.155 -4.866 1.00 40.47 H +ATOM 3593 HG23 ILE A 243 36.598 7.551 -3.181 1.00 40.47 H +ATOM 3594 HD11 ILE A 243 34.284 4.344 -1.342 1.00 41.65 H +ATOM 3595 HD12 ILE A 243 35.006 4.057 -2.917 1.00 41.65 H +ATOM 3596 HD13 ILE A 243 35.912 4.930 -1.687 1.00 41.65 H +ATOM 3597 N HIS A 244 34.874 8.872 -6.667 1.00 44.46 N +ATOM 3598 CA HIS A 244 35.465 9.037 -7.994 1.00 47.53 C +ATOM 3599 C HIS A 244 36.957 8.733 -7.886 1.00 47.71 C +ATOM 3600 O HIS A 244 37.603 9.276 -6.996 1.00 47.71 O +ATOM 3601 CB HIS A 244 35.233 10.474 -8.489 1.00 49.46 C +ATOM 3602 CG HIS A 244 33.777 10.794 -8.685 1.00 52.62 C +ATOM 3603 ND1 HIS A 244 33.068 10.377 -9.815 1.00 53.91 N +ATOM 3604 CD2 HIS A 244 32.917 11.459 -7.836 1.00 52.34 C +ATOM 3605 CE1 HIS A 244 31.825 10.785 -9.607 1.00 52.76 C +ATOM 3606 NE2 HIS A 244 31.678 11.428 -8.450 1.00 53.06 N +ATOM 3607 H HIS A 244 34.966 9.663 -6.042 1.00 44.46 H +ATOM 3608 HA HIS A 244 35.003 8.345 -8.703 1.00 47.53 H +ATOM 3609 HB3 HIS A 244 35.744 10.631 -9.440 1.00 49.46 H +ATOM 3610 HB2 HIS A 244 35.656 11.195 -7.789 1.00 49.46 H +ATOM 3611 HD2 HIS A 244 33.081 11.910 -6.869 1.00 52.34 H +ATOM 3612 HE1 HIS A 244 31.016 10.606 -10.300 1.00 52.76 H +ATOM 3613 HE2 HIS A 244 30.815 11.798 -8.084 1.00 53.06 H +ATOM 3614 N MET A 245 37.457 7.850 -8.758 1.00 48.94 N +ATOM 3615 CA MET A 245 38.824 7.338 -8.731 1.00 49.37 C +ATOM 3616 C MET A 245 39.421 7.438 -10.134 1.00 51.21 C +ATOM 3617 O MET A 245 38.759 7.086 -11.108 1.00 50.79 O +ATOM 3618 CB MET A 245 38.819 5.865 -8.272 1.00 47.53 C +ATOM 3619 CG MET A 245 38.271 5.654 -6.855 1.00 47.54 C +ATOM 3620 SD MET A 245 37.955 3.929 -6.414 1.00 44.84 S +ATOM 3621 CE MET A 245 36.293 3.751 -7.119 1.00 45.83 C +ATOM 3622 H MET A 245 36.852 7.437 -9.457 1.00 48.94 H +ATOM 3623 HA MET A 245 39.444 7.918 -8.045 1.00 49.37 H +ATOM 3624 HB3 MET A 245 39.834 5.467 -8.312 1.00 47.53 H +ATOM 3625 HB2 MET A 245 38.237 5.267 -8.972 1.00 47.53 H +ATOM 3626 HG3 MET A 245 37.325 6.176 -6.737 1.00 47.54 H +ATOM 3627 HG2 MET A 245 38.961 6.087 -6.134 1.00 47.54 H +ATOM 3628 HE1 MET A 245 35.952 2.719 -7.071 1.00 45.83 H +ATOM 3629 HE2 MET A 245 35.584 4.362 -6.562 1.00 45.83 H +ATOM 3630 HE3 MET A 245 36.276 4.068 -8.160 1.00 45.83 H +ATOM 3631 N LYS A 246 40.684 7.866 -10.183 1.00 52.65 N +ATOM 3632 CA LYS A 246 41.535 7.895 -11.359 1.00 54.10 C +ATOM 3633 C LYS A 246 42.818 7.169 -10.943 1.00 54.52 C +ATOM 3634 O LYS A 246 43.819 7.799 -10.602 1.00 54.51 O +ATOM 3635 CB LYS A 246 41.739 9.358 -11.806 1.00 54.81 C +ATOM 3636 CG LYS A 246 42.485 9.497 -13.141 1.00 57.30 C +ATOM 3637 CD LYS A 246 42.701 10.970 -13.530 1.00 58.78 C +ATOM 3638 CE LYS A 246 43.164 11.179 -14.981 1.00 60.80 C +ATOM 3639 NZ LYS A 246 42.095 10.892 -15.956 1.00 61.59 N1+ +ATOM 3640 H LYS A 246 41.126 8.187 -9.332 1.00 52.65 H +ATOM 3641 HA LYS A 246 41.081 7.338 -12.181 1.00 54.10 H +ATOM 3642 HB3 LYS A 246 42.254 9.926 -11.031 1.00 54.81 H +ATOM 3643 HB2 LYS A 246 40.760 9.829 -11.914 1.00 54.81 H +ATOM 3644 HG3 LYS A 246 41.921 8.974 -13.913 1.00 57.30 H +ATOM 3645 HG2 LYS A 246 43.454 9.000 -13.088 1.00 57.30 H +ATOM 3646 HD3 LYS A 246 43.469 11.377 -12.874 1.00 58.78 H +ATOM 3647 HD2 LYS A 246 41.801 11.554 -13.329 1.00 58.78 H +ATOM 3648 HE3 LYS A 246 44.032 10.555 -15.198 1.00 60.80 H +ATOM 3649 HE2 LYS A 246 43.476 12.215 -15.118 1.00 60.80 H +ATOM 3650 HZ1 LYS A 246 41.307 11.498 -15.780 1.00 61.59 H +ATOM 3651 HZ2 LYS A 246 42.444 11.052 -16.890 1.00 61.59 H +ATOM 3652 HZ3 LYS A 246 41.808 9.928 -15.866 1.00 61.59 H +ATOM 3653 N GLU A 247 42.715 5.832 -10.913 1.00 55.12 N +ATOM 3654 CA GLU A 247 43.784 4.911 -10.550 1.00 56.95 C +ATOM 3655 C GLU A 247 44.915 4.946 -11.578 1.00 58.47 C +ATOM 3656 O GLU A 247 44.640 4.787 -12.762 1.00 58.51 O +ATOM 3657 CB GLU A 247 43.189 3.496 -10.407 1.00 56.93 C +ATOM 3658 CG GLU A 247 44.225 2.401 -10.073 1.00 58.97 C +ATOM 3659 CD GLU A 247 43.569 1.035 -9.857 1.00 60.88 C +ATOM 3660 OE1 GLU A 247 42.999 0.506 -10.837 1.00 62.91 O +ATOM 3661 OE2 GLU A 247 43.629 0.548 -8.706 1.00 61.38 O1- +ATOM 3662 H GLU A 247 41.860 5.400 -11.234 1.00 55.12 H +ATOM 3663 HA GLU A 247 44.178 5.209 -9.579 1.00 56.95 H +ATOM 3664 HB3 GLU A 247 42.663 3.231 -11.326 1.00 56.93 H +ATOM 3665 HB2 GLU A 247 42.429 3.516 -9.626 1.00 56.93 H +ATOM 3666 HG3 GLU A 247 44.795 2.691 -9.188 1.00 58.97 H +ATOM 3667 HG2 GLU A 247 44.950 2.292 -10.880 1.00 58.97 H +ATOM 3668 N THR A 248 46.150 5.112 -11.092 1.00 59.07 N +ATOM 3669 CA THR A 248 47.364 5.048 -11.894 1.00 60.38 C +ATOM 3670 C THR A 248 48.174 3.841 -11.380 1.00 60.78 C +ATOM 3671 O THR A 248 49.039 3.969 -10.512 1.00 60.10 O +ATOM 3672 CB THR A 248 48.164 6.380 -11.808 1.00 61.01 C +ATOM 3673 OG1 THR A 248 48.631 6.673 -10.505 1.00 63.16 O +ATOM 3674 CG2 THR A 248 47.349 7.593 -12.286 1.00 61.02 C +ATOM 3675 H THR A 248 46.288 5.253 -10.101 1.00 59.07 H +ATOM 3676 HA THR A 248 47.135 4.874 -12.946 1.00 60.38 H +ATOM 3677 HB THR A 248 49.041 6.290 -12.451 1.00 61.01 H +ATOM 3678 HG1 THR A 248 49.173 5.935 -10.211 1.00 63.16 H +ATOM 3679 HG21 THR A 248 46.540 7.829 -11.593 1.00 61.02 H +ATOM 3680 HG22 THR A 248 47.976 8.481 -12.372 1.00 61.02 H +ATOM 3681 HG23 THR A 248 46.897 7.411 -13.258 1.00 61.02 H +ATOM 3682 N THR A 249 47.830 2.661 -11.924 1.00 61.35 N +ATOM 3683 CA THR A 249 48.451 1.356 -11.655 1.00 61.85 C +ATOM 3684 C THR A 249 49.974 1.367 -11.930 1.00 61.20 C +ATOM 3685 O THR A 249 50.436 2.222 -12.687 1.00 61.63 O +ATOM 3686 CB THR A 249 47.775 0.282 -12.555 1.00 62.62 C +ATOM 3687 OG1 THR A 249 46.380 0.301 -12.329 1.00 63.50 O +ATOM 3688 CG2 THR A 249 48.237 -1.174 -12.374 1.00 63.08 C +ATOM 3689 H THR A 249 47.096 2.643 -12.619 1.00 61.35 H +ATOM 3690 HA THR A 249 48.287 1.113 -10.603 1.00 61.85 H +ATOM 3691 HB THR A 249 47.925 0.556 -13.600 1.00 62.62 H +ATOM 3692 HG1 THR A 249 45.978 -0.434 -12.800 1.00 63.50 H +ATOM 3693 HG21 THR A 249 49.255 -1.308 -12.728 1.00 63.08 H +ATOM 3694 HG22 THR A 249 48.182 -1.491 -11.333 1.00 63.08 H +ATOM 3695 HG23 THR A 249 47.620 -1.853 -12.965 1.00 63.08 H +ATOM 3696 N ILE A 250 50.739 0.444 -11.314 1.00 60.81 N +ATOM 3697 CA ILE A 250 52.208 0.371 -11.433 1.00 60.26 C +ATOM 3698 C ILE A 250 52.738 0.202 -12.880 1.00 60.18 C +ATOM 3699 O ILE A 250 53.884 0.564 -13.145 1.00 60.31 O +ATOM 3700 CB ILE A 250 52.833 -0.742 -10.532 1.00 60.33 C +ATOM 3701 CG1 ILE A 250 52.798 -2.204 -11.054 1.00 59.91 C +ATOM 3702 CG2 ILE A 250 52.350 -0.643 -9.073 1.00 59.68 C +ATOM 3703 CD1 ILE A 250 51.405 -2.813 -11.267 1.00 59.13 C +ATOM 3704 H ILE A 250 50.309 -0.236 -10.705 1.00 60.81 H +ATOM 3705 HA ILE A 250 52.589 1.331 -11.079 1.00 60.26 H +ATOM 3706 HB ILE A 250 53.896 -0.500 -10.486 1.00 60.33 H +ATOM 3707 HG13 ILE A 250 53.348 -2.837 -10.358 1.00 59.91 H +ATOM 3708 HG12 ILE A 250 53.356 -2.284 -11.988 1.00 59.91 H +ATOM 3709 HG21 ILE A 250 52.903 -1.328 -8.430 1.00 59.68 H +ATOM 3710 HG22 ILE A 250 52.501 0.364 -8.681 1.00 59.68 H +ATOM 3711 HG23 ILE A 250 51.292 -0.878 -8.971 1.00 59.68 H +ATOM 3712 HD11 ILE A 250 51.460 -3.901 -11.245 1.00 59.13 H +ATOM 3713 HD12 ILE A 250 50.690 -2.503 -10.506 1.00 59.13 H +ATOM 3714 HD13 ILE A 250 51.009 -2.537 -12.240 1.00 59.13 H +ATOM 3715 N ASP A 251 51.877 -0.296 -13.783 1.00 60.25 N +ATOM 3716 CA ASP A 251 52.093 -0.443 -15.227 1.00 60.38 C +ATOM 3717 C ASP A 251 51.906 0.869 -16.021 1.00 59.91 C +ATOM 3718 O ASP A 251 52.124 0.866 -17.232 1.00 60.56 O +ATOM 3719 CB ASP A 251 51.210 -1.577 -15.810 1.00 60.98 C +ATOM 3720 CG ASP A 251 51.362 -2.949 -15.123 1.00 62.11 C +ATOM 3721 OD1 ASP A 251 52.484 -3.264 -14.662 1.00 61.91 O +ATOM 3722 OD2 ASP A 251 50.386 -3.726 -15.198 1.00 62.45 O1- +ATOM 3723 H ASP A 251 50.959 -0.569 -13.462 1.00 60.25 H +ATOM 3724 HA ASP A 251 53.135 -0.719 -15.386 1.00 60.38 H +ATOM 3725 HB3 ASP A 251 51.435 -1.722 -16.868 1.00 60.98 H +ATOM 3726 HB2 ASP A 251 50.162 -1.280 -15.744 1.00 60.98 H +ATOM 3727 N GLY A 252 51.533 1.965 -15.340 1.00 59.46 N +ATOM 3728 CA GLY A 252 51.425 3.314 -15.890 1.00 58.92 C +ATOM 3729 C GLY A 252 50.054 3.604 -16.519 1.00 59.26 C +ATOM 3730 O GLY A 252 49.792 4.764 -16.834 1.00 59.89 O +ATOM 3731 H GLY A 252 51.351 1.878 -14.347 1.00 59.46 H +ATOM 3732 HA3 GLY A 252 52.207 3.491 -16.631 1.00 58.92 H +ATOM 3733 HA2 GLY A 252 51.593 4.024 -15.080 1.00 58.92 H +ATOM 3734 N GLU A 253 49.181 2.592 -16.697 1.00 59.20 N +ATOM 3735 CA GLU A 253 47.828 2.766 -17.232 1.00 59.24 C +ATOM 3736 C GLU A 253 46.901 3.473 -16.229 1.00 59.28 C +ATOM 3737 O GLU A 253 46.977 3.209 -15.027 1.00 59.03 O +ATOM 3738 CB GLU A 253 47.239 1.422 -17.710 1.00 58.97 C +ATOM 3739 CG GLU A 253 47.239 0.276 -16.668 1.00 60.46 C +ATOM 3740 CD GLU A 253 46.358 -0.937 -17.017 1.00 61.44 C +ATOM 3741 OE1 GLU A 253 46.334 -1.858 -16.171 1.00 62.15 O +ATOM 3742 OE2 GLU A 253 45.713 -0.943 -18.091 1.00 61.94 O1- +ATOM 3743 H GLU A 253 49.438 1.656 -16.422 1.00 59.20 H +ATOM 3744 HA GLU A 253 47.908 3.405 -18.115 1.00 59.24 H +ATOM 3745 HB3 GLU A 253 47.776 1.095 -18.601 1.00 58.97 H +ATOM 3746 HB2 GLU A 253 46.218 1.616 -18.042 1.00 58.97 H +ATOM 3747 HG3 GLU A 253 46.911 0.649 -15.699 1.00 60.46 H +ATOM 3748 HG2 GLU A 253 48.261 -0.074 -16.521 1.00 60.46 H +ATOM 3749 N GLU A 254 46.051 4.360 -16.766 1.00 59.88 N +ATOM 3750 CA GLU A 254 45.186 5.249 -15.999 1.00 60.07 C +ATOM 3751 C GLU A 254 43.718 4.831 -16.186 1.00 59.53 C +ATOM 3752 O GLU A 254 43.112 5.189 -17.197 1.00 59.70 O +ATOM 3753 CB GLU A 254 45.443 6.709 -16.427 1.00 61.29 C +ATOM 3754 CG GLU A 254 46.924 7.132 -16.311 1.00 62.36 C +ATOM 3755 CD GLU A 254 47.130 8.637 -16.518 1.00 63.74 C +ATOM 3756 OE1 GLU A 254 46.738 9.130 -17.600 1.00 64.15 O +ATOM 3757 OE2 GLU A 254 47.679 9.276 -15.594 1.00 63.61 O1- +ATOM 3758 H GLU A 254 46.043 4.499 -17.766 1.00 59.88 H +ATOM 3759 HA GLU A 254 45.447 5.191 -14.948 1.00 60.07 H +ATOM 3760 HB3 GLU A 254 44.829 7.369 -15.813 1.00 61.29 H +ATOM 3761 HB2 GLU A 254 45.111 6.858 -17.456 1.00 61.29 H +ATOM 3762 HG3 GLU A 254 47.521 6.610 -17.060 1.00 62.36 H +ATOM 3763 HG2 GLU A 254 47.330 6.821 -15.348 1.00 62.36 H +ATOM 3764 N LEU A 255 43.180 4.067 -15.219 1.00 58.86 N +ATOM 3765 CA LEU A 255 41.805 3.560 -15.232 1.00 58.29 C +ATOM 3766 C LEU A 255 40.913 4.453 -14.360 1.00 57.75 C +ATOM 3767 O LEU A 255 41.251 4.697 -13.202 1.00 57.53 O +ATOM 3768 CB LEU A 255 41.739 2.102 -14.708 1.00 58.62 C +ATOM 3769 CG LEU A 255 42.695 1.080 -15.367 1.00 59.01 C +ATOM 3770 CD1 LEU A 255 42.701 1.131 -16.908 1.00 58.57 C +ATOM 3771 CD2 LEU A 255 44.110 1.121 -14.761 1.00 59.86 C +ATOM 3772 H LEU A 255 43.733 3.839 -14.403 1.00 58.86 H +ATOM 3773 HA LEU A 255 41.415 3.576 -16.252 1.00 58.29 H +ATOM 3774 HB3 LEU A 255 40.718 1.748 -14.855 1.00 58.62 H +ATOM 3775 HB2 LEU A 255 41.892 2.077 -13.627 1.00 58.62 H +ATOM 3776 HG LEU A 255 42.291 0.103 -15.096 1.00 59.01 H +ATOM 3777 HD11 LEU A 255 42.773 0.126 -17.324 1.00 58.57 H +ATOM 3778 HD12 LEU A 255 41.789 1.575 -17.307 1.00 58.57 H +ATOM 3779 HD13 LEU A 255 43.542 1.705 -17.299 1.00 58.57 H +ATOM 3780 HD21 LEU A 255 44.449 0.119 -14.496 1.00 59.86 H +ATOM 3781 HD22 LEU A 255 44.831 1.533 -15.462 1.00 59.86 H +ATOM 3782 HD23 LEU A 255 44.162 1.728 -13.856 1.00 59.86 H +ATOM 3783 N VAL A 256 39.772 4.886 -14.918 1.00 57.07 N +ATOM 3784 CA VAL A 256 38.769 5.674 -14.203 1.00 55.73 C +ATOM 3785 C VAL A 256 37.654 4.739 -13.697 1.00 54.78 C +ATOM 3786 O VAL A 256 37.149 3.923 -14.470 1.00 54.63 O +ATOM 3787 CB VAL A 256 38.147 6.774 -15.109 1.00 56.83 C +ATOM 3788 CG1 VAL A 256 37.027 7.586 -14.422 1.00 57.15 C +ATOM 3789 CG2 VAL A 256 39.229 7.743 -15.624 1.00 57.77 C +ATOM 3790 H VAL A 256 39.545 4.628 -15.868 1.00 57.07 H +ATOM 3791 HA VAL A 256 39.237 6.171 -13.355 1.00 55.73 H +ATOM 3792 HB VAL A 256 37.708 6.293 -15.984 1.00 56.83 H +ATOM 3793 HG11 VAL A 256 36.685 8.401 -15.061 1.00 57.15 H +ATOM 3794 HG12 VAL A 256 36.150 6.978 -14.200 1.00 57.15 H +ATOM 3795 HG13 VAL A 256 37.374 8.025 -13.486 1.00 57.15 H +ATOM 3796 HG21 VAL A 256 38.797 8.514 -16.263 1.00 57.77 H +ATOM 3797 HG22 VAL A 256 39.733 8.243 -14.796 1.00 57.77 H +ATOM 3798 HG23 VAL A 256 39.988 7.228 -16.213 1.00 57.77 H +ATOM 3799 N LYS A 257 37.297 4.882 -12.411 1.00 51.70 N +ATOM 3800 CA LYS A 257 36.267 4.096 -11.731 1.00 48.93 C +ATOM 3801 C LYS A 257 35.394 5.013 -10.863 1.00 46.97 C +ATOM 3802 O LYS A 257 35.898 5.988 -10.307 1.00 45.71 O +ATOM 3803 CB LYS A 257 36.932 3.004 -10.863 1.00 50.03 C +ATOM 3804 CG LYS A 257 37.610 1.885 -11.674 1.00 50.79 C +ATOM 3805 CD LYS A 257 38.182 0.733 -10.824 1.00 50.90 C +ATOM 3806 CE LYS A 257 39.599 0.953 -10.258 1.00 50.77 C +ATOM 3807 NZ LYS A 257 39.631 1.866 -9.101 1.00 52.08 N1+ +ATOM 3808 H LYS A 257 37.745 5.597 -11.851 1.00 51.70 H +ATOM 3809 HA LYS A 257 35.617 3.621 -12.468 1.00 48.93 H +ATOM 3810 HB3 LYS A 257 36.171 2.541 -10.233 1.00 50.03 H +ATOM 3811 HB2 LYS A 257 37.646 3.464 -10.184 1.00 50.03 H +ATOM 3812 HG3 LYS A 257 38.403 2.295 -12.300 1.00 50.79 H +ATOM 3813 HG2 LYS A 257 36.874 1.470 -12.364 1.00 50.79 H +ATOM 3814 HD3 LYS A 257 38.185 -0.176 -11.428 1.00 50.90 H +ATOM 3815 HD2 LYS A 257 37.501 0.527 -10.001 1.00 50.90 H +ATOM 3816 HE3 LYS A 257 40.268 1.325 -11.034 1.00 50.77 H +ATOM 3817 HE2 LYS A 257 40.004 -0.002 -9.923 1.00 50.77 H +ATOM 3818 HZ1 LYS A 257 39.030 1.505 -8.371 1.00 52.08 H +ATOM 3819 HZ2 LYS A 257 40.576 1.935 -8.747 1.00 52.08 H +ATOM 3820 HZ3 LYS A 257 39.307 2.780 -9.379 1.00 52.08 H +ATOM 3821 N ILE A 258 34.106 4.658 -10.739 1.00 44.56 N +ATOM 3822 CA ILE A 258 33.141 5.328 -9.869 1.00 42.44 C +ATOM 3823 C ILE A 258 32.493 4.263 -8.973 1.00 40.52 C +ATOM 3824 O ILE A 258 31.740 3.424 -9.467 1.00 38.13 O +ATOM 3825 CB ILE A 258 32.027 6.079 -10.663 1.00 43.22 C +ATOM 3826 CG1 ILE A 258 32.645 7.190 -11.544 1.00 43.77 C +ATOM 3827 CG2 ILE A 258 30.926 6.672 -9.747 1.00 45.13 C +ATOM 3828 CD1 ILE A 258 31.642 7.914 -12.454 1.00 43.79 C +ATOM 3829 H ILE A 258 33.760 3.844 -11.234 1.00 44.56 H +ATOM 3830 HA ILE A 258 33.644 6.058 -9.234 1.00 42.44 H +ATOM 3831 HB ILE A 258 31.547 5.364 -11.335 1.00 43.22 H +ATOM 3832 HG13 ILE A 258 33.426 6.775 -12.181 1.00 43.77 H +ATOM 3833 HG12 ILE A 258 33.145 7.917 -10.906 1.00 43.77 H +ATOM 3834 HG21 ILE A 258 30.165 7.201 -10.320 1.00 45.13 H +ATOM 3835 HG22 ILE A 258 30.392 5.911 -9.178 1.00 45.13 H +ATOM 3836 HG23 ILE A 258 31.351 7.380 -9.034 1.00 45.13 H +ATOM 3837 HD11 ILE A 258 32.147 8.348 -13.316 1.00 43.79 H +ATOM 3838 HD12 ILE A 258 30.876 7.234 -12.828 1.00 43.79 H +ATOM 3839 HD13 ILE A 258 31.143 8.726 -11.925 1.00 43.79 H +ATOM 3840 N GLY A 259 32.801 4.332 -7.672 1.00 37.82 N +ATOM 3841 CA GLY A 259 32.202 3.496 -6.640 1.00 36.40 C +ATOM 3842 C GLY A 259 31.053 4.262 -5.984 1.00 34.07 C +ATOM 3843 O GLY A 259 31.104 5.487 -5.890 1.00 31.38 O +ATOM 3844 H GLY A 259 33.422 5.067 -7.355 1.00 37.82 H +ATOM 3845 HA3 GLY A 259 32.954 3.321 -5.874 1.00 36.40 H +ATOM 3846 HA2 GLY A 259 31.876 2.528 -7.023 1.00 36.40 H +ATOM 3847 N LYS A 260 30.053 3.529 -5.474 1.00 34.92 N +ATOM 3848 CA LYS A 260 28.978 4.071 -4.644 1.00 35.62 C +ATOM 3849 C LYS A 260 28.524 3.011 -3.631 1.00 34.43 C +ATOM 3850 O LYS A 260 28.368 1.848 -3.994 1.00 33.78 O +ATOM 3851 CB LYS A 260 27.843 4.620 -5.535 1.00 38.36 C +ATOM 3852 CG LYS A 260 26.584 5.118 -4.799 1.00 43.96 C +ATOM 3853 CD LYS A 260 25.539 5.668 -5.789 1.00 46.47 C +ATOM 3854 CE LYS A 260 24.143 5.904 -5.188 1.00 47.84 C +ATOM 3855 NZ LYS A 260 24.126 6.991 -4.194 1.00 49.34 N1+ +ATOM 3856 H LYS A 260 30.055 2.524 -5.588 1.00 34.92 H +ATOM 3857 HA LYS A 260 29.389 4.904 -4.081 1.00 35.62 H +ATOM 3858 HB3 LYS A 260 27.538 3.834 -6.221 1.00 38.36 H +ATOM 3859 HB2 LYS A 260 28.235 5.428 -6.153 1.00 38.36 H +ATOM 3860 HG3 LYS A 260 26.861 5.884 -4.074 1.00 43.96 H +ATOM 3861 HG2 LYS A 260 26.135 4.301 -4.233 1.00 43.96 H +ATOM 3862 HD3 LYS A 260 25.439 4.972 -6.623 1.00 46.47 H +ATOM 3863 HD2 LYS A 260 25.914 6.594 -6.227 1.00 46.47 H +ATOM 3864 HE3 LYS A 260 23.769 4.990 -4.727 1.00 47.84 H +ATOM 3865 HE2 LYS A 260 23.443 6.165 -5.982 1.00 47.84 H +ATOM 3866 HZ1 LYS A 260 24.433 7.853 -4.623 1.00 49.34 H +ATOM 3867 HZ2 LYS A 260 23.190 7.109 -3.834 1.00 49.34 H +ATOM 3868 HZ3 LYS A 260 24.746 6.759 -3.432 1.00 49.34 H +ATOM 3869 N LEU A 261 28.303 3.443 -2.382 1.00 33.81 N +ATOM 3870 CA LEU A 261 27.833 2.610 -1.279 1.00 31.60 C +ATOM 3871 C LEU A 261 26.693 3.348 -0.570 1.00 29.63 C +ATOM 3872 O LEU A 261 26.902 4.487 -0.160 1.00 29.87 O +ATOM 3873 CB LEU A 261 29.019 2.310 -0.339 1.00 29.94 C +ATOM 3874 CG LEU A 261 28.707 1.493 0.936 1.00 31.43 C +ATOM 3875 CD1 LEU A 261 28.100 0.114 0.637 1.00 27.52 C +ATOM 3876 CD2 LEU A 261 29.960 1.351 1.820 1.00 29.62 C +ATOM 3877 H LEU A 261 28.470 4.416 -2.158 1.00 33.81 H +ATOM 3878 HA LEU A 261 27.465 1.662 -1.659 1.00 31.60 H +ATOM 3879 HB3 LEU A 261 29.463 3.253 -0.035 1.00 29.94 H +ATOM 3880 HB2 LEU A 261 29.794 1.809 -0.911 1.00 29.94 H +ATOM 3881 HG LEU A 261 27.977 2.052 1.518 1.00 31.43 H +ATOM 3882 HD11 LEU A 261 28.088 -0.516 1.527 1.00 27.52 H +ATOM 3883 HD12 LEU A 261 27.070 0.195 0.288 1.00 27.52 H +ATOM 3884 HD13 LEU A 261 28.681 -0.408 -0.118 1.00 27.52 H +ATOM 3885 HD21 LEU A 261 30.315 0.320 1.865 1.00 29.62 H +ATOM 3886 HD22 LEU A 261 30.791 1.955 1.455 1.00 29.62 H +ATOM 3887 HD23 LEU A 261 29.750 1.662 2.843 1.00 29.62 H +ATOM 3888 N ASN A 262 25.536 2.685 -0.416 1.00 30.06 N +ATOM 3889 CA ASN A 262 24.382 3.200 0.329 1.00 27.76 C +ATOM 3890 C ASN A 262 24.290 2.460 1.665 1.00 25.27 C +ATOM 3891 O ASN A 262 24.167 1.239 1.685 1.00 25.48 O +ATOM 3892 CB ASN A 262 23.073 3.000 -0.463 1.00 28.70 C +ATOM 3893 CG ASN A 262 23.064 3.717 -1.813 1.00 33.27 C +ATOM 3894 OD1 ASN A 262 23.089 4.945 -1.868 1.00 35.47 O +ATOM 3895 ND2 ASN A 262 23.018 2.949 -2.903 1.00 30.78 N +ATOM 3896 H ASN A 262 25.441 1.753 -0.799 1.00 30.06 H +ATOM 3897 HA ASN A 262 24.491 4.266 0.533 1.00 27.76 H +ATOM 3898 HB3 ASN A 262 22.231 3.384 0.114 1.00 28.70 H +ATOM 3899 HB2 ASN A 262 22.878 1.940 -0.607 1.00 28.70 H +ATOM 3900 HD22 ASN A 262 22.995 3.360 -3.824 1.00 30.78 H +ATOM 3901 HD21 ASN A 262 23.005 1.940 -2.812 1.00 30.78 H +ATOM 3902 N LEU A 263 24.334 3.219 2.762 1.00 25.22 N +ATOM 3903 CA LEU A 263 24.276 2.707 4.124 1.00 25.09 C +ATOM 3904 C LEU A 263 22.918 3.140 4.677 1.00 22.26 C +ATOM 3905 O LEU A 263 22.766 4.266 5.153 1.00 22.01 O +ATOM 3906 CB LEU A 263 25.496 3.239 4.911 1.00 27.62 C +ATOM 3907 CG LEU A 263 26.846 2.806 4.287 1.00 30.92 C +ATOM 3908 CD1 LEU A 263 28.031 3.570 4.886 1.00 34.54 C +ATOM 3909 CD2 LEU A 263 27.074 1.283 4.334 1.00 30.34 C +ATOM 3910 H LEU A 263 24.449 4.222 2.678 1.00 25.22 H +ATOM 3911 HA LEU A 263 24.313 1.617 4.137 1.00 25.09 H +ATOM 3912 HB3 LEU A 263 25.446 2.904 5.948 1.00 27.62 H +ATOM 3913 HB2 LEU A 263 25.458 4.327 4.950 1.00 27.62 H +ATOM 3914 HG LEU A 263 26.841 3.099 3.238 1.00 30.92 H +ATOM 3915 HD11 LEU A 263 28.952 3.354 4.345 1.00 34.54 H +ATOM 3916 HD12 LEU A 263 27.874 4.646 4.822 1.00 34.54 H +ATOM 3917 HD13 LEU A 263 28.191 3.299 5.928 1.00 34.54 H +ATOM 3918 HD21 LEU A 263 28.055 1.027 4.732 1.00 30.34 H +ATOM 3919 HD22 LEU A 263 26.334 0.773 4.945 1.00 30.34 H +ATOM 3920 HD23 LEU A 263 27.009 0.849 3.337 1.00 30.34 H +ATOM 3921 N VAL A 264 21.940 2.242 4.499 1.00 21.33 N +ATOM 3922 CA VAL A 264 20.529 2.499 4.732 1.00 21.12 C +ATOM 3923 C VAL A 264 20.145 1.974 6.121 1.00 20.78 C +ATOM 3924 O VAL A 264 20.395 0.811 6.423 1.00 22.61 O +ATOM 3925 CB VAL A 264 19.640 1.807 3.661 1.00 22.88 C +ATOM 3926 CG1 VAL A 264 18.133 2.074 3.863 1.00 19.18 C +ATOM 3927 CG2 VAL A 264 20.061 2.208 2.236 1.00 19.56 C +ATOM 3928 H VAL A 264 22.165 1.325 4.132 1.00 21.33 H +ATOM 3929 HA VAL A 264 20.354 3.570 4.673 1.00 21.12 H +ATOM 3930 HB VAL A 264 19.789 0.730 3.725 1.00 22.88 H +ATOM 3931 HG11 VAL A 264 17.544 1.672 3.041 1.00 19.18 H +ATOM 3932 HG12 VAL A 264 17.761 1.613 4.777 1.00 19.18 H +ATOM 3933 HG13 VAL A 264 17.925 3.143 3.922 1.00 19.18 H +ATOM 3934 HG21 VAL A 264 19.474 1.677 1.491 1.00 19.56 H +ATOM 3935 HG22 VAL A 264 19.939 3.276 2.069 1.00 19.56 H +ATOM 3936 HG23 VAL A 264 21.104 1.960 2.036 1.00 19.56 H +ATOM 3937 N ASP A 265 19.531 2.845 6.926 1.00 21.91 N +ATOM 3938 CA ASP A 265 19.002 2.547 8.249 1.00 22.53 C +ATOM 3939 C ASP A 265 17.505 2.839 8.163 1.00 21.18 C +ATOM 3940 O ASP A 265 17.105 3.999 8.094 1.00 19.87 O +ATOM 3941 CB ASP A 265 19.778 3.337 9.328 1.00 23.03 C +ATOM 3942 CG ASP A 265 19.279 3.361 10.784 1.00 26.46 C +ATOM 3943 OD1 ASP A 265 18.330 2.628 11.137 1.00 25.06 O +ATOM 3944 OD2 ASP A 265 19.921 4.108 11.553 1.00 29.68 O1- +ATOM 3945 H ASP A 265 19.354 3.784 6.589 1.00 21.91 H +ATOM 3946 HA ASP A 265 19.118 1.487 8.475 1.00 22.53 H +ATOM 3947 HB3 ASP A 265 19.882 4.365 8.991 1.00 23.03 H +ATOM 3948 HB2 ASP A 265 20.793 2.940 9.350 1.00 23.03 H +ATOM 3949 N LEU A 266 16.721 1.757 8.122 1.00 19.19 N +ATOM 3950 CA LEU A 266 15.273 1.789 7.967 1.00 20.84 C +ATOM 3951 C LEU A 266 14.579 2.204 9.268 1.00 20.61 C +ATOM 3952 O LEU A 266 15.143 2.039 10.350 1.00 20.90 O +ATOM 3953 CB LEU A 266 14.803 0.386 7.531 1.00 17.59 C +ATOM 3954 CG LEU A 266 15.381 -0.068 6.173 1.00 21.63 C +ATOM 3955 CD1 LEU A 266 15.095 -1.554 5.947 1.00 18.98 C +ATOM 3956 CD2 LEU A 266 14.833 0.777 5.013 1.00 19.35 C +ATOM 3957 H LEU A 266 17.135 0.839 8.215 1.00 19.19 H +ATOM 3958 HA LEU A 266 15.020 2.519 7.196 1.00 20.84 H +ATOM 3959 HB3 LEU A 266 13.713 0.353 7.484 1.00 17.59 H +ATOM 3960 HB2 LEU A 266 15.084 -0.335 8.301 1.00 17.59 H +ATOM 3961 HG LEU A 266 16.466 0.035 6.182 1.00 21.63 H +ATOM 3962 HD11 LEU A 266 15.381 -1.883 4.949 1.00 18.98 H +ATOM 3963 HD12 LEU A 266 15.647 -2.165 6.661 1.00 18.98 H +ATOM 3964 HD13 LEU A 266 14.032 -1.752 6.071 1.00 18.98 H +ATOM 3965 HD21 LEU A 266 14.946 0.276 4.052 1.00 19.35 H +ATOM 3966 HD22 LEU A 266 13.773 0.980 5.155 1.00 19.35 H +ATOM 3967 HD23 LEU A 266 15.349 1.734 4.940 1.00 19.35 H +ATOM 3968 N ALA A 267 13.331 2.675 9.129 1.00 21.47 N +ATOM 3969 CA ALA A 267 12.390 2.869 10.230 1.00 19.08 C +ATOM 3970 C ALA A 267 12.118 1.549 10.960 1.00 19.61 C +ATOM 3971 O ALA A 267 12.099 0.499 10.316 1.00 18.68 O +ATOM 3972 CB ALA A 267 11.079 3.422 9.666 1.00 18.56 C +ATOM 3973 H ALA A 267 12.955 2.799 8.198 1.00 21.47 H +ATOM 3974 HA ALA A 267 12.812 3.596 10.924 1.00 19.08 H +ATOM 3975 HB1 ALA A 267 10.395 3.692 10.470 1.00 18.56 H +ATOM 3976 HB2 ALA A 267 11.258 4.314 9.066 1.00 18.56 H +ATOM 3977 HB3 ALA A 267 10.573 2.692 9.033 1.00 18.56 H +ATOM 3978 N GLY A 268 11.906 1.640 12.281 1.00 20.90 N +ATOM 3979 CA GLY A 268 11.627 0.527 13.183 1.00 21.41 C +ATOM 3980 C GLY A 268 10.481 -0.354 12.668 1.00 22.97 C +ATOM 3981 O GLY A 268 9.420 0.151 12.303 1.00 21.66 O +ATOM 3982 H GLY A 268 11.923 2.560 12.704 1.00 20.90 H +ATOM 3983 HA3 GLY A 268 11.344 0.954 14.142 1.00 21.41 H +ATOM 3984 HA2 GLY A 268 12.535 -0.057 13.338 1.00 21.41 H +ATOM 3985 N SER A 269 10.715 -1.674 12.655 1.00 23.42 N +ATOM 3986 CA SER A 269 9.807 -2.677 12.104 1.00 24.42 C +ATOM 3987 C SER A 269 8.610 -3.066 12.996 1.00 27.82 C +ATOM 3988 O SER A 269 7.819 -3.892 12.540 1.00 27.45 O +ATOM 3989 CB SER A 269 10.635 -3.908 11.686 1.00 22.75 C +ATOM 3990 OG SER A 269 11.128 -4.632 12.793 1.00 25.27 O +ATOM 3991 H SER A 269 11.603 -2.028 12.986 1.00 23.42 H +ATOM 3992 HA SER A 269 9.382 -2.263 11.189 1.00 24.42 H +ATOM 3993 HB3 SER A 269 11.466 -3.623 11.043 1.00 22.75 H +ATOM 3994 HB2 SER A 269 10.007 -4.583 11.110 1.00 22.75 H +ATOM 3995 HG SER A 269 11.645 -5.375 12.469 1.00 25.27 H +ATOM 3996 N GLU A 270 8.484 -2.509 14.219 1.00 30.78 N +ATOM 3997 CA GLU A 270 7.446 -2.890 15.187 1.00 34.86 C +ATOM 3998 C GLU A 270 6.014 -2.668 14.677 1.00 37.87 C +ATOM 3999 O GLU A 270 5.767 -1.746 13.900 1.00 37.82 O +ATOM 4000 CB GLU A 270 7.677 -2.271 16.597 1.00 34.89 C +ATOM 4001 CG GLU A 270 7.064 -0.883 16.938 1.00 37.74 C +ATOM 4002 CD GLU A 270 7.750 0.331 16.298 1.00 43.02 C +ATOM 4003 OE1 GLU A 270 8.632 0.912 16.971 1.00 35.23 O +ATOM 4004 OE2 GLU A 270 7.397 0.674 15.149 1.00 47.66 O1- +ATOM 4005 H GLU A 270 9.168 -1.834 14.538 1.00 30.78 H +ATOM 4006 HA GLU A 270 7.586 -3.959 15.296 1.00 34.86 H +ATOM 4007 HB3 GLU A 270 8.734 -2.288 16.849 1.00 34.89 H +ATOM 4008 HB2 GLU A 270 7.248 -2.972 17.314 1.00 34.89 H +ATOM 4009 HG3 GLU A 270 7.103 -0.757 18.022 1.00 37.74 H +ATOM 4010 HG2 GLU A 270 6.000 -0.854 16.705 1.00 37.74 H +ATOM 4011 N ASN A 271 5.093 -3.516 15.160 1.00 41.83 N +ATOM 4012 CA ASN A 271 3.653 -3.420 14.910 1.00 44.48 C +ATOM 4013 C ASN A 271 3.085 -2.097 15.443 1.00 45.67 C +ATOM 4014 O ASN A 271 3.433 -1.684 16.551 1.00 46.37 O +ATOM 4015 CB ASN A 271 2.931 -4.602 15.597 1.00 47.15 C +ATOM 4016 CG ASN A 271 3.222 -5.969 14.971 1.00 50.68 C +ATOM 4017 OD1 ASN A 271 3.251 -6.109 13.750 1.00 51.46 O +ATOM 4018 ND2 ASN A 271 3.409 -6.993 15.806 1.00 52.35 N +ATOM 4019 H ASN A 271 5.382 -4.244 15.803 1.00 41.83 H +ATOM 4020 HA ASN A 271 3.521 -3.479 13.828 1.00 44.48 H +ATOM 4021 HB3 ASN A 271 1.851 -4.459 15.531 1.00 47.15 H +ATOM 4022 HB2 ASN A 271 3.170 -4.622 16.663 1.00 47.15 H +ATOM 4023 HD22 ASN A 271 3.582 -7.920 15.447 1.00 52.35 H +ATOM 4024 HD21 ASN A 271 3.401 -6.849 16.806 1.00 52.35 H +ATOM 4025 N ILE A 272 2.195 -1.486 14.649 1.00 13.83 N +ATOM 4026 CA ILE A 272 1.460 -0.288 15.034 1.00 15.42 C +ATOM 4027 C ILE A 272 0.055 -0.677 15.526 1.00 16.71 C +ATOM 4028 O ILE A 272 -0.660 -1.417 14.847 1.00 17.84 O +ATOM 4029 CB ILE A 272 1.359 0.732 13.855 1.00 0.00 C +ATOM 4030 CG1 ILE A 272 0.739 2.089 14.265 1.00 0.00 C +ATOM 4031 CG2 ILE A 272 0.636 0.199 12.597 1.00 0.00 C +ATOM 4032 CD1 ILE A 272 1.489 2.818 15.390 1.00 0.00 C +ATOM 4033 HB ILE A 272 2.385 0.939 13.546 1.00 0.00 H +ATOM 4034 HG12 ILE A 272 0.710 2.745 13.399 1.00 0.00 H +ATOM 4035 HG13 ILE A 272 -0.305 1.958 14.546 1.00 0.00 H +ATOM 4036 HG21 ILE A 272 0.745 0.894 11.765 1.00 0.00 H +ATOM 4037 HG22 ILE A 272 1.045 -0.756 12.271 1.00 0.00 H +ATOM 4038 HG23 ILE A 272 -0.434 0.071 12.759 1.00 0.00 H +ATOM 4039 HD11 ILE A 272 1.318 3.893 15.335 1.00 0.00 H +ATOM 4040 HD12 ILE A 272 1.152 2.483 16.371 1.00 0.00 H +ATOM 4041 HD13 ILE A 272 2.565 2.652 15.328 1.00 0.00 H +ATOM 4042 H ILE A 272 1.951 -1.893 13.758 1.00 13.83 H +ATOM 4043 HA ILE A 272 1.988 0.206 15.852 1.00 15.42 H +ATOM 4044 N GLY A 273 -0.321 -0.123 16.688 1.00 17.08 N +ATOM 4045 CA GLY A 273 -1.707 -0.053 17.131 1.00 15.97 C +ATOM 4046 C GLY A 273 -2.224 1.274 16.576 1.00 17.17 C +ATOM 4047 O GLY A 273 -1.744 2.333 16.984 1.00 15.94 O +ATOM 4048 HA3 GLY A 273 -1.743 -0.038 18.221 1.00 15.97 H +ATOM 4049 H GLY A 273 0.342 0.445 17.196 1.00 17.08 H +ATOM 4050 HA2 GLY A 273 -2.303 -0.901 16.788 1.00 15.97 H +ATOM 4051 N ARG A 274 -3.170 1.206 15.626 1.00 14.58 N +ATOM 4052 CA ARG A 274 -3.710 2.361 14.904 1.00 15.78 C +ATOM 4053 C ARG A 274 -4.465 3.351 15.808 1.00 16.40 C +ATOM 4054 O ARG A 274 -4.947 2.978 16.879 1.00 14.34 O +ATOM 4055 CB ARG A 274 -4.683 1.882 13.807 1.00 0.00 C +ATOM 4056 CG ARG A 274 -4.110 0.939 12.736 1.00 0.00 C +ATOM 4057 CD ARG A 274 -5.173 0.730 11.646 1.00 0.00 C +ATOM 4058 NE ARG A 274 -4.850 -0.312 10.660 1.00 0.00 N +ATOM 4059 CZ ARG A 274 -5.648 -0.682 9.636 1.00 0.00 C +ATOM 4060 NH1 ARG A 274 -6.825 -0.080 9.392 1.00 0.00 N +ATOM 4061 NH2 ARG A 274 -5.258 -1.682 8.836 1.00 0.00 N1+ +ATOM 4062 HB2 ARG A 274 -5.538 1.392 14.279 1.00 0.00 H +ATOM 4063 HB3 ARG A 274 -5.095 2.753 13.294 1.00 0.00 H +ATOM 4064 HG2 ARG A 274 -3.252 1.449 12.296 1.00 0.00 H +ATOM 4065 HG3 ARG A 274 -3.741 -0.004 13.141 1.00 0.00 H +ATOM 4066 HD2 ARG A 274 -6.158 0.577 12.082 1.00 0.00 H +ATOM 4067 HD3 ARG A 274 -5.223 1.648 11.059 1.00 0.00 H +ATOM 4068 HE ARG A 274 -3.971 -0.791 10.791 1.00 0.00 H +ATOM 4069 HH12 ARG A 274 -7.416 -0.376 8.629 1.00 0.00 H +ATOM 4070 HH11 ARG A 274 -7.136 0.672 9.995 1.00 0.00 H +ATOM 4071 HH22 ARG A 274 -5.843 -1.982 8.070 1.00 0.00 H +ATOM 4072 HH21 ARG A 274 -4.378 -2.151 8.997 1.00 0.00 H +ATOM 4073 H ARG A 274 -3.523 0.303 15.343 1.00 14.58 H +ATOM 4074 HA ARG A 274 -2.875 2.886 14.435 1.00 15.78 H +ATOM 4075 N SER A 275 -4.634 4.577 15.287 1.00 14.55 N +ATOM 4076 CA SER A 275 -5.642 5.542 15.722 1.00 16.42 C +ATOM 4077 C SER A 275 -7.041 5.056 15.281 1.00 17.16 C +ATOM 4078 O SER A 275 -7.532 5.453 14.228 1.00 16.93 O +ATOM 4079 CB SER A 275 -5.237 6.937 15.190 1.00 0.00 C +ATOM 4080 OG SER A 275 -5.114 6.983 13.779 1.00 0.00 O +ATOM 4081 HB2 SER A 275 -5.971 7.682 15.497 1.00 0.00 H +ATOM 4082 HB3 SER A 275 -4.285 7.241 15.628 1.00 0.00 H +ATOM 4083 HG SER A 275 -4.912 7.884 13.516 1.00 0.00 H +ATOM 4084 H SER A 275 -4.195 4.801 14.406 1.00 14.55 H +ATOM 4085 HA SER A 275 -5.633 5.592 16.813 1.00 16.42 H +ATOM 4086 N GLY A 276 -7.623 4.142 16.081 1.00 15.23 N +ATOM 4087 CA GLY A 276 -8.789 3.319 15.736 1.00 16.84 C +ATOM 4088 C GLY A 276 -10.083 4.105 15.468 1.00 16.88 C +ATOM 4089 O GLY A 276 -10.978 3.576 14.811 1.00 16.65 O +ATOM 4090 HA3 GLY A 276 -8.971 2.619 16.551 1.00 16.84 H +ATOM 4091 H GLY A 276 -7.128 3.868 16.918 1.00 15.23 H +ATOM 4092 HA2 GLY A 276 -8.544 2.721 14.859 1.00 16.84 H +ATOM 4093 N ALA A 277 -10.172 5.363 15.934 0.50 17.32 N +ATOM 4094 CA ALA A 277 -11.259 6.295 15.628 0.50 21.27 C +ATOM 4095 C ALA A 277 -11.269 6.770 14.161 0.50 23.22 C +ATOM 4096 O ALA A 277 -12.330 7.156 13.670 0.50 25.56 O +ATOM 4097 CB ALA A 277 -11.154 7.497 16.578 1.00 0.00 C +ATOM 4098 HB1 ALA A 277 -10.208 8.027 16.450 1.00 0.00 H +ATOM 4099 HB2 ALA A 277 -11.960 8.211 16.405 1.00 0.00 H +ATOM 4100 HB3 ALA A 277 -11.219 7.180 17.619 1.00 0.00 H +ATOM 4101 H ALA A 277 -9.405 5.739 16.473 1.00 17.32 H +ATOM 4102 HA ALA A 277 -12.207 5.789 15.820 1.00 21.27 H +ATOM 4103 N VAL A 278 -10.101 6.733 13.496 1.00 20.27 N +ATOM 4104 CA VAL A 278 -9.903 7.185 12.120 1.00 20.59 C +ATOM 4105 C VAL A 278 -10.267 6.104 11.081 1.00 19.48 C +ATOM 4106 O VAL A 278 -10.578 6.480 9.959 1.00 18.81 O +ATOM 4107 CB VAL A 278 -8.430 7.644 11.878 1.00 0.00 C +ATOM 4108 CG1 VAL A 278 -8.113 8.110 10.438 1.00 0.00 C +ATOM 4109 CG2 VAL A 278 -8.026 8.757 12.863 1.00 0.00 C +ATOM 4110 HB VAL A 278 -7.772 6.797 12.070 1.00 0.00 H +ATOM 4111 HG11 VAL A 278 -7.115 8.546 10.376 1.00 0.00 H +ATOM 4112 HG12 VAL A 278 -8.127 7.286 9.725 1.00 0.00 H +ATOM 4113 HG13 VAL A 278 -8.823 8.865 10.099 1.00 0.00 H +ATOM 4114 HG21 VAL A 278 -7.001 9.086 12.691 1.00 0.00 H +ATOM 4115 HG22 VAL A 278 -8.675 9.628 12.764 1.00 0.00 H +ATOM 4116 HG23 VAL A 278 -8.078 8.418 13.898 1.00 0.00 H +ATOM 4117 H VAL A 278 -9.275 6.379 13.962 1.00 20.27 H +ATOM 4118 HA VAL A 278 -10.555 8.042 11.939 1.00 20.59 H +ATOM 4119 N ASP A 279 -10.264 4.806 11.440 1.00 16.88 N +ATOM 4120 CA ASP A 279 -10.481 3.666 10.523 1.00 15.78 C +ATOM 4121 C ASP A 279 -11.818 3.643 9.743 1.00 14.21 C +ATOM 4122 O ASP A 279 -11.919 2.900 8.766 1.00 16.58 O +ATOM 4123 CB ASP A 279 -10.245 2.299 11.216 1.00 0.00 C +ATOM 4124 CG ASP A 279 -8.841 2.072 11.805 1.00 0.00 C +ATOM 4125 OD1 ASP A 279 -7.871 2.700 11.324 1.00 0.00 O +ATOM 4126 OD2 ASP A 279 -8.731 1.143 12.633 1.00 0.00 O1- +ATOM 4127 HB2 ASP A 279 -10.970 2.182 12.023 1.00 0.00 H +ATOM 4128 HB3 ASP A 279 -10.425 1.486 10.511 1.00 0.00 H +ATOM 4129 H ASP A 279 -10.019 4.563 12.390 1.00 16.88 H +ATOM 4130 HA ASP A 279 -9.725 3.773 9.743 1.00 15.78 H +ATOM 4131 N LYS A 280 -12.794 4.471 10.148 1.00 16.18 N +ATOM 4132 CA LYS A 280 -14.050 4.729 9.437 1.00 16.76 C +ATOM 4133 C LYS A 280 -13.888 5.639 8.192 1.00 17.04 C +ATOM 4134 O LYS A 280 -14.762 5.619 7.326 1.00 18.73 O +ATOM 4135 CB LYS A 280 -15.038 5.302 10.477 1.00 0.00 C +ATOM 4136 CG LYS A 280 -16.442 5.659 9.960 1.00 0.00 C +ATOM 4137 CD LYS A 280 -17.382 6.064 11.102 1.00 0.00 C +ATOM 4138 CE LYS A 280 -18.753 6.540 10.598 1.00 0.00 C +ATOM 4139 NZ LYS A 280 -19.634 6.933 11.711 1.00 0.00 N1+ +ATOM 4140 HB2 LYS A 280 -15.144 4.572 11.282 1.00 0.00 H +ATOM 4141 HB3 LYS A 280 -14.601 6.190 10.937 1.00 0.00 H +ATOM 4142 HG2 LYS A 280 -16.378 6.486 9.251 1.00 0.00 H +ATOM 4143 HG3 LYS A 280 -16.862 4.813 9.415 1.00 0.00 H +ATOM 4144 HD2 LYS A 280 -17.511 5.214 11.775 1.00 0.00 H +ATOM 4145 HD3 LYS A 280 -16.910 6.852 11.692 1.00 0.00 H +ATOM 4146 HE2 LYS A 280 -18.633 7.395 9.930 1.00 0.00 H +ATOM 4147 HE3 LYS A 280 -19.240 5.750 10.025 1.00 0.00 H +ATOM 4148 HZ1 LYS A 280 -19.206 7.684 12.233 1.00 0.00 H +ATOM 4149 HZ2 LYS A 280 -20.523 7.243 11.345 1.00 0.00 H +ATOM 4150 HZ3 LYS A 280 -19.781 6.141 12.321 1.00 0.00 H +ATOM 4151 H LYS A 280 -12.628 5.043 10.963 1.00 16.18 H +ATOM 4152 HA LYS A 280 -14.444 3.773 9.089 1.00 16.76 H +ATOM 4153 N ARG A 281 -12.786 6.411 8.122 1.00 17.25 N +ATOM 4154 CA ARG A 281 -12.413 7.331 7.043 1.00 16.47 C +ATOM 4155 C ARG A 281 -12.039 6.565 5.763 1.00 18.22 C +ATOM 4156 O ARG A 281 -10.873 6.214 5.576 1.00 17.69 O +ATOM 4157 CB ARG A 281 -11.258 8.226 7.560 1.00 0.00 C +ATOM 4158 CG ARG A 281 -10.642 9.271 6.615 1.00 0.00 C +ATOM 4159 CD ARG A 281 -11.616 10.269 5.976 1.00 0.00 C +ATOM 4160 NE ARG A 281 -10.845 11.345 5.330 1.00 0.00 N +ATOM 4161 CZ ARG A 281 -11.113 12.659 5.250 1.00 0.00 C +ATOM 4162 NH1 ARG A 281 -12.265 13.188 5.688 1.00 0.00 N +ATOM 4163 NH2 ARG A 281 -10.180 13.461 4.721 1.00 0.00 N1+ +ATOM 4164 HB2 ARG A 281 -11.576 8.729 8.474 1.00 0.00 H +ATOM 4165 HB3 ARG A 281 -10.425 7.585 7.842 1.00 0.00 H +ATOM 4166 HG2 ARG A 281 -9.812 9.780 7.108 1.00 0.00 H +ATOM 4167 HG3 ARG A 281 -10.181 8.713 5.801 1.00 0.00 H +ATOM 4168 HD2 ARG A 281 -12.137 9.774 5.156 1.00 0.00 H +ATOM 4169 HD3 ARG A 281 -12.375 10.609 6.680 1.00 0.00 H +ATOM 4170 HE ARG A 281 -9.934 11.057 4.992 1.00 0.00 H +ATOM 4171 HH12 ARG A 281 -12.434 14.181 5.625 1.00 0.00 H +ATOM 4172 HH11 ARG A 281 -12.968 12.589 6.094 1.00 0.00 H +ATOM 4173 HH22 ARG A 281 -10.333 14.455 4.645 1.00 0.00 H +ATOM 4174 HH21 ARG A 281 -9.286 13.073 4.448 1.00 0.00 H +ATOM 4175 H ARG A 281 -12.107 6.343 8.871 1.00 17.25 H +ATOM 4176 HA ARG A 281 -13.272 7.970 6.829 1.00 16.47 H +ATOM 4177 N ALA A 282 -13.044 6.336 4.902 1.00 19.52 N +ATOM 4178 CA ALA A 282 -12.904 5.703 3.592 1.00 19.44 C +ATOM 4179 C ALA A 282 -12.391 6.711 2.545 1.00 21.06 C +ATOM 4180 O ALA A 282 -13.111 7.061 1.610 1.00 20.72 O +ATOM 4181 CB ALA A 282 -14.249 5.064 3.207 1.00 0.00 C +ATOM 4182 HB1 ALA A 282 -14.186 4.560 2.241 1.00 0.00 H +ATOM 4183 HB2 ALA A 282 -14.552 4.318 3.943 1.00 0.00 H +ATOM 4184 HB3 ALA A 282 -15.045 5.807 3.144 1.00 0.00 H +ATOM 4185 H ALA A 282 -13.979 6.626 5.152 1.00 19.52 H +ATOM 4186 HA ALA A 282 -12.169 4.899 3.663 1.00 19.44 H +ATOM 4187 N ARG A 283 -11.140 7.151 2.742 1.00 20.98 N +ATOM 4188 CA ARG A 283 -10.361 7.987 1.834 1.00 20.56 C +ATOM 4189 C ARG A 283 -8.867 7.890 2.193 1.00 19.71 C +ATOM 4190 O ARG A 283 -8.040 7.843 1.282 1.00 21.33 O +ATOM 4191 CB ARG A 283 -10.856 9.453 1.813 1.00 0.00 C +ATOM 4192 CG ARG A 283 -10.199 10.274 0.683 1.00 0.00 C +ATOM 4193 CD ARG A 283 -9.815 11.709 1.078 1.00 0.00 C +ATOM 4194 NE ARG A 283 -8.888 12.297 0.094 1.00 0.00 N +ATOM 4195 CZ ARG A 283 -7.556 12.092 0.021 1.00 0.00 C +ATOM 4196 NH1 ARG A 283 -6.885 11.364 0.927 1.00 0.00 N +ATOM 4197 NH2 ARG A 283 -6.874 12.631 -0.997 1.00 0.00 N1+ +ATOM 4198 HB2 ARG A 283 -11.939 9.492 1.689 1.00 0.00 H +ATOM 4199 HB3 ARG A 283 -10.655 9.907 2.783 1.00 0.00 H +ATOM 4200 HG2 ARG A 283 -9.369 9.760 0.198 1.00 0.00 H +ATOM 4201 HG3 ARG A 283 -10.960 10.342 -0.096 1.00 0.00 H +ATOM 4202 HD2 ARG A 283 -10.709 12.329 0.998 1.00 0.00 H +ATOM 4203 HD3 ARG A 283 -9.478 11.805 2.108 1.00 0.00 H +ATOM 4204 HE ARG A 283 -9.324 12.843 -0.635 1.00 0.00 H +ATOM 4205 HH12 ARG A 283 -5.892 11.211 0.838 1.00 0.00 H +ATOM 4206 HH11 ARG A 283 -7.368 10.987 1.736 1.00 0.00 H +ATOM 4207 HH22 ARG A 283 -5.877 12.491 -1.074 1.00 0.00 H +ATOM 4208 HH21 ARG A 283 -7.348 13.184 -1.696 1.00 0.00 H +ATOM 4209 H ARG A 283 -10.636 6.795 3.544 1.00 20.98 H +ATOM 4210 HA ARG A 283 -10.484 7.566 0.833 1.00 20.56 H +ATOM 4211 N GLU A 284 -8.548 7.823 3.499 1.00 21.43 N +ATOM 4212 CA GLU A 284 -7.213 7.479 3.995 1.00 20.61 C +ATOM 4213 C GLU A 284 -7.036 5.952 4.037 1.00 20.80 C +ATOM 4214 O GLU A 284 -8.017 5.212 4.134 1.00 19.82 O +ATOM 4215 CB GLU A 284 -6.952 8.120 5.382 1.00 0.00 C +ATOM 4216 CG GLU A 284 -6.329 9.535 5.334 1.00 0.00 C +ATOM 4217 CD GLU A 284 -7.333 10.675 5.127 1.00 0.00 C +ATOM 4218 OE1 GLU A 284 -7.797 10.851 3.979 1.00 0.00 O +ATOM 4219 OE2 GLU A 284 -7.623 11.375 6.120 1.00 0.00 O1- +ATOM 4220 HB2 GLU A 284 -7.878 8.149 5.958 1.00 0.00 H +ATOM 4221 HB3 GLU A 284 -6.286 7.484 5.967 1.00 0.00 H +ATOM 4222 HG2 GLU A 284 -5.798 9.707 6.272 1.00 0.00 H +ATOM 4223 HG3 GLU A 284 -5.561 9.586 4.560 1.00 0.00 H +ATOM 4224 H GLU A 284 -9.273 7.884 4.198 1.00 21.43 H +ATOM 4225 HA GLU A 284 -6.466 7.864 3.299 1.00 20.61 H +ATOM 4226 N ALA A 285 -5.769 5.522 3.946 1.00 20.97 N +ATOM 4227 CA ALA A 285 -5.365 4.119 3.890 1.00 20.77 C +ATOM 4228 C ALA A 285 -5.089 3.530 5.282 1.00 20.48 C +ATOM 4229 O ALA A 285 -4.831 4.271 6.233 1.00 20.59 O +ATOM 4230 CB ALA A 285 -4.108 4.031 3.009 1.00 0.00 C +ATOM 4231 HB1 ALA A 285 -4.330 4.338 1.986 1.00 0.00 H +ATOM 4232 HB2 ALA A 285 -3.312 4.677 3.378 1.00 0.00 H +ATOM 4233 HB3 ALA A 285 -3.717 3.014 2.964 1.00 0.00 H +ATOM 4234 H ALA A 285 -5.020 6.196 3.896 1.00 20.97 H +ATOM 4235 HA ALA A 285 -6.155 3.530 3.419 1.00 20.77 H +ATOM 4236 N GLY A 286 -5.105 2.187 5.350 1.00 19.09 N +ATOM 4237 CA GLY A 286 -4.703 1.409 6.521 1.00 17.64 C +ATOM 4238 C GLY A 286 -3.176 1.280 6.506 1.00 16.69 C +ATOM 4239 O GLY A 286 -2.641 0.267 6.055 1.00 15.61 O +ATOM 4240 HA3 GLY A 286 -5.159 0.420 6.467 1.00 17.64 H +ATOM 4241 H GLY A 286 -5.331 1.662 4.519 1.00 19.09 H +ATOM 4242 HA2 GLY A 286 -5.044 1.874 7.447 1.00 17.64 H +ATOM 4243 N ASN A 287 -2.496 2.330 6.985 1.00 18.01 N +ATOM 4244 CA ASN A 287 -1.044 2.496 6.983 1.00 16.78 C +ATOM 4245 C ASN A 287 -0.629 3.506 8.069 1.00 17.94 C +ATOM 4246 O ASN A 287 -1.492 4.106 8.711 1.00 15.20 O +ATOM 4247 CB ASN A 287 -0.543 2.912 5.561 1.00 0.00 C +ATOM 4248 CG ASN A 287 -0.861 4.337 5.074 1.00 0.00 C +ATOM 4249 OD1 ASN A 287 -1.742 5.020 5.591 1.00 0.00 O +ATOM 4250 ND2 ASN A 287 -0.134 4.792 4.051 1.00 0.00 N +ATOM 4251 HB2 ASN A 287 0.542 2.850 5.546 1.00 0.00 H +ATOM 4252 HB3 ASN A 287 -0.894 2.201 4.813 1.00 0.00 H +ATOM 4253 HD22 ASN A 287 -0.300 5.721 3.691 1.00 0.00 H +ATOM 4254 HD21 ASN A 287 0.570 4.212 3.614 1.00 0.00 H +ATOM 4255 H ASN A 287 -3.011 3.130 7.329 1.00 18.01 H +ATOM 4256 HA ASN A 287 -0.566 1.556 7.265 1.00 16.78 H +ATOM 4257 N ILE A 288 0.688 3.744 8.165 1.00 39.42 N +ATOM 4258 CA ILE A 288 1.245 5.043 8.559 1.00 36.53 C +ATOM 4259 C ILE A 288 2.668 5.256 8.016 1.00 31.50 C +ATOM 4260 O ILE A 288 3.021 6.407 7.762 1.00 34.96 O +ATOM 4261 CB ILE A 288 1.211 5.423 10.079 1.00 39.81 C +ATOM 4262 CG1 ILE A 288 1.167 4.244 11.074 1.00 41.18 C +ATOM 4263 CG2 ILE A 288 0.086 6.432 10.379 1.00 39.92 C +ATOM 4264 CD1 ILE A 288 2.422 3.361 11.081 1.00 43.90 C +ATOM 4265 HA ILE A 288 0.646 5.780 8.018 1.00 36.53 H +ATOM 4266 HB ILE A 288 2.123 5.971 10.324 1.00 39.81 H +ATOM 4267 HG13 ILE A 288 0.281 3.633 10.901 1.00 41.18 H +ATOM 4268 HG12 ILE A 288 1.044 4.649 12.079 1.00 41.18 H +ATOM 4269 HG21 ILE A 288 0.153 6.797 11.404 1.00 39.92 H +ATOM 4270 HG22 ILE A 288 0.150 7.302 9.725 1.00 39.92 H +ATOM 4271 HG23 ILE A 288 -0.903 5.995 10.257 1.00 39.92 H +ATOM 4272 HD11 ILE A 288 2.221 2.410 10.593 1.00 43.90 H +ATOM 4273 HD12 ILE A 288 3.265 3.831 10.576 1.00 43.90 H +ATOM 4274 HD13 ILE A 288 2.741 3.143 12.100 1.00 43.90 H +ATOM 4275 H ILE A 288 1.322 3.154 7.647 1.00 39.42 H +ATOM 4276 N ASN A 289 3.438 4.173 7.812 1.00 28.46 N +ATOM 4277 CA ASN A 289 4.759 4.223 7.193 1.00 23.85 C +ATOM 4278 C ASN A 289 4.670 3.513 5.837 1.00 21.26 C +ATOM 4279 O ASN A 289 4.866 2.300 5.758 1.00 18.44 O +ATOM 4280 CB ASN A 289 5.815 3.594 8.132 1.00 23.77 C +ATOM 4281 CG ASN A 289 7.244 4.043 7.803 1.00 25.10 C +ATOM 4282 OD1 ASN A 289 7.622 4.158 6.638 1.00 25.42 O +ATOM 4283 ND2 ASN A 289 8.049 4.290 8.836 1.00 14.33 N +ATOM 4284 H ASN A 289 3.106 3.252 8.066 1.00 28.46 H +ATOM 4285 HA ASN A 289 5.078 5.242 6.963 1.00 23.85 H +ATOM 4286 HB3 ASN A 289 5.754 2.506 8.161 1.00 23.77 H +ATOM 4287 HB2 ASN A 289 5.605 3.925 9.151 1.00 23.77 H +ATOM 4288 HD22 ASN A 289 8.997 4.605 8.686 1.00 14.33 H +ATOM 4289 HD21 ASN A 289 7.720 4.166 9.783 1.00 14.33 H +ATOM 4290 N GLN A 290 4.359 4.298 4.794 1.00 21.33 N +ATOM 4291 CA GLN A 290 4.189 3.826 3.424 1.00 21.12 C +ATOM 4292 C GLN A 290 5.474 3.227 2.823 1.00 19.80 C +ATOM 4293 O GLN A 290 5.379 2.219 2.126 1.00 17.84 O +ATOM 4294 CB GLN A 290 3.600 4.974 2.574 1.00 22.69 C +ATOM 4295 CG GLN A 290 3.310 4.652 1.092 1.00 21.91 C +ATOM 4296 CD GLN A 290 2.296 3.518 0.906 1.00 24.64 C +ATOM 4297 OE1 GLN A 290 1.446 3.284 1.764 1.00 22.56 O +ATOM 4298 NE2 GLN A 290 2.362 2.823 -0.229 1.00 26.54 N +ATOM 4299 H GLN A 290 4.231 5.292 4.940 1.00 21.33 H +ATOM 4300 HA GLN A 290 3.454 3.020 3.471 1.00 21.12 H +ATOM 4301 HB3 GLN A 290 4.270 5.828 2.626 1.00 22.69 H +ATOM 4302 HB2 GLN A 290 2.676 5.318 3.041 1.00 22.69 H +ATOM 4303 HG3 GLN A 290 4.236 4.407 0.570 1.00 21.91 H +ATOM 4304 HG2 GLN A 290 2.916 5.541 0.600 1.00 21.91 H +ATOM 4305 HE22 GLN A 290 1.714 2.070 -0.411 1.00 26.54 H +ATOM 4306 HE21 GLN A 290 3.058 3.058 -0.927 1.00 26.54 H +ATOM 4307 N SER A 291 6.640 3.814 3.142 1.00 19.05 N +ATOM 4308 CA SER A 291 7.958 3.328 2.729 1.00 20.94 C +ATOM 4309 C SER A 291 8.326 1.947 3.288 1.00 20.92 C +ATOM 4310 O SER A 291 8.857 1.126 2.540 1.00 21.32 O +ATOM 4311 CB SER A 291 9.036 4.383 3.048 1.00 20.43 C +ATOM 4312 OG SER A 291 9.212 5.251 1.948 1.00 20.74 O +ATOM 4313 H SER A 291 6.632 4.656 3.702 1.00 19.05 H +ATOM 4314 HA SER A 291 7.932 3.178 1.655 1.00 20.94 H +ATOM 4315 HB3 SER A 291 9.999 3.917 3.252 1.00 20.43 H +ATOM 4316 HB2 SER A 291 8.778 4.964 3.934 1.00 20.43 H +ATOM 4317 HG SER A 291 8.467 5.867 1.940 1.00 20.74 H +ATOM 4318 N LEU A 292 8.008 1.704 4.571 1.00 19.79 N +ATOM 4319 CA LEU A 292 8.260 0.428 5.240 1.00 20.51 C +ATOM 4320 C LEU A 292 7.312 -0.687 4.760 1.00 21.92 C +ATOM 4321 O LEU A 292 7.773 -1.810 4.557 1.00 19.80 O +ATOM 4322 CB LEU A 292 8.196 0.637 6.767 1.00 21.65 C +ATOM 4323 CG LEU A 292 8.647 -0.567 7.624 1.00 25.71 C +ATOM 4324 CD1 LEU A 292 10.086 -1.034 7.309 1.00 23.44 C +ATOM 4325 CD2 LEU A 292 8.463 -0.257 9.121 1.00 25.41 C +ATOM 4326 H LEU A 292 7.554 2.420 5.121 1.00 19.79 H +ATOM 4327 HA LEU A 292 9.276 0.128 4.976 1.00 20.51 H +ATOM 4328 HB3 LEU A 292 7.175 0.907 7.039 1.00 21.65 H +ATOM 4329 HB2 LEU A 292 8.807 1.498 7.038 1.00 21.65 H +ATOM 4330 HG LEU A 292 7.981 -1.402 7.403 1.00 25.71 H +ATOM 4331 HD11 LEU A 292 10.645 -1.305 8.205 1.00 23.44 H +ATOM 4332 HD12 LEU A 292 10.069 -1.916 6.668 1.00 23.44 H +ATOM 4333 HD13 LEU A 292 10.667 -0.271 6.793 1.00 23.44 H +ATOM 4334 HD21 LEU A 292 7.907 -1.056 9.612 1.00 25.41 H +ATOM 4335 HD22 LEU A 292 9.414 -0.151 9.641 1.00 25.41 H +ATOM 4336 HD23 LEU A 292 7.912 0.669 9.286 1.00 25.41 H +ATOM 4337 N LEU A 293 6.025 -0.350 4.553 1.00 20.92 N +ATOM 4338 CA LEU A 293 5.007 -1.251 4.004 1.00 22.29 C +ATOM 4339 C LEU A 293 5.330 -1.695 2.573 1.00 22.16 C +ATOM 4340 O LEU A 293 5.236 -2.887 2.282 1.00 23.04 O +ATOM 4341 CB LEU A 293 3.624 -0.569 4.031 1.00 21.25 C +ATOM 4342 CG LEU A 293 3.002 -0.458 5.436 1.00 24.69 C +ATOM 4343 CD1 LEU A 293 1.803 0.504 5.422 1.00 21.82 C +ATOM 4344 CD2 LEU A 293 2.644 -1.833 6.037 1.00 24.44 C +ATOM 4345 H LEU A 293 5.722 0.595 4.752 1.00 20.92 H +ATOM 4346 HA LEU A 293 4.983 -2.148 4.625 1.00 22.29 H +ATOM 4347 HB3 LEU A 293 2.923 -1.109 3.393 1.00 21.25 H +ATOM 4348 HB2 LEU A 293 3.719 0.424 3.588 1.00 21.25 H +ATOM 4349 HG LEU A 293 3.754 -0.014 6.087 1.00 24.69 H +ATOM 4350 HD11 LEU A 293 1.941 1.272 6.182 1.00 21.82 H +ATOM 4351 HD12 LEU A 293 1.690 1.012 4.464 1.00 21.82 H +ATOM 4352 HD13 LEU A 293 0.854 0.008 5.627 1.00 21.82 H +ATOM 4353 HD21 LEU A 293 1.641 -1.863 6.462 1.00 24.44 H +ATOM 4354 HD22 LEU A 293 2.699 -2.629 5.294 1.00 24.44 H +ATOM 4355 HD23 LEU A 293 3.335 -2.092 6.839 1.00 24.44 H +ATOM 4356 N THR A 294 5.724 -0.734 1.721 1.00 22.88 N +ATOM 4357 CA THR A 294 6.076 -0.982 0.326 1.00 21.29 C +ATOM 4358 C THR A 294 7.383 -1.775 0.168 1.00 22.41 C +ATOM 4359 O THR A 294 7.451 -2.590 -0.746 1.00 21.52 O +ATOM 4360 CB THR A 294 6.203 0.323 -0.492 1.00 20.03 C +ATOM 4361 OG1 THR A 294 5.003 1.058 -0.389 1.00 16.51 O +ATOM 4362 CG2 THR A 294 6.453 0.118 -1.993 1.00 20.26 C +ATOM 4363 H THR A 294 5.782 0.225 2.038 1.00 22.88 H +ATOM 4364 HA THR A 294 5.275 -1.577 -0.114 1.00 21.29 H +ATOM 4365 HB THR A 294 7.003 0.929 -0.067 1.00 20.03 H +ATOM 4366 HG1 THR A 294 4.942 1.413 0.505 1.00 16.51 H +ATOM 4367 HG21 THR A 294 6.440 1.066 -2.530 1.00 20.26 H +ATOM 4368 HG22 THR A 294 7.416 -0.345 -2.197 1.00 20.26 H +ATOM 4369 HG23 THR A 294 5.687 -0.524 -2.427 1.00 20.26 H +ATOM 4370 N LEU A 295 8.366 -1.583 1.069 1.00 23.24 N +ATOM 4371 CA LEU A 295 9.595 -2.382 1.122 1.00 22.73 C +ATOM 4372 C LEU A 295 9.312 -3.875 1.365 1.00 22.80 C +ATOM 4373 O LEU A 295 9.913 -4.710 0.692 1.00 22.35 O +ATOM 4374 CB LEU A 295 10.562 -1.789 2.174 1.00 22.23 C +ATOM 4375 CG LEU A 295 11.905 -2.541 2.346 1.00 25.11 C +ATOM 4376 CD1 LEU A 295 12.750 -2.545 1.057 1.00 20.75 C +ATOM 4377 CD2 LEU A 295 12.686 -2.005 3.558 1.00 21.13 C +ATOM 4378 H LEU A 295 8.254 -0.885 1.793 1.00 23.24 H +ATOM 4379 HA LEU A 295 10.072 -2.306 0.145 1.00 22.73 H +ATOM 4380 HB3 LEU A 295 10.050 -1.767 3.137 1.00 22.23 H +ATOM 4381 HB2 LEU A 295 10.769 -0.748 1.924 1.00 22.23 H +ATOM 4382 HG LEU A 295 11.692 -3.582 2.579 1.00 25.11 H +ATOM 4383 HD11 LEU A 295 13.813 -2.393 1.245 1.00 20.75 H +ATOM 4384 HD12 LEU A 295 12.653 -3.502 0.543 1.00 20.75 H +ATOM 4385 HD13 LEU A 295 12.433 -1.767 0.364 1.00 20.75 H +ATOM 4386 HD21 LEU A 295 12.902 -2.811 4.260 1.00 21.13 H +ATOM 4387 HD22 LEU A 295 13.636 -1.555 3.274 1.00 21.13 H +ATOM 4388 HD23 LEU A 295 12.129 -1.243 4.105 1.00 21.13 H +ATOM 4389 N GLY A 296 8.369 -4.172 2.276 1.00 23.61 N +ATOM 4390 CA GLY A 296 7.920 -5.530 2.575 1.00 22.93 C +ATOM 4391 C GLY A 296 7.180 -6.155 1.384 1.00 24.51 C +ATOM 4392 O GLY A 296 7.392 -7.331 1.104 1.00 24.67 O +ATOM 4393 H GLY A 296 7.924 -3.421 2.787 1.00 23.61 H +ATOM 4394 HA3 GLY A 296 7.254 -5.502 3.437 1.00 22.93 H +ATOM 4395 HA2 GLY A 296 8.774 -6.153 2.844 1.00 22.93 H +ATOM 4396 N ARG A 297 6.356 -5.370 0.667 1.00 23.60 N +ATOM 4397 CA ARG A 297 5.608 -5.798 -0.522 1.00 23.93 C +ATOM 4398 C ARG A 297 6.494 -5.977 -1.768 1.00 23.58 C +ATOM 4399 O ARG A 297 6.197 -6.857 -2.573 1.00 23.29 O +ATOM 4400 CB ARG A 297 4.473 -4.797 -0.798 1.00 24.98 C +ATOM 4401 CG ARG A 297 3.398 -4.782 0.303 1.00 23.29 C +ATOM 4402 CD ARG A 297 2.517 -3.531 0.221 1.00 25.05 C +ATOM 4403 NE ARG A 297 1.533 -3.471 1.316 1.00 23.01 N +ATOM 4404 CZ ARG A 297 0.821 -2.392 1.694 1.00 22.41 C +ATOM 4405 NH1 ARG A 297 0.936 -1.208 1.076 1.00 24.72 N +ATOM 4406 NH2 ARG A 297 -0.030 -2.499 2.721 1.00 19.41 N1+ +ATOM 4407 H ARG A 297 6.227 -4.408 0.949 1.00 23.60 H +ATOM 4408 HA ARG A 297 5.152 -6.765 -0.306 1.00 23.93 H +ATOM 4409 HB3 ARG A 297 3.985 -5.040 -1.743 1.00 24.98 H +ATOM 4410 HB2 ARG A 297 4.898 -3.801 -0.929 1.00 24.98 H +ATOM 4411 HG3 ARG A 297 3.835 -4.865 1.298 1.00 23.29 H +ATOM 4412 HG2 ARG A 297 2.780 -5.672 0.179 1.00 23.29 H +ATOM 4413 HD3 ARG A 297 1.963 -3.529 -0.718 1.00 25.05 H +ATOM 4414 HD2 ARG A 297 3.150 -2.646 0.230 1.00 25.05 H +ATOM 4415 HE ARG A 297 1.391 -4.336 1.817 1.00 23.01 H +ATOM 4416 HH12 ARG A 297 0.377 -0.413 1.363 1.00 24.72 H +ATOM 4417 HH11 ARG A 297 1.571 -1.105 0.292 1.00 24.72 H +ATOM 4418 HH22 ARG A 297 -0.572 -1.699 3.017 1.00 19.41 H +ATOM 4419 HH21 ARG A 297 -0.142 -3.378 3.206 1.00 19.41 H +ATOM 4420 N VAL A 298 7.569 -5.179 -1.896 1.00 24.92 N +ATOM 4421 CA VAL A 298 8.597 -5.324 -2.930 1.00 24.78 C +ATOM 4422 C VAL A 298 9.428 -6.600 -2.718 1.00 27.12 C +ATOM 4423 O VAL A 298 9.617 -7.341 -3.679 1.00 27.82 O +ATOM 4424 CB VAL A 298 9.517 -4.068 -3.026 1.00 23.28 C +ATOM 4425 CG1 VAL A 298 10.884 -4.277 -3.713 1.00 22.42 C +ATOM 4426 CG2 VAL A 298 8.779 -2.922 -3.738 1.00 24.57 C +ATOM 4427 H VAL A 298 7.723 -4.443 -1.219 1.00 24.92 H +ATOM 4428 HA VAL A 298 8.085 -5.436 -3.886 1.00 24.78 H +ATOM 4429 HB VAL A 298 9.728 -3.728 -2.011 1.00 23.28 H +ATOM 4430 HG11 VAL A 298 11.404 -3.329 -3.847 1.00 22.42 H +ATOM 4431 HG12 VAL A 298 11.547 -4.914 -3.126 1.00 22.42 H +ATOM 4432 HG13 VAL A 298 10.769 -4.725 -4.700 1.00 22.42 H +ATOM 4433 HG21 VAL A 298 9.370 -2.008 -3.739 1.00 24.57 H +ATOM 4434 HG22 VAL A 298 8.568 -3.176 -4.777 1.00 24.57 H +ATOM 4435 HG23 VAL A 298 7.827 -2.690 -3.264 1.00 24.57 H +ATOM 4436 N ILE A 299 9.844 -6.865 -1.466 1.00 27.82 N +ATOM 4437 CA ILE A 299 10.501 -8.110 -1.055 1.00 30.85 C +ATOM 4438 C ILE A 299 9.614 -9.347 -1.296 1.00 32.84 C +ATOM 4439 O ILE A 299 10.116 -10.335 -1.827 1.00 33.53 O +ATOM 4440 CB ILE A 299 10.977 -8.048 0.432 1.00 28.95 C +ATOM 4441 CG1 ILE A 299 12.201 -7.106 0.550 1.00 27.94 C +ATOM 4442 CG2 ILE A 299 11.256 -9.415 1.115 1.00 27.72 C +ATOM 4443 CD1 ILE A 299 12.596 -6.762 1.990 1.00 30.35 C +ATOM 4444 H ILE A 299 9.659 -6.198 -0.728 1.00 27.82 H +ATOM 4445 HA ILE A 299 11.384 -8.225 -1.688 1.00 30.85 H +ATOM 4446 HB ILE A 299 10.172 -7.583 1.004 1.00 28.95 H +ATOM 4447 HG13 ILE A 299 12.011 -6.176 0.014 1.00 27.94 H +ATOM 4448 HG12 ILE A 299 13.063 -7.544 0.054 1.00 27.94 H +ATOM 4449 HG21 ILE A 299 11.655 -9.289 2.122 1.00 27.72 H +ATOM 4450 HG22 ILE A 299 10.348 -10.006 1.228 1.00 27.72 H +ATOM 4451 HG23 ILE A 299 11.971 -10.018 0.559 1.00 27.72 H +ATOM 4452 HD11 ILE A 299 12.945 -5.732 2.065 1.00 30.35 H +ATOM 4453 HD12 ILE A 299 11.750 -6.876 2.664 1.00 30.35 H +ATOM 4454 HD13 ILE A 299 13.397 -7.412 2.346 1.00 30.35 H +ATOM 4455 N THR A 300 8.315 -9.246 -0.964 1.00 33.27 N +ATOM 4456 CA THR A 300 7.307 -10.282 -1.203 1.00 34.38 C +ATOM 4457 C THR A 300 7.119 -10.599 -2.697 1.00 34.53 C +ATOM 4458 O THR A 300 7.111 -11.773 -3.058 1.00 38.06 O +ATOM 4459 CB THR A 300 5.925 -9.904 -0.600 1.00 33.97 C +ATOM 4460 OG1 THR A 300 6.051 -9.752 0.800 1.00 33.69 O +ATOM 4461 CG2 THR A 300 4.781 -10.901 -0.854 1.00 35.88 C +ATOM 4462 H THR A 300 7.983 -8.393 -0.533 1.00 33.27 H +ATOM 4463 HA THR A 300 7.659 -11.189 -0.715 1.00 34.38 H +ATOM 4464 HB THR A 300 5.617 -8.936 -0.994 1.00 33.97 H +ATOM 4465 HG1 THR A 300 6.568 -8.957 0.975 1.00 33.69 H +ATOM 4466 HG21 THR A 300 3.886 -10.623 -0.296 1.00 35.88 H +ATOM 4467 HG22 THR A 300 4.496 -10.933 -1.905 1.00 35.88 H +ATOM 4468 HG23 THR A 300 5.058 -11.909 -0.550 1.00 35.88 H +ATOM 4469 N ALA A 301 7.025 -9.554 -3.536 1.00 34.90 N +ATOM 4470 CA ALA A 301 6.903 -9.676 -4.986 1.00 35.29 C +ATOM 4471 C ALA A 301 8.136 -10.310 -5.653 1.00 36.92 C +ATOM 4472 O ALA A 301 7.967 -11.109 -6.572 1.00 36.87 O +ATOM 4473 CB ALA A 301 6.605 -8.299 -5.592 1.00 33.23 C +ATOM 4474 H ALA A 301 7.034 -8.612 -3.168 1.00 34.90 H +ATOM 4475 HA ALA A 301 6.048 -10.326 -5.182 1.00 35.29 H +ATOM 4476 HB1 ALA A 301 6.523 -8.362 -6.676 1.00 33.23 H +ATOM 4477 HB2 ALA A 301 5.663 -7.898 -5.217 1.00 33.23 H +ATOM 4478 HB3 ALA A 301 7.389 -7.578 -5.359 1.00 33.23 H +ATOM 4479 N LEU A 302 9.341 -9.972 -5.165 1.00 35.19 N +ATOM 4480 CA LEU A 302 10.617 -10.501 -5.649 1.00 36.10 C +ATOM 4481 C LEU A 302 10.817 -11.994 -5.333 1.00 37.90 C +ATOM 4482 O LEU A 302 11.231 -12.731 -6.229 1.00 38.70 O +ATOM 4483 CB LEU A 302 11.775 -9.653 -5.082 1.00 33.95 C +ATOM 4484 CG LEU A 302 11.927 -8.270 -5.752 1.00 33.02 C +ATOM 4485 CD1 LEU A 302 12.863 -7.367 -4.932 1.00 30.87 C +ATOM 4486 CD2 LEU A 302 12.384 -8.368 -7.219 1.00 32.24 C +ATOM 4487 H LEU A 302 9.397 -9.297 -4.413 1.00 35.19 H +ATOM 4488 HA LEU A 302 10.625 -10.408 -6.735 1.00 36.10 H +ATOM 4489 HB3 LEU A 302 12.720 -10.188 -5.189 1.00 33.95 H +ATOM 4490 HB2 LEU A 302 11.626 -9.535 -4.008 1.00 33.95 H +ATOM 4491 HG LEU A 302 10.952 -7.786 -5.759 1.00 33.02 H +ATOM 4492 HD11 LEU A 302 12.589 -6.320 -5.056 1.00 30.87 H +ATOM 4493 HD12 LEU A 302 12.821 -7.589 -3.866 1.00 30.87 H +ATOM 4494 HD13 LEU A 302 13.899 -7.481 -5.246 1.00 30.87 H +ATOM 4495 HD21 LEU A 302 13.063 -7.560 -7.487 1.00 32.24 H +ATOM 4496 HD22 LEU A 302 12.891 -9.310 -7.427 1.00 32.24 H +ATOM 4497 HD23 LEU A 302 11.531 -8.303 -7.893 1.00 32.24 H +ATOM 4498 N VAL A 303 10.523 -12.413 -4.089 1.00 38.90 N +ATOM 4499 CA VAL A 303 10.735 -13.791 -3.625 1.00 41.75 C +ATOM 4500 C VAL A 303 9.666 -14.775 -4.143 1.00 43.21 C +ATOM 4501 O VAL A 303 10.007 -15.927 -4.411 1.00 42.07 O +ATOM 4502 CB VAL A 303 10.807 -13.895 -2.074 1.00 41.73 C +ATOM 4503 CG1 VAL A 303 11.944 -13.029 -1.510 1.00 42.94 C +ATOM 4504 CG2 VAL A 303 9.489 -13.646 -1.318 1.00 45.02 C +ATOM 4505 H VAL A 303 10.190 -11.752 -3.399 1.00 38.90 H +ATOM 4506 HA VAL A 303 11.698 -14.128 -4.015 1.00 41.75 H +ATOM 4507 HB VAL A 303 11.085 -14.922 -1.831 1.00 41.73 H +ATOM 4508 HG11 VAL A 303 11.874 -12.941 -0.429 1.00 42.94 H +ATOM 4509 HG12 VAL A 303 12.917 -13.453 -1.757 1.00 42.94 H +ATOM 4510 HG13 VAL A 303 11.931 -12.017 -1.903 1.00 42.94 H +ATOM 4511 HG21 VAL A 303 9.646 -13.631 -0.239 1.00 45.02 H +ATOM 4512 HG22 VAL A 303 9.054 -12.694 -1.601 1.00 45.02 H +ATOM 4513 HG23 VAL A 303 8.753 -14.425 -1.514 1.00 45.02 H +ATOM 4514 N GLU A 304 8.419 -14.302 -4.321 1.00 45.70 N +ATOM 4515 CA GLU A 304 7.319 -15.062 -4.926 1.00 49.45 C +ATOM 4516 C GLU A 304 7.352 -15.055 -6.465 1.00 51.34 C +ATOM 4517 O GLU A 304 6.543 -15.753 -7.076 1.00 52.06 O +ATOM 4518 CB GLU A 304 5.968 -14.524 -4.409 1.00 49.94 C +ATOM 4519 CG GLU A 304 5.766 -14.754 -2.895 1.00 53.37 C +ATOM 4520 CD GLU A 304 4.437 -14.240 -2.318 1.00 56.10 C +ATOM 4521 OE1 GLU A 304 3.721 -13.481 -3.009 1.00 59.28 O +ATOM 4522 OE2 GLU A 304 4.166 -14.611 -1.154 1.00 56.03 O1- +ATOM 4523 H GLU A 304 8.204 -13.349 -4.058 1.00 45.70 H +ATOM 4524 HA GLU A 304 7.402 -16.106 -4.619 1.00 49.45 H +ATOM 4525 HB3 GLU A 304 5.148 -15.001 -4.949 1.00 49.94 H +ATOM 4526 HB2 GLU A 304 5.896 -13.460 -4.641 1.00 49.94 H +ATOM 4527 HG3 GLU A 304 6.568 -14.277 -2.334 1.00 53.37 H +ATOM 4528 HG2 GLU A 304 5.842 -15.822 -2.687 1.00 53.37 H +ATOM 4529 N ARG A 305 8.267 -14.269 -7.063 1.00 52.96 N +ATOM 4530 CA ARG A 305 8.451 -14.085 -8.506 1.00 55.80 C +ATOM 4531 C ARG A 305 7.221 -13.496 -9.225 1.00 56.10 C +ATOM 4532 O ARG A 305 7.021 -13.758 -10.411 1.00 58.37 O +ATOM 4533 CB ARG A 305 8.973 -15.374 -9.180 1.00 56.75 C +ATOM 4534 CG ARG A 305 10.239 -15.954 -8.517 1.00 57.95 C +ATOM 4535 CD ARG A 305 11.136 -16.732 -9.495 1.00 60.70 C +ATOM 4536 NE ARG A 305 11.780 -15.824 -10.464 1.00 64.39 N +ATOM 4537 CZ ARG A 305 12.596 -16.142 -11.484 1.00 65.17 C +ATOM 4538 NH1 ARG A 305 12.973 -17.406 -11.728 1.00 65.84 N +ATOM 4539 NH2 ARG A 305 13.042 -15.161 -12.279 1.00 65.41 N1+ +ATOM 4540 H ARG A 305 8.893 -13.734 -6.478 1.00 52.96 H +ATOM 4541 HA ARG A 305 9.232 -13.330 -8.600 1.00 55.80 H +ATOM 4542 HB3 ARG A 305 9.176 -15.150 -10.228 1.00 56.75 H +ATOM 4543 HB2 ARG A 305 8.197 -16.141 -9.195 1.00 56.75 H +ATOM 4544 HG3 ARG A 305 10.010 -16.547 -7.630 1.00 57.95 H +ATOM 4545 HG2 ARG A 305 10.817 -15.106 -8.144 1.00 57.95 H +ATOM 4546 HD3 ARG A 305 10.501 -17.385 -10.095 1.00 60.70 H +ATOM 4547 HD2 ARG A 305 11.843 -17.377 -8.972 1.00 60.70 H +ATOM 4548 HE ARG A 305 11.549 -14.849 -10.341 1.00 64.39 H +ATOM 4549 HH12 ARG A 305 13.586 -17.624 -12.500 1.00 65.84 H +ATOM 4550 HH11 ARG A 305 12.642 -18.151 -11.133 1.00 65.84 H +ATOM 4551 HH22 ARG A 305 13.655 -15.370 -13.054 1.00 65.41 H +ATOM 4552 HH21 ARG A 305 12.766 -14.204 -12.115 1.00 65.41 H +ATOM 4553 N THR A 306 6.430 -12.696 -8.490 1.00 55.97 N +ATOM 4554 CA THR A 306 5.245 -11.991 -8.971 1.00 55.57 C +ATOM 4555 C THR A 306 5.644 -10.969 -10.065 1.00 54.94 C +ATOM 4556 O THR A 306 6.546 -10.170 -9.800 1.00 56.07 O +ATOM 4557 CB THR A 306 4.586 -11.200 -7.810 1.00 55.82 C +ATOM 4558 OG1 THR A 306 4.186 -12.106 -6.799 1.00 55.58 O +ATOM 4559 CG2 THR A 306 3.334 -10.393 -8.204 1.00 56.42 C +ATOM 4560 H THR A 306 6.702 -12.498 -7.537 1.00 55.97 H +ATOM 4561 HA THR A 306 4.537 -12.745 -9.307 1.00 55.57 H +ATOM 4562 HB THR A 306 5.313 -10.515 -7.373 1.00 55.82 H +ATOM 4563 HG1 THR A 306 4.963 -12.539 -6.437 1.00 55.58 H +ATOM 4564 HG21 THR A 306 2.893 -9.910 -7.331 1.00 56.42 H +ATOM 4565 HG22 THR A 306 3.556 -9.606 -8.922 1.00 56.42 H +ATOM 4566 HG23 THR A 306 2.573 -11.038 -8.645 1.00 56.42 H +ATOM 4567 N PRO A 307 5.012 -11.029 -11.265 1.00 54.81 N +ATOM 4568 CA PRO A 307 5.316 -10.129 -12.400 1.00 54.33 C +ATOM 4569 C PRO A 307 5.409 -8.623 -12.091 1.00 52.41 C +ATOM 4570 O PRO A 307 6.333 -7.975 -12.581 1.00 53.53 O +ATOM 4571 CB PRO A 307 4.195 -10.423 -13.411 1.00 54.49 C +ATOM 4572 CG PRO A 307 3.832 -11.872 -13.152 1.00 55.69 C +ATOM 4573 CD PRO A 307 3.988 -12.008 -11.644 1.00 55.25 C +ATOM 4574 HA PRO A 307 6.269 -10.462 -12.816 1.00 54.33 H +ATOM 4575 HB3 PRO A 307 4.505 -10.254 -14.442 1.00 54.49 H +ATOM 4576 HB2 PRO A 307 3.323 -9.794 -13.221 1.00 54.49 H +ATOM 4577 HG3 PRO A 307 4.559 -12.515 -13.650 1.00 55.69 H +ATOM 4578 HG2 PRO A 307 2.840 -12.145 -13.513 1.00 55.69 H +ATOM 4579 HD2 PRO A 307 3.055 -11.761 -11.136 1.00 55.25 H +ATOM 4580 HD3 PRO A 307 4.261 -13.035 -11.403 1.00 55.25 H +ATOM 4581 N HIS A 308 4.480 -8.115 -11.264 1.00 49.84 N +ATOM 4582 CA HIS A 308 4.475 -6.737 -10.785 1.00 47.05 C +ATOM 4583 C HIS A 308 5.226 -6.639 -9.449 1.00 44.45 C +ATOM 4584 O HIS A 308 4.877 -7.347 -8.504 1.00 44.53 O +ATOM 4585 CB HIS A 308 3.017 -6.256 -10.651 1.00 48.81 C +ATOM 4586 CG HIS A 308 2.866 -4.820 -10.204 1.00 50.00 C +ATOM 4587 ND1 HIS A 308 3.509 -3.758 -10.852 1.00 49.02 N +ATOM 4588 CD2 HIS A 308 2.134 -4.318 -9.148 1.00 51.40 C +ATOM 4589 CE1 HIS A 308 3.149 -2.677 -10.172 1.00 50.89 C +ATOM 4590 NE2 HIS A 308 2.335 -2.949 -9.151 1.00 51.97 N +ATOM 4591 H HIS A 308 3.760 -8.716 -10.891 1.00 49.84 H +ATOM 4592 HA HIS A 308 4.970 -6.097 -11.520 1.00 47.05 H +ATOM 4593 HB3 HIS A 308 2.471 -6.894 -9.955 1.00 48.81 H +ATOM 4594 HB2 HIS A 308 2.511 -6.353 -11.612 1.00 48.81 H +ATOM 4595 HD2 HIS A 308 1.513 -4.808 -8.413 1.00 51.40 H +ATOM 4596 HE1 HIS A 308 3.485 -1.681 -10.418 1.00 50.89 H +ATOM 4597 HE2 HIS A 308 1.946 -2.282 -8.497 1.00 51.97 H +ATOM 4598 N VAL A 309 6.210 -5.730 -9.399 1.00 40.26 N +ATOM 4599 CA VAL A 309 6.958 -5.388 -8.193 1.00 35.27 C +ATOM 4600 C VAL A 309 6.672 -3.893 -7.912 1.00 31.25 C +ATOM 4601 O VAL A 309 7.007 -3.063 -8.761 1.00 30.60 O +ATOM 4602 CB VAL A 309 8.486 -5.578 -8.400 1.00 34.02 C +ATOM 4603 CG1 VAL A 309 9.287 -5.234 -7.127 1.00 31.38 C +ATOM 4604 CG2 VAL A 309 8.829 -7.015 -8.837 1.00 34.36 C +ATOM 4605 H VAL A 309 6.421 -5.179 -10.219 1.00 40.26 H +ATOM 4606 HA VAL A 309 6.664 -6.036 -7.372 1.00 35.27 H +ATOM 4607 HB VAL A 309 8.828 -4.920 -9.200 1.00 34.02 H +ATOM 4608 HG11 VAL A 309 10.335 -5.511 -7.234 1.00 31.38 H +ATOM 4609 HG12 VAL A 309 9.256 -4.169 -6.900 1.00 31.38 H +ATOM 4610 HG13 VAL A 309 8.902 -5.772 -6.261 1.00 31.38 H +ATOM 4611 HG21 VAL A 309 9.898 -7.121 -9.014 1.00 34.36 H +ATOM 4612 HG22 VAL A 309 8.543 -7.741 -8.076 1.00 34.36 H +ATOM 4613 HG23 VAL A 309 8.328 -7.291 -9.764 1.00 34.36 H +ATOM 4614 N PRO A 310 6.005 -3.573 -6.776 1.00 30.38 N +ATOM 4615 CA PRO A 310 5.485 -2.217 -6.504 1.00 29.30 C +ATOM 4616 C PRO A 310 6.547 -1.196 -6.030 1.00 28.73 C +ATOM 4617 O PRO A 310 6.369 -0.589 -4.976 1.00 27.93 O +ATOM 4618 CB PRO A 310 4.382 -2.493 -5.462 1.00 29.27 C +ATOM 4619 CG PRO A 310 4.892 -3.683 -4.673 1.00 29.44 C +ATOM 4620 CD PRO A 310 5.557 -4.524 -5.753 1.00 29.54 C +ATOM 4621 HA PRO A 310 5.019 -1.802 -7.400 1.00 29.30 H +ATOM 4622 HB3 PRO A 310 3.462 -2.770 -5.979 1.00 29.27 H +ATOM 4623 HB2 PRO A 310 4.139 -1.651 -4.814 1.00 29.27 H +ATOM 4624 HG3 PRO A 310 4.108 -4.216 -4.134 1.00 29.44 H +ATOM 4625 HG2 PRO A 310 5.635 -3.352 -3.947 1.00 29.44 H +ATOM 4626 HD2 PRO A 310 6.373 -5.115 -5.340 1.00 29.54 H +ATOM 4627 HD3 PRO A 310 4.826 -5.203 -6.196 1.00 29.54 H +ATOM 4628 N TYR A 311 7.620 -0.987 -6.819 1.00 28.68 N +ATOM 4629 CA TYR A 311 8.672 0.003 -6.543 1.00 29.45 C +ATOM 4630 C TYR A 311 8.145 1.442 -6.443 1.00 28.70 C +ATOM 4631 O TYR A 311 8.620 2.187 -5.594 1.00 24.95 O +ATOM 4632 CB TYR A 311 9.757 -0.010 -7.637 1.00 31.49 C +ATOM 4633 CG TYR A 311 10.513 -1.304 -7.844 1.00 34.07 C +ATOM 4634 CD1 TYR A 311 11.369 -1.804 -6.839 1.00 35.28 C +ATOM 4635 CD2 TYR A 311 10.416 -1.974 -9.080 1.00 36.40 C +ATOM 4636 CE1 TYR A 311 12.137 -2.959 -7.084 1.00 36.88 C +ATOM 4637 CE2 TYR A 311 11.189 -3.121 -9.326 1.00 39.34 C +ATOM 4638 CZ TYR A 311 12.055 -3.610 -8.332 1.00 38.02 C +ATOM 4639 OH TYR A 311 12.803 -4.719 -8.591 1.00 38.99 O +ATOM 4640 H TYR A 311 7.717 -1.523 -7.672 1.00 28.68 H +ATOM 4641 HA TYR A 311 9.129 -0.259 -5.588 1.00 29.45 H +ATOM 4642 HB3 TYR A 311 10.508 0.751 -7.414 1.00 31.49 H +ATOM 4643 HB2 TYR A 311 9.318 0.290 -8.591 1.00 31.49 H +ATOM 4644 HD1 TYR A 311 11.455 -1.293 -5.891 1.00 35.28 H +ATOM 4645 HD2 TYR A 311 9.767 -1.597 -9.857 1.00 36.40 H +ATOM 4646 HE1 TYR A 311 12.791 -3.336 -6.314 1.00 36.88 H +ATOM 4647 HE2 TYR A 311 11.118 -3.623 -10.280 1.00 39.34 H +ATOM 4648 HH TYR A 311 13.397 -4.944 -7.864 1.00 38.99 H +ATOM 4649 N ARG A 312 7.188 1.807 -7.311 1.00 28.58 N +ATOM 4650 CA ARG A 312 6.659 3.166 -7.431 1.00 28.46 C +ATOM 4651 C ARG A 312 5.696 3.596 -6.313 1.00 24.21 C +ATOM 4652 O ARG A 312 5.388 4.787 -6.238 1.00 25.31 O +ATOM 4653 CB ARG A 312 6.044 3.356 -8.827 1.00 35.11 C +ATOM 4654 CG ARG A 312 7.102 3.240 -9.934 1.00 41.09 C +ATOM 4655 CD ARG A 312 6.584 3.695 -11.308 1.00 45.95 C +ATOM 4656 NE ARG A 312 7.696 3.974 -12.232 1.00 49.55 N +ATOM 4657 CZ ARG A 312 8.467 5.079 -12.213 1.00 51.02 C +ATOM 4658 NH1 ARG A 312 8.266 6.062 -11.323 1.00 53.12 N +ATOM 4659 NH2 ARG A 312 9.460 5.204 -13.102 1.00 51.89 N1+ +ATOM 4660 H ARG A 312 6.829 1.128 -7.966 1.00 28.58 H +ATOM 4661 HA ARG A 312 7.497 3.854 -7.366 1.00 28.46 H +ATOM 4662 HB3 ARG A 312 5.599 4.351 -8.887 1.00 35.11 H +ATOM 4663 HB2 ARG A 312 5.231 2.647 -8.994 1.00 35.11 H +ATOM 4664 HG3 ARG A 312 7.356 2.182 -10.010 1.00 41.09 H +ATOM 4665 HG2 ARG A 312 8.031 3.744 -9.660 1.00 41.09 H +ATOM 4666 HD3 ARG A 312 5.854 4.503 -11.250 1.00 45.95 H +ATOM 4667 HD2 ARG A 312 6.065 2.852 -11.766 1.00 45.95 H +ATOM 4668 HE ARG A 312 7.905 3.251 -12.905 1.00 49.55 H +ATOM 4669 HH12 ARG A 312 8.822 6.911 -11.373 1.00 53.12 H +ATOM 4670 HH11 ARG A 312 7.512 5.999 -10.656 1.00 53.12 H +ATOM 4671 HH22 ARG A 312 10.008 6.053 -13.123 1.00 51.89 H +ATOM 4672 HH21 ARG A 312 9.644 4.480 -13.781 1.00 51.89 H +ATOM 4673 N GLU A 313 5.258 2.660 -5.455 1.00 23.86 N +ATOM 4674 CA GLU A 313 4.308 2.931 -4.375 1.00 23.27 C +ATOM 4675 C GLU A 313 4.916 3.625 -3.136 1.00 22.41 C +ATOM 4676 O GLU A 313 4.150 3.962 -2.235 1.00 20.21 O +ATOM 4677 CB GLU A 313 3.521 1.649 -4.026 1.00 23.76 C +ATOM 4678 CG GLU A 313 2.783 1.049 -5.251 1.00 28.94 C +ATOM 4679 CD GLU A 313 1.772 -0.074 -4.958 1.00 31.02 C +ATOM 4680 OE1 GLU A 313 1.386 -0.741 -5.943 1.00 28.97 O +ATOM 4681 OE2 GLU A 313 1.392 -0.263 -3.781 1.00 31.90 O1- +ATOM 4682 H GLU A 313 5.566 1.702 -5.551 1.00 23.86 H +ATOM 4683 HA GLU A 313 3.572 3.640 -4.760 1.00 23.27 H +ATOM 4684 HB3 GLU A 313 2.808 1.881 -3.234 1.00 23.76 H +ATOM 4685 HB2 GLU A 313 4.197 0.900 -3.617 1.00 23.76 H +ATOM 4686 HG3 GLU A 313 3.518 0.669 -5.963 1.00 28.94 H +ATOM 4687 HG2 GLU A 313 2.241 1.842 -5.767 1.00 28.94 H +ATOM 4688 N SER A 314 6.237 3.885 -3.112 1.00 21.60 N +ATOM 4689 CA SER A 314 6.876 4.691 -2.067 1.00 21.14 C +ATOM 4690 C SER A 314 8.168 5.363 -2.542 1.00 20.47 C +ATOM 4691 O SER A 314 8.789 4.903 -3.498 1.00 20.55 O +ATOM 4692 CB SER A 314 7.115 3.854 -0.795 1.00 20.33 C +ATOM 4693 OG SER A 314 8.272 3.039 -0.874 1.00 17.31 O +ATOM 4694 H SER A 314 6.828 3.597 -3.879 1.00 21.60 H +ATOM 4695 HA SER A 314 6.182 5.497 -1.822 1.00 21.14 H +ATOM 4696 HB3 SER A 314 6.244 3.259 -0.538 1.00 20.33 H +ATOM 4697 HB2 SER A 314 7.258 4.536 0.041 1.00 20.33 H +ATOM 4698 HG SER A 314 8.167 2.414 -1.599 1.00 17.31 H +ATOM 4699 N LYS A 315 8.568 6.408 -1.800 1.00 21.93 N +ATOM 4700 CA LYS A 315 9.823 7.142 -1.964 1.00 24.01 C +ATOM 4701 C LYS A 315 11.064 6.248 -1.788 1.00 23.64 C +ATOM 4702 O LYS A 315 11.952 6.307 -2.637 1.00 23.92 O +ATOM 4703 CB LYS A 315 9.868 8.328 -0.972 1.00 25.23 C +ATOM 4704 CG LYS A 315 8.738 9.365 -1.122 1.00 30.47 C +ATOM 4705 CD LYS A 315 8.782 10.164 -2.430 1.00 34.06 C +ATOM 4706 CE LYS A 315 7.603 11.137 -2.569 1.00 40.37 C +ATOM 4707 NZ LYS A 315 7.659 11.880 -3.839 1.00 44.85 N1+ +ATOM 4708 H LYS A 315 7.987 6.703 -1.024 1.00 21.93 H +ATOM 4709 HA LYS A 315 9.848 7.526 -2.985 1.00 24.01 H +ATOM 4710 HB3 LYS A 315 10.825 8.844 -1.059 1.00 25.23 H +ATOM 4711 HB2 LYS A 315 9.831 7.938 0.046 1.00 25.23 H +ATOM 4712 HG3 LYS A 315 8.799 10.059 -0.283 1.00 30.47 H +ATOM 4713 HG2 LYS A 315 7.768 8.880 -1.031 1.00 30.47 H +ATOM 4714 HD3 LYS A 315 8.796 9.486 -3.282 1.00 34.06 H +ATOM 4715 HD2 LYS A 315 9.714 10.729 -2.450 1.00 34.06 H +ATOM 4716 HE3 LYS A 315 7.605 11.853 -1.747 1.00 40.37 H +ATOM 4717 HE2 LYS A 315 6.658 10.593 -2.522 1.00 40.37 H +ATOM 4718 HZ1 LYS A 315 7.645 11.229 -4.610 1.00 44.85 H +ATOM 4719 HZ2 LYS A 315 6.864 12.499 -3.902 1.00 44.85 H +ATOM 4720 HZ3 LYS A 315 8.511 12.422 -3.871 1.00 44.85 H +ATOM 4721 N LEU A 316 11.089 5.425 -0.722 1.00 22.60 N +ATOM 4722 CA LEU A 316 12.199 4.528 -0.375 1.00 21.91 C +ATOM 4723 C LEU A 316 12.537 3.524 -1.485 1.00 21.21 C +ATOM 4724 O LEU A 316 13.696 3.436 -1.881 1.00 22.09 O +ATOM 4725 CB LEU A 316 11.882 3.800 0.951 1.00 22.01 C +ATOM 4726 CG LEU A 316 12.999 2.887 1.506 1.00 23.74 C +ATOM 4727 CD1 LEU A 316 14.245 3.698 1.908 1.00 23.65 C +ATOM 4728 CD2 LEU A 316 12.484 2.037 2.680 1.00 21.42 C +ATOM 4729 H LEU A 316 10.308 5.422 -0.079 1.00 22.60 H +ATOM 4730 HA LEU A 316 13.077 5.158 -0.226 1.00 21.91 H +ATOM 4731 HB3 LEU A 316 10.970 3.215 0.817 1.00 22.01 H +ATOM 4732 HB2 LEU A 316 11.655 4.540 1.715 1.00 22.01 H +ATOM 4733 HG LEU A 316 13.297 2.177 0.734 1.00 23.74 H +ATOM 4734 HD11 LEU A 316 14.887 3.140 2.591 1.00 23.65 H +ATOM 4735 HD12 LEU A 316 14.841 3.954 1.033 1.00 23.65 H +ATOM 4736 HD13 LEU A 316 13.975 4.631 2.402 1.00 23.65 H +ATOM 4737 HD21 LEU A 316 12.783 0.994 2.569 1.00 21.42 H +ATOM 4738 HD22 LEU A 316 12.876 2.398 3.628 1.00 21.42 H +ATOM 4739 HD23 LEU A 316 11.399 2.052 2.762 1.00 21.42 H +ATOM 4740 N THR A 317 11.516 2.793 -1.956 1.00 20.82 N +ATOM 4741 CA THR A 317 11.660 1.732 -2.951 1.00 21.01 C +ATOM 4742 C THR A 317 11.792 2.248 -4.401 1.00 22.51 C +ATOM 4743 O THR A 317 12.246 1.472 -5.239 1.00 24.89 O +ATOM 4744 CB THR A 317 10.476 0.741 -2.867 1.00 20.28 C +ATOM 4745 OG1 THR A 317 9.239 1.389 -3.069 1.00 19.26 O +ATOM 4746 CG2 THR A 317 10.406 0.013 -1.519 1.00 21.44 C +ATOM 4747 H THR A 317 10.584 2.932 -1.588 1.00 20.82 H +ATOM 4748 HA THR A 317 12.575 1.177 -2.728 1.00 21.01 H +ATOM 4749 HB THR A 317 10.586 -0.012 -3.648 1.00 20.28 H +ATOM 4750 HG1 THR A 317 9.195 1.713 -3.977 1.00 19.26 H +ATOM 4751 HG21 THR A 317 9.618 -0.737 -1.530 1.00 21.44 H +ATOM 4752 HG22 THR A 317 11.343 -0.503 -1.310 1.00 21.44 H +ATOM 4753 HG23 THR A 317 10.207 0.695 -0.691 1.00 21.44 H +ATOM 4754 N ARG A 318 11.474 3.530 -4.672 1.00 24.39 N +ATOM 4755 CA ARG A 318 11.843 4.211 -5.922 1.00 24.64 C +ATOM 4756 C ARG A 318 13.339 4.554 -5.939 1.00 24.75 C +ATOM 4757 O ARG A 318 14.006 4.280 -6.936 1.00 22.73 O +ATOM 4758 CB ARG A 318 11.035 5.513 -6.102 1.00 26.49 C +ATOM 4759 CG ARG A 318 9.578 5.282 -6.509 1.00 30.67 C +ATOM 4760 CD ARG A 318 8.700 6.540 -6.458 1.00 32.24 C +ATOM 4761 NE ARG A 318 9.039 7.522 -7.503 1.00 37.00 N +ATOM 4762 CZ ARG A 318 8.560 8.777 -7.606 1.00 39.39 C +ATOM 4763 NH1 ARG A 318 7.674 9.276 -6.730 1.00 42.30 N +ATOM 4764 NH2 ARG A 318 8.972 9.552 -8.616 1.00 40.43 N1+ +ATOM 4765 H ARG A 318 11.077 4.109 -3.945 1.00 24.39 H +ATOM 4766 HA ARG A 318 11.641 3.552 -6.769 1.00 24.64 H +ATOM 4767 HB3 ARG A 318 11.498 6.121 -6.881 1.00 26.49 H +ATOM 4768 HB2 ARG A 318 11.080 6.105 -5.188 1.00 26.49 H +ATOM 4769 HG3 ARG A 318 9.116 4.507 -5.913 1.00 30.67 H +ATOM 4770 HG2 ARG A 318 9.596 4.898 -7.530 1.00 30.67 H +ATOM 4771 HD3 ARG A 318 8.892 7.041 -5.508 1.00 32.24 H +ATOM 4772 HD2 ARG A 318 7.641 6.285 -6.461 1.00 32.24 H +ATOM 4773 HE ARG A 318 9.701 7.210 -8.198 1.00 37.00 H +ATOM 4774 HH12 ARG A 318 7.284 10.196 -6.868 1.00 42.30 H +ATOM 4775 HH11 ARG A 318 7.321 8.689 -5.984 1.00 42.30 H +ATOM 4776 HH22 ARG A 318 8.631 10.497 -8.713 1.00 40.43 H +ATOM 4777 HH21 ARG A 318 9.590 9.185 -9.332 1.00 40.43 H +ATOM 4778 N ILE A 319 13.825 5.147 -4.834 1.00 24.38 N +ATOM 4779 CA ILE A 319 15.213 5.573 -4.641 1.00 25.59 C +ATOM 4780 C ILE A 319 16.201 4.390 -4.594 1.00 25.42 C +ATOM 4781 O ILE A 319 17.299 4.508 -5.137 1.00 25.60 O +ATOM 4782 CB ILE A 319 15.347 6.455 -3.356 1.00 26.11 C +ATOM 4783 CG1 ILE A 319 14.636 7.814 -3.564 1.00 27.58 C +ATOM 4784 CG2 ILE A 319 16.790 6.700 -2.857 1.00 26.26 C +ATOM 4785 CD1 ILE A 319 14.237 8.535 -2.268 1.00 29.91 C +ATOM 4786 H ILE A 319 13.199 5.341 -4.064 1.00 24.38 H +ATOM 4787 HA ILE A 319 15.488 6.184 -5.503 1.00 25.59 H +ATOM 4788 HB ILE A 319 14.819 5.934 -2.555 1.00 26.11 H +ATOM 4789 HG13 ILE A 319 13.730 7.674 -4.148 1.00 27.58 H +ATOM 4790 HG12 ILE A 319 15.266 8.468 -4.166 1.00 27.58 H +ATOM 4791 HG21 ILE A 319 16.806 7.378 -2.004 1.00 26.26 H +ATOM 4792 HG22 ILE A 319 17.275 5.783 -2.526 1.00 26.26 H +ATOM 4793 HG23 ILE A 319 17.406 7.145 -3.639 1.00 26.26 H +ATOM 4794 HD11 ILE A 319 14.615 9.556 -2.268 1.00 29.91 H +ATOM 4795 HD12 ILE A 319 13.153 8.602 -2.178 1.00 29.91 H +ATOM 4796 HD13 ILE A 319 14.606 8.031 -1.374 1.00 29.91 H +ATOM 4797 N LEU A 320 15.774 3.273 -3.983 1.00 23.39 N +ATOM 4798 CA LEU A 320 16.553 2.046 -3.809 1.00 23.27 C +ATOM 4799 C LEU A 320 16.024 0.900 -4.693 1.00 22.23 C +ATOM 4800 O LEU A 320 16.201 -0.263 -4.328 1.00 18.72 O +ATOM 4801 CB LEU A 320 16.543 1.650 -2.312 1.00 23.58 C +ATOM 4802 CG LEU A 320 17.160 2.689 -1.352 1.00 25.87 C +ATOM 4803 CD1 LEU A 320 16.935 2.246 0.099 1.00 25.90 C +ATOM 4804 CD2 LEU A 320 18.655 2.952 -1.628 1.00 25.98 C +ATOM 4805 H LEU A 320 14.859 3.273 -3.551 1.00 23.39 H +ATOM 4806 HA LEU A 320 17.586 2.207 -4.119 1.00 23.27 H +ATOM 4807 HB3 LEU A 320 17.081 0.713 -2.168 1.00 23.58 H +ATOM 4808 HB2 LEU A 320 15.514 1.445 -2.012 1.00 23.58 H +ATOM 4809 HG LEU A 320 16.623 3.630 -1.471 1.00 25.87 H +ATOM 4810 HD11 LEU A 320 17.117 3.064 0.796 1.00 25.90 H +ATOM 4811 HD12 LEU A 320 15.916 1.893 0.258 1.00 25.90 H +ATOM 4812 HD13 LEU A 320 17.601 1.426 0.358 1.00 25.90 H +ATOM 4813 HD21 LEU A 320 19.249 2.942 -0.714 1.00 25.98 H +ATOM 4814 HD22 LEU A 320 19.087 2.205 -2.295 1.00 25.98 H +ATOM 4815 HD23 LEU A 320 18.799 3.927 -2.093 1.00 25.98 H +ATOM 4816 N GLN A 321 15.407 1.223 -5.846 1.00 21.93 N +ATOM 4817 CA GLN A 321 14.906 0.249 -6.824 1.00 25.12 C +ATOM 4818 C GLN A 321 15.974 -0.748 -7.309 1.00 23.77 C +ATOM 4819 O GLN A 321 15.700 -1.947 -7.354 1.00 25.82 O +ATOM 4820 CB GLN A 321 14.206 0.987 -7.991 1.00 25.91 C +ATOM 4821 CG GLN A 321 13.803 0.080 -9.178 1.00 35.95 C +ATOM 4822 CD GLN A 321 12.874 0.714 -10.217 1.00 39.40 C +ATOM 4823 OE1 GLN A 321 12.394 0.014 -11.104 1.00 43.71 O +ATOM 4824 NE2 GLN A 321 12.623 2.024 -10.141 1.00 41.83 N +ATOM 4825 H GLN A 321 15.287 2.197 -6.086 1.00 21.93 H +ATOM 4826 HA GLN A 321 14.142 -0.339 -6.310 1.00 25.12 H +ATOM 4827 HB3 GLN A 321 14.853 1.786 -8.357 1.00 25.91 H +ATOM 4828 HB2 GLN A 321 13.316 1.476 -7.595 1.00 25.91 H +ATOM 4829 HG3 GLN A 321 13.309 -0.815 -8.802 1.00 35.95 H +ATOM 4830 HG2 GLN A 321 14.693 -0.256 -9.712 1.00 35.95 H +ATOM 4831 HE22 GLN A 321 12.032 2.464 -10.830 1.00 41.83 H +ATOM 4832 HE21 GLN A 321 13.039 2.584 -9.411 1.00 41.83 H +ATOM 4833 N ASP A 322 17.174 -0.234 -7.626 1.00 25.83 N +ATOM 4834 CA ASP A 322 18.310 -1.015 -8.114 1.00 27.25 C +ATOM 4835 C ASP A 322 18.931 -1.931 -7.032 1.00 28.86 C +ATOM 4836 O ASP A 322 19.571 -2.922 -7.381 1.00 28.79 O +ATOM 4837 CB ASP A 322 19.382 -0.093 -8.743 1.00 28.99 C +ATOM 4838 CG ASP A 322 20.349 -0.795 -9.709 1.00 32.05 C +ATOM 4839 OD1 ASP A 322 19.857 -1.492 -10.624 1.00 27.75 O +ATOM 4840 OD2 ASP A 322 21.569 -0.580 -9.559 1.00 31.15 O1- +ATOM 4841 H ASP A 322 17.328 0.763 -7.538 1.00 25.83 H +ATOM 4842 HA ASP A 322 17.902 -1.664 -8.887 1.00 27.25 H +ATOM 4843 HB3 ASP A 322 19.936 0.416 -7.951 1.00 28.99 H +ATOM 4844 HB2 ASP A 322 18.893 0.709 -9.298 1.00 28.99 H +ATOM 4845 N SER A 323 18.711 -1.613 -5.746 1.00 28.11 N +ATOM 4846 CA SER A 323 19.153 -2.419 -4.602 1.00 26.92 C +ATOM 4847 C SER A 323 18.236 -3.628 -4.332 1.00 28.99 C +ATOM 4848 O SER A 323 18.616 -4.507 -3.563 1.00 30.38 O +ATOM 4849 CB SER A 323 19.220 -1.520 -3.354 1.00 24.83 C +ATOM 4850 OG SER A 323 20.107 -0.443 -3.569 1.00 25.15 O +ATOM 4851 H SER A 323 18.146 -0.804 -5.528 1.00 28.11 H +ATOM 4852 HA SER A 323 20.152 -2.810 -4.795 1.00 26.92 H +ATOM 4853 HB3 SER A 323 19.580 -2.087 -2.495 1.00 24.83 H +ATOM 4854 HB2 SER A 323 18.239 -1.134 -3.082 1.00 24.83 H +ATOM 4855 HG SER A 323 19.763 0.099 -4.283 1.00 25.15 H +ATOM 4856 N LEU A 324 17.047 -3.653 -4.948 1.00 28.47 N +ATOM 4857 CA LEU A 324 16.007 -4.642 -4.701 1.00 29.95 C +ATOM 4858 C LEU A 324 15.714 -5.360 -6.023 1.00 32.13 C +ATOM 4859 O LEU A 324 14.773 -4.995 -6.721 1.00 30.55 O +ATOM 4860 CB LEU A 324 14.776 -3.901 -4.127 1.00 26.21 C +ATOM 4861 CG LEU A 324 14.992 -3.285 -2.725 1.00 28.34 C +ATOM 4862 CD1 LEU A 324 13.824 -2.358 -2.345 1.00 24.74 C +ATOM 4863 CD2 LEU A 324 15.268 -4.347 -1.641 1.00 26.31 C +ATOM 4864 H LEU A 324 16.799 -2.905 -5.582 1.00 28.47 H +ATOM 4865 HA LEU A 324 16.330 -5.402 -3.987 1.00 29.95 H +ATOM 4866 HB3 LEU A 324 13.923 -4.579 -4.082 1.00 26.21 H +ATOM 4867 HB2 LEU A 324 14.495 -3.107 -4.820 1.00 26.21 H +ATOM 4868 HG LEU A 324 15.870 -2.640 -2.778 1.00 28.34 H +ATOM 4869 HD11 LEU A 324 14.170 -1.530 -1.725 1.00 24.74 H +ATOM 4870 HD12 LEU A 324 13.347 -1.919 -3.223 1.00 24.74 H +ATOM 4871 HD13 LEU A 324 13.049 -2.890 -1.795 1.00 24.74 H +ATOM 4872 HD21 LEU A 324 14.682 -4.177 -0.738 1.00 26.31 H +ATOM 4873 HD22 LEU A 324 15.038 -5.356 -1.986 1.00 26.31 H +ATOM 4874 HD23 LEU A 324 16.319 -4.334 -1.347 1.00 26.31 H +ATOM 4875 N GLY A 325 16.541 -6.365 -6.353 1.00 33.04 N +ATOM 4876 CA GLY A 325 16.398 -7.173 -7.566 1.00 35.57 C +ATOM 4877 C GLY A 325 17.047 -6.528 -8.804 1.00 36.92 C +ATOM 4878 O GLY A 325 16.805 -6.999 -9.916 1.00 37.76 O +ATOM 4879 H GLY A 325 17.297 -6.616 -5.731 1.00 33.04 H +ATOM 4880 HA3 GLY A 325 15.348 -7.383 -7.772 1.00 35.57 H +ATOM 4881 HA2 GLY A 325 16.874 -8.131 -7.383 1.00 35.57 H +ATOM 4882 N GLY A 326 17.848 -5.463 -8.629 1.00 36.99 N +ATOM 4883 CA GLY A 326 18.547 -4.767 -9.708 1.00 35.83 C +ATOM 4884 C GLY A 326 20.015 -5.204 -9.764 1.00 36.25 C +ATOM 4885 O GLY A 326 20.351 -6.339 -9.431 1.00 36.30 O +ATOM 4886 H GLY A 326 18.015 -5.127 -7.692 1.00 36.99 H +ATOM 4887 HA3 GLY A 326 18.475 -3.698 -9.542 1.00 35.83 H +ATOM 4888 HA2 GLY A 326 18.087 -4.949 -10.679 1.00 35.83 H +ATOM 4889 N ARG A 327 20.876 -4.291 -10.238 1.00 34.63 N +ATOM 4890 CA ARG A 327 22.294 -4.513 -10.534 1.00 36.55 C +ATOM 4891 C ARG A 327 23.259 -4.020 -9.437 1.00 36.94 C +ATOM 4892 O ARG A 327 24.462 -3.961 -9.692 1.00 38.93 O +ATOM 4893 CB ARG A 327 22.628 -3.865 -11.892 1.00 38.14 C +ATOM 4894 CG ARG A 327 21.859 -4.470 -13.075 1.00 42.41 C +ATOM 4895 CD ARG A 327 22.327 -3.867 -14.405 1.00 46.96 C +ATOM 4896 NE ARG A 327 21.543 -4.365 -15.547 1.00 51.13 N +ATOM 4897 CZ ARG A 327 21.654 -3.970 -16.830 1.00 54.30 C +ATOM 4898 NH1 ARG A 327 22.509 -3.008 -17.211 1.00 55.38 N +ATOM 4899 NH2 ARG A 327 20.886 -4.556 -17.757 1.00 54.29 N1+ +ATOM 4900 H ARG A 327 20.530 -3.364 -10.461 1.00 34.63 H +ATOM 4901 HA ARG A 327 22.468 -5.583 -10.626 1.00 36.55 H +ATOM 4902 HB3 ARG A 327 23.692 -3.980 -12.104 1.00 38.14 H +ATOM 4903 HB2 ARG A 327 22.442 -2.791 -11.843 1.00 38.14 H +ATOM 4904 HG3 ARG A 327 20.777 -4.393 -12.959 1.00 42.41 H +ATOM 4905 HG2 ARG A 327 22.092 -5.536 -13.080 1.00 42.41 H +ATOM 4906 HD3 ARG A 327 23.346 -4.210 -14.594 1.00 46.96 H +ATOM 4907 HD2 ARG A 327 22.365 -2.778 -14.361 1.00 46.96 H +ATOM 4908 HE ARG A 327 20.874 -5.088 -15.328 1.00 51.13 H +ATOM 4909 HH12 ARG A 327 22.580 -2.730 -18.179 1.00 55.38 H +ATOM 4910 HH11 ARG A 327 23.098 -2.558 -16.525 1.00 55.38 H +ATOM 4911 HH22 ARG A 327 20.956 -4.279 -18.726 1.00 54.29 H +ATOM 4912 HH21 ARG A 327 20.236 -5.284 -17.501 1.00 54.29 H +ATOM 4913 N THR A 328 22.747 -3.688 -8.245 1.00 34.16 N +ATOM 4914 CA THR A 328 23.559 -3.342 -7.077 1.00 31.72 C +ATOM 4915 C THR A 328 23.710 -4.595 -6.192 1.00 30.02 C +ATOM 4916 O THR A 328 22.729 -5.311 -5.995 1.00 30.34 O +ATOM 4917 CB THR A 328 22.844 -2.225 -6.270 1.00 31.13 C +ATOM 4918 OG1 THR A 328 22.993 -0.998 -6.956 1.00 32.46 O +ATOM 4919 CG2 THR A 328 23.300 -1.990 -4.826 1.00 28.96 C +ATOM 4920 H THR A 328 21.749 -3.742 -8.095 1.00 34.16 H +ATOM 4921 HA THR A 328 24.548 -2.990 -7.375 1.00 31.72 H +ATOM 4922 HB THR A 328 21.779 -2.434 -6.245 1.00 31.13 H +ATOM 4923 HG1 THR A 328 22.532 -1.051 -7.801 1.00 32.46 H +ATOM 4924 HG21 THR A 328 22.845 -1.086 -4.430 1.00 28.96 H +ATOM 4925 HG22 THR A 328 23.018 -2.808 -4.165 1.00 28.96 H +ATOM 4926 HG23 THR A 328 24.376 -1.865 -4.778 1.00 28.96 H +ATOM 4927 N ARG A 329 24.920 -4.825 -5.647 1.00 29.31 N +ATOM 4928 CA ARG A 329 25.159 -5.848 -4.622 1.00 29.30 C +ATOM 4929 C ARG A 329 24.519 -5.399 -3.301 1.00 26.80 C +ATOM 4930 O ARG A 329 24.894 -4.345 -2.795 1.00 29.25 O +ATOM 4931 CB ARG A 329 26.676 -6.102 -4.459 1.00 30.11 C +ATOM 4932 CG ARG A 329 27.028 -7.054 -3.295 1.00 31.58 C +ATOM 4933 CD ARG A 329 28.530 -7.319 -3.128 1.00 32.48 C +ATOM 4934 NE ARG A 329 28.805 -8.080 -1.897 1.00 36.20 N +ATOM 4935 CZ ARG A 329 29.960 -8.660 -1.517 1.00 37.53 C +ATOM 4936 NH1 ARG A 329 31.079 -8.578 -2.250 1.00 35.50 N +ATOM 4937 NH2 ARG A 329 29.991 -9.349 -0.370 1.00 37.85 N1+ +ATOM 4938 H ARG A 329 25.689 -4.196 -5.843 1.00 29.31 H +ATOM 4939 HA ARG A 329 24.692 -6.783 -4.941 1.00 29.30 H +ATOM 4940 HB3 ARG A 329 27.182 -5.151 -4.296 1.00 30.11 H +ATOM 4941 HB2 ARG A 329 27.075 -6.500 -5.392 1.00 30.11 H +ATOM 4942 HG3 ARG A 329 26.549 -8.003 -3.543 1.00 31.58 H +ATOM 4943 HG2 ARG A 329 26.599 -6.744 -2.344 1.00 31.58 H +ATOM 4944 HD3 ARG A 329 29.129 -6.411 -3.215 1.00 32.48 H +ATOM 4945 HD2 ARG A 329 28.828 -7.985 -3.937 1.00 32.48 H +ATOM 4946 HE ARG A 329 28.011 -8.160 -1.272 1.00 36.20 H +ATOM 4947 HH12 ARG A 329 31.942 -8.995 -1.935 1.00 35.50 H +ATOM 4948 HH11 ARG A 329 31.068 -8.087 -3.140 1.00 35.50 H +ATOM 4949 HH22 ARG A 329 30.850 -9.774 -0.052 1.00 37.85 H +ATOM 4950 HH21 ARG A 329 29.159 -9.437 0.200 1.00 37.85 H +ATOM 4951 N THR A 330 23.585 -6.195 -2.764 1.00 27.34 N +ATOM 4952 CA THR A 330 22.833 -5.805 -1.574 1.00 27.33 C +ATOM 4953 C THR A 330 22.998 -6.817 -0.436 1.00 28.41 C +ATOM 4954 O THR A 330 22.941 -8.026 -0.661 1.00 25.07 O +ATOM 4955 CB THR A 330 21.336 -5.609 -1.892 1.00 28.09 C +ATOM 4956 OG1 THR A 330 21.251 -4.518 -2.784 1.00 26.38 O +ATOM 4957 CG2 THR A 330 20.423 -5.299 -0.692 1.00 25.58 C +ATOM 4958 H THR A 330 23.317 -7.057 -3.217 1.00 27.34 H +ATOM 4959 HA THR A 330 23.184 -4.846 -1.209 1.00 27.33 H +ATOM 4960 HB THR A 330 20.953 -6.483 -2.414 1.00 28.09 H +ATOM 4961 HG1 THR A 330 20.321 -4.374 -2.990 1.00 26.38 H +ATOM 4962 HG21 THR A 330 19.409 -5.070 -1.018 1.00 25.58 H +ATOM 4963 HG22 THR A 330 20.346 -6.139 -0.003 1.00 25.58 H +ATOM 4964 HG23 THR A 330 20.795 -4.440 -0.132 1.00 25.58 H +ATOM 4965 N SER A 331 23.172 -6.258 0.770 1.00 29.22 N +ATOM 4966 CA SER A 331 23.208 -6.960 2.044 1.00 28.06 C +ATOM 4967 C SER A 331 22.117 -6.397 2.968 1.00 27.09 C +ATOM 4968 O SER A 331 21.711 -5.247 2.801 1.00 26.08 O +ATOM 4969 CB SER A 331 24.594 -6.766 2.691 1.00 30.03 C +ATOM 4970 OG SER A 331 25.566 -7.557 2.044 1.00 34.99 O +ATOM 4971 H SER A 331 23.211 -5.249 0.838 1.00 29.22 H +ATOM 4972 HA SER A 331 23.008 -8.013 1.876 1.00 28.06 H +ATOM 4973 HB3 SER A 331 24.578 -7.064 3.740 1.00 30.03 H +ATOM 4974 HB2 SER A 331 24.898 -5.719 2.665 1.00 30.03 H +ATOM 4975 HG SER A 331 25.398 -8.478 2.258 1.00 34.99 H +ATOM 4976 N ILE A 332 21.676 -7.210 3.940 1.00 26.63 N +ATOM 4977 CA ILE A 332 20.734 -6.799 4.982 1.00 25.76 C +ATOM 4978 C ILE A 332 21.270 -7.288 6.338 1.00 25.56 C +ATOM 4979 O ILE A 332 21.546 -8.477 6.483 1.00 25.03 O +ATOM 4980 CB ILE A 332 19.301 -7.385 4.767 1.00 25.98 C +ATOM 4981 CG1 ILE A 332 18.706 -6.971 3.397 1.00 25.58 C +ATOM 4982 CG2 ILE A 332 18.322 -7.013 5.910 1.00 24.93 C +ATOM 4983 CD1 ILE A 332 17.372 -7.647 3.060 1.00 24.29 C +ATOM 4984 H ILE A 332 22.042 -8.151 4.015 1.00 26.63 H +ATOM 4985 HA ILE A 332 20.665 -5.712 5.022 1.00 25.76 H +ATOM 4986 HB ILE A 332 19.387 -8.473 4.759 1.00 25.98 H +ATOM 4987 HG13 ILE A 332 19.402 -7.207 2.594 1.00 25.58 H +ATOM 4988 HG12 ILE A 332 18.567 -5.893 3.361 1.00 25.58 H +ATOM 4989 HG21 ILE A 332 17.328 -7.427 5.742 1.00 24.93 H +ATOM 4990 HG22 ILE A 332 18.640 -7.398 6.879 1.00 24.93 H +ATOM 4991 HG23 ILE A 332 18.217 -5.931 6.002 1.00 24.93 H +ATOM 4992 HD11 ILE A 332 17.191 -7.638 1.985 1.00 24.29 H +ATOM 4993 HD12 ILE A 332 17.363 -8.684 3.392 1.00 24.29 H +ATOM 4994 HD13 ILE A 332 16.534 -7.133 3.532 1.00 24.29 H +ATOM 4995 N ILE A 333 21.373 -6.369 7.310 1.00 23.67 N +ATOM 4996 CA ILE A 333 21.724 -6.674 8.694 1.00 22.02 C +ATOM 4997 C ILE A 333 20.440 -6.573 9.539 1.00 22.07 C +ATOM 4998 O ILE A 333 19.974 -5.473 9.831 1.00 19.54 O +ATOM 4999 CB ILE A 333 22.815 -5.724 9.275 1.00 22.12 C +ATOM 5000 CG1 ILE A 333 24.092 -5.708 8.397 1.00 19.60 C +ATOM 5001 CG2 ILE A 333 23.164 -6.116 10.732 1.00 21.06 C +ATOM 5002 CD1 ILE A 333 25.101 -4.611 8.762 1.00 20.16 C +ATOM 5003 H ILE A 333 21.156 -5.400 7.112 1.00 23.67 H +ATOM 5004 HA ILE A 333 22.112 -7.688 8.772 1.00 22.02 H +ATOM 5005 HB ILE A 333 22.423 -4.704 9.285 1.00 22.12 H +ATOM 5006 HG13 ILE A 333 23.830 -5.571 7.348 1.00 19.60 H +ATOM 5007 HG12 ILE A 333 24.590 -6.673 8.455 1.00 19.60 H +ATOM 5008 HG21 ILE A 333 24.005 -5.553 11.122 1.00 21.06 H +ATOM 5009 HG22 ILE A 333 22.333 -5.948 11.417 1.00 21.06 H +ATOM 5010 HG23 ILE A 333 23.435 -7.170 10.800 1.00 21.06 H +ATOM 5011 HD11 ILE A 333 25.798 -4.441 7.943 1.00 20.16 H +ATOM 5012 HD12 ILE A 333 24.605 -3.663 8.976 1.00 20.16 H +ATOM 5013 HD13 ILE A 333 25.694 -4.891 9.633 1.00 20.16 H +ATOM 5014 N ALA A 334 19.885 -7.739 9.893 1.00 19.22 N +ATOM 5015 CA ALA A 334 18.684 -7.884 10.708 1.00 21.48 C +ATOM 5016 C ALA A 334 19.051 -7.877 12.199 1.00 23.05 C +ATOM 5017 O ALA A 334 19.550 -8.875 12.713 1.00 22.81 O +ATOM 5018 CB ALA A 334 17.975 -9.180 10.297 1.00 20.70 C +ATOM 5019 H ALA A 334 20.340 -8.603 9.622 1.00 19.22 H +ATOM 5020 HA ALA A 334 17.999 -7.067 10.492 1.00 21.48 H +ATOM 5021 HB1 ALA A 334 17.090 -9.364 10.906 1.00 20.70 H +ATOM 5022 HB2 ALA A 334 17.653 -9.122 9.257 1.00 20.70 H +ATOM 5023 HB3 ALA A 334 18.631 -10.046 10.386 1.00 20.70 H +ATOM 5024 N THR A 335 18.818 -6.745 12.873 1.00 22.98 N +ATOM 5025 CA THR A 335 19.144 -6.551 14.283 1.00 22.61 C +ATOM 5026 C THR A 335 17.963 -6.989 15.178 1.00 23.15 C +ATOM 5027 O THR A 335 16.813 -6.705 14.845 1.00 20.17 O +ATOM 5028 CB THR A 335 19.513 -5.071 14.550 1.00 24.16 C +ATOM 5029 OG1 THR A 335 18.447 -4.191 14.261 1.00 25.56 O +ATOM 5030 CG2 THR A 335 20.736 -4.617 13.739 1.00 21.73 C +ATOM 5031 H THR A 335 18.379 -5.959 12.407 1.00 22.98 H +ATOM 5032 HA THR A 335 20.018 -7.151 14.513 1.00 22.61 H +ATOM 5033 HB THR A 335 19.746 -4.953 15.609 1.00 24.16 H +ATOM 5034 HG1 THR A 335 17.770 -4.296 14.940 1.00 25.56 H +ATOM 5035 HG21 THR A 335 21.008 -3.591 13.976 1.00 21.73 H +ATOM 5036 HG22 THR A 335 21.604 -5.240 13.954 1.00 21.73 H +ATOM 5037 HG23 THR A 335 20.550 -4.660 12.666 1.00 21.73 H +ATOM 5038 N ILE A 336 18.265 -7.699 16.280 1.00 21.79 N +ATOM 5039 CA ILE A 336 17.268 -8.275 17.194 1.00 23.08 C +ATOM 5040 C ILE A 336 17.679 -8.119 18.672 1.00 23.78 C +ATOM 5041 O ILE A 336 18.863 -7.976 18.979 1.00 23.15 O +ATOM 5042 CB ILE A 336 17.006 -9.791 16.908 1.00 23.04 C +ATOM 5043 CG1 ILE A 336 18.258 -10.693 17.057 1.00 23.18 C +ATOM 5044 CG2 ILE A 336 16.309 -9.996 15.549 1.00 22.42 C +ATOM 5045 CD1 ILE A 336 17.981 -12.195 16.922 1.00 22.53 C +ATOM 5046 H ILE A 336 19.233 -7.901 16.497 1.00 21.79 H +ATOM 5047 HA ILE A 336 16.329 -7.733 17.086 1.00 23.08 H +ATOM 5048 HB ILE A 336 16.289 -10.135 17.656 1.00 23.04 H +ATOM 5049 HG13 ILE A 336 18.712 -10.544 18.034 1.00 23.18 H +ATOM 5050 HG12 ILE A 336 19.011 -10.404 16.323 1.00 23.18 H +ATOM 5051 HG21 ILE A 336 15.961 -11.021 15.422 1.00 22.42 H +ATOM 5052 HG22 ILE A 336 15.432 -9.356 15.458 1.00 22.42 H +ATOM 5053 HG23 ILE A 336 16.976 -9.770 14.716 1.00 22.42 H +ATOM 5054 HD11 ILE A 336 18.867 -12.770 17.186 1.00 22.53 H +ATOM 5055 HD12 ILE A 336 17.172 -12.513 17.580 1.00 22.53 H +ATOM 5056 HD13 ILE A 336 17.714 -12.465 15.900 1.00 22.53 H +ATOM 5057 N SER A 337 16.668 -8.167 19.555 1.00 25.88 N +ATOM 5058 CA SER A 337 16.814 -8.197 21.010 1.00 27.99 C +ATOM 5059 C SER A 337 16.876 -9.661 21.508 1.00 28.21 C +ATOM 5060 O SER A 337 16.176 -10.506 20.948 1.00 24.65 O +ATOM 5061 CB SER A 337 15.593 -7.484 21.625 1.00 29.04 C +ATOM 5062 OG SER A 337 15.634 -7.507 23.039 1.00 32.61 O +ATOM 5063 H SER A 337 15.721 -8.266 19.211 1.00 25.88 H +ATOM 5064 HA SER A 337 17.712 -7.637 21.272 1.00 27.99 H +ATOM 5065 HB3 SER A 337 14.664 -7.951 21.296 1.00 29.04 H +ATOM 5066 HB2 SER A 337 15.554 -6.443 21.309 1.00 29.04 H +ATOM 5067 HG SER A 337 14.790 -7.178 23.372 1.00 32.61 H +ATOM 5068 N PRO A 338 17.658 -9.931 22.578 1.00 30.07 N +ATOM 5069 CA PRO A 338 17.649 -11.235 23.264 1.00 31.62 C +ATOM 5070 C PRO A 338 16.479 -11.459 24.246 1.00 32.46 C +ATOM 5071 O PRO A 338 16.252 -12.608 24.622 1.00 33.11 O +ATOM 5072 CB PRO A 338 18.993 -11.243 24.008 1.00 30.65 C +ATOM 5073 CG PRO A 338 19.242 -9.783 24.348 1.00 32.34 C +ATOM 5074 CD PRO A 338 18.653 -9.031 23.162 1.00 30.98 C +ATOM 5075 HA PRO A 338 17.639 -12.047 22.539 1.00 31.62 H +ATOM 5076 HB3 PRO A 338 19.779 -11.612 23.350 1.00 30.65 H +ATOM 5077 HB2 PRO A 338 19.001 -11.869 24.901 1.00 30.65 H +ATOM 5078 HG3 PRO A 338 20.290 -9.549 24.539 1.00 32.34 H +ATOM 5079 HG2 PRO A 338 18.678 -9.521 25.242 1.00 32.34 H +ATOM 5080 HD2 PRO A 338 18.230 -8.078 23.479 1.00 30.98 H +ATOM 5081 HD3 PRO A 338 19.414 -8.834 22.409 1.00 30.98 H +ATOM 5082 N ALA A 339 15.796 -10.384 24.679 1.00 30.89 N +ATOM 5083 CA ALA A 339 14.817 -10.410 25.770 1.00 29.88 C +ATOM 5084 C ALA A 339 13.478 -11.059 25.385 1.00 31.52 C +ATOM 5085 O ALA A 339 12.995 -10.862 24.270 1.00 27.09 O +ATOM 5086 CB ALA A 339 14.592 -8.976 26.268 1.00 31.10 C +ATOM 5087 H ALA A 339 16.020 -9.470 24.309 1.00 30.89 H +ATOM 5088 HA ALA A 339 15.253 -10.985 26.590 1.00 29.88 H +ATOM 5089 HB1 ALA A 339 13.924 -8.954 27.129 1.00 31.10 H +ATOM 5090 HB2 ALA A 339 15.531 -8.512 26.572 1.00 31.10 H +ATOM 5091 HB3 ALA A 339 14.154 -8.349 25.494 1.00 31.10 H +ATOM 5092 N SER A 340 12.893 -11.791 26.348 1.00 31.98 N +ATOM 5093 CA SER A 340 11.622 -12.516 26.238 1.00 34.26 C +ATOM 5094 C SER A 340 10.394 -11.650 25.894 1.00 34.39 C +ATOM 5095 O SER A 340 9.469 -12.153 25.256 1.00 35.26 O +ATOM 5096 CB SER A 340 11.413 -13.321 27.535 1.00 34.41 C +ATOM 5097 OG SER A 340 11.082 -12.502 28.641 1.00 35.04 O +ATOM 5098 H SER A 340 13.360 -11.883 27.239 1.00 31.98 H +ATOM 5099 HA SER A 340 11.743 -13.233 25.427 1.00 34.26 H +ATOM 5100 HB3 SER A 340 12.316 -13.879 27.777 1.00 34.41 H +ATOM 5101 HB2 SER A 340 10.617 -14.054 27.398 1.00 34.41 H +ATOM 5102 HG SER A 340 10.189 -12.168 28.521 1.00 35.04 H +ATOM 5103 N LEU A 341 10.421 -10.371 26.305 1.00 35.73 N +ATOM 5104 CA LEU A 341 9.390 -9.361 26.045 1.00 37.29 C +ATOM 5105 C LEU A 341 9.254 -8.984 24.558 1.00 36.72 C +ATOM 5106 O LEU A 341 8.204 -8.476 24.163 1.00 36.23 O +ATOM 5107 CB LEU A 341 9.729 -8.094 26.862 1.00 41.08 C +ATOM 5108 CG LEU A 341 9.662 -8.271 28.396 1.00 46.36 C +ATOM 5109 CD1 LEU A 341 10.236 -7.035 29.119 1.00 46.09 C +ATOM 5110 CD2 LEU A 341 8.241 -8.625 28.883 1.00 46.76 C +ATOM 5111 H LEU A 341 11.225 -10.048 26.824 1.00 35.73 H +ATOM 5112 HA LEU A 341 8.429 -9.764 26.365 1.00 37.29 H +ATOM 5113 HB3 LEU A 341 9.056 -7.281 26.583 1.00 41.08 H +ATOM 5114 HB2 LEU A 341 10.728 -7.758 26.579 1.00 41.08 H +ATOM 5115 HG LEU A 341 10.314 -9.105 28.661 1.00 46.36 H +ATOM 5116 HD11 LEU A 341 10.936 -7.335 29.901 1.00 46.09 H +ATOM 5117 HD12 LEU A 341 10.780 -6.377 28.440 1.00 46.09 H +ATOM 5118 HD13 LEU A 341 9.462 -6.429 29.590 1.00 46.09 H +ATOM 5119 HD21 LEU A 341 7.937 -8.041 29.752 1.00 46.76 H +ATOM 5120 HD22 LEU A 341 7.490 -8.459 28.110 1.00 46.76 H +ATOM 5121 HD23 LEU A 341 8.185 -9.675 29.171 1.00 46.76 H +ATOM 5122 N ASN A 342 10.316 -9.227 23.776 1.00 33.70 N +ATOM 5123 CA ASN A 342 10.427 -8.851 22.369 1.00 33.45 C +ATOM 5124 C ASN A 342 10.262 -10.054 21.427 1.00 33.28 C +ATOM 5125 O ASN A 342 10.554 -9.897 20.245 1.00 31.23 O +ATOM 5126 CB ASN A 342 11.779 -8.136 22.130 1.00 34.11 C +ATOM 5127 CG ASN A 342 12.017 -6.929 23.046 1.00 35.86 C +ATOM 5128 OD1 ASN A 342 12.997 -6.893 23.782 1.00 37.36 O +ATOM 5129 ND2 ASN A 342 11.125 -5.939 23.021 1.00 39.01 N +ATOM 5130 H ASN A 342 11.134 -9.666 24.178 1.00 33.70 H +ATOM 5131 HA ASN A 342 9.627 -8.170 22.080 1.00 33.45 H +ATOM 5132 HB3 ASN A 342 11.852 -7.793 21.099 1.00 34.11 H +ATOM 5133 HB2 ASN A 342 12.598 -8.843 22.271 1.00 34.11 H +ATOM 5134 HD22 ASN A 342 11.256 -5.129 23.609 1.00 39.01 H +ATOM 5135 HD21 ASN A 342 10.298 -6.000 22.443 1.00 39.01 H +ATOM 5136 N LEU A 343 9.791 -11.209 21.939 1.00 32.73 N +ATOM 5137 CA LEU A 343 9.600 -12.474 21.216 1.00 31.59 C +ATOM 5138 C LEU A 343 8.869 -12.338 19.870 1.00 31.46 C +ATOM 5139 O LEU A 343 9.404 -12.795 18.863 1.00 31.83 O +ATOM 5140 CB LEU A 343 8.906 -13.497 22.150 1.00 31.98 C +ATOM 5141 CG LEU A 343 8.491 -14.860 21.533 1.00 32.11 C +ATOM 5142 CD1 LEU A 343 9.664 -15.621 20.892 1.00 31.95 C +ATOM 5143 CD2 LEU A 343 7.759 -15.739 22.565 1.00 37.07 C +ATOM 5144 H LEU A 343 9.558 -11.238 22.922 1.00 32.73 H +ATOM 5145 HA LEU A 343 10.604 -12.840 20.998 1.00 31.59 H +ATOM 5146 HB3 LEU A 343 8.012 -13.029 22.565 1.00 31.98 H +ATOM 5147 HB2 LEU A 343 9.557 -13.686 23.004 1.00 31.98 H +ATOM 5148 HG LEU A 343 7.767 -14.660 20.743 1.00 32.11 H +ATOM 5149 HD11 LEU A 343 9.305 -16.462 20.300 1.00 31.95 H +ATOM 5150 HD12 LEU A 343 10.257 -14.991 20.231 1.00 31.95 H +ATOM 5151 HD13 LEU A 343 10.335 -16.021 21.647 1.00 31.95 H +ATOM 5152 HD21 LEU A 343 6.801 -16.084 22.174 1.00 37.07 H +ATOM 5153 HD22 LEU A 343 8.337 -16.621 22.838 1.00 37.07 H +ATOM 5154 HD23 LEU A 343 7.554 -15.199 23.490 1.00 37.07 H +ATOM 5155 N GLU A 344 7.684 -11.703 19.875 1.00 32.34 N +ATOM 5156 CA GLU A 344 6.853 -11.503 18.686 1.00 30.85 C +ATOM 5157 C GLU A 344 7.560 -10.700 17.578 1.00 28.00 C +ATOM 5158 O GLU A 344 7.491 -11.098 16.416 1.00 28.52 O +ATOM 5159 CB GLU A 344 5.503 -10.883 19.105 1.00 33.98 C +ATOM 5160 CG GLU A 344 4.516 -10.626 17.938 1.00 42.77 C +ATOM 5161 CD GLU A 344 3.134 -10.090 18.346 1.00 47.25 C +ATOM 5162 OE1 GLU A 344 2.268 -10.053 17.443 1.00 48.91 O +ATOM 5163 OE2 GLU A 344 2.947 -9.717 19.527 1.00 49.27 O1- +ATOM 5164 H GLU A 344 7.318 -11.337 20.745 1.00 32.34 H +ATOM 5165 HA GLU A 344 6.644 -12.494 18.278 1.00 30.85 H +ATOM 5166 HB3 GLU A 344 5.691 -9.947 19.635 1.00 33.98 H +ATOM 5167 HB2 GLU A 344 5.029 -11.549 19.828 1.00 33.98 H +ATOM 5168 HG3 GLU A 344 4.377 -11.553 17.380 1.00 42.77 H +ATOM 5169 HG2 GLU A 344 4.942 -9.905 17.239 1.00 42.77 H +ATOM 5170 N GLU A 345 8.252 -9.617 17.970 1.00 25.97 N +ATOM 5171 CA GLU A 345 8.998 -8.749 17.059 1.00 27.03 C +ATOM 5172 C GLU A 345 10.326 -9.344 16.580 1.00 26.23 C +ATOM 5173 O GLU A 345 10.704 -9.108 15.435 1.00 23.96 O +ATOM 5174 CB GLU A 345 9.219 -7.366 17.704 1.00 27.74 C +ATOM 5175 CG GLU A 345 7.931 -6.605 18.094 1.00 31.24 C +ATOM 5176 CD GLU A 345 6.999 -6.187 16.946 1.00 33.29 C +ATOM 5177 OE1 GLU A 345 5.950 -5.599 17.283 1.00 35.69 O +ATOM 5178 OE2 GLU A 345 7.323 -6.421 15.760 1.00 35.01 O1- +ATOM 5179 H GLU A 345 8.278 -9.368 18.948 1.00 25.97 H +ATOM 5180 HA GLU A 345 8.395 -8.643 16.161 1.00 27.03 H +ATOM 5181 HB3 GLU A 345 9.821 -6.740 17.043 1.00 27.74 H +ATOM 5182 HB2 GLU A 345 9.818 -7.495 18.606 1.00 27.74 H +ATOM 5183 HG3 GLU A 345 8.213 -5.696 18.624 1.00 31.24 H +ATOM 5184 HG2 GLU A 345 7.357 -7.196 18.809 1.00 31.24 H +ATOM 5185 N THR A 346 10.992 -10.133 17.435 1.00 25.10 N +ATOM 5186 CA THR A 346 12.191 -10.889 17.085 1.00 25.31 C +ATOM 5187 C THR A 346 11.876 -11.987 16.053 1.00 26.27 C +ATOM 5188 O THR A 346 12.596 -12.070 15.064 1.00 25.60 O +ATOM 5189 CB THR A 346 12.841 -11.524 18.339 1.00 24.58 C +ATOM 5190 OG1 THR A 346 13.329 -10.480 19.153 1.00 20.56 O +ATOM 5191 CG2 THR A 346 14.004 -12.499 18.087 1.00 23.70 C +ATOM 5192 H THR A 346 10.649 -10.254 18.380 1.00 25.10 H +ATOM 5193 HA THR A 346 12.908 -10.197 16.635 1.00 25.31 H +ATOM 5194 HB THR A 346 12.079 -12.047 18.920 1.00 24.58 H +ATOM 5195 HG1 THR A 346 13.567 -10.859 20.008 1.00 20.56 H +ATOM 5196 HG21 THR A 346 14.502 -12.770 19.018 1.00 23.70 H +ATOM 5197 HG22 THR A 346 13.653 -13.426 17.636 1.00 23.70 H +ATOM 5198 HG23 THR A 346 14.751 -12.062 17.424 1.00 23.70 H +ATOM 5199 N LEU A 347 10.775 -12.739 16.246 1.00 25.55 N +ATOM 5200 CA LEU A 347 10.278 -13.718 15.274 1.00 27.06 C +ATOM 5201 C LEU A 347 9.847 -13.071 13.949 1.00 26.24 C +ATOM 5202 O LEU A 347 10.187 -13.618 12.903 1.00 22.77 O +ATOM 5203 CB LEU A 347 9.115 -14.548 15.862 1.00 29.01 C +ATOM 5204 CG LEU A 347 9.513 -15.536 16.978 1.00 31.73 C +ATOM 5205 CD1 LEU A 347 8.254 -16.211 17.562 1.00 34.42 C +ATOM 5206 CD2 LEU A 347 10.555 -16.569 16.505 1.00 33.31 C +ATOM 5207 H LEU A 347 10.216 -12.610 17.080 1.00 25.55 H +ATOM 5208 HA LEU A 347 11.105 -14.390 15.037 1.00 27.06 H +ATOM 5209 HB3 LEU A 347 8.641 -15.118 15.061 1.00 29.01 H +ATOM 5210 HB2 LEU A 347 8.347 -13.869 16.237 1.00 29.01 H +ATOM 5211 HG LEU A 347 9.984 -14.983 17.788 1.00 31.73 H +ATOM 5212 HD11 LEU A 347 8.416 -17.258 17.818 1.00 34.42 H +ATOM 5213 HD12 LEU A 347 7.937 -15.701 18.471 1.00 34.42 H +ATOM 5214 HD13 LEU A 347 7.414 -16.175 16.868 1.00 34.42 H +ATOM 5215 HD21 LEU A 347 10.474 -17.520 17.030 1.00 33.31 H +ATOM 5216 HD22 LEU A 347 10.464 -16.771 15.438 1.00 33.31 H +ATOM 5217 HD23 LEU A 347 11.566 -16.202 16.679 1.00 33.31 H +ATOM 5218 N SER A 348 9.157 -11.916 14.006 1.00 25.08 N +ATOM 5219 CA SER A 348 8.751 -11.138 12.831 1.00 25.81 C +ATOM 5220 C SER A 348 9.954 -10.669 11.989 1.00 25.76 C +ATOM 5221 O SER A 348 9.922 -10.822 10.769 1.00 26.65 O +ATOM 5222 CB SER A 348 7.854 -9.959 13.265 1.00 27.51 C +ATOM 5223 OG SER A 348 7.412 -9.202 12.155 1.00 31.87 O +ATOM 5224 H SER A 348 8.897 -11.532 14.906 1.00 25.08 H +ATOM 5225 HA SER A 348 8.151 -11.798 12.202 1.00 25.81 H +ATOM 5226 HB3 SER A 348 8.387 -9.297 13.946 1.00 27.51 H +ATOM 5227 HB2 SER A 348 6.977 -10.326 13.799 1.00 27.51 H +ATOM 5228 HG SER A 348 6.989 -8.396 12.475 1.00 31.87 H +ATOM 5229 N THR A 349 11.003 -10.163 12.660 1.00 24.55 N +ATOM 5230 CA THR A 349 12.247 -9.724 12.031 1.00 23.43 C +ATOM 5231 C THR A 349 13.052 -10.879 11.410 1.00 24.65 C +ATOM 5232 O THR A 349 13.573 -10.697 10.312 1.00 23.30 O +ATOM 5233 CB THR A 349 13.139 -8.939 13.030 1.00 24.23 C +ATOM 5234 OG1 THR A 349 12.512 -7.695 13.268 1.00 21.82 O +ATOM 5235 CG2 THR A 349 14.592 -8.659 12.595 1.00 22.09 C +ATOM 5236 H THR A 349 10.949 -10.059 13.665 1.00 24.55 H +ATOM 5237 HA THR A 349 11.964 -9.061 11.215 1.00 23.43 H +ATOM 5238 HB THR A 349 13.169 -9.469 13.983 1.00 24.23 H +ATOM 5239 HG1 THR A 349 11.669 -7.850 13.708 1.00 21.82 H +ATOM 5240 HG21 THR A 349 15.081 -7.968 13.280 1.00 22.09 H +ATOM 5241 HG22 THR A 349 15.195 -9.568 12.582 1.00 22.09 H +ATOM 5242 HG23 THR A 349 14.630 -8.216 11.601 1.00 22.09 H +ATOM 5243 N LEU A 350 13.109 -12.041 12.084 1.00 25.56 N +ATOM 5244 CA LEU A 350 13.788 -13.237 11.584 1.00 27.20 C +ATOM 5245 C LEU A 350 13.072 -13.869 10.381 1.00 27.84 C +ATOM 5246 O LEU A 350 13.756 -14.253 9.437 1.00 27.94 O +ATOM 5247 CB LEU A 350 13.974 -14.263 12.718 1.00 26.67 C +ATOM 5248 CG LEU A 350 14.993 -13.826 13.793 1.00 28.29 C +ATOM 5249 CD1 LEU A 350 14.977 -14.792 14.987 1.00 28.78 C +ATOM 5250 CD2 LEU A 350 16.412 -13.625 13.243 1.00 27.19 C +ATOM 5251 H LEU A 350 12.660 -12.122 12.987 1.00 25.56 H +ATOM 5252 HA LEU A 350 14.774 -12.932 11.228 1.00 27.20 H +ATOM 5253 HB3 LEU A 350 14.302 -15.218 12.304 1.00 26.67 H +ATOM 5254 HB2 LEU A 350 13.004 -14.458 13.180 1.00 26.67 H +ATOM 5255 HG LEU A 350 14.691 -12.855 14.175 1.00 28.29 H +ATOM 5256 HD11 LEU A 350 15.048 -14.239 15.922 1.00 28.78 H +ATOM 5257 HD12 LEU A 350 14.062 -15.384 15.020 1.00 28.78 H +ATOM 5258 HD13 LEU A 350 15.810 -15.494 14.961 1.00 28.78 H +ATOM 5259 HD21 LEU A 350 17.171 -13.922 13.964 1.00 27.19 H +ATOM 5260 HD22 LEU A 350 16.574 -14.193 12.328 1.00 27.19 H +ATOM 5261 HD23 LEU A 350 16.593 -12.574 13.014 1.00 27.19 H +ATOM 5262 N GLU A 351 11.729 -13.918 10.405 1.00 29.78 N +ATOM 5263 CA GLU A 351 10.897 -14.351 9.279 1.00 31.65 C +ATOM 5264 C GLU A 351 11.052 -13.447 8.047 1.00 31.57 C +ATOM 5265 O GLU A 351 11.253 -13.967 6.952 1.00 32.81 O +ATOM 5266 CB GLU A 351 9.415 -14.442 9.706 1.00 34.82 C +ATOM 5267 CG GLU A 351 9.089 -15.628 10.644 1.00 41.40 C +ATOM 5268 CD GLU A 351 9.012 -17.019 9.990 1.00 44.64 C +ATOM 5269 OE1 GLU A 351 8.808 -17.977 10.768 1.00 46.61 O +ATOM 5270 OE2 GLU A 351 9.166 -17.130 8.752 1.00 43.42 O1- +ATOM 5271 H GLU A 351 11.231 -13.603 11.229 1.00 29.78 H +ATOM 5272 HA GLU A 351 11.241 -15.345 8.987 1.00 31.65 H +ATOM 5273 HB3 GLU A 351 8.760 -14.465 8.833 1.00 34.82 H +ATOM 5274 HB2 GLU A 351 9.146 -13.523 10.228 1.00 34.82 H +ATOM 5275 HG3 GLU A 351 8.128 -15.437 11.124 1.00 41.40 H +ATOM 5276 HG2 GLU A 351 9.823 -15.674 11.447 1.00 41.40 H +ATOM 5277 N TYR A 352 11.003 -12.121 8.257 1.00 31.02 N +ATOM 5278 CA TYR A 352 11.183 -11.096 7.226 1.00 29.54 C +ATOM 5279 C TYR A 352 12.561 -11.175 6.549 1.00 30.19 C +ATOM 5280 O TYR A 352 12.638 -11.172 5.320 1.00 29.15 O +ATOM 5281 CB TYR A 352 10.941 -9.712 7.861 1.00 31.28 C +ATOM 5282 CG TYR A 352 10.909 -8.538 6.899 1.00 31.74 C +ATOM 5283 CD1 TYR A 352 12.105 -7.957 6.423 1.00 32.52 C +ATOM 5284 CD2 TYR A 352 9.666 -7.997 6.508 1.00 34.47 C +ATOM 5285 CE1 TYR A 352 12.057 -6.833 5.578 1.00 34.85 C +ATOM 5286 CE2 TYR A 352 9.619 -6.861 5.679 1.00 34.55 C +ATOM 5287 CZ TYR A 352 10.814 -6.273 5.225 1.00 34.94 C +ATOM 5288 OH TYR A 352 10.764 -5.148 4.458 1.00 38.19 O +ATOM 5289 H TYR A 352 10.828 -11.777 9.193 1.00 31.02 H +ATOM 5290 HA TYR A 352 10.422 -11.259 6.461 1.00 29.54 H +ATOM 5291 HB3 TYR A 352 11.686 -9.508 8.630 1.00 31.28 H +ATOM 5292 HB2 TYR A 352 9.983 -9.726 8.383 1.00 31.28 H +ATOM 5293 HD1 TYR A 352 13.063 -8.353 6.724 1.00 32.52 H +ATOM 5294 HD2 TYR A 352 8.745 -8.431 6.867 1.00 34.47 H +ATOM 5295 HE1 TYR A 352 12.977 -6.384 5.232 1.00 34.85 H +ATOM 5296 HE2 TYR A 352 8.666 -6.434 5.408 1.00 34.55 H +ATOM 5297 HH TYR A 352 11.632 -4.825 4.208 1.00 38.19 H +ATOM 5298 N ALA A 353 13.613 -11.259 7.380 1.00 27.84 N +ATOM 5299 CA ALA A 353 15.006 -11.392 6.971 1.00 29.40 C +ATOM 5300 C ALA A 353 15.267 -12.694 6.196 1.00 30.72 C +ATOM 5301 O ALA A 353 15.927 -12.648 5.161 1.00 30.09 O +ATOM 5302 CB ALA A 353 15.882 -11.289 8.228 1.00 27.70 C +ATOM 5303 H ALA A 353 13.452 -11.242 8.379 1.00 27.84 H +ATOM 5304 HA ALA A 353 15.244 -10.552 6.315 1.00 29.40 H +ATOM 5305 HB1 ALA A 353 16.944 -11.308 7.999 1.00 27.70 H +ATOM 5306 HB2 ALA A 353 15.690 -10.351 8.749 1.00 27.70 H +ATOM 5307 HB3 ALA A 353 15.681 -12.101 8.928 1.00 27.70 H +ATOM 5308 N HIS A 354 14.709 -13.816 6.684 1.00 33.52 N +ATOM 5309 CA HIS A 354 14.829 -15.146 6.081 1.00 36.23 C +ATOM 5310 C HIS A 354 14.273 -15.219 4.648 1.00 36.11 C +ATOM 5311 O HIS A 354 14.891 -15.860 3.800 1.00 35.43 O +ATOM 5312 CB HIS A 354 14.171 -16.190 7.008 1.00 39.61 C +ATOM 5313 CG HIS A 354 14.169 -17.595 6.464 1.00 43.40 C +ATOM 5314 ND1 HIS A 354 13.043 -18.192 5.920 1.00 45.98 N +ATOM 5315 CD2 HIS A 354 15.174 -18.530 6.362 1.00 45.87 C +ATOM 5316 CE1 HIS A 354 13.408 -19.407 5.506 1.00 46.42 C +ATOM 5317 NE2 HIS A 354 14.687 -19.680 5.739 1.00 47.89 N +ATOM 5318 H HIS A 354 14.176 -13.770 7.543 1.00 33.52 H +ATOM 5319 HA HIS A 354 15.893 -15.380 6.021 1.00 36.23 H +ATOM 5320 HB3 HIS A 354 13.144 -15.904 7.235 1.00 39.61 H +ATOM 5321 HB2 HIS A 354 14.701 -16.216 7.961 1.00 39.61 H +ATOM 5322 HD1 HIS A 354 12.122 -17.784 5.848 1.00 45.98 H +ATOM 5323 HD2 HIS A 354 16.207 -18.456 6.670 1.00 45.87 H +ATOM 5324 HE1 HIS A 354 12.730 -20.102 5.032 1.00 46.42 H +ATOM 5325 N ARG A 355 13.143 -14.537 4.402 1.00 36.76 N +ATOM 5326 CA ARG A 355 12.517 -14.414 3.086 1.00 38.68 C +ATOM 5327 C ARG A 355 13.401 -13.656 2.087 1.00 37.05 C +ATOM 5328 O ARG A 355 13.551 -14.125 0.961 1.00 37.00 O +ATOM 5329 CB ARG A 355 11.158 -13.712 3.231 1.00 42.28 C +ATOM 5330 CG ARG A 355 10.110 -14.551 3.984 1.00 47.63 C +ATOM 5331 CD ARG A 355 8.919 -13.729 4.514 1.00 52.45 C +ATOM 5332 NE ARG A 355 8.232 -12.974 3.451 1.00 57.27 N +ATOM 5333 CZ ARG A 355 7.507 -13.472 2.432 1.00 59.95 C +ATOM 5334 NH1 ARG A 355 7.277 -14.783 2.267 1.00 61.16 N +ATOM 5335 NH2 ARG A 355 6.986 -12.630 1.539 1.00 59.95 N1+ +ATOM 5336 H ARG A 355 12.695 -14.036 5.158 1.00 36.76 H +ATOM 5337 HA ARG A 355 12.352 -15.418 2.688 1.00 38.68 H +ATOM 5338 HB3 ARG A 355 10.762 -13.487 2.239 1.00 42.28 H +ATOM 5339 HB2 ARG A 355 11.291 -12.749 3.725 1.00 42.28 H +ATOM 5340 HG3 ARG A 355 10.586 -15.024 4.839 1.00 47.63 H +ATOM 5341 HG2 ARG A 355 9.776 -15.392 3.378 1.00 47.63 H +ATOM 5342 HD3 ARG A 355 9.230 -13.064 5.319 1.00 52.45 H +ATOM 5343 HD2 ARG A 355 8.187 -14.406 4.955 1.00 52.45 H +ATOM 5344 HE ARG A 355 8.369 -11.974 3.483 1.00 57.27 H +ATOM 5345 HH12 ARG A 355 6.718 -15.114 1.494 1.00 61.16 H +ATOM 5346 HH11 ARG A 355 7.646 -15.447 2.932 1.00 61.16 H +ATOM 5347 HH22 ARG A 355 6.427 -12.984 0.775 1.00 59.95 H +ATOM 5348 HH21 ARG A 355 7.088 -11.629 1.640 1.00 59.95 H +ATOM 5349 N ALA A 356 13.994 -12.531 2.528 1.00 35.18 N +ATOM 5350 CA ALA A 356 14.840 -11.652 1.719 1.00 33.47 C +ATOM 5351 C ALA A 356 16.122 -12.299 1.155 1.00 34.33 C +ATOM 5352 O ALA A 356 16.671 -11.759 0.196 1.00 32.89 O +ATOM 5353 CB ALA A 356 15.169 -10.392 2.530 1.00 31.30 C +ATOM 5354 H ALA A 356 13.837 -12.235 3.482 1.00 35.18 H +ATOM 5355 HA ALA A 356 14.239 -11.344 0.861 1.00 33.47 H +ATOM 5356 HB1 ALA A 356 15.697 -9.665 1.913 1.00 31.30 H +ATOM 5357 HB2 ALA A 356 14.260 -9.909 2.892 1.00 31.30 H +ATOM 5358 HB3 ALA A 356 15.793 -10.619 3.394 1.00 31.30 H +ATOM 5359 N LYS A 357 16.542 -13.454 1.707 1.00 34.54 N +ATOM 5360 CA LYS A 357 17.620 -14.300 1.182 1.00 38.30 C +ATOM 5361 C LYS A 357 17.369 -14.808 -0.252 1.00 40.22 C +ATOM 5362 O LYS A 357 18.329 -14.975 -1.002 1.00 40.04 O +ATOM 5363 CB LYS A 357 17.807 -15.533 2.085 1.00 38.47 C +ATOM 5364 CG LYS A 357 18.277 -15.247 3.521 1.00 39.23 C +ATOM 5365 CD LYS A 357 18.350 -16.526 4.374 1.00 41.33 C +ATOM 5366 CE LYS A 357 19.476 -17.487 3.943 1.00 42.15 C +ATOM 5367 NZ LYS A 357 19.315 -18.824 4.536 1.00 41.28 N1+ +ATOM 5368 H LYS A 357 16.036 -13.828 2.497 1.00 34.54 H +ATOM 5369 HA LYS A 357 18.540 -13.714 1.182 1.00 38.30 H +ATOM 5370 HB3 LYS A 357 18.539 -16.183 1.606 1.00 38.47 H +ATOM 5371 HB2 LYS A 357 16.878 -16.104 2.112 1.00 38.47 H +ATOM 5372 HG3 LYS A 357 17.600 -14.541 4.001 1.00 39.23 H +ATOM 5373 HG2 LYS A 357 19.256 -14.769 3.492 1.00 39.23 H +ATOM 5374 HD3 LYS A 357 17.383 -17.032 4.329 1.00 41.33 H +ATOM 5375 HD2 LYS A 357 18.487 -16.248 5.420 1.00 41.33 H +ATOM 5376 HE3 LYS A 357 20.448 -17.078 4.222 1.00 42.15 H +ATOM 5377 HE2 LYS A 357 19.495 -17.633 2.866 1.00 42.15 H +ATOM 5378 HZ1 LYS A 357 18.442 -19.226 4.225 1.00 41.28 H +ATOM 5379 HZ2 LYS A 357 20.081 -19.417 4.251 1.00 41.28 H +ATOM 5380 HZ3 LYS A 357 19.302 -18.745 5.545 1.00 41.28 H +ATOM 5381 N ASN A 358 16.092 -15.061 -0.589 1.00 41.32 N +ATOM 5382 CA ASN A 358 15.650 -15.622 -1.871 1.00 42.57 C +ATOM 5383 C ASN A 358 15.533 -14.572 -2.994 1.00 43.12 C +ATOM 5384 O ASN A 358 15.154 -14.949 -4.103 1.00 44.49 O +ATOM 5385 CB ASN A 358 14.309 -16.374 -1.669 1.00 45.39 C +ATOM 5386 CG ASN A 358 14.402 -17.633 -0.795 1.00 48.23 C +ATOM 5387 OD1 ASN A 358 15.486 -18.106 -0.459 1.00 51.21 O +ATOM 5388 ND2 ASN A 358 13.247 -18.198 -0.441 1.00 48.45 N +ATOM 5389 H ASN A 358 15.361 -14.884 0.088 1.00 41.32 H +ATOM 5390 HA ASN A 358 16.405 -16.345 -2.187 1.00 42.57 H +ATOM 5391 HB3 ASN A 358 13.921 -16.708 -2.632 1.00 45.39 H +ATOM 5392 HB2 ASN A 358 13.557 -15.703 -1.253 1.00 45.39 H +ATOM 5393 HD22 ASN A 358 13.249 -19.033 0.126 1.00 48.45 H +ATOM 5394 HD21 ASN A 358 12.367 -17.799 -0.735 1.00 48.45 H +ATOM 5395 N ILE A 359 15.870 -13.298 -2.724 1.00 41.07 N +ATOM 5396 CA ILE A 359 15.922 -12.247 -3.742 1.00 40.73 C +ATOM 5397 C ILE A 359 17.249 -12.346 -4.515 1.00 41.82 C +ATOM 5398 O ILE A 359 18.304 -12.456 -3.893 1.00 42.57 O +ATOM 5399 CB ILE A 359 15.808 -10.820 -3.132 1.00 40.12 C +ATOM 5400 CG1 ILE A 359 14.491 -10.680 -2.342 1.00 40.44 C +ATOM 5401 CG2 ILE A 359 15.912 -9.700 -4.197 1.00 39.64 C +ATOM 5402 CD1 ILE A 359 14.395 -9.422 -1.478 1.00 41.20 C +ATOM 5403 H ILE A 359 16.188 -13.046 -1.799 1.00 41.07 H +ATOM 5404 HA ILE A 359 15.089 -12.384 -4.434 1.00 40.73 H +ATOM 5405 HB ILE A 359 16.629 -10.691 -2.426 1.00 40.12 H +ATOM 5406 HG13 ILE A 359 14.369 -11.526 -1.668 1.00 40.44 H +ATOM 5407 HG12 ILE A 359 13.644 -10.718 -3.026 1.00 40.44 H +ATOM 5408 HG21 ILE A 359 15.784 -8.708 -3.769 1.00 39.64 H +ATOM 5409 HG22 ILE A 359 16.881 -9.688 -4.691 1.00 39.64 H +ATOM 5410 HG23 ILE A 359 15.152 -9.819 -4.970 1.00 39.64 H +ATOM 5411 HD11 ILE A 359 13.471 -9.461 -0.913 1.00 41.20 H +ATOM 5412 HD12 ILE A 359 15.216 -9.362 -0.764 1.00 41.20 H +ATOM 5413 HD13 ILE A 359 14.376 -8.506 -2.067 1.00 41.20 H +ATOM 5414 N LEU A 360 17.148 -12.289 -5.851 1.00 42.09 N +ATOM 5415 CA LEU A 360 18.259 -12.379 -6.793 1.00 44.36 C +ATOM 5416 C LEU A 360 18.584 -10.983 -7.347 1.00 43.24 C +ATOM 5417 O LEU A 360 17.731 -10.392 -8.009 1.00 43.73 O +ATOM 5418 CB LEU A 360 17.838 -13.359 -7.916 1.00 47.52 C +ATOM 5419 CG LEU A 360 18.827 -13.511 -9.095 1.00 50.60 C +ATOM 5420 CD1 LEU A 360 20.160 -14.139 -8.649 1.00 52.74 C +ATOM 5421 CD2 LEU A 360 18.178 -14.305 -10.241 1.00 52.55 C +ATOM 5422 H LEU A 360 16.232 -12.178 -6.268 1.00 42.09 H +ATOM 5423 HA LEU A 360 19.144 -12.779 -6.296 1.00 44.36 H +ATOM 5424 HB3 LEU A 360 16.879 -13.029 -8.320 1.00 47.52 H +ATOM 5425 HB2 LEU A 360 17.647 -14.341 -7.479 1.00 47.52 H +ATOM 5426 HG LEU A 360 19.053 -12.529 -9.510 1.00 50.60 H +ATOM 5427 HD11 LEU A 360 20.456 -14.983 -9.272 1.00 52.74 H +ATOM 5428 HD12 LEU A 360 20.959 -13.402 -8.693 1.00 52.74 H +ATOM 5429 HD13 LEU A 360 20.120 -14.502 -7.622 1.00 52.74 H +ATOM 5430 HD21 LEU A 360 18.918 -14.645 -10.967 1.00 52.55 H +ATOM 5431 HD22 LEU A 360 17.650 -15.184 -9.870 1.00 52.55 H +ATOM 5432 HD23 LEU A 360 17.458 -13.689 -10.780 1.00 52.55 H +ATOM 5433 N ASN A 361 19.826 -10.525 -7.120 1.00 42.13 N +ATOM 5434 CA ASN A 361 20.409 -9.317 -7.721 1.00 44.33 C +ATOM 5435 C ASN A 361 21.481 -9.727 -8.753 1.00 45.70 C +ATOM 5436 O ASN A 361 21.829 -10.904 -8.863 1.00 46.71 O +ATOM 5437 CB ASN A 361 21.000 -8.406 -6.611 1.00 42.58 C +ATOM 5438 CG ASN A 361 19.954 -7.713 -5.722 1.00 42.14 C +ATOM 5439 OD1 ASN A 361 18.849 -8.206 -5.519 1.00 39.55 O +ATOM 5440 ND2 ASN A 361 20.302 -6.554 -5.167 1.00 40.89 N +ATOM 5441 H ASN A 361 20.470 -11.086 -6.578 1.00 42.13 H +ATOM 5442 HA ASN A 361 19.623 -8.764 -8.240 1.00 44.33 H +ATOM 5443 HB3 ASN A 361 21.589 -7.613 -7.074 1.00 42.58 H +ATOM 5444 HB2 ASN A 361 21.690 -8.964 -5.978 1.00 42.58 H +ATOM 5445 HD22 ASN A 361 19.656 -6.060 -4.566 1.00 40.89 H +ATOM 5446 HD21 ASN A 361 21.210 -6.144 -5.357 1.00 40.89 H +ATOM 5447 N LYS A 362 21.952 -8.738 -9.527 1.00 46.44 N +ATOM 5448 CA LYS A 362 22.835 -8.915 -10.684 1.00 48.00 C +ATOM 5449 C LYS A 362 24.015 -7.925 -10.624 1.00 47.90 C +ATOM 5450 O LYS A 362 24.285 -7.235 -11.609 1.00 48.26 O +ATOM 5451 CB LYS A 362 21.999 -8.754 -11.976 1.00 48.16 C +ATOM 5452 CG LYS A 362 20.896 -9.814 -12.162 1.00 50.94 C +ATOM 5453 CD LYS A 362 20.050 -9.600 -13.427 1.00 53.33 C +ATOM 5454 CE LYS A 362 19.194 -8.321 -13.372 1.00 55.16 C +ATOM 5455 NZ LYS A 362 18.323 -8.195 -14.553 1.00 55.37 N1+ +ATOM 5456 H LYS A 362 21.599 -7.799 -9.388 1.00 46.44 H +ATOM 5457 HA LYS A 362 23.276 -9.914 -10.680 1.00 48.00 H +ATOM 5458 HB3 LYS A 362 22.656 -8.802 -12.846 1.00 48.16 H +ATOM 5459 HB2 LYS A 362 21.562 -7.756 -11.977 1.00 48.16 H +ATOM 5460 HG3 LYS A 362 20.227 -9.826 -11.302 1.00 50.94 H +ATOM 5461 HG2 LYS A 362 21.355 -10.803 -12.199 1.00 50.94 H +ATOM 5462 HD3 LYS A 362 19.409 -10.471 -13.565 1.00 53.33 H +ATOM 5463 HD2 LYS A 362 20.709 -9.569 -14.297 1.00 53.33 H +ATOM 5464 HE3 LYS A 362 19.817 -7.429 -13.320 1.00 55.16 H +ATOM 5465 HE2 LYS A 362 18.567 -8.327 -12.480 1.00 55.16 H +ATOM 5466 HZ1 LYS A 362 17.768 -7.355 -14.460 1.00 55.37 H +ATOM 5467 HZ2 LYS A 362 18.883 -8.146 -15.391 1.00 55.37 H +ATOM 5468 HZ3 LYS A 362 17.708 -8.995 -14.604 1.00 55.37 H +HETATM 5469 N NME A 363 24.687 -7.866 -9.462 1.00 0.00 N +HETATM 5470 C NME A 363 25.822 -6.985 -9.210 1.00 0.00 C +HETATM 5471 H NME A 363 24.395 -8.463 -8.702 1.00 0.00 H +HETATM 5472 H1 NME A 363 26.066 -6.336 -10.052 1.00 0.00 H +HETATM 5473 H2 NME A 363 25.607 -6.348 -8.351 1.00 0.00 H +HETATM 5474 H3 NME A 363 26.705 -7.577 -8.974 1.00 0.00 H +TER 5475 NME A 363 +HETATM 5476 O HOH A 372 14.127 2.495 15.237 1.00 20.25 O +HETATM 5477 H1 HOH A 372 13.297 2.286 15.760 1.00 20.25 H +HETATM 5478 H2 HOH A 372 14.921 2.463 15.861 1.00 20.25 H +HETATM 5479 O HOH A 377 22.168 -5.652 17.068 1.00 24.29 O +HETATM 5480 H1 HOH A 377 21.799 -6.550 16.818 1.00 24.29 H +HETATM 5481 H2 HOH A 377 21.449 -5.112 17.515 1.00 24.29 H +HETATM 5482 O HOH A 395 14.808 3.792 12.670 1.00 27.35 O +HETATM 5483 H1 HOH A 395 15.161 3.112 12.024 1.00 27.35 H +HETATM 5484 H2 HOH A 395 14.745 3.389 13.587 1.00 27.35 H +HETATM 5485 O HOH A 419 26.199 -7.665 18.971 1.00 30.83 O +HETATM 5486 H1 HOH A 419 25.560 -8.426 19.111 1.00 30.83 H +HETATM 5487 H2 HOH A 419 26.576 -7.383 19.855 1.00 30.83 H +HETATM 5488 O HOH A 468 30.820 15.098 19.149 1.00 67.44 O +HETATM 5489 H1 HOH A 468 29.991 15.360 19.644 1.00 67.44 H +HETATM 5490 H2 HOH A 468 31.104 15.865 18.563 1.00 67.44 H +HETATM 5491 O HOH A 484 27.842 -6.299 21.160 1.00 38.37 O +HETATM 5492 H1 HOH A 484 28.606 -6.492 20.537 1.00 38.37 H +HETATM 5493 H2 HOH A 484 27.781 -7.031 21.842 1.00 38.37 H +HETATM 5494 O HOH A 499 22.332 5.193 9.602 1.00 41.21 O +HETATM 5495 H1 HOH A 499 22.732 5.985 10.074 1.00 41.21 H +HETATM 5496 H2 HOH A 499 21.557 4.857 10.143 1.00 41.21 H +CONECT 5476 5477 5478 +CONECT 5477 5476 +CONECT 5478 5476 +CONECT 5479 5480 5481 +CONECT 5480 5479 +CONECT 5481 5479 +CONECT 5482 5483 5484 +CONECT 5483 5482 +CONECT 5484 5482 +CONECT 5485 5486 5487 +CONECT 5486 5485 +CONECT 5487 5485 +CONECT 5488 5489 5490 +CONECT 5489 5488 +CONECT 5490 5488 +CONECT 5491 5492 5493 +CONECT 5492 5491 +CONECT 5493 5491 +CONECT 5494 5495 5496 +CONECT 5495 5494 +CONECT 5496 5494 +END diff --git a/cofactors/eg5_python_tutorial.ipynb b/cofactors/eg5_python_tutorial.ipynb new file mode 100644 index 0000000..f16811c --- /dev/null +++ b/cofactors/eg5_python_tutorial.ipynb @@ -0,0 +1,629 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "35354229", + "metadata": {}, + "source": [ + "# Setting up a relative binding free energy network\n", + "\n", + "This tutorial gives a step-by-step process to set up a relative binding free energy (RBFE) simulation campaign using OpenFE when dealing with cofactors.\n", + "\n", + "**Note**: This notebook acts as a supplement to the original RBFE python tutorial, and should only be used as an example of how the code can be extended to deal with arbitrary spectator molecules." + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "id": "fc97de03", + "metadata": {}, + "outputs": [], + "source": [ + "%matplotlib inline\n", + "import openfe" + ] + }, + { + "cell_type": "markdown", + "id": "2fea29c3", + "metadata": {}, + "source": [ + "## Loading the ligands\n", + "\n", + "First we must load the chemical models between which we wish to calculate free energies.\n", + "In this example these are initially stored in a molfile (`.sdf`) containing multiple molecules.\n", + "This can be loaded using the `SDMolSupplier` class from rdkit and passed to openfe.\n", + "\n", + "#### About the data\n", + "\n", + "Here we are loading the positive ligands from the protein-ligand benchmark set's EG5 system. As charge corrections have yet to be fully implemented in OpenFE, we will stick to doing transformations without net charges for now." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "41cf8be7", + "metadata": {}, + "outputs": [], + "source": [ + "from rdkit import Chem\n", + "supp = Chem.SDMolSupplier(\"eg5_ligands_positive.sdf\", removeHs=False)\n", + "ligands = [openfe.SmallMoleculeComponent.from_rdkit(mol) for mol in supp]" + ] + }, + { + "cell_type": "markdown", + "id": "6963be83", + "metadata": {}, + "source": [ + "## Creating the `LigandNetwork`\n", + "\n", + "The first step is to create a `LigandNetwork`, which is a network with small molecules as nodes, and atom mappings, the description of how to alchemically mutate between the molecules, as its edges.\n", + "\n", + "The pipeline for creating a `LigandNetwork` can involve three components:\n", + "\n", + "* **Atom Mapper**: Proposes potential atom mappings (descriptions of the alchemical change) for pairs of ligands. We will use the `LomapAtomMapper`.\n", + "* **Scorer**: Given an atom mapping, provides an estimate of the quality of that mapping (lower scores are better). We will use `default_lomap_scorer`.\n", + "* **Network Planner**: Creates the actual `LigandNetwork`; different network planners provide different strategies. We will create a minimal spanning network with the `generate_minimal_spanning_network` method.\n", + "\n", + "Each of these components could be replaced by other options." + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "5a3cf244", + "metadata": {}, + "outputs": [], + "source": [ + "mapper = openfe.LomapAtomMapper(max3d=1.0, element_change=False, threed=True)\n", + "scorer = openfe.lomap_scorers.default_lomap_score\n", + "network_planner = openfe.ligand_network_planning.generate_minimal_spanning_network" + ] + }, + { + "cell_type": "markdown", + "id": "acc13581", + "metadata": {}, + "source": [ + "The exact call signature depends on the network planner: a minimal spanning network requires a score, whereas that is optional for a radial network (but a radial network needs the central ligand to be provided)." + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "f6e7bce5", + "metadata": {}, + "outputs": [ + { + "data": { + "application/vnd.jupyter.widget-view+json": { + "model_id": "914f18f109784f7d90dda0f260826a06", + "version_major": 2, + "version_minor": 0 + }, + "text/plain": [ + " 1%|1 | 2/171 [00:02<03:34, 1.27s/it]" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "ligand_network = network_planner(\n", + " ligands=ligands,\n", + " mappers=[mapper],\n", + " scorer=scorer\n", + ")" + ] + }, + { + "cell_type": "markdown", + "id": "b7492637", + "metadata": {}, + "source": [ + "Now we can look at the overall structure of the `LigandNetwork`:" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "id": "e6ca6131", + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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", + "text/plain": [ + "
" + ] + }, + "execution_count": 5, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "from openfe.utils.atommapping_network_plotting import plot_atommapping_network\n", + "plot_atommapping_network(ligand_network)" + ] + }, + { + "cell_type": "markdown", + "id": "5f99678c", + "metadata": {}, + "source": [ + "We can also inspect the individual atom mappings:" + ] + }, + { + "cell_type": "code", + "execution_count": 6, + "id": "c55cbcac", + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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", + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "# get the first edge; it automatically displays in a Jupyter notebook\n", + "mapping = next(iter(ligand_network.edges))\n", + "mapping" + ] + }, + { + "cell_type": "markdown", + "id": "dd0c96d7", + "metadata": {}, + "source": [ + "To get the score for this mapping, we inspect its `annotations` attribute. Arbitrary annotations can be added when a mapping is created, although our network generator only includes the score." + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "id": "6b7492d7", + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'score': 0.3296799539643607}" + ] + }, + "execution_count": 7, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "# lower score is better\n", + "mapping.annotations" + ] + }, + { + "cell_type": "markdown", + "id": "838d9c49", + "metadata": {}, + "source": [ + "We can also use the py3dmol openfe interface to visualise our mappings in 3D" + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "id": "e665b583", + "metadata": {}, + "outputs": [], + "source": [ + "from ipywidgets import interact, widgets\n", + "from openfe.utils.visualization_3D import view_mapping_3d\n", + "\n", + "edges = list(ligand_network.edges)\n", + "\n", + "def display_edge_3d(index):\n", + " view = view_mapping_3d(edges[index], spheres=True, show_atomIDs=True)\n", + " view.show()" + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "id": "e9326f0c", + "metadata": {}, + "outputs": [ + { + "data": { + "application/vnd.jupyter.widget-view+json": { + "model_id": "9f4d7b210ff84b7fad4b9f2cf114a47c", + "version_major": 2, + "version_minor": 0 + }, + "text/plain": [ + "interactive(children=(IntSlider(value=0, description='index', max=17), Output()), _dom_classes=('widget-intera…" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "# traverse through all views\n", + "interact(display_edge_3d, index=widgets.IntSlider(min=0, max=len(edges)-1, step=1));" + ] + }, + { + "cell_type": "markdown", + "id": "30b276b6", + "metadata": {}, + "source": [ + "You can output the ligand network to the same `graphml` format as we saw in the CLI tutorial with the following:" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "2263838f", + "metadata": {}, + "outputs": [], + "source": [ + "with open(\"ligand_network.graphml\", mode='w') as f:\n", + " f.write(ligand_network.to_graphml())" + ] + }, + { + "cell_type": "markdown", + "id": "056924a3", + "metadata": {}, + "source": [ + "## Creating a single `Transformation`\n", + "\n", + "The `LigandNetwork` only knows about the small molecules and the alchemical connections between them. It doesn't know anything about environment (e.g., solvent) or about the `Protocol` that will be used during the simulation.\n", + "\n", + "That information in included in a `Transformation`. Each of these transformations corresponds to a single leg of the simulation campaign, so for each edge in the `LigandNetwork`, we will create two `Transformation`s: one for the complex and one for solvent.\n", + "\n", + "In practice, this will be done for each edge of the `LigandNetwork` in a loop, but for illustrative purposes we'll dive into the details of creating a single transformation. In particular, we'll create the solvent leg for the pair of molecules we selecting for the mapping above." + ] + }, + { + "cell_type": "markdown", + "id": "d0cb1329", + "metadata": {}, + "source": [ + "### Creating `ChemicalSystem`s\n", + "\n", + "OpenFE describes complex molecular systems as being composed of `Component`s. For example, we have `SmallMoleculeComponent` for each small molecule being perturbed in the `LigandNetwork`. We will also create a `SolventComponent` to describe the solvent, a `ProteinComponent` for our EG5 complex simulations, and an extra `SmallMoleculeCompoinent` for the ATP cofactor bound to EG5.\n", + "\n", + "The `Component`s are joined in a `ChemicalSystem`, which describes all the particles in the simulation." + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "id": "9d2fbc22", + "metadata": {}, + "outputs": [], + "source": [ + "# defaults are water with NaCl at 0.15 M\n", + "solvent = openfe.SolventComponent()" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "3f1706ee", + "metadata": {}, + "outputs": [], + "source": [ + "# load in the EG5 protein\n", + "protein = openfe.ProteinComponent.from_pdb_file(\"./eg5_protein.pdb\")" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "18e9cba5", + "metadata": {}, + "outputs": [], + "source": [ + "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", + "supp = Chem.SDMolSupplier(\"eg5_cofactor.sdf\", removeHs=False)\n", + "cofactor = [openfe.SmallMoleculeComponent.from_rdkit(mol) for mol in supp][0]" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "710285ca", + "metadata": {}, + "outputs": [], + "source": [ + "systemA = openfe.ChemicalSystem({\n", + " 'ligand': mapping.componentA,\n", + " 'solvent': solvent,\n", + " 'protein': protein,\n", + " 'cofactor': cofactor,\n", + "})\n", + "systemB = openfe.ChemicalSystem({\n", + " 'ligand': mapping.componentB,\n", + " 'solvent': solvent,\n", + " 'protein': protein,\n", + " 'cofactor': cofactor,\n", + "})" + ] + }, + { + "cell_type": "markdown", + "id": "340d1a6e", + "metadata": {}, + "source": [ + "### Creating a `Protocol`\n", + "\n", + "The actual simulation is performed by a `Protocol`. We'll use an OpenMM-based hybrid topology relative free energy `Protocol`." + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "3f394a0d", + "metadata": { + "scrolled": true + }, + "outputs": [], + "source": [ + "from openfe.protocols.openmm_rfe import RelativeHybridTopologyProtocol" + ] + }, + { + "cell_type": "markdown", + "id": "3bddfa3c", + "metadata": {}, + "source": [ + "The easiest way to customize protocol settings is to start with the default settings, and modify them. Many settings carry units with them." + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "id": "fb839094", + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "'PME'" + ] + }, + "execution_count": 16, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "settings = RelativeHybridTopologyProtocol.default_settings()\n", + "settings.system_settings.nonbonded_method # display default value" + ] + }, + { + "cell_type": "markdown", + "id": "56658a3a", + "metadata": {}, + "source": [ + "We'll use the default settings for the protocol we'll use later, to match the behavior of the CLI." + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "7adf42d6", + "metadata": {}, + "outputs": [], + "source": [ + "default_settings = RelativeHybridTopologyProtocol.default_settings()\n", + "protocol = RelativeHybridTopologyProtocol(default_settings)" + ] + }, + { + "cell_type": "markdown", + "id": "318ff872", + "metadata": {}, + "source": [ + "### Creating the `Transformation`\n", + "\n", + "Once we have the mapping, the two `ChemicalSystem`s, and the `Protocol`, creating the `Transformation` is easy:" + ] + }, + { + "cell_type": "code", + "execution_count": 18, + "id": "44ba94ca", + "metadata": {}, + "outputs": [], + "source": [ + "transformation = openfe.Transformation(\n", + " systemA,\n", + " systemB,\n", + " protocol,\n", + " mapping={'ligand': mapping},\n", + ")" + ] + }, + { + "cell_type": "markdown", + "id": "4283dfe4", + "metadata": {}, + "source": [ + "To summarize, this `Transformation` contains:\n", + "- chemical models of both sides of the alchemical transformation in `systemA` and `systemB`\n", + "- the correspondence of items in these two sides in `mapping` \n", + "- a description of the exact computational algorithm to use to perform the estimate in `protocol`" + ] + }, + { + "cell_type": "markdown", + "id": "1e29d1c8", + "metadata": {}, + "source": [ + "## Creating the `AlchemicalNetwork`\n", + "\n", + "The `AlchemicalNetwork` contains all the information needed to run the entire campaign. It consists of a `Transformation` for each leg of the campaign. We'll loop over all the mappings, and then loop over the legs. In that inner loop, we'll make each transformation." + ] + }, + { + "cell_type": "code", + "execution_count": 19, + "id": "66666a80", + "metadata": {}, + "outputs": [], + "source": [ + "transformations = []\n", + "for mapping in ligand_network.edges:\n", + " for leg in ['solvent', 'complex']:\n", + " # use the solvent and protein created above\n", + " sysA_dict = {'ligand': mapping.componentA,\n", + " 'solvent': solvent}\n", + " sysB_dict = {'ligand': mapping.componentB,\n", + " 'solvent': solvent}\n", + " \n", + " if leg == 'complex':\n", + " sysA_dict['protein'] = protein\n", + " sysB_dict['protein'] = protein\n", + " \n", + " # we don't have to name objects, but it can make things (like filenames) more convenient\n", + " sysA = openfe.ChemicalSystem(sysA_dict, name=f\"{mapping.componentA.name}_{leg}\")\n", + " sysB = openfe.ChemicalSystem(sysB_dict, name=f\"{mapping.componentB.name}_{leg}\")\n", + " \n", + " prefix = \"easy_rbfe_\" # prefix is only to exactly reproduce CLI\n", + " \n", + " transformation = openfe.Transformation(\n", + " stateA=sysA,\n", + " stateB=sysB,\n", + " mapping={'ligand': mapping},\n", + " protocol=protocol, # use protocol created above\n", + " name=f\"{prefix}{sysA.name}_{sysB.name}\"\n", + " )\n", + " transformations.append(transformation)\n", + "\n", + "network = openfe.AlchemicalNetwork(transformations)" + ] + }, + { + "cell_type": "markdown", + "id": "6c61fe36", + "metadata": {}, + "source": [ + "## Writing the `AlchemicalNetwork` to disk\n", + "\n", + "We'll write out each transformation to disk, so that they can be run independently using the `openfe quickrun` command:" + ] + }, + { + "cell_type": "code", + "execution_count": 20, + "id": "d6cebd9a", + "metadata": {}, + "outputs": [], + "source": [ + "import pathlib\n", + "# first we create the directory\n", + "transformation_dir = pathlib.Path(\"transformations\")\n", + "transformation_dir.mkdir(exist_ok=True)\n", + "\n", + "# then we write out each transformation\n", + "for transformation in network.edges:\n", + " transformation.dump(transformation_dir / f\"{transformation.name}.json\")" + ] + }, + { + "cell_type": "code", + "execution_count": 21, + "id": "b96b57a9", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "easy_rbfe_lig_CHEMBL1082248_complex_lig_CHEMBL1082249_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1082248_complex_lig_CHEMBL1096002_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1082248_solvent_lig_CHEMBL1082249_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1082248_solvent_lig_CHEMBL1096002_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1083517_complex_lig_CHEMBL1086409_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1083517_solvent_lig_CHEMBL1086409_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1083836_complex_lig_CHEMBL1082248_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1083836_solvent_lig_CHEMBL1082248_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1084143_complex_lig_CHEMBL1086410_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1084143_solvent_lig_CHEMBL1086410_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1084678_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1085666_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1096003_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1084678_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1085666_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1096003_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1084935_complex_lig_CHEMBL1084935_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1084935_complex_lig_CHEMBL1086410_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1084935_solvent_lig_CHEMBL1084935_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1084935_solvent_lig_CHEMBL1086410_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1077204_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1084676_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1086409_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1077204_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1084676_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1086409_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1085692_complex_lig_CHEMBL1082248_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1085692_solvent_lig_CHEMBL1082248_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1086409_complex_lig_CHEMBL1082248_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1086409_complex_lig_CHEMBL1093087_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1086409_solvent_lig_CHEMBL1082248_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1086409_solvent_lig_CHEMBL1093087_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1086410_complex_lig_CHEMBL1077227_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1086410_complex_lig_CHEMBL1082248_complex.json\r\n", + "easy_rbfe_lig_CHEMBL1086410_solvent_lig_CHEMBL1077227_solvent.json\r\n", + "easy_rbfe_lig_CHEMBL1086410_solvent_lig_CHEMBL1082248_solvent.json\r\n" + ] + } + ], + "source": [ + "!ls transformations/" + ] + }, + { + "cell_type": "markdown", + "id": "c30e8ae2", + "metadata": {}, + "source": [ + "Each of these individual `.json` files contains a `Transformation`, which contains all the information to run the calculation. These could be farmed out as individual jobs on a HPC cluster. These files are identical to what were created in setup stage of the CLI tutorial; for details on running them, follow from the section on running simulations in the CLI tutorial" + ] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.9.16" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} From 07574c8a0616e35df4fa6628ff7ef2bade701f11 Mon Sep 17 00:00:00 2001 From: IAlibay Date: Mon, 11 Dec 2023 21:14:47 +0000 Subject: [PATCH 02/12] Update for cofactors & user charges --- cofactors/eg5_python_tutorial.ipynb | 138 ++++++++++++++++++---------- 1 file changed, 88 insertions(+), 50 deletions(-) diff --git a/cofactors/eg5_python_tutorial.ipynb b/cofactors/eg5_python_tutorial.ipynb index f16811c..6159de9 100644 --- a/cofactors/eg5_python_tutorial.ipynb +++ b/cofactors/eg5_python_tutorial.ipynb @@ -36,7 +36,9 @@ "\n", "#### About the data\n", "\n", - "Here we are loading the positive ligands from the protein-ligand benchmark set's EG5 system. As charge corrections have yet to be fully implemented in OpenFE, we will stick to doing transformations without net charges for now." + "Here we are loading the positive ligands from the protein-ligand benchmark set's EG5 system. As charge corrections have yet to be fully implemented in OpenFE, we will stick to doing transformations without net charges for now.\n", + "\n", + "**Note:** We add user charges to our input ligands by going through OpenFF molecules first. This avoids any issues with inconsistent partial charge assignment." ] }, { @@ -44,11 +46,32 @@ "execution_count": 2, "id": "41cf8be7", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/ialibay/software/mambaforge/install/envs/alchemiscale-client-0.2.1/lib/python3.10/site-packages/gufe/components/explicitmoleculecomponent.py:79: UserWarning: Partial charges have been provided, these will preferentially be used instead of generating new partial charges\n", + " warnings.warn(wmsg)\n" + ] + } + ], "source": [ "from rdkit import Chem\n", - "supp = Chem.SDMolSupplier(\"eg5_ligands_positive.sdf\", removeHs=False)\n", - "ligands = [openfe.SmallMoleculeComponent.from_rdkit(mol) for mol in supp]" + "from openff.toolkit import Molecule\n", + "\n", + "# Create a list of OpenFF molecules\n", + "offmols = [\n", + " Molecule.from_rdkit(m)\n", + " for m in Chem.SDMolSupplier(\"eg5_ligands_positive.sdf\", removeHs=False)\n", + "]\n", + "\n", + "# Assign partial charges via AM1BCC\n", + "for mol in offmols:\n", + " mol.assign_partial_charges('am1bcc', use_conformers=mol.conformers)\n", + "\n", + "# Now we convert them to SmallMoleculeComponent\n", + "ligands = [openfe.SmallMoleculeComponent.from_openff(mol) for mol in offmols]" ] }, { @@ -98,12 +121,12 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "914f18f109784f7d90dda0f260826a06", + "model_id": "fc3165e5064f40818ac341d278fdeb59", "version_major": 2, "version_minor": 0 }, "text/plain": [ - " 1%|1 | 2/171 [00:02<03:34, 1.27s/it]" + " 3%|2 | 5/171 [00:01<00:50, 3.30it/s]" ] }, "metadata": {}, @@ -134,7 +157,7 @@ "outputs": [ { "data": { - "image/png": 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", + "image/png": 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", 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", + "image/png": 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", "text/plain": [ "" ] @@ -197,7 +220,7 @@ { "data": { "text/plain": [ - "{'score': 0.3296799539643607}" + "{'score': 0.4065696597405991}" ] }, "execution_count": 7, @@ -244,7 +267,7 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "9f4d7b210ff84b7fad4b9f2cf114a47c", + "model_id": "d146d590d7ab4621afa4c69a65a8156f", "version_major": 2, "version_minor": 0 }, @@ -333,11 +356,22 @@ "execution_count": 13, "id": "18e9cba5", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/ialibay/software/mambaforge/install/envs/alchemiscale-client-0.2.1/lib/python3.10/site-packages/gufe/components/explicitmoleculecomponent.py:79: UserWarning: Partial charges have been provided, these will preferentially be used instead of generating new partial charges\n", + " warnings.warn(wmsg)\n" + ] + } + ], "source": [ "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", - "supp = Chem.SDMolSupplier(\"eg5_cofactor.sdf\", removeHs=False)\n", - "cofactor = [openfe.SmallMoleculeComponent.from_rdkit(mol) for mol in supp][0]" + "# We also go through OpenFF to assign partial charges\n", + "offmol = [Molecule.from_rdkit(m) for m in Chem.SDMolSupplier(\"eg5_cofactor.sdf\", removeHs=False)][0]\n", + "offmol.assign_partial_charges('am1bcc', use_conformers=offmol.conformers)\n", + "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)" ] }, { @@ -347,6 +381,8 @@ "metadata": {}, "outputs": [], "source": [ + "# Note: if you had multiple cofactors you could add any additional cofactor\n", + "# as additional dictionary entries in both of the ChemicalSystem definitions\n", "systemA = openfe.ChemicalSystem({\n", " 'ligand': mapping.componentA,\n", " 'solvent': solvent,\n", @@ -496,7 +532,9 @@ " \n", " if leg == 'complex':\n", " sysA_dict['protein'] = protein\n", + " sysA_dict['cofactor'] = cofactor\n", " sysB_dict['protein'] = protein\n", + " sysB_dict['cofactor'] = cofactor\n", " \n", " # we don't have to name objects, but it can make things (like filenames) more convenient\n", " sysA = openfe.ChemicalSystem(sysA_dict, name=f\"{mapping.componentA.name}_{leg}\")\n", @@ -553,42 +591,42 @@ "name": "stdout", "output_type": "stream", "text": [ - "easy_rbfe_lig_CHEMBL1082248_complex_lig_CHEMBL1082249_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1082248_complex_lig_CHEMBL1096002_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1082248_solvent_lig_CHEMBL1082249_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1082248_solvent_lig_CHEMBL1096002_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1083517_complex_lig_CHEMBL1086409_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1083517_solvent_lig_CHEMBL1086409_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1083836_complex_lig_CHEMBL1082248_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1083836_solvent_lig_CHEMBL1082248_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1084143_complex_lig_CHEMBL1086410_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1084143_solvent_lig_CHEMBL1086410_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1084678_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1085666_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1096003_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1084678_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1085666_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1096003_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1084935_complex_lig_CHEMBL1084935_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1084935_complex_lig_CHEMBL1086410_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1084935_solvent_lig_CHEMBL1084935_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1084935_solvent_lig_CHEMBL1086410_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1077204_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1084676_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1086409_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1077204_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1084676_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1086409_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1085692_complex_lig_CHEMBL1082248_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1085692_solvent_lig_CHEMBL1082248_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1086409_complex_lig_CHEMBL1082248_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1086409_complex_lig_CHEMBL1093087_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1086409_solvent_lig_CHEMBL1082248_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1086409_solvent_lig_CHEMBL1093087_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1086410_complex_lig_CHEMBL1077227_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1086410_complex_lig_CHEMBL1082248_complex.json\r\n", - "easy_rbfe_lig_CHEMBL1086410_solvent_lig_CHEMBL1077227_solvent.json\r\n", - "easy_rbfe_lig_CHEMBL1086410_solvent_lig_CHEMBL1082248_solvent.json\r\n" + "easy_rbfe_lig_CHEMBL1082248_complex_lig_CHEMBL1082249_complex.json\n", + "easy_rbfe_lig_CHEMBL1082248_complex_lig_CHEMBL1096002_complex.json\n", + "easy_rbfe_lig_CHEMBL1082248_solvent_lig_CHEMBL1082249_solvent.json\n", + "easy_rbfe_lig_CHEMBL1082248_solvent_lig_CHEMBL1096002_solvent.json\n", + "easy_rbfe_lig_CHEMBL1083517_complex_lig_CHEMBL1086409_complex.json\n", + "easy_rbfe_lig_CHEMBL1083517_solvent_lig_CHEMBL1086409_solvent.json\n", + "easy_rbfe_lig_CHEMBL1083836_complex_lig_CHEMBL1082248_complex.json\n", + "easy_rbfe_lig_CHEMBL1083836_solvent_lig_CHEMBL1082248_solvent.json\n", + "easy_rbfe_lig_CHEMBL1084143_complex_lig_CHEMBL1086410_complex.json\n", + "easy_rbfe_lig_CHEMBL1084143_solvent_lig_CHEMBL1086410_solvent.json\n", + "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1084678_complex.json\n", + "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1085666_complex.json\n", + "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1096003_complex.json\n", + "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1084678_solvent.json\n", + "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1085666_solvent.json\n", + "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1096003_solvent.json\n", + "easy_rbfe_lig_CHEMBL1084935_complex_lig_CHEMBL1084935_complex.json\n", + "easy_rbfe_lig_CHEMBL1084935_complex_lig_CHEMBL1086410_complex.json\n", + "easy_rbfe_lig_CHEMBL1084935_solvent_lig_CHEMBL1084935_solvent.json\n", + "easy_rbfe_lig_CHEMBL1084935_solvent_lig_CHEMBL1086410_solvent.json\n", + "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1077204_complex.json\n", + "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1084676_complex.json\n", + "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1086409_complex.json\n", + "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1077204_solvent.json\n", + "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1084676_solvent.json\n", + "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1086409_solvent.json\n", + "easy_rbfe_lig_CHEMBL1085692_complex_lig_CHEMBL1082248_complex.json\n", + "easy_rbfe_lig_CHEMBL1085692_solvent_lig_CHEMBL1082248_solvent.json\n", + "easy_rbfe_lig_CHEMBL1086409_complex_lig_CHEMBL1082248_complex.json\n", + "easy_rbfe_lig_CHEMBL1086409_complex_lig_CHEMBL1093087_complex.json\n", + "easy_rbfe_lig_CHEMBL1086409_solvent_lig_CHEMBL1082248_solvent.json\n", + "easy_rbfe_lig_CHEMBL1086409_solvent_lig_CHEMBL1093087_solvent.json\n", + "easy_rbfe_lig_CHEMBL1086410_complex_lig_CHEMBL1077227_complex.json\n", + "easy_rbfe_lig_CHEMBL1086410_complex_lig_CHEMBL1082248_complex.json\n", + "easy_rbfe_lig_CHEMBL1086410_solvent_lig_CHEMBL1077227_solvent.json\n", + "easy_rbfe_lig_CHEMBL1086410_solvent_lig_CHEMBL1082248_solvent.json\n" ] } ], @@ -621,7 +659,7 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.9.16" + "version": "3.10.13" } }, "nbformat": 4, From fcc20dda41173cc133d09e759868658eedb2a143 Mon Sep 17 00:00:00 2001 From: richard gowers Date: Wed, 31 Jan 2024 14:46:44 +0000 Subject: [PATCH 03/12] a few tweaks to eg5 notebook --- cofactors/eg5_python_tutorial.ipynb | 47 ++++++++++++++--------------- 1 file changed, 23 insertions(+), 24 deletions(-) diff --git a/cofactors/eg5_python_tutorial.ipynb b/cofactors/eg5_python_tutorial.ipynb index 6159de9..eee4363 100644 --- a/cofactors/eg5_python_tutorial.ipynb +++ b/cofactors/eg5_python_tutorial.ipynb @@ -5,7 +5,7 @@ "id": "35354229", "metadata": {}, "source": [ - "# Setting up a relative binding free energy network\n", + "# Setting up a RBFE network for a system with cofactors\n", "\n", "This tutorial gives a step-by-step process to set up a relative binding free energy (RBFE) simulation campaign using OpenFE when dealing with cofactors.\n", "\n", @@ -51,7 +51,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "/home/ialibay/software/mambaforge/install/envs/alchemiscale-client-0.2.1/lib/python3.10/site-packages/gufe/components/explicitmoleculecomponent.py:79: UserWarning: Partial charges have been provided, these will preferentially be used instead of generating new partial charges\n", + "/home/richard/miniconda3/envs/openfe_stable/lib/python3.11/site-packages/gufe/components/explicitmoleculecomponent.py:79: UserWarning: Partial charges have been provided, these will preferentially be used instead of generating new partial charges\n", " warnings.warn(wmsg)\n" ] } @@ -83,10 +83,10 @@ "\n", "The first step is to create a `LigandNetwork`, which is a network with small molecules as nodes, and atom mappings, the description of how to alchemically mutate between the molecules, as its edges.\n", "\n", - "The pipeline for creating a `LigandNetwork` can involve three components:\n", + "The pipeline for creating a `LigandNetwork` involves three components:\n", "\n", "* **Atom Mapper**: Proposes potential atom mappings (descriptions of the alchemical change) for pairs of ligands. We will use the `LomapAtomMapper`.\n", - "* **Scorer**: Given an atom mapping, provides an estimate of the quality of that mapping (lower scores are better). We will use `default_lomap_scorer`.\n", + "* **Scorer**: Given an atom mapping, provides an estimate of the quality of that mapping (higher scores are better). We will use `default_lomap_scorer`.\n", "* **Network Planner**: Creates the actual `LigandNetwork`; different network planners provide different strategies. We will create a minimal spanning network with the `generate_minimal_spanning_network` method.\n", "\n", "Each of these components could be replaced by other options." @@ -121,12 +121,12 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "fc3165e5064f40818ac341d278fdeb59", + "model_id": "65211ee36b3d4cea971643c08cdb920b", "version_major": 2, "version_minor": 0 }, "text/plain": [ - " 3%|2 | 5/171 [00:01<00:50, 3.30it/s]" + " 23%|##2 | 39/171 [00:01<00:05, 25.66it/s]" ] }, "metadata": {}, @@ -136,7 +136,7 @@ "source": [ "ligand_network = network_planner(\n", " ligands=ligands,\n", - " mappers=[mapper],\n", + " mappers=mapper,\n", " scorer=scorer\n", ")" ] @@ -157,7 +157,7 @@ "outputs": [ { "data": { - "image/png": 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", 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", 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" ] @@ -188,7 +188,7 @@ "outputs": [ { "data": { - "image/png": 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", + "image/png": 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", "text/plain": [ "" ] @@ -220,7 +220,7 @@ { "data": { "text/plain": [ - "{'score': 0.4065696597405991}" + "{'score': 0.49658530379140947}" ] }, "execution_count": 7, @@ -229,7 +229,7 @@ } ], "source": [ - "# lower score is better\n", + "# higher score is better\n", "mapping.annotations" ] }, @@ -267,7 +267,7 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "d146d590d7ab4621afa4c69a65a8156f", + "model_id": "4e79e70b2af24d5a95a0830fd8bc229e", "version_major": 2, "version_minor": 0 }, @@ -361,7 +361,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "/home/ialibay/software/mambaforge/install/envs/alchemiscale-client-0.2.1/lib/python3.10/site-packages/gufe/components/explicitmoleculecomponent.py:79: UserWarning: Partial charges have been provided, these will preferentially be used instead of generating new partial charges\n", + "/home/richard/miniconda3/envs/openfe_stable/lib/python3.11/site-packages/gufe/components/explicitmoleculecomponent.py:79: UserWarning: Partial charges have been provided, these will preferentially be used instead of generating new partial charges\n", " warnings.warn(wmsg)\n" ] } @@ -369,7 +369,7 @@ "source": [ "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", "# We also go through OpenFF to assign partial charges\n", - "offmol = [Molecule.from_rdkit(m) for m in Chem.SDMolSupplier(\"eg5_cofactor.sdf\", removeHs=False)][0]\n", + "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"eg5_cofactor.sdf\", removeHs=False))\n", "offmol.assign_partial_charges('am1bcc', use_conformers=offmol.conformers)\n", "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)" ] @@ -434,19 +434,18 @@ "metadata": {}, "outputs": [ { - "data": { - "text/plain": [ - "'PME'" - ] - }, - "execution_count": 16, - "metadata": {}, - "output_type": "execute_result" + "name": "stdout", + "output_type": "stream", + "text": [ + "PME\n", + "5.0 nanosecond\n" + ] } ], "source": [ "settings = RelativeHybridTopologyProtocol.default_settings()\n", - "settings.system_settings.nonbonded_method # display default value" + "print(settings.system_settings.nonbonded_method) # display default value\n", + "print(settings.simulation_settings.production_length)" ] }, { @@ -659,7 +658,7 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.10.13" + "version": "3.11.7" } }, "nbformat": 4, From 4e26dba43ca1ecea1e58d2f98c5a20dfcd723609 Mon Sep 17 00:00:00 2001 From: Alyssa Travitz Date: Fri, 16 Jan 2026 09:16:54 -0800 Subject: [PATCH 04/12] add cookbook --- cookbook/cofactors/cofactors.ipynb | 120 +++++++++++++++++++++++++++++ 1 file changed, 120 insertions(+) create mode 100644 cookbook/cofactors/cofactors.ipynb diff --git a/cookbook/cofactors/cofactors.ipynb b/cookbook/cofactors/cofactors.ipynb new file mode 100644 index 0000000..3b2d063 --- /dev/null +++ b/cookbook/cofactors/cofactors.ipynb @@ -0,0 +1,120 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "35354229", + "metadata": {}, + "source": [ + "# Defining Cofactors\n", + "\n", + "You can define cofactors, any small molecules that are not the bound ligand, using the openfe CLI during the planning phase or directly using the Python API.\n", + "\n", + "Similar to `ligand` definition, `cofactors` can be loaded from an SDF file format." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "fc97de03", + "metadata": {}, + "outputs": [], + "source": [ + "%matplotlib inline\n", + "import openfe" + ] + }, + { + "cell_type": "markdown", + "id": "d18da4a7-0001-4c04-8f9b-b197f3a1f1b5", + "metadata": {}, + "source": [ + "## CLI: define cofactors during ``openfe plan-*``" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "c93bdced-2862-465e-b9df-2110ee05b996", + "metadata": {}, + "outputs": [], + "source": [ + "! openfe" + ] + }, + { + "cell_type": "markdown", + "id": "a51b59e7-480c-45f9-9a7c-bf0aee1a0d8c", + "metadata": {}, + "source": [ + "## Python API: define cofactors in the ``ChemicalSystem``s " + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "371dc488-80a5-40ad-bf51-9cd5d8d4aeea", + "metadata": {}, + "outputs": [], + "source": [ + "from rdkit import Chem\n", + "from openff.toolkit import Molecule\n", + "\n", + "# Create a list of OpenFF molecules\n", + "offmols = [\n", + " Molecule.from_rdkit(m)\n", + " for m in Chem.SDMolSupplier(\"eg5_ligands_positive.sdf\", removeHs=False)\n", + "]\n", + "\n", + "# Assign partial charges via AM1BCC\n", + "for mol in offmols:\n", + " mol.assign_partial_charges('am1bcc', use_conformers=mol.conformers)\n", + "\n", + "# Now we convert them to SmallMoleculeComponent\n", + "ligands = [openfe.SmallMoleculeComponent.from_openff(mol) for mol in offmols]" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "0526c65b-b69c-47a3-8ca0-056fa76f4aee", + "metadata": {}, + "outputs": [], + "source": [ + "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", + "# We also go through OpenFF to assign partial charges\n", + "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"eg5_cofactor.sdf\", removeHs=False))\n", + "offmol.assign_partial_charges('am1bcc', use_conformers=offmol.conformers)\n", + "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "e7c5da37-eff9-4f63-a8b8-00248d193972", + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.13.11" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} From a60874254c1d55cbe8a7c66539ce2e972464612b Mon Sep 17 00:00:00 2001 From: Alyssa Travitz Date: Fri, 16 Jan 2026 10:16:47 -0800 Subject: [PATCH 05/12] adding cli instructions --- cookbook/cofactors/cofactors.ipynb | 235 ++++++++++++++++++++++++++++- 1 file changed, 228 insertions(+), 7 deletions(-) diff --git a/cookbook/cofactors/cofactors.ipynb b/cookbook/cofactors/cofactors.ipynb index 3b2d063..b1c26a9 100644 --- a/cookbook/cofactors/cofactors.ipynb +++ b/cookbook/cofactors/cofactors.ipynb @@ -33,12 +33,31 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 13, "id": "c93bdced-2862-465e-b9df-2110ee05b996", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/pty.py:95: DeprecationWarning: This process (pid=60788) is multi-threaded, use of forkpty() may lead to deadlocks in the child.\n", + " pid, fd = os.forkpty()\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Usage: openfe plan-rbfe-network [OPTIONS]\n", + "Try 'openfe plan-rbfe-network -h' for help.\n", + "\n", + "Error: Invalid value for '-M' / '--molecules': Path 'ligands.sdf' does not exist.\n" + ] + } + ], "source": [ - "! openfe" + "! openfe plan-rbfe-network -M ligands.sdf -p protein.pdb --cofactors cofactors.sdf" ] }, { @@ -49,12 +68,65 @@ "## Python API: define cofactors in the ``ChemicalSystem``s " ] }, + { + "cell_type": "markdown", + "id": "7e56bd3b-9897-4761-a97b-fa6162bfa31b", + "metadata": {}, + "source": [ + "### Load the ligands and cofactors" + ] + }, { "cell_type": "code", - "execution_count": null, + "execution_count": 8, "id": "371dc488-80a5-40ad-bf51-9cd5d8d4aeea", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n", + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n" + ] + } + ], "source": [ "from rdkit import Chem\n", "from openff.toolkit import Molecule\n", @@ -75,10 +147,19 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 7, "id": "0526c65b-b69c-47a3-8ca0-056fa76f4aee", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n" + ] + } + ], "source": [ "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", "# We also go through OpenFF to assign partial charges\n", @@ -87,12 +168,152 @@ "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)" ] }, + { + "cell_type": "markdown", + "id": "4e299fd3-8554-4a22-9829-804cf02df1f8", + "metadata": {}, + "source": [ + "### Create the Network" + ] + }, { "cell_type": "code", "execution_count": null, "id": "e7c5da37-eff9-4f63-a8b8-00248d193972", "metadata": {}, "outputs": [], + "source": [ + "mapper = openfe.LomapAtomMapper(max3d=1.0, element_change=False, threed=True)\n", + "scorer = openfe.lomap_scorers.default_lomap_score\n", + "network_planner = openfe.ligand_network_planning.generate_minimal_spanning_network" + ] + }, + { + "cell_type": "markdown", + "id": "69bbf2d0-11dd-4ded-8786-86d84cf20075", + "metadata": {}, + "source": [ + "### Create the Chemical Systems" + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "id": "92015cf3-f55f-4ffd-b333-d26874ea6ff3", + "metadata": {}, + "outputs": [], + "source": [ + "# defaults are water with NaCl at 0.15 M\n", + "solvent = openfe.SolventComponent()\n", + "\n", + "# load in the EG5 protein\n", + "protein = openfe.ProteinComponent.from_pdb_file(\"./eg5_protein.pdb\")" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "ba9a0ab0-1b18-47f2-84f9-5a60da3a556c", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", + " return method(*args, **kwargs)\n" + ] + } + ], + "source": [ + "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", + "# We also go through OpenFF to assign partial charges\n", + "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"eg5_cofactor.sdf\", removeHs=False))\n", + "offmol.assign_partial_charges('am1bcc', use_conformers=offmol.conformers)\n", + "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)" + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "id": "49ae8a9b-3391-4dc3-8be0-5885724d5880", + "metadata": {}, + "outputs": [ + { + "ename": "NameError", + "evalue": "name 'mapping' is not defined", + "output_type": "error", + "traceback": [ + "\u001b[31m---------------------------------------------------------------------------\u001b[39m", + "\u001b[31mNameError\u001b[39m Traceback (most recent call last)", + "\u001b[36mCell\u001b[39m\u001b[36m \u001b[39m\u001b[32mIn[11]\u001b[39m\u001b[32m, line 4\u001b[39m\n\u001b[32m 1\u001b[39m \u001b[38;5;66;03m# Note: if you had multiple cofactors you could add any additional cofactor\u001b[39;00m\n\u001b[32m 2\u001b[39m \u001b[38;5;66;03m# as additional dictionary entries in both of the ChemicalSystem definitions\u001b[39;00m\n\u001b[32m 3\u001b[39m systemA = openfe.ChemicalSystem({\n\u001b[32m----> \u001b[39m\u001b[32m4\u001b[39m \u001b[33m'\u001b[39m\u001b[33mligand\u001b[39m\u001b[33m'\u001b[39m: \u001b[43mmapping\u001b[49m.componentA,\n\u001b[32m 5\u001b[39m \u001b[33m'\u001b[39m\u001b[33msolvent\u001b[39m\u001b[33m'\u001b[39m: solvent,\n\u001b[32m 6\u001b[39m \u001b[33m'\u001b[39m\u001b[33mprotein\u001b[39m\u001b[33m'\u001b[39m: protein,\n\u001b[32m 7\u001b[39m \u001b[33m'\u001b[39m\u001b[33mcofactor\u001b[39m\u001b[33m'\u001b[39m: cofactor,\n\u001b[32m 8\u001b[39m })\n\u001b[32m 9\u001b[39m systemB = openfe.ChemicalSystem({\n\u001b[32m 10\u001b[39m \u001b[33m'\u001b[39m\u001b[33mligand\u001b[39m\u001b[33m'\u001b[39m: mapping.componentB,\n\u001b[32m 11\u001b[39m \u001b[33m'\u001b[39m\u001b[33msolvent\u001b[39m\u001b[33m'\u001b[39m: solvent,\n\u001b[32m 12\u001b[39m \u001b[33m'\u001b[39m\u001b[33mprotein\u001b[39m\u001b[33m'\u001b[39m: protein,\n\u001b[32m 13\u001b[39m \u001b[33m'\u001b[39m\u001b[33mcofactor\u001b[39m\u001b[33m'\u001b[39m: cofactor,\n\u001b[32m 14\u001b[39m })\n", + "\u001b[31mNameError\u001b[39m: name 'mapping' is not defined" + ] + } + ], + "source": [ + "# Note: if you had multiple cofactors you could add any additional cofactor\n", + "# as additional dictionary entries in both of the ChemicalSystem definitions\n", + "systemA = openfe.ChemicalSystem({\n", + " 'ligand': mapping.componentA,\n", + " 'solvent': solvent,\n", + " 'protein': protein,\n", + " 'cofactor': cofactor,\n", + "})\n", + "systemB = openfe.ChemicalSystem({\n", + " 'ligand': mapping.componentB,\n", + " 'solvent': solvent,\n", + " 'protein': protein,\n", + " 'cofactor': cofactor,\n", + "})" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "e7789300-be71-4b77-8448-364b884c4ace", + "metadata": {}, + "outputs": [], + "source": [ + "transformations = []\n", + "for mapping in ligand_network.edges:\n", + " for leg in ['solvent', 'complex']:\n", + " # use the solvent and protein created above\n", + " sysA_dict = {'ligand': mapping.componentA,\n", + " 'solvent': solvent}\n", + " sysB_dict = {'ligand': mapping.componentB,\n", + " 'solvent': solvent}\n", + " \n", + " if leg == 'complex':\n", + " sysA_dict['protein'] = protein\n", + " sysA_dict['cofactor'] = cofactor\n", + " sysB_dict['protein'] = protein\n", + " sysB_dict['cofactor'] = cofactor\n", + " \n", + " # we don't have to name objects, but it can make things (like filenames) more convenient\n", + " sysA = openfe.ChemicalSystem(sysA_dict, name=f\"{mapping.componentA.name}_{leg}\")\n", + " sysB = openfe.ChemicalSystem(sysB_dict, name=f\"{mapping.componentB.name}_{leg}\")\n", + " \n", + " prefix = \"easy_rbfe_\" # prefix is only to exactly reproduce CLI\n", + " \n", + " transformation = openfe.Transformation(\n", + " stateA=sysA,\n", + " stateB=sysB,\n", + " mapping={'ligand': mapping},\n", + " protocol=protocol, # use protocol created above\n", + " name=f\"{prefix}{sysA.name}_{sysB.name}\"\n", + " )\n", + " transformations.append(transformation)\n", + "\n", + "network = openfe.AlchemicalNetwork(transformations)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "3f26c125-4e93-492e-a235-ed5c7d4f4927", + "metadata": {}, + "outputs": [], "source": [] } ], From 703f8f4d2cf5a084264b1d25f60f26c8cc2dd468 Mon Sep 17 00:00:00 2001 From: Alyssa Travitz Date: Fri, 16 Jan 2026 13:28:57 -0800 Subject: [PATCH 06/12] add cofactors notebook as cookbook --- cofactors/eg5_python_tutorial.ipynb | 666 ------------------ .../assets/cofactors}/eg5_cofactor.sdf | 0 .../assets/cofactors}/eg5_ligands.sdf | 0 .../cofactors}/eg5_ligands_positive.sdf | 0 .../assets/cofactors}/eg5_protein.pdb | 0 cookbook/cofactors/cofactors.ipynb | 341 --------- cookbook/cofactors_rbfe.ipynb | 283 ++++++++ 7 files changed, 283 insertions(+), 1007 deletions(-) delete mode 100644 cofactors/eg5_python_tutorial.ipynb rename {cofactors => cookbook/assets/cofactors}/eg5_cofactor.sdf (100%) rename {cofactors => cookbook/assets/cofactors}/eg5_ligands.sdf (100%) rename {cofactors => cookbook/assets/cofactors}/eg5_ligands_positive.sdf (100%) rename {cofactors => cookbook/assets/cofactors}/eg5_protein.pdb (100%) delete mode 100644 cookbook/cofactors/cofactors.ipynb create mode 100644 cookbook/cofactors_rbfe.ipynb diff --git a/cofactors/eg5_python_tutorial.ipynb b/cofactors/eg5_python_tutorial.ipynb deleted file mode 100644 index eee4363..0000000 --- a/cofactors/eg5_python_tutorial.ipynb +++ /dev/null @@ -1,666 +0,0 @@ -{ - "cells": [ - { - "cell_type": "markdown", - "id": "35354229", - "metadata": {}, - "source": [ - "# Setting up a RBFE network for a system with cofactors\n", - "\n", - "This tutorial gives a step-by-step process to set up a relative binding free energy (RBFE) simulation campaign using OpenFE when dealing with cofactors.\n", - "\n", - "**Note**: This notebook acts as a supplement to the original RBFE python tutorial, and should only be used as an example of how the code can be extended to deal with arbitrary spectator molecules." - ] - }, - { - "cell_type": "code", - "execution_count": 1, - "id": "fc97de03", - "metadata": {}, - "outputs": [], - "source": [ - "%matplotlib inline\n", - "import openfe" - ] - }, - { - "cell_type": "markdown", - "id": "2fea29c3", - "metadata": {}, - "source": [ - "## Loading the ligands\n", - "\n", - "First we must load the chemical models between which we wish to calculate free energies.\n", - "In this example these are initially stored in a molfile (`.sdf`) containing multiple molecules.\n", - "This can be loaded using the `SDMolSupplier` class from rdkit and passed to openfe.\n", - "\n", - "#### About the data\n", - "\n", - "Here we are loading the positive ligands from the protein-ligand benchmark set's EG5 system. As charge corrections have yet to be fully implemented in OpenFE, we will stick to doing transformations without net charges for now.\n", - "\n", - "**Note:** We add user charges to our input ligands by going through OpenFF molecules first. This avoids any issues with inconsistent partial charge assignment." - ] - }, - { - "cell_type": "code", - "execution_count": 2, - "id": "41cf8be7", - "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/home/richard/miniconda3/envs/openfe_stable/lib/python3.11/site-packages/gufe/components/explicitmoleculecomponent.py:79: UserWarning: Partial charges have been provided, these will preferentially be used instead of generating new partial charges\n", - " warnings.warn(wmsg)\n" - ] - } - ], - "source": [ - "from rdkit import Chem\n", - "from openff.toolkit import Molecule\n", - "\n", - "# Create a list of OpenFF molecules\n", - "offmols = [\n", - " Molecule.from_rdkit(m)\n", - " for m in Chem.SDMolSupplier(\"eg5_ligands_positive.sdf\", removeHs=False)\n", - "]\n", - "\n", - "# Assign partial charges via AM1BCC\n", - "for mol in offmols:\n", - " mol.assign_partial_charges('am1bcc', use_conformers=mol.conformers)\n", - "\n", - "# Now we convert them to SmallMoleculeComponent\n", - "ligands = [openfe.SmallMoleculeComponent.from_openff(mol) for mol in offmols]" - ] - }, - { - "cell_type": "markdown", - "id": "6963be83", - "metadata": {}, - "source": [ - "## Creating the `LigandNetwork`\n", - "\n", - "The first step is to create a `LigandNetwork`, which is a network with small molecules as nodes, and atom mappings, the description of how to alchemically mutate between the molecules, as its edges.\n", - "\n", - "The pipeline for creating a `LigandNetwork` involves three components:\n", - "\n", - "* **Atom Mapper**: Proposes potential atom mappings (descriptions of the alchemical change) for pairs of ligands. We will use the `LomapAtomMapper`.\n", - "* **Scorer**: Given an atom mapping, provides an estimate of the quality of that mapping (higher scores are better). We will use `default_lomap_scorer`.\n", - "* **Network Planner**: Creates the actual `LigandNetwork`; different network planners provide different strategies. We will create a minimal spanning network with the `generate_minimal_spanning_network` method.\n", - "\n", - "Each of these components could be replaced by other options." - ] - }, - { - "cell_type": "code", - "execution_count": 3, - "id": "5a3cf244", - "metadata": {}, - "outputs": [], - "source": [ - "mapper = openfe.LomapAtomMapper(max3d=1.0, element_change=False, threed=True)\n", - "scorer = openfe.lomap_scorers.default_lomap_score\n", - "network_planner = openfe.ligand_network_planning.generate_minimal_spanning_network" - ] - }, - { - "cell_type": "markdown", - "id": "acc13581", - "metadata": {}, - "source": [ - "The exact call signature depends on the network planner: a minimal spanning network requires a score, whereas that is optional for a radial network (but a radial network needs the central ligand to be provided)." - ] - }, - { - "cell_type": "code", - "execution_count": 4, - "id": "f6e7bce5", - "metadata": {}, - "outputs": [ - { - "data": { - "application/vnd.jupyter.widget-view+json": { - "model_id": "65211ee36b3d4cea971643c08cdb920b", - "version_major": 2, - "version_minor": 0 - }, - "text/plain": [ - " 23%|##2 | 39/171 [00:01<00:05, 25.66it/s]" - ] - }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "ligand_network = network_planner(\n", - " ligands=ligands,\n", - " mappers=mapper,\n", - " scorer=scorer\n", - ")" - ] - }, - { - "cell_type": "markdown", - "id": "b7492637", - "metadata": {}, - "source": [ - "Now we can look at the overall structure of the `LigandNetwork`:" - ] - }, - { - "cell_type": "code", - "execution_count": 5, - "id": "e6ca6131", - "metadata": {}, - "outputs": [ - { - "data": { - "image/png": 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", - "text/plain": [ - "
" - ] - }, - "execution_count": 5, - "metadata": {}, - "output_type": "execute_result" - } - ], - "source": [ - "from openfe.utils.atommapping_network_plotting import plot_atommapping_network\n", - "plot_atommapping_network(ligand_network)" - ] - }, - { - "cell_type": "markdown", - "id": "5f99678c", - "metadata": {}, - "source": [ - "We can also inspect the individual atom mappings:" - ] - }, - { - "cell_type": "code", - "execution_count": 6, - "id": "c55cbcac", - "metadata": {}, - "outputs": [ - { - "data": { - "image/png": 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", - "text/plain": [ - "" - ] - }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "# get the first edge; it automatically displays in a Jupyter notebook\n", - "mapping = next(iter(ligand_network.edges))\n", - "mapping" - ] - }, - { - "cell_type": "markdown", - "id": "dd0c96d7", - "metadata": {}, - "source": [ - "To get the score for this mapping, we inspect its `annotations` attribute. Arbitrary annotations can be added when a mapping is created, although our network generator only includes the score." - ] - }, - { - "cell_type": "code", - "execution_count": 7, - "id": "6b7492d7", - "metadata": {}, - "outputs": [ - { - "data": { - "text/plain": [ - "{'score': 0.49658530379140947}" - ] - }, - "execution_count": 7, - "metadata": {}, - "output_type": "execute_result" - } - ], - "source": [ - "# higher score is better\n", - "mapping.annotations" - ] - }, - { - "cell_type": "markdown", - "id": "838d9c49", - "metadata": {}, - "source": [ - "We can also use the py3dmol openfe interface to visualise our mappings in 3D" - ] - }, - { - "cell_type": "code", - "execution_count": 8, - "id": "e665b583", - "metadata": {}, - "outputs": [], - "source": [ - "from ipywidgets import interact, widgets\n", - "from openfe.utils.visualization_3D import view_mapping_3d\n", - "\n", - "edges = list(ligand_network.edges)\n", - "\n", - "def display_edge_3d(index):\n", - " view = view_mapping_3d(edges[index], spheres=True, show_atomIDs=True)\n", - " view.show()" - ] - }, - { - "cell_type": "code", - "execution_count": 9, - "id": "e9326f0c", - "metadata": {}, - "outputs": [ - { - "data": { - "application/vnd.jupyter.widget-view+json": { - "model_id": "4e79e70b2af24d5a95a0830fd8bc229e", - "version_major": 2, - "version_minor": 0 - }, - "text/plain": [ - "interactive(children=(IntSlider(value=0, description='index', max=17), Output()), _dom_classes=('widget-intera…" - ] - }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "# traverse through all views\n", - "interact(display_edge_3d, index=widgets.IntSlider(min=0, max=len(edges)-1, step=1));" - ] - }, - { - "cell_type": "markdown", - "id": "30b276b6", - "metadata": {}, - "source": [ - "You can output the ligand network to the same `graphml` format as we saw in the CLI tutorial with the following:" - ] - }, - { - "cell_type": "code", - "execution_count": 10, - "id": "2263838f", - "metadata": {}, - "outputs": [], - "source": [ - "with open(\"ligand_network.graphml\", mode='w') as f:\n", - " f.write(ligand_network.to_graphml())" - ] - }, - { - "cell_type": "markdown", - "id": "056924a3", - "metadata": {}, - "source": [ - "## Creating a single `Transformation`\n", - "\n", - "The `LigandNetwork` only knows about the small molecules and the alchemical connections between them. It doesn't know anything about environment (e.g., solvent) or about the `Protocol` that will be used during the simulation.\n", - "\n", - "That information in included in a `Transformation`. Each of these transformations corresponds to a single leg of the simulation campaign, so for each edge in the `LigandNetwork`, we will create two `Transformation`s: one for the complex and one for solvent.\n", - "\n", - "In practice, this will be done for each edge of the `LigandNetwork` in a loop, but for illustrative purposes we'll dive into the details of creating a single transformation. In particular, we'll create the solvent leg for the pair of molecules we selecting for the mapping above." - ] - }, - { - "cell_type": "markdown", - "id": "d0cb1329", - "metadata": {}, - "source": [ - "### Creating `ChemicalSystem`s\n", - "\n", - "OpenFE describes complex molecular systems as being composed of `Component`s. For example, we have `SmallMoleculeComponent` for each small molecule being perturbed in the `LigandNetwork`. We will also create a `SolventComponent` to describe the solvent, a `ProteinComponent` for our EG5 complex simulations, and an extra `SmallMoleculeCompoinent` for the ATP cofactor bound to EG5.\n", - "\n", - "The `Component`s are joined in a `ChemicalSystem`, which describes all the particles in the simulation." - ] - }, - { - "cell_type": "code", - "execution_count": 11, - "id": "9d2fbc22", - "metadata": {}, - "outputs": [], - "source": [ - "# defaults are water with NaCl at 0.15 M\n", - "solvent = openfe.SolventComponent()" - ] - }, - { - "cell_type": "code", - "execution_count": 12, - "id": "3f1706ee", - "metadata": {}, - "outputs": [], - "source": [ - "# load in the EG5 protein\n", - "protein = openfe.ProteinComponent.from_pdb_file(\"./eg5_protein.pdb\")" - ] - }, - { - "cell_type": "code", - "execution_count": 13, - "id": "18e9cba5", - "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/home/richard/miniconda3/envs/openfe_stable/lib/python3.11/site-packages/gufe/components/explicitmoleculecomponent.py:79: UserWarning: Partial charges have been provided, these will preferentially be used instead of generating new partial charges\n", - " warnings.warn(wmsg)\n" - ] - } - ], - "source": [ - "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", - "# We also go through OpenFF to assign partial charges\n", - "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"eg5_cofactor.sdf\", removeHs=False))\n", - "offmol.assign_partial_charges('am1bcc', use_conformers=offmol.conformers)\n", - "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)" - ] - }, - { - "cell_type": "code", - "execution_count": 14, - "id": "710285ca", - "metadata": {}, - "outputs": [], - "source": [ - "# Note: if you had multiple cofactors you could add any additional cofactor\n", - "# as additional dictionary entries in both of the ChemicalSystem definitions\n", - "systemA = openfe.ChemicalSystem({\n", - " 'ligand': mapping.componentA,\n", - " 'solvent': solvent,\n", - " 'protein': protein,\n", - " 'cofactor': cofactor,\n", - "})\n", - "systemB = openfe.ChemicalSystem({\n", - " 'ligand': mapping.componentB,\n", - " 'solvent': solvent,\n", - " 'protein': protein,\n", - " 'cofactor': cofactor,\n", - "})" - ] - }, - { - "cell_type": "markdown", - "id": "340d1a6e", - "metadata": {}, - "source": [ - "### Creating a `Protocol`\n", - "\n", - "The actual simulation is performed by a `Protocol`. We'll use an OpenMM-based hybrid topology relative free energy `Protocol`." - ] - }, - { - "cell_type": "code", - "execution_count": 15, - "id": "3f394a0d", - "metadata": { - "scrolled": true - }, - "outputs": [], - "source": [ - "from openfe.protocols.openmm_rfe import RelativeHybridTopologyProtocol" - ] - }, - { - "cell_type": "markdown", - "id": "3bddfa3c", - "metadata": {}, - "source": [ - "The easiest way to customize protocol settings is to start with the default settings, and modify them. Many settings carry units with them." - ] - }, - { - "cell_type": "code", - "execution_count": 16, - "id": "fb839094", - "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "PME\n", - "5.0 nanosecond\n" - ] - } - ], - "source": [ - "settings = RelativeHybridTopologyProtocol.default_settings()\n", - "print(settings.system_settings.nonbonded_method) # display default value\n", - "print(settings.simulation_settings.production_length)" - ] - }, - { - "cell_type": "markdown", - "id": "56658a3a", - "metadata": {}, - "source": [ - "We'll use the default settings for the protocol we'll use later, to match the behavior of the CLI." - ] - }, - { - "cell_type": "code", - "execution_count": 17, - "id": "7adf42d6", - "metadata": {}, - "outputs": [], - "source": [ - "default_settings = RelativeHybridTopologyProtocol.default_settings()\n", - "protocol = RelativeHybridTopologyProtocol(default_settings)" - ] - }, - { - "cell_type": "markdown", - "id": "318ff872", - "metadata": {}, - "source": [ - "### Creating the `Transformation`\n", - "\n", - "Once we have the mapping, the two `ChemicalSystem`s, and the `Protocol`, creating the `Transformation` is easy:" - ] - }, - { - "cell_type": "code", - "execution_count": 18, - "id": "44ba94ca", - "metadata": {}, - "outputs": [], - "source": [ - "transformation = openfe.Transformation(\n", - " systemA,\n", - " systemB,\n", - " protocol,\n", - " mapping={'ligand': mapping},\n", - ")" - ] - }, - { - "cell_type": "markdown", - "id": "4283dfe4", - "metadata": {}, - "source": [ - "To summarize, this `Transformation` contains:\n", - "- chemical models of both sides of the alchemical transformation in `systemA` and `systemB`\n", - "- the correspondence of items in these two sides in `mapping` \n", - "- a description of the exact computational algorithm to use to perform the estimate in `protocol`" - ] - }, - { - "cell_type": "markdown", - "id": "1e29d1c8", - "metadata": {}, - "source": [ - "## Creating the `AlchemicalNetwork`\n", - "\n", - "The `AlchemicalNetwork` contains all the information needed to run the entire campaign. It consists of a `Transformation` for each leg of the campaign. We'll loop over all the mappings, and then loop over the legs. In that inner loop, we'll make each transformation." - ] - }, - { - "cell_type": "code", - "execution_count": 19, - "id": "66666a80", - "metadata": {}, - "outputs": [], - "source": [ - "transformations = []\n", - "for mapping in ligand_network.edges:\n", - " for leg in ['solvent', 'complex']:\n", - " # use the solvent and protein created above\n", - " sysA_dict = {'ligand': mapping.componentA,\n", - " 'solvent': solvent}\n", - " sysB_dict = {'ligand': mapping.componentB,\n", - " 'solvent': solvent}\n", - " \n", - " if leg == 'complex':\n", - " sysA_dict['protein'] = protein\n", - " sysA_dict['cofactor'] = cofactor\n", - " sysB_dict['protein'] = protein\n", - " sysB_dict['cofactor'] = cofactor\n", - " \n", - " # we don't have to name objects, but it can make things (like filenames) more convenient\n", - " sysA = openfe.ChemicalSystem(sysA_dict, name=f\"{mapping.componentA.name}_{leg}\")\n", - " sysB = openfe.ChemicalSystem(sysB_dict, name=f\"{mapping.componentB.name}_{leg}\")\n", - " \n", - " prefix = \"easy_rbfe_\" # prefix is only to exactly reproduce CLI\n", - " \n", - " transformation = openfe.Transformation(\n", - " stateA=sysA,\n", - " stateB=sysB,\n", - " mapping={'ligand': mapping},\n", - " protocol=protocol, # use protocol created above\n", - " name=f\"{prefix}{sysA.name}_{sysB.name}\"\n", - " )\n", - " transformations.append(transformation)\n", - "\n", - "network = openfe.AlchemicalNetwork(transformations)" - ] - }, - { - "cell_type": "markdown", - "id": "6c61fe36", - "metadata": {}, - "source": [ - "## Writing the `AlchemicalNetwork` to disk\n", - "\n", - "We'll write out each transformation to disk, so that they can be run independently using the `openfe quickrun` command:" - ] - }, - { - "cell_type": "code", - "execution_count": 20, - "id": "d6cebd9a", - "metadata": {}, - "outputs": [], - "source": [ - "import pathlib\n", - "# first we create the directory\n", - "transformation_dir = pathlib.Path(\"transformations\")\n", - "transformation_dir.mkdir(exist_ok=True)\n", - "\n", - "# then we write out each transformation\n", - "for transformation in network.edges:\n", - " transformation.dump(transformation_dir / f\"{transformation.name}.json\")" - ] - }, - { - "cell_type": "code", - "execution_count": 21, - "id": "b96b57a9", - "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "easy_rbfe_lig_CHEMBL1082248_complex_lig_CHEMBL1082249_complex.json\n", - "easy_rbfe_lig_CHEMBL1082248_complex_lig_CHEMBL1096002_complex.json\n", - "easy_rbfe_lig_CHEMBL1082248_solvent_lig_CHEMBL1082249_solvent.json\n", - "easy_rbfe_lig_CHEMBL1082248_solvent_lig_CHEMBL1096002_solvent.json\n", - "easy_rbfe_lig_CHEMBL1083517_complex_lig_CHEMBL1086409_complex.json\n", - "easy_rbfe_lig_CHEMBL1083517_solvent_lig_CHEMBL1086409_solvent.json\n", - "easy_rbfe_lig_CHEMBL1083836_complex_lig_CHEMBL1082248_complex.json\n", - "easy_rbfe_lig_CHEMBL1083836_solvent_lig_CHEMBL1082248_solvent.json\n", - "easy_rbfe_lig_CHEMBL1084143_complex_lig_CHEMBL1086410_complex.json\n", - "easy_rbfe_lig_CHEMBL1084143_solvent_lig_CHEMBL1086410_solvent.json\n", - "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1084678_complex.json\n", - "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1085666_complex.json\n", - "easy_rbfe_lig_CHEMBL1084677_complex_lig_CHEMBL1096003_complex.json\n", - "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1084678_solvent.json\n", - "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1085666_solvent.json\n", - "easy_rbfe_lig_CHEMBL1084677_solvent_lig_CHEMBL1096003_solvent.json\n", - "easy_rbfe_lig_CHEMBL1084935_complex_lig_CHEMBL1084935_complex.json\n", - "easy_rbfe_lig_CHEMBL1084935_complex_lig_CHEMBL1086410_complex.json\n", - "easy_rbfe_lig_CHEMBL1084935_solvent_lig_CHEMBL1084935_solvent.json\n", - "easy_rbfe_lig_CHEMBL1084935_solvent_lig_CHEMBL1086410_solvent.json\n", - "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1077204_complex.json\n", - "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1084676_complex.json\n", - "easy_rbfe_lig_CHEMBL1085666_complex_lig_CHEMBL1086409_complex.json\n", - "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1077204_solvent.json\n", - "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1084676_solvent.json\n", - "easy_rbfe_lig_CHEMBL1085666_solvent_lig_CHEMBL1086409_solvent.json\n", - "easy_rbfe_lig_CHEMBL1085692_complex_lig_CHEMBL1082248_complex.json\n", - "easy_rbfe_lig_CHEMBL1085692_solvent_lig_CHEMBL1082248_solvent.json\n", - "easy_rbfe_lig_CHEMBL1086409_complex_lig_CHEMBL1082248_complex.json\n", - "easy_rbfe_lig_CHEMBL1086409_complex_lig_CHEMBL1093087_complex.json\n", - "easy_rbfe_lig_CHEMBL1086409_solvent_lig_CHEMBL1082248_solvent.json\n", - "easy_rbfe_lig_CHEMBL1086409_solvent_lig_CHEMBL1093087_solvent.json\n", - "easy_rbfe_lig_CHEMBL1086410_complex_lig_CHEMBL1077227_complex.json\n", - "easy_rbfe_lig_CHEMBL1086410_complex_lig_CHEMBL1082248_complex.json\n", - "easy_rbfe_lig_CHEMBL1086410_solvent_lig_CHEMBL1077227_solvent.json\n", - "easy_rbfe_lig_CHEMBL1086410_solvent_lig_CHEMBL1082248_solvent.json\n" - ] - } - ], - "source": [ - "!ls transformations/" - ] - }, - { - "cell_type": "markdown", - "id": "c30e8ae2", - "metadata": {}, - "source": [ - "Each of these individual `.json` files contains a `Transformation`, which contains all the information to run the calculation. These could be farmed out as individual jobs on a HPC cluster. These files are identical to what were created in setup stage of the CLI tutorial; for details on running them, follow from the section on running simulations in the CLI tutorial" - ] - } - ], - "metadata": { - "kernelspec": { - "display_name": "Python 3 (ipykernel)", - "language": "python", - "name": "python3" - }, - "language_info": { - "codemirror_mode": { - "name": "ipython", - "version": 3 - }, - "file_extension": ".py", - "mimetype": "text/x-python", - "name": "python", - "nbconvert_exporter": "python", - "pygments_lexer": "ipython3", - "version": "3.11.7" - } - }, - "nbformat": 4, - "nbformat_minor": 5 -} diff --git a/cofactors/eg5_cofactor.sdf b/cookbook/assets/cofactors/eg5_cofactor.sdf similarity index 100% rename from cofactors/eg5_cofactor.sdf rename to cookbook/assets/cofactors/eg5_cofactor.sdf diff --git a/cofactors/eg5_ligands.sdf b/cookbook/assets/cofactors/eg5_ligands.sdf similarity index 100% rename from cofactors/eg5_ligands.sdf rename to cookbook/assets/cofactors/eg5_ligands.sdf diff --git a/cofactors/eg5_ligands_positive.sdf b/cookbook/assets/cofactors/eg5_ligands_positive.sdf similarity index 100% rename from cofactors/eg5_ligands_positive.sdf rename to cookbook/assets/cofactors/eg5_ligands_positive.sdf diff --git a/cofactors/eg5_protein.pdb b/cookbook/assets/cofactors/eg5_protein.pdb similarity index 100% rename from cofactors/eg5_protein.pdb rename to cookbook/assets/cofactors/eg5_protein.pdb diff --git a/cookbook/cofactors/cofactors.ipynb b/cookbook/cofactors/cofactors.ipynb deleted file mode 100644 index b1c26a9..0000000 --- a/cookbook/cofactors/cofactors.ipynb +++ /dev/null @@ -1,341 +0,0 @@ -{ - "cells": [ - { - "cell_type": "markdown", - "id": "35354229", - "metadata": {}, - "source": [ - "# Defining Cofactors\n", - "\n", - "You can define cofactors, any small molecules that are not the bound ligand, using the openfe CLI during the planning phase or directly using the Python API.\n", - "\n", - "Similar to `ligand` definition, `cofactors` can be loaded from an SDF file format." - ] - }, - { - "cell_type": "code", - "execution_count": 2, - "id": "fc97de03", - "metadata": {}, - "outputs": [], - "source": [ - "%matplotlib inline\n", - "import openfe" - ] - }, - { - "cell_type": "markdown", - "id": "d18da4a7-0001-4c04-8f9b-b197f3a1f1b5", - "metadata": {}, - "source": [ - "## CLI: define cofactors during ``openfe plan-*``" - ] - }, - { - "cell_type": "code", - "execution_count": 13, - "id": "c93bdced-2862-465e-b9df-2110ee05b996", - "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/pty.py:95: DeprecationWarning: This process (pid=60788) is multi-threaded, use of forkpty() may lead to deadlocks in the child.\n", - " pid, fd = os.forkpty()\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Usage: openfe plan-rbfe-network [OPTIONS]\n", - "Try 'openfe plan-rbfe-network -h' for help.\n", - "\n", - "Error: Invalid value for '-M' / '--molecules': Path 'ligands.sdf' does not exist.\n" - ] - } - ], - "source": [ - "! openfe plan-rbfe-network -M ligands.sdf -p protein.pdb --cofactors cofactors.sdf" - ] - }, - { - "cell_type": "markdown", - "id": "a51b59e7-480c-45f9-9a7c-bf0aee1a0d8c", - "metadata": {}, - "source": [ - "## Python API: define cofactors in the ``ChemicalSystem``s " - ] - }, - { - "cell_type": "markdown", - "id": "7e56bd3b-9897-4761-a97b-fa6162bfa31b", - "metadata": {}, - "source": [ - "### Load the ligands and cofactors" - ] - }, - { - "cell_type": "code", - "execution_count": 8, - "id": "371dc488-80a5-40ad-bf51-9cd5d8d4aeea", - "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n", - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n" - ] - } - ], - "source": [ - "from rdkit import Chem\n", - "from openff.toolkit import Molecule\n", - "\n", - "# Create a list of OpenFF molecules\n", - "offmols = [\n", - " Molecule.from_rdkit(m)\n", - " for m in Chem.SDMolSupplier(\"eg5_ligands_positive.sdf\", removeHs=False)\n", - "]\n", - "\n", - "# Assign partial charges via AM1BCC\n", - "for mol in offmols:\n", - " mol.assign_partial_charges('am1bcc', use_conformers=mol.conformers)\n", - "\n", - "# Now we convert them to SmallMoleculeComponent\n", - "ligands = [openfe.SmallMoleculeComponent.from_openff(mol) for mol in offmols]" - ] - }, - { - "cell_type": "code", - "execution_count": 7, - "id": "0526c65b-b69c-47a3-8ca0-056fa76f4aee", - "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n" - ] - } - ], - "source": [ - "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", - "# We also go through OpenFF to assign partial charges\n", - "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"eg5_cofactor.sdf\", removeHs=False))\n", - "offmol.assign_partial_charges('am1bcc', use_conformers=offmol.conformers)\n", - "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)" - ] - }, - { - "cell_type": "markdown", - "id": "4e299fd3-8554-4a22-9829-804cf02df1f8", - "metadata": {}, - "source": [ - "### Create the Network" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "e7c5da37-eff9-4f63-a8b8-00248d193972", - "metadata": {}, - "outputs": [], - "source": [ - "mapper = openfe.LomapAtomMapper(max3d=1.0, element_change=False, threed=True)\n", - "scorer = openfe.lomap_scorers.default_lomap_score\n", - "network_planner = openfe.ligand_network_planning.generate_minimal_spanning_network" - ] - }, - { - "cell_type": "markdown", - "id": "69bbf2d0-11dd-4ded-8786-86d84cf20075", - "metadata": {}, - "source": [ - "### Create the Chemical Systems" - ] - }, - { - "cell_type": "code", - "execution_count": 9, - "id": "92015cf3-f55f-4ffd-b333-d26874ea6ff3", - "metadata": {}, - "outputs": [], - "source": [ - "# defaults are water with NaCl at 0.15 M\n", - "solvent = openfe.SolventComponent()\n", - "\n", - "# load in the EG5 protein\n", - "protein = openfe.ProteinComponent.from_pdb_file(\"./eg5_protein.pdb\")" - ] - }, - { - "cell_type": "code", - "execution_count": 10, - "id": "ba9a0ab0-1b18-47f2-84f9-5a60da3a556c", - "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/openff/toolkit/utils/toolkit_registry.py:262: UserWarning: `NAGLToolkitWrapper.assign_partial_charges` was passed optional argument `use_conformers` which will not be used. OpenFF NAGL does not generate conformers as part of assigning partial charges.\n", - " return method(*args, **kwargs)\n" - ] - } - ], - "source": [ - "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", - "# We also go through OpenFF to assign partial charges\n", - "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"eg5_cofactor.sdf\", removeHs=False))\n", - "offmol.assign_partial_charges('am1bcc', use_conformers=offmol.conformers)\n", - "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)" - ] - }, - { - "cell_type": "code", - "execution_count": 11, - "id": "49ae8a9b-3391-4dc3-8be0-5885724d5880", - "metadata": {}, - "outputs": [ - { - "ename": "NameError", - "evalue": "name 'mapping' is not defined", - "output_type": "error", - "traceback": [ - "\u001b[31m---------------------------------------------------------------------------\u001b[39m", - "\u001b[31mNameError\u001b[39m Traceback (most recent call last)", - "\u001b[36mCell\u001b[39m\u001b[36m \u001b[39m\u001b[32mIn[11]\u001b[39m\u001b[32m, line 4\u001b[39m\n\u001b[32m 1\u001b[39m \u001b[38;5;66;03m# Note: if you had multiple cofactors you could add any additional cofactor\u001b[39;00m\n\u001b[32m 2\u001b[39m \u001b[38;5;66;03m# as additional dictionary entries in both of the ChemicalSystem definitions\u001b[39;00m\n\u001b[32m 3\u001b[39m systemA = openfe.ChemicalSystem({\n\u001b[32m----> \u001b[39m\u001b[32m4\u001b[39m \u001b[33m'\u001b[39m\u001b[33mligand\u001b[39m\u001b[33m'\u001b[39m: \u001b[43mmapping\u001b[49m.componentA,\n\u001b[32m 5\u001b[39m \u001b[33m'\u001b[39m\u001b[33msolvent\u001b[39m\u001b[33m'\u001b[39m: solvent,\n\u001b[32m 6\u001b[39m \u001b[33m'\u001b[39m\u001b[33mprotein\u001b[39m\u001b[33m'\u001b[39m: protein,\n\u001b[32m 7\u001b[39m \u001b[33m'\u001b[39m\u001b[33mcofactor\u001b[39m\u001b[33m'\u001b[39m: cofactor,\n\u001b[32m 8\u001b[39m })\n\u001b[32m 9\u001b[39m systemB = openfe.ChemicalSystem({\n\u001b[32m 10\u001b[39m \u001b[33m'\u001b[39m\u001b[33mligand\u001b[39m\u001b[33m'\u001b[39m: mapping.componentB,\n\u001b[32m 11\u001b[39m \u001b[33m'\u001b[39m\u001b[33msolvent\u001b[39m\u001b[33m'\u001b[39m: solvent,\n\u001b[32m 12\u001b[39m \u001b[33m'\u001b[39m\u001b[33mprotein\u001b[39m\u001b[33m'\u001b[39m: protein,\n\u001b[32m 13\u001b[39m \u001b[33m'\u001b[39m\u001b[33mcofactor\u001b[39m\u001b[33m'\u001b[39m: cofactor,\n\u001b[32m 14\u001b[39m })\n", - "\u001b[31mNameError\u001b[39m: name 'mapping' is not defined" - ] - } - ], - "source": [ - "# Note: if you had multiple cofactors you could add any additional cofactor\n", - "# as additional dictionary entries in both of the ChemicalSystem definitions\n", - "systemA = openfe.ChemicalSystem({\n", - " 'ligand': mapping.componentA,\n", - " 'solvent': solvent,\n", - " 'protein': protein,\n", - " 'cofactor': cofactor,\n", - "})\n", - "systemB = openfe.ChemicalSystem({\n", - " 'ligand': mapping.componentB,\n", - " 'solvent': solvent,\n", - " 'protein': protein,\n", - " 'cofactor': cofactor,\n", - "})" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "e7789300-be71-4b77-8448-364b884c4ace", - "metadata": {}, - "outputs": [], - "source": [ - "transformations = []\n", - "for mapping in ligand_network.edges:\n", - " for leg in ['solvent', 'complex']:\n", - " # use the solvent and protein created above\n", - " sysA_dict = {'ligand': mapping.componentA,\n", - " 'solvent': solvent}\n", - " sysB_dict = {'ligand': mapping.componentB,\n", - " 'solvent': solvent}\n", - " \n", - " if leg == 'complex':\n", - " sysA_dict['protein'] = protein\n", - " sysA_dict['cofactor'] = cofactor\n", - " sysB_dict['protein'] = protein\n", - " sysB_dict['cofactor'] = cofactor\n", - " \n", - " # we don't have to name objects, but it can make things (like filenames) more convenient\n", - " sysA = openfe.ChemicalSystem(sysA_dict, name=f\"{mapping.componentA.name}_{leg}\")\n", - " sysB = openfe.ChemicalSystem(sysB_dict, name=f\"{mapping.componentB.name}_{leg}\")\n", - " \n", - " prefix = \"easy_rbfe_\" # prefix is only to exactly reproduce CLI\n", - " \n", - " transformation = openfe.Transformation(\n", - " stateA=sysA,\n", - " stateB=sysB,\n", - " mapping={'ligand': mapping},\n", - " protocol=protocol, # use protocol created above\n", - " name=f\"{prefix}{sysA.name}_{sysB.name}\"\n", - " )\n", - " transformations.append(transformation)\n", - "\n", - "network = openfe.AlchemicalNetwork(transformations)" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "3f26c125-4e93-492e-a235-ed5c7d4f4927", - "metadata": {}, - "outputs": [], - "source": [] - } - ], - "metadata": { - "kernelspec": { - "display_name": "Python 3 (ipykernel)", - "language": "python", - "name": "python3" - }, - "language_info": { - "codemirror_mode": { - "name": "ipython", - "version": 3 - }, - "file_extension": ".py", - "mimetype": "text/x-python", - "name": "python", - "nbconvert_exporter": "python", - "pygments_lexer": "ipython3", - "version": "3.13.11" - } - }, - "nbformat": 4, - "nbformat_minor": 5 -} diff --git a/cookbook/cofactors_rbfe.ipynb b/cookbook/cofactors_rbfe.ipynb new file mode 100644 index 0000000..c16e576 --- /dev/null +++ b/cookbook/cofactors_rbfe.ipynb @@ -0,0 +1,283 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "35354229", + "metadata": {}, + "source": [ + "# Defining Cofactors\n", + "\n", + "This cookbook demonstrates how to define cofactors (any small molecules that are not the bound ligand) with 1) the ``openfe`` CLI during the planning phase and 2) directly using the Python API.\n", + "\n", + "Similar to `ligand` definition, `cofactors` can be loaded from in SDF file format, and multiple molecules can be defined in a single file." + ] + }, + { + "cell_type": "markdown", + "id": "d18da4a7-0001-4c04-8f9b-b197f3a1f1b5", + "metadata": {}, + "source": [ + "## 1) CLI: define cofactors during ``openfe plan-rbfe-network``" + ] + }, + { + "cell_type": "markdown", + "id": "bf120991-50ab-4e6a-af73-2cf471c3d3c4", + "metadata": {}, + "source": [ + "When using openfe's CLI, including cofactors in an RBFE calculation is as simple as passing in the ``-C`` argument with the path to the SDf file containing cofactors:\n", + "\n", + "```bash\n", + "openfe plan-rbfe-network -M ligands.sdf -p protein.pdb -C cofactors.sdf\n", + "```" + ] + }, + { + "cell_type": "markdown", + "id": "a51b59e7-480c-45f9-9a7c-bf0aee1a0d8c", + "metadata": {}, + "source": [ + "## 2) Python API: define cofactors in the ``ChemicalSystem``s " + ] + }, + { + "cell_type": "markdown", + "id": "5b2f982c-1340-4272-905e-93a2d6221997", + "metadata": {}, + "source": [ + "If using the ``openfe`` Python API to set up an RBFE network, cofactors need to be included when constructing the ``ChemicalSystem``s." + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "id": "fc97de03", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/mdtraj/core/selection.py:47: DeprecationWarning: 'enablePackrat' deprecated - use 'enable_packrat'\n", + " ParserElement.enablePackrat(cache_size_limit=304)\n" + ] + } + ], + "source": [ + "import openfe" + ] + }, + { + "cell_type": "markdown", + "id": "7e56bd3b-9897-4761-a97b-fa6162bfa31b", + "metadata": {}, + "source": [ + "### Define the components (protein, ligands, cofactors)" + ] + }, + { + "cell_type": "markdown", + "id": "f7490fec-f420-466b-8e5b-5465f37f3d9b", + "metadata": {}, + "source": [ + "Define the ligands, protein, and solvent in the same way as a typical RBFE calculation:" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "371dc488-80a5-40ad-bf51-9cd5d8d4aeea", + "metadata": { + "scrolled": true + }, + "outputs": [], + "source": [ + "from rdkit import Chem\n", + "from openff.toolkit import Molecule\n", + "\n", + "# Create a list of OpenFF molecules\n", + "offmols = [\n", + " Molecule.from_rdkit(m)\n", + " for m in Chem.SDMolSupplier(\"assets/cofactors/eg5_ligands_positive.sdf\", removeHs=False)\n", + "]\n", + "\n", + "# Assign partial charges via AM1BCC\n", + "for mol in offmols:\n", + " mol.assign_partial_charges('am1bcc')\n", + "\n", + "# Now we convert them to SmallMoleculeComponent\n", + "ligands = [openfe.SmallMoleculeComponent.from_openff(mol) for mol in offmols]\n", + "\n", + "# defaults are water with NaCl at 0.15 M\n", + "solvent = openfe.SolventComponent()\n", + "\n", + "# load in the EG5 protein\n", + "protein = openfe.ProteinComponent.from_pdb_file(\"assets/cofactors/eg5_ligands_positive.sdfeg5_protein.pdb\")" + ] + }, + { + "cell_type": "markdown", + "id": "7f42ca46-9edf-4dc6-abe5-bfbc8c2e6b48", + "metadata": {}, + "source": [ + "Load the cofactor(s) to be included in the simulations:" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "1523c2dc-b71a-473e-b02f-77475245ae43", + "metadata": {}, + "outputs": [], + "source": [ + "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", + "# We also go through OpenFF to assign partial charges\n", + "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"assets/cofactors/eg5_cofactor.sdf\", removeHs=False))\n", + "offmol.assign_partial_charges('am1bcc', use_conformers=offmol.conformers)\n", + "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)\n", + "cofactor" + ] + }, + { + "cell_type": "markdown", + "id": "5722a218-82e4-4e59-94d2-9e47e8e3c00a", + "metadata": {}, + "source": [ + "### Create the Ligand Network\n", + "\n", + "(This doesn't require any specific cofactor steps, but is included for completeness)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "e7c5da37-eff9-4f63-a8b8-00248d193972", + "metadata": {}, + "outputs": [], + "source": [ + "mapper = openfe.LomapAtomMapper(max3d=1.0, element_change=False, threed=True)\n", + "scorer = openfe.lomap_scorers.default_lomap_score\n", + "network_planner = openfe.ligand_network_planning.generate_minimal_spanning_network\n", + "\n", + "ligand_network = network_planner(\n", + " ligands=ligands,\n", + " mappers=mapper,\n", + " scorer=scorer\n", + ")" + ] + }, + { + "cell_type": "markdown", + "id": "7afd9801-9a9d-4cda-a68f-e531a2b31180", + "metadata": {}, + "source": [ + "### Define an RBFE Protocol\n", + "\n", + "(This doesn't require any specific cofactor steps, but is included for completeness)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "32f36cd0-fb77-4d26-8354-3282bc2f1db4", + "metadata": {}, + "outputs": [], + "source": [ + "from openfe.protocols.openmm_rfe import RelativeHybridTopologyProtocol\n", + "\n", + "default_settings = RelativeHybridTopologyProtocol.default_settings()\n", + "protocol = RelativeHybridTopologyProtocol(default_settings)" + ] + }, + { + "cell_type": "markdown", + "id": "9f7e445f-e99a-433a-9987-8cfdf05bf21e", + "metadata": {}, + "source": [ + "### Create an ``AlchemicalNetwork`` that includes cofactors\n", + "\n", + "When creating the legs of``AlchemicalNetwork``, you must explicitly define the cofactors as part of the complex legs' ``ChemicalSystem``s." + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "c7f13bd1-5bd4-493a-bbc5-9a11a9b1adfe", + "metadata": {}, + "outputs": [], + "source": [ + "transformations = []\n", + "for mapping in ligand_network.edges:\n", + " for leg in ['solvent', 'complex']:\n", + " # use the solvent and protein created above\n", + " sysA_dict = {'ligand': mapping.componentA,\n", + " 'solvent': solvent}\n", + " sysB_dict = {'ligand': mapping.componentB,\n", + " 'solvent': solvent}\n", + " \n", + " if leg == 'complex':\n", + " sysA_dict['protein'] = protein\n", + " sysB_dict['protein'] = protein\n", + " # Add cofactors to both sysA and sysB \n", + " sysA_dict['cofactor'] = cofactor\n", + " sysB_dict['cofactor'] = cofactor \n", + " \n", + " # we don't have to name objects, but it can make things (like filenames) more convenient\n", + " sysA = openfe.ChemicalSystem(sysA_dict, name=f\"{mapping.componentA.name}_{leg}\")\n", + " sysB = openfe.ChemicalSystem(sysB_dict, name=f\"{mapping.componentB.name}_{leg}\")\n", + " \n", + " prefix = \"rbfe_\" # prefix is only to exactly reproduce CLI\n", + " \n", + " transformation = openfe.Transformation(\n", + " stateA=sysA,\n", + " stateB=sysB,\n", + " mapping={'ligand': mapping},\n", + " protocol=protocol, # use protocol created above\n", + " name=f\"{prefix}{sysA.name}_{sysB.name}\"\n", + " )\n", + " transformations.append(transformation)\n", + "\n", + "network = openfe.AlchemicalNetwork(transformations)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "775f4201-7fad-4e2e-801b-56696524ed8d", + "metadata": {}, + "outputs": [], + "source": [ + "network" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "43bc4e63-4517-40bd-9d2e-db7d4ac5eb24", + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.13.11" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} From 51bf4e05bb21a3ddf4311081d1c8f1e120f49a1a Mon Sep 17 00:00:00 2001 From: Alyssa Travitz Date: Tue, 20 Jan 2026 07:58:01 -0800 Subject: [PATCH 07/12] fix path typo --- cookbook/cofactors_rbfe.ipynb | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/cookbook/cofactors_rbfe.ipynb b/cookbook/cofactors_rbfe.ipynb index c16e576..2237276 100644 --- a/cookbook/cofactors_rbfe.ipynb +++ b/cookbook/cofactors_rbfe.ipynb @@ -112,7 +112,7 @@ "solvent = openfe.SolventComponent()\n", "\n", "# load in the EG5 protein\n", - "protein = openfe.ProteinComponent.from_pdb_file(\"assets/cofactors/eg5_ligands_positive.sdfeg5_protein.pdb\")" + "protein = openfe.ProteinComponent.from_pdb_file(\"assets/cofactors/eg5_protein.pdb\")" ] }, { From a6dfa57f37b1c1122b08aa15a392459a11dbd10a Mon Sep 17 00:00:00 2001 From: Alyssa Travitz Date: Tue, 20 Jan 2026 09:30:53 -0800 Subject: [PATCH 08/12] pre-charge molecules --- cookbook/assets/cofactors/eg5_cofactor.sdf | 87 - .../assets/cofactors/eg5_cofactor_charged.sdf | 98 + cookbook/assets/cofactors/eg5_ligands.sdf | 6968 ---------------- .../assets/cofactors/eg5_ligands_charged.sdf | 7321 +++++++++++++++++ .../assets/cofactors/eg5_ligands_positive.sdf | 4864 ----------- cookbook/cofactors_rbfe.ipynb | 43 +- 6 files changed, 7439 insertions(+), 11942 deletions(-) delete mode 100644 cookbook/assets/cofactors/eg5_cofactor.sdf create mode 100644 cookbook/assets/cofactors/eg5_cofactor_charged.sdf delete mode 100644 cookbook/assets/cofactors/eg5_ligands.sdf create mode 100644 cookbook/assets/cofactors/eg5_ligands_charged.sdf delete mode 100644 cookbook/assets/cofactors/eg5_ligands_positive.sdf diff --git a/cookbook/assets/cofactors/eg5_cofactor.sdf b/cookbook/assets/cofactors/eg5_cofactor.sdf deleted file mode 100644 index c0529b6..0000000 --- a/cookbook/assets/cofactors/eg5_cofactor.sdf +++ /dev/null @@ -1,87 +0,0 @@ -3L9H - 3D - Schrodinger Suite 2021-1. - 39 41 0 0 1 0 999 V2000 - 17.7103 1.3810 16.7258 P 0 0 0 0 0 0 - 16.2918 1.9380 16.9415 O 0 0 0 0 0 0 - 17.7048 -0.1381 16.4765 O 0 5 0 0 0 0 - 18.4945 2.1622 15.6604 O 0 5 0 0 0 0 - 20.1704 1.9553 18.6598 P 0 0 0 0 0 0 - 21.0614 1.4768 17.5414 O 0 0 0 0 0 0 - 20.2345 3.3559 19.2252 O 0 5 0 0 0 0 - 18.5522 1.6400 18.2257 O 0 0 0 0 0 0 - 20.3327 0.8377 19.9634 O 0 0 0 0 0 0 - 19.5869 1.0879 21.1452 C 0 0 0 0 0 0 - 20.4613 1.1653 22.4074 C 0 0 1 0 0 0 - 21.0911 -0.0950 22.5958 O 0 0 0 0 0 0 - 21.6078 2.1760 22.3912 C 0 0 1 0 0 0 - 21.7761 2.7834 23.6633 O 0 0 0 0 0 0 - 22.8150 1.3580 21.9342 C 0 0 1 0 0 0 - 24.0771 1.7580 22.4399 O 0 0 0 0 0 0 - 22.4830 -0.0283 22.4899 C 0 0 2 0 0 0 - 22.9954 -1.1724 21.6426 N 0 0 0 0 0 0 - 22.4947 -1.6440 20.4842 C 0 0 0 0 0 0 - 23.2096 -2.5994 19.9459 N 0 0 0 0 0 0 - 24.2457 -2.7439 20.7874 C 0 0 0 0 0 0 - 25.3696 -3.6002 20.7533 C 0 0 0 0 0 0 - 25.5873 -4.5319 19.7432 N 0 0 0 0 0 0 - 26.2748 -3.5190 21.7663 N 0 0 0 0 0 0 - 26.0465 -2.6305 22.7424 C 0 0 0 0 0 0 - 25.0272 -1.7702 22.8844 N 0 0 0 0 0 0 - 24.1457 -1.8743 21.8585 C 0 0 0 0 0 0 - 18.9006 0.2596 21.2825 H 0 0 0 0 0 0 - 18.9668 1.9826 21.0671 H 0 0 0 0 0 0 - 19.7967 1.3439 23.2547 H 0 0 0 0 0 0 - 21.4113 2.9719 21.6708 H 0 0 0 0 0 0 - 22.6054 3.2689 23.6516 H 0 0 0 0 0 0 - 22.8340 1.3030 20.8442 H 0 0 0 0 0 0 - 24.3615 2.5656 21.9940 H 0 0 0 0 0 0 - 22.8770 -0.1608 23.5002 H 0 0 0 0 0 0 - 21.5746 -1.2447 20.0891 H 0 0 0 0 0 0 - 26.3917 -5.1389 19.8129 H 0 0 0 0 0 0 - 24.9075 -4.6313 19.0027 H 0 0 0 0 0 0 - 26.7890 -2.6030 23.5264 H 0 0 0 0 0 0 - 1 2 2 0 0 0 - 1 3 1 0 0 0 - 1 4 1 0 0 0 - 1 8 1 0 0 0 - 5 6 2 0 0 0 - 5 7 1 0 0 0 - 5 8 1 0 0 0 - 5 9 1 0 0 0 - 9 10 1 0 0 0 - 10 11 1 0 0 0 - 10 28 1 0 0 0 - 10 29 1 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 11 30 1 0 0 0 - 12 17 1 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 13 31 1 0 0 0 - 14 32 1 0 0 0 - 15 16 1 0 0 0 - 15 17 1 0 0 0 - 15 33 1 0 0 0 - 16 34 1 0 0 0 - 17 18 1 0 0 0 - 17 35 1 0 0 0 - 18 19 1 0 0 0 - 18 27 1 0 0 0 - 19 20 2 0 0 0 - 19 36 1 0 0 0 - 20 21 1 0 0 0 - 21 22 1 0 0 0 - 21 27 2 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 23 37 1 0 0 0 - 23 38 1 0 0 0 - 24 25 1 0 0 0 - 25 26 2 0 0 0 - 25 39 1 0 0 0 - 26 27 1 0 0 0 -M CHG 3 3 -1 4 -1 7 -1 -M END -$$$$ diff --git a/cookbook/assets/cofactors/eg5_cofactor_charged.sdf b/cookbook/assets/cofactors/eg5_cofactor_charged.sdf new file mode 100644 index 0000000..f5a45e9 --- /dev/null +++ b/cookbook/assets/cofactors/eg5_cofactor_charged.sdf @@ -0,0 +1,98 @@ +3L9H + RDKit 3D + + 39 41 0 0 0 0 0 0 0 0999 V2000 + 17.7103 1.3810 16.7258 P 0 0 0 0 0 5 0 0 0 0 0 0 + 16.2918 1.9380 16.9415 O 0 0 0 0 0 0 0 0 0 0 0 0 + 17.7048 -0.1381 16.4765 O 0 0 0 0 0 0 0 0 0 0 0 0 + 18.4945 2.1622 15.6604 O 0 0 0 0 0 0 0 0 0 0 0 0 + 20.1704 1.9553 18.6598 P 0 0 1 0 0 5 0 0 0 0 0 0 + 21.0614 1.4768 17.5414 O 0 0 0 0 0 0 0 0 0 0 0 0 + 20.2345 3.3559 19.2252 O 0 0 0 0 0 0 0 0 0 0 0 0 + 18.5522 1.6400 18.2257 O 0 0 0 0 0 0 0 0 0 0 0 0 + 20.3327 0.8377 19.9634 O 0 0 0 0 0 0 0 0 0 0 0 0 + 19.5869 1.0879 21.1452 C 0 0 0 0 0 0 0 0 0 0 0 0 + 20.4613 1.1653 22.4074 C 0 0 1 0 0 0 0 0 0 0 0 0 + 21.0911 -0.0950 22.5958 O 0 0 0 0 0 0 0 0 0 0 0 0 + 21.6078 2.1760 22.3912 C 0 0 1 0 0 0 0 0 0 0 0 0 + 21.7761 2.7834 23.6633 O 0 0 0 0 0 0 0 0 0 0 0 0 + 22.8150 1.3580 21.9342 C 0 0 1 0 0 0 0 0 0 0 0 0 + 24.0771 1.7580 22.4399 O 0 0 0 0 0 0 0 0 0 0 0 0 + 22.4830 -0.0283 22.4899 C 0 0 2 0 0 0 0 0 0 0 0 0 + 22.9954 -1.1724 21.6426 N 0 0 0 0 0 0 0 0 0 0 0 0 + 22.4947 -1.6440 20.4842 C 0 0 0 0 0 0 0 0 0 0 0 0 + 23.2096 -2.5994 19.9459 N 0 0 0 0 0 0 0 0 0 0 0 0 + 24.2457 -2.7439 20.7874 C 0 0 0 0 0 0 0 0 0 0 0 0 + 25.3696 -3.6002 20.7533 C 0 0 0 0 0 0 0 0 0 0 0 0 + 25.5873 -4.5319 19.7432 N 0 0 0 0 0 0 0 0 0 0 0 0 + 26.2748 -3.5190 21.7663 N 0 0 0 0 0 0 0 0 0 0 0 0 + 26.0465 -2.6305 22.7424 C 0 0 0 0 0 0 0 0 0 0 0 0 + 25.0272 -1.7702 22.8844 N 0 0 0 0 0 0 0 0 0 0 0 0 + 24.1457 -1.8743 21.8585 C 0 0 0 0 0 0 0 0 0 0 0 0 + 18.9006 0.2596 21.2825 H 0 0 0 0 0 0 0 0 0 0 0 0 + 18.9668 1.9826 21.0671 H 0 0 0 0 0 0 0 0 0 0 0 0 + 19.7967 1.3439 23.2547 H 0 0 0 0 0 0 0 0 0 0 0 0 + 21.4113 2.9719 21.6708 H 0 0 0 0 0 0 0 0 0 0 0 0 + 22.6054 3.2689 23.6516 H 0 0 0 0 0 0 0 0 0 0 0 0 + 22.8340 1.3030 20.8442 H 0 0 0 0 0 0 0 0 0 0 0 0 + 24.3615 2.5656 21.9940 H 0 0 0 0 0 0 0 0 0 0 0 0 + 22.8770 -0.1608 23.5002 H 0 0 0 0 0 0 0 0 0 0 0 0 + 21.5746 -1.2447 20.0891 H 0 0 0 0 0 0 0 0 0 0 0 0 + 26.3917 -5.1389 19.8129 H 0 0 0 0 0 0 0 0 0 0 0 0 + 24.9075 -4.6313 19.0027 H 0 0 0 0 0 0 0 0 0 0 0 0 + 26.7890 -2.6030 23.5264 H 0 0 0 0 0 0 0 0 0 0 0 0 + 1 2 2 0 + 1 3 1 0 + 1 4 1 0 + 1 8 1 0 + 5 6 2 0 + 5 7 1 1 + 5 8 1 0 + 5 9 1 0 + 9 10 1 0 + 10 11 1 0 + 10 28 1 0 + 10 29 1 0 + 11 12 1 0 + 11 13 1 0 + 11 30 1 1 + 12 17 1 0 + 13 14 1 0 + 13 15 1 0 + 13 31 1 6 + 14 32 1 0 + 15 16 1 0 + 15 17 1 0 + 15 33 1 6 + 16 34 1 0 + 17 18 1 0 + 17 35 1 1 + 18 19 1 0 + 18 27 1 0 + 19 20 2 0 + 19 36 1 0 + 20 21 1 0 + 21 22 1 0 + 21 27 2 0 + 22 23 1 0 + 22 24 2 0 + 23 37 1 0 + 23 38 1 0 + 24 25 1 0 + 25 26 2 0 + 25 39 1 0 + 26 27 1 0 +M CHG 3 3 -1 4 -1 7 -1 +M END + +> +3L9H + +> +1.3988487435897436 -0.91321825641025633 -0.91321825641025633 -0.91321825641025633 1.5677487435897437 -0.67705125641025643 -0.67705125641025643 -0.77085125641025642 -0.59125125641025633 +0.1833487435897436 0.088048743589743572 -0.42865125641025642 0.064048743589743579 -0.59785125641025638 0.080048743589743579 -0.6198512564102564 0.27474874358974355 -0.28105125641025647 +0.35164874358974357 -0.76515125641025639 -0.11125125641025642 0.54814874358974364 -0.89255125641025634 -0.77805125641025641 0.56384874358974357 -0.71505125641025635 0.38374874358974354 +0.06664874358974357 0.06664874358974357 0.034648743589743576 0.16864874358974358 0.38094874358974357 0.11064874358974358 0.40294874358974359 0.042648743589743576 0.15174874358974358 +0.35724874358974357 0.35724874358974357 0.0010487435897435762 + +$$$$ diff --git a/cookbook/assets/cofactors/eg5_ligands.sdf b/cookbook/assets/cofactors/eg5_ligands.sdf deleted file mode 100644 index aa4d5fc..0000000 --- a/cookbook/assets/cofactors/eg5_ligands.sdf +++ /dev/null @@ -1,6968 +0,0 @@ -lig_CHEMBL1084677 - 3D - Schrodinger Suite 2022-3. - 62 65 0 0 1 0 999 V2000 - 34.2542 7.0437 16.2339 H 0 0 0 0 0 0 - 33.2715 7.3883 15.9458 C 0 0 0 0 0 0 - 32.1380 6.9883 16.6772 C 0 0 0 0 0 0 - 32.2499 6.3285 17.5256 H 0 0 0 0 0 0 - 30.8557 7.4292 16.2989 C 0 0 0 0 0 0 - 29.9912 7.1088 16.8615 H 0 0 0 0 0 0 - 30.7062 8.2894 15.1925 C 0 0 0 0 0 0 - 29.3313 8.7880 14.7833 C 0 0 2 0 0 0 - 28.6004 8.3418 15.4588 H 0 0 0 0 0 0 - 29.0044 8.3026 13.4488 N 0 0 0 0 0 0 - 29.1849 7.3206 13.2786 H 0 0 0 0 0 0 - 27.9860 8.9333 12.7222 C 0 0 0 0 0 0 - 27.5855 8.3637 11.4988 C 0 0 0 0 0 0 - 28.0386 7.4499 11.1440 H 0 0 0 0 0 0 - 26.5960 8.9881 10.7181 C 0 0 0 0 0 0 - 26.3100 8.5553 9.7715 H 0 0 0 0 0 0 - 25.9966 10.1902 11.1482 C 0 0 0 0 0 0 - 24.9967 10.9078 10.2617 C 0 0 0 0 0 0 - 24.3239 10.0297 9.5193 F 0 0 0 0 0 0 - 24.1307 11.6216 10.9820 F 0 0 0 0 0 0 - 25.6561 11.7367 9.4531 F 0 0 0 0 0 0 - 26.3831 10.7503 12.3807 C 0 0 0 0 0 0 - 25.9427 11.6792 12.7138 H 0 0 0 0 0 0 - 27.3766 10.1330 13.1649 C 0 0 0 0 0 0 - 27.7988 10.7860 14.4654 C 0 0 1 0 0 0 - 27.8007 11.8677 14.3097 H 0 0 0 0 0 0 - 26.8580 10.4746 15.4889 O 0 0 0 0 0 0 - 27.0928 11.1374 16.7245 C 0 0 1 0 0 0 - 27.1324 12.2104 16.5278 H 0 0 0 0 0 0 - 25.8590 10.8714 17.6225 C 0 0 0 0 0 0 - 25.4112 11.8150 17.9353 H 0 0 0 0 0 0 - 25.0855 10.3441 17.0626 H 0 0 0 0 0 0 - 26.1853 10.1005 18.8244 N 0 0 2 0 0 0 - 27.0764 9.6113 18.7919 H 0 0 0 0 0 0 - 24.9719 9.2915 19.7374 S 0 0 0 0 0 0 - 25.5924 8.9242 21.0181 O 0 0 0 0 0 0 - 23.7609 10.1244 19.7158 O 0 0 0 0 0 0 - 24.6388 7.7414 18.7894 C 0 0 0 0 0 0 - 23.9878 7.9819 17.9480 H 0 0 0 0 0 0 - 25.5857 7.3890 18.3782 H 0 0 0 0 0 0 - 24.0180 6.6801 19.7211 C 0 0 0 0 0 0 - 24.6238 6.5917 20.6237 H 0 0 0 0 0 0 - 23.0282 6.9919 20.0587 H 0 0 0 0 0 0 - 23.9849 5.3305 19.1168 N 0 3 0 0 0 0 - 24.6079 5.2929 18.3232 H 0 0 0 0 0 0 - 22.6414 4.8701 18.7249 C 0 0 0 0 0 0 - 22.6853 3.8588 18.3177 H 0 0 0 0 0 0 - 22.2023 5.5270 17.9747 H 0 0 0 0 0 0 - 21.9849 4.8552 19.5947 H 0 0 0 0 0 0 - 28.4632 10.6801 17.2790 C 0 0 0 0 0 0 - 28.6908 11.2040 18.2079 H 0 0 0 0 0 0 - 28.4445 9.6151 17.5109 H 0 0 0 0 0 0 - 29.5727 10.9364 16.2549 C 0 0 0 0 0 0 - 29.7064 12.0140 16.1439 H 0 0 0 0 0 0 - 30.5223 10.5541 16.6259 H 0 0 0 0 0 0 - 29.2119 10.3320 14.8821 C 0 0 1 0 0 0 - 29.9134 10.7527 14.1598 H 0 0 0 0 0 0 - 31.8434 8.6760 14.4516 C 0 0 0 0 0 0 - 31.7359 9.3184 13.5900 H 0 0 0 0 0 0 - 33.1218 8.2241 14.8254 C 0 0 0 0 0 0 - 33.9850 8.5255 14.2529 H 0 0 0 0 0 0 - 24.3474 4.6960 19.8319 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 60 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 58 1 0 0 0 - 8 56 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 56 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 50 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 35 36 2 0 0 0 - 35 37 2 0 0 0 - 35 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 62 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 53 1 0 0 0 - 53 54 1 0 0 0 - 53 55 1 0 0 0 - 53 56 1 0 0 0 - 56 57 1 0 0 0 - 58 59 1 0 0 0 - 58 60 2 0 0 0 - 60 61 1 0 0 0 -M CHG 1 44 1 -M END -> -ligprep_eg5.smi - -> -14 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdUyg9TykoPU8pW0NIMl1bQ0gyXVtOSF1bQ0gzXQ== - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0112 - -> - 0.0108 - -> - 0.0003 - -> - -0.0000 - -> -0.0108481 - -> -1 - -> -1 - -> -S-OPLS - -> -31.394 - -> -1 - -> -lig_CHEMBL1084677-1 - -> -glide-grid_EG5-3L9H - -> -14 - -> -8 - -> --9.52685998914813 - -> --0.288692726943883 - -> --0.925991831413369 - -> --2.11872433414547 - -> --9.52685998914813 - -> --4.55621898545261 - -> --0.332915304848589 - -> --0 - -> --1.18169917993037 - -> --51.0294227600098 - -> --10.0400190353394 - -> -0.605472246693747 - -> --0.00402477230891625 - -> --102.064413920816 - -> --61.0694417953491 - -> -6.86161708831787 - -> -32 - -> -272 - -> --0 - -> -0.0708102401621492 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1083517 - 3D - Schrodinger Suite 2022-3. - 52 55 0 0 1 0 999 V2000 - 35.2150 7.0627 16.1224 H 0 0 0 0 0 0 - 34.3851 7.0863 16.6133 O 0 0 0 0 0 0 - 33.2187 7.3991 15.9900 C 0 0 0 0 0 0 - 32.0532 6.9700 16.6427 C 0 0 0 0 0 0 - 32.1269 6.3432 17.5198 H 0 0 0 0 0 0 - 30.7902 7.3882 16.2019 C 0 0 0 0 0 0 - 29.9035 7.0674 16.7268 H 0 0 0 0 0 0 - 30.6956 8.2539 15.1011 C 0 0 0 0 0 0 - 29.3360 8.7758 14.6921 C 0 0 2 0 0 0 - 28.5956 8.3334 15.3606 H 0 0 0 0 0 0 - 29.0087 8.3044 13.3589 N 0 0 0 0 0 0 - 29.1850 7.3248 13.1712 H 0 0 0 0 0 0 - 27.9670 8.9305 12.6690 C 0 0 0 0 0 0 - 27.5512 8.3641 11.4514 C 0 0 0 0 0 0 - 28.0014 7.4495 11.0971 H 0 0 0 0 0 0 - 26.5551 8.9915 10.6838 C 0 0 0 0 0 0 - 26.2576 8.5653 9.7373 H 0 0 0 0 0 0 - 25.9698 10.1944 11.1294 C 0 0 0 0 0 0 - 24.9691 10.9274 10.2592 C 0 0 0 0 0 0 - 24.2743 10.0646 9.5189 F 0 0 0 0 0 0 - 24.1286 11.6470 11.0028 F 0 0 0 0 0 0 - 25.6292 11.7532 9.4489 F 0 0 0 0 0 0 - 26.3599 10.7421 12.3670 C 0 0 0 0 0 0 - 25.9220 11.6682 12.7092 H 0 0 0 0 0 0 - 27.3562 10.1191 13.1405 C 0 0 0 0 0 0 - 27.8061 10.7739 14.4356 C 0 0 1 0 0 0 - 27.8143 11.8524 14.2661 H 0 0 0 0 0 0 - 26.8951 10.4887 15.5032 O 0 0 0 0 0 0 - 27.1855 11.1940 16.7075 C 0 0 1 0 0 0 - 27.2620 12.2523 16.4497 H 0 0 0 0 0 0 - 25.9840 11.0721 17.6855 C 0 0 0 0 0 0 - 25.7994 12.0375 18.1592 H 0 0 0 0 0 0 - 25.0809 10.8564 17.1119 H 0 0 0 0 0 0 - 26.1267 10.0401 18.7390 N 0 3 0 0 0 0 - 25.2144 9.6269 18.8832 H 0 0 0 0 0 0 - 26.5903 10.5324 20.0533 C 0 0 0 0 0 0 - 26.6588 9.7015 20.7563 H 0 0 0 0 0 0 - 25.8875 11.2595 20.4616 H 0 0 0 0 0 0 - 27.5710 11.0015 19.9899 H 0 0 0 0 0 0 - 28.5544 10.7150 17.2353 C 0 0 0 0 0 0 - 28.8333 11.2672 18.1319 H 0 0 0 0 0 0 - 28.5125 9.6597 17.5055 H 0 0 0 0 0 0 - 29.6411 10.9156 16.1734 C 0 0 0 0 0 0 - 29.8138 11.9852 16.0476 H 0 0 0 0 0 0 - 30.5861 10.5046 16.5250 H 0 0 0 0 0 0 - 29.2294 10.3181 14.8100 C 0 0 1 0 0 0 - 29.9142 10.7354 14.0691 H 0 0 0 0 0 0 - 31.8630 8.6324 14.3985 C 0 0 0 0 0 0 - 31.7885 9.2808 13.5377 H 0 0 0 0 0 0 - 33.1307 8.2013 14.8381 C 0 0 0 0 0 0 - 34.0146 8.5386 14.3232 H 0 0 0 0 0 0 - 26.7380 9.3111 18.3991 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 50 1 0 0 0 - 3 4 2 0 0 0 - 4 5 1 0 0 0 - 4 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 2 0 0 0 - 8 9 1 0 0 0 - 8 48 1 0 0 0 - 9 46 1 0 0 0 - 9 10 1 0 0 0 - 9 11 1 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 13 25 1 0 0 0 - 13 14 2 0 0 0 - 14 15 1 0 0 0 - 14 16 1 0 0 0 - 16 17 1 0 0 0 - 16 18 2 0 0 0 - 18 19 1 0 0 0 - 18 23 1 0 0 0 - 19 20 1 0 0 0 - 19 21 1 0 0 0 - 19 22 1 0 0 0 - 23 24 1 0 0 0 - 23 25 2 0 0 0 - 25 26 1 0 0 0 - 26 46 1 0 0 0 - 26 27 1 0 0 0 - 26 28 1 0 0 0 - 28 29 1 0 0 0 - 29 30 1 0 0 0 - 29 31 1 0 0 0 - 29 40 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 31 34 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 52 1 0 0 0 - 36 37 1 0 0 0 - 36 38 1 0 0 0 - 36 39 1 0 0 0 - 40 41 1 0 0 0 - 40 42 1 0 0 0 - 40 43 1 0 0 0 - 43 44 1 0 0 0 - 43 45 1 0 0 0 - 43 46 1 0 0 0 - 46 47 1 0 0 0 - 48 49 1 0 0 0 - 48 50 2 0 0 0 - 50 51 1 0 0 0 -M CHG 1 34 1 -M END -> -ligprep_eg5.smi - -> -8 - -> -53161 - -> -0 - -> -W09IXWMxW2NIXVtjSF1jKFtjSF1bY0hdMSlbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0030 - -> - 0.0023 - -> - 0.0006 - -> - -0.0000 - -> -0.00234401 - -> -1 - -> -1 - -> -S-OPLS - -> -37.6632 - -> -1 - -> -lig_CHEMBL1083517-1 - -> -glide-grid_EG5-3L9H - -> -8 - -> -5 - -> --9.27353612538142 - -> --0.331197718763622 - -> --1.00571133919091 - -> --2.1406044205901 - -> --9.27353612538142 - -> --4.56840923087722 - -> --0.348796882604425 - -> --0 - -> --1.78888792667203 - -> --37.3650360107422 - -> --8.86820888519287 - -> -0.631041048088293 - -> -0 - -> --49.8936169088365 - -> --46.2332448959351 - -> -0.289697885513306 - -> -2 - -> -1 - -> --0 - -> -0.0821186776411881 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084143 - 3D - Schrodinger Suite 2022-3. - 74 77 0 0 1 0 999 V2000 - 34.2890 7.0549 16.2089 H 0 0 0 0 0 0 - 33.2984 7.3883 15.9243 C 0 0 0 0 0 0 - 32.1748 6.9864 16.6702 C 0 0 0 0 0 0 - 32.3011 6.3366 17.5241 H 0 0 0 0 0 0 - 30.8852 7.4111 16.2998 C 0 0 0 0 0 0 - 30.0283 7.0927 16.8776 H 0 0 0 0 0 0 - 30.7181 8.2597 15.1890 C 0 0 0 0 0 0 - 29.3371 8.7553 14.7970 C 0 0 2 0 0 0 - 28.6147 8.3142 15.4846 H 0 0 0 0 0 0 - 28.9954 8.2646 13.4668 N 0 0 0 0 0 0 - 29.1817 7.2859 13.2856 H 0 0 0 0 0 0 - 27.9850 8.9027 12.7335 C 0 0 0 0 0 0 - 27.5838 8.3471 11.5048 C 0 0 0 0 0 0 - 28.0245 7.4273 11.1494 H 0 0 0 0 0 0 - 26.6054 8.9883 10.7188 C 0 0 0 0 0 0 - 26.3155 8.5593 9.7706 H 0 0 0 0 0 0 - 26.0246 10.2002 11.1471 C 0 0 0 0 0 0 - 25.0447 10.9358 10.2428 C 0 0 0 0 0 0 - 24.5209 10.1894 9.6425 H 0 0 0 0 0 0 - 25.8202 11.8722 9.3174 C 0 0 0 0 0 0 - 26.5217 11.3047 8.7190 H 0 0 0 0 0 0 - 26.3842 12.5889 9.9073 H 0 0 0 0 0 0 - 25.1858 12.4509 8.6482 H 0 0 0 0 0 0 - 23.9982 11.7308 11.0279 C 0 0 0 0 0 0 - 23.5851 11.1146 11.8148 H 0 0 0 0 0 0 - 23.1856 12.0850 10.3954 H 0 0 0 0 0 0 - 24.4472 12.5883 11.5172 H 0 0 0 0 0 0 - 26.4188 10.7448 12.3854 C 0 0 0 0 0 0 - 26.0129 11.6846 12.7263 H 0 0 0 0 0 0 - 27.3915 10.1074 13.1771 C 0 0 0 0 0 0 - 27.8193 10.7625 14.4739 C 0 0 1 0 0 0 - 27.8404 11.8400 14.3009 H 0 0 0 0 0 0 - 26.8751 10.4887 15.5085 O 0 0 0 0 0 0 - 27.1349 11.2013 16.7104 C 0 0 1 0 0 0 - 27.2230 12.2583 16.4512 H 0 0 0 0 0 0 - 25.9065 11.0792 17.6423 C 0 0 0 0 0 0 - 25.6969 12.0572 18.0783 H 0 0 0 0 0 0 - 25.0158 10.7989 17.0789 H 0 0 0 0 0 0 - 26.1209 10.1352 18.7397 N 0 0 2 0 0 0 - 26.5354 9.2575 18.4329 H 0 0 0 0 0 0 - 24.8976 9.9019 19.9272 S 0 0 0 0 0 0 - 25.5502 9.2695 21.0852 O 0 0 0 0 0 0 - 24.1680 11.1677 20.0755 O 0 0 0 0 0 0 - 23.7931 8.6664 19.1292 C 0 0 0 0 0 0 - 22.8511 8.6615 19.6775 H 0 0 0 0 0 0 - 23.5836 8.9936 18.1103 H 0 0 0 0 0 0 - 24.4548 7.2835 19.1769 C 0 0 0 0 0 0 - 25.4377 7.3882 18.7187 H 0 0 0 0 0 0 - 24.6483 7.0012 20.2152 H 0 0 0 0 0 0 - 23.7014 6.1590 18.4469 C 0 0 0 0 0 0 - 22.8764 6.5536 17.8506 H 0 0 0 0 0 0 - 24.3926 5.7064 17.7347 H 0 0 0 0 0 0 - 23.2128 5.1113 19.3791 N 0 3 0 0 0 0 - 21.9566 5.5037 20.0506 C 0 0 0 0 0 0 - 21.1631 5.6873 19.3242 H 0 0 0 0 0 0 - 22.0949 6.4065 20.6434 H 0 0 0 0 0 0 - 21.6157 4.7174 20.7189 H 0 0 0 0 0 0 - 23.1062 3.7878 18.7314 C 0 0 0 0 0 0 - 22.3851 3.7976 17.9183 H 0 0 0 0 0 0 - 22.7907 3.0286 19.4476 H 0 0 0 0 0 0 - 24.0648 3.4746 18.3206 H 0 0 0 0 0 0 - 28.4845 10.7217 17.2882 C 0 0 0 0 0 0 - 28.7225 11.2681 18.2016 H 0 0 0 0 0 0 - 28.4314 9.6659 17.5566 H 0 0 0 0 0 0 - 29.6040 10.9126 16.2590 C 0 0 0 0 0 0 - 29.7788 11.9821 16.1283 H 0 0 0 0 0 0 - 30.5385 10.5037 16.6411 H 0 0 0 0 0 0 - 29.2265 10.2992 14.8915 C 0 0 1 0 0 0 - 29.9262 10.7113 14.1625 H 0 0 0 0 0 0 - 31.8450 8.6445 14.4306 C 0 0 0 0 0 0 - 31.7244 9.2812 13.5660 H 0 0 0 0 0 0 - 33.1304 8.2083 14.7950 C 0 0 0 0 0 0 - 33.9836 8.5120 14.2094 H 0 0 0 0 0 0 - 23.9189 4.9883 20.1044 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 72 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 70 1 0 0 0 - 8 68 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 30 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 28 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 24 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 20 23 1 0 0 0 - 24 25 1 0 0 0 - 24 26 1 0 0 0 - 24 27 1 0 0 0 - 28 29 1 0 0 0 - 28 30 2 0 0 0 - 30 31 1 0 0 0 - 31 68 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 33 34 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 62 1 0 0 0 - 36 37 1 0 0 0 - 36 38 1 0 0 0 - 36 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 41 42 2 0 0 0 - 41 43 2 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 1 0 0 0 - 47 50 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 53 1 0 0 0 - 53 54 1 0 0 0 - 53 58 1 0 0 0 - 53 74 1 0 0 0 - 54 55 1 0 0 0 - 54 56 1 0 0 0 - 54 57 1 0 0 0 - 58 59 1 0 0 0 - 58 60 1 0 0 0 - 58 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 1 0 0 0 - 62 65 1 0 0 0 - 65 66 1 0 0 0 - 65 67 1 0 0 0 - 65 68 1 0 0 0 - 68 69 1 0 0 0 - 70 71 1 0 0 0 - 70 72 2 0 0 0 - 72 73 1 0 0 0 -M CHG 1 53 1 -M END -> -ligprep_eg5.smi - -> -11 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoW2NIXVtjSF00KVtDSF0oW0NIM10pW0NIM10pW0NIMl1bQ0gyXVtDQEBIXShPMylbQ0gyXVtOSF1TKD1PKSg9TylbQ0gyXVtDSDJdW0NIMl1OKFtDSDNdKVtDSDNd - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0133 - -> - 0.0127 - -> - 0.0006 - -> - -0.0000 - -> -0.0127395 - -> -1 - -> -1 - -> -S-OPLS - -> -44.0586 - -> -1 - -> -lig_CHEMBL1084143-1 - -> -glide-grid_EG5-3L9H - -> -11 - -> -9 - -> --9.17707146718083 - -> --0.269913866681789 - -> --0.874416146802926 - -> --2.02747249523591 - -> --9.17707146718083 - -> --5.19710641060366 - -> --0.35763212329897 - -> --0 - -> --0.276346688977199 - -> --52.4617805480957 - -> --9.07236576080322 - -> -0.686425891697789 - -> --0.0484682444735191 - -> --86.3049340602711 - -> --61.5341463088989 - -> -10.7834968566895 - -> -289 - -> -91 - -> --0 - -> -0.0671303869202424 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084678 - 3D - Schrodinger Suite 2022-3. - 65 68 0 0 1 0 999 V2000 - 34.2901 7.0565 16.2136 H 0 0 0 0 0 0 - 33.2995 7.3873 15.9295 C 0 0 0 0 0 0 - 32.1778 6.9787 16.6753 C 0 0 0 0 0 0 - 32.3050 6.3301 17.5322 H 0 0 0 0 0 0 - 30.8866 7.4067 16.3086 C 0 0 0 0 0 0 - 30.0301 7.0823 16.8801 H 0 0 0 0 0 0 - 30.7145 8.2568 15.1962 C 0 0 0 0 0 0 - 29.3293 8.7443 14.8041 C 0 0 2 0 0 0 - 28.6081 8.2941 15.4920 H 0 0 0 0 0 0 - 28.9931 8.2645 13.4713 N 0 0 0 0 0 0 - 29.1869 7.2880 13.2845 H 0 0 0 0 0 0 - 27.9692 8.8970 12.7508 C 0 0 0 0 0 0 - 27.5882 8.3519 11.5097 C 0 0 0 0 0 0 - 28.0549 7.4502 11.1422 H 0 0 0 0 0 0 - 26.6126 8.9887 10.7240 C 0 0 0 0 0 0 - 26.3484 8.5772 9.7601 H 0 0 0 0 0 0 - 25.9978 10.1764 11.1739 C 0 0 0 0 0 0 - 25.0086 10.9022 10.2778 C 0 0 0 0 0 0 - 24.3521 10.0288 9.5189 F 0 0 0 0 0 0 - 24.1311 11.6175 10.9771 F 0 0 0 0 0 0 - 25.6753 11.7419 9.4872 F 0 0 0 0 0 0 - 26.3591 10.7125 12.4272 C 0 0 0 0 0 0 - 25.9084 11.6313 12.7667 H 0 0 0 0 0 0 - 27.3466 10.0831 13.2149 C 0 0 0 0 0 0 - 27.7805 10.7322 14.5166 C 0 0 1 0 0 0 - 27.7884 11.8109 14.3449 H 0 0 0 0 0 0 - 26.8584 10.4471 15.5733 O 0 0 0 0 0 0 - 27.1415 11.1474 16.7856 C 0 0 1 0 0 0 - 27.2231 12.2033 16.5214 H 0 0 0 0 0 0 - 25.9199 11.0574 17.7473 C 0 0 0 0 0 0 - 25.7172 12.0397 18.1713 H 0 0 0 0 0 0 - 25.0336 10.8167 17.1554 H 0 0 0 0 0 0 - 26.0557 10.0953 18.8632 N 0 0 1 0 0 0 - 26.6812 10.6336 20.0756 C 0 0 0 0 0 0 - 27.4336 11.3930 19.8512 H 0 0 0 0 0 0 - 27.1585 9.8367 20.6515 H 0 0 0 0 0 0 - 25.9231 11.1026 20.7053 H 0 0 0 0 0 0 - 24.7771 8.9769 19.1435 S 0 0 0 0 0 0 - 24.9663 8.4020 20.4811 O 0 0 0 0 0 0 - 23.4957 9.6156 18.7933 O 0 0 0 0 0 0 - 25.1849 7.7114 17.9133 C 0 0 0 0 0 0 - 25.2672 8.2114 16.9528 H 0 0 0 0 0 0 - 26.1848 7.3883 18.1628 H 0 0 0 0 0 0 - 24.1255 6.5997 17.8066 C 0 0 0 0 0 0 - 23.1743 7.0772 17.5655 H 0 0 0 0 0 0 - 24.3850 5.9897 16.9491 H 0 0 0 0 0 0 - 23.9442 5.6681 19.0135 C 0 0 0 0 0 0 - 24.7849 4.9897 19.1183 H 0 0 0 0 0 0 - 23.8338 6.2194 19.9454 H 0 0 0 0 0 0 - 22.7559 4.8180 18.8438 N 0 3 0 0 0 0 - 22.6304 4.2164 19.6444 H 0 0 0 0 0 0 - 22.8369 4.2362 18.0220 H 0 0 0 0 0 0 - 28.5122 10.6850 17.3186 C 0 0 0 0 0 0 - 28.7961 11.2429 18.2115 H 0 0 0 0 0 0 - 28.4729 9.6284 17.5935 H 0 0 0 0 0 0 - 29.6049 10.8986 16.2626 C 0 0 0 0 0 0 - 29.7590 11.9716 16.1323 H 0 0 0 0 0 0 - 30.5547 10.5046 16.6223 H 0 0 0 0 0 0 - 29.2027 10.2853 14.9065 C 0 0 1 0 0 0 - 29.8840 10.7043 14.1647 H 0 0 0 0 0 0 - 31.8398 8.6541 14.4419 C 0 0 0 0 0 0 - 31.7177 9.2919 13.5834 H 0 0 0 0 0 0 - 33.1291 8.2148 14.8055 C 0 0 0 0 0 0 - 33.9844 8.5276 14.2288 H 0 0 0 0 0 0 - 21.9230 5.3877 18.7539 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 63 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 61 1 0 0 0 - 8 59 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 59 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 53 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 38 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 38 39 2 0 0 0 - 38 40 2 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 1 0 0 0 - 47 50 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 65 1 0 0 0 - 53 54 1 0 0 0 - 53 55 1 0 0 0 - 53 56 1 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 56 59 1 0 0 0 - 59 60 1 0 0 0 - 61 62 1 0 0 0 - 61 63 2 0 0 0 - 63 64 1 0 0 0 -M CHG 1 50 1 -M END -> -ligprep_eg5.smi - -> -15 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1OKFtDSDNdKVMoPU8pKD1PKVtDSDJdW0NIMl1bQ0gyXVtOSDJd - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0036 - -> - 0.0036 - -> - 0.0000 - -> - -0.0000 - -> -0.00359995 - -> -1 - -> -1 - -> -S-OPLS - -> -43.8047 - -> -1 - -> -lig_CHEMBL1084678-1 - -> -glide-grid_EG5-3L9H - -> -15 - -> -8 - -> --9.0727226745557 - -> --0.266844784545756 - -> --0.86447351210763 - -> --2.00441892006052 - -> --9.0727226745557 - -> --4.58223689535746 - -> --0.153504303299394 - -> --0 - -> --1.08986131754344 - -> --50.2855339050293 - -> --8.04208660125732 - -> -0.574649666667813 - -> --0.101180139583156 - -> --92.3566109530651 - -> --58.3276205062866 - -> -3.94855976104736 - -> -6 - -> -13 - -> --0 - -> -0.0908595054518094 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1078691 - 3D - Schrodinger Suite 2022-3. - 52 55 0 0 1 0 999 V2000 - 35.1506 6.9961 16.0497 H 0 0 0 0 0 0 - 34.3743 7.0705 16.5998 O 0 0 0 0 0 0 - 33.2046 7.3830 15.9898 C 0 0 0 0 0 0 - 32.0447 6.9520 16.6533 C 0 0 0 0 0 0 - 32.1282 6.3166 17.5227 H 0 0 0 0 0 0 - 30.7825 7.3762 16.2356 C 0 0 0 0 0 0 - 29.9005 7.0576 16.7698 H 0 0 0 0 0 0 - 30.6855 8.2450 15.1420 C 0 0 0 0 0 0 - 29.3301 8.7627 14.7491 C 0 0 2 0 0 0 - 28.5854 8.3128 15.4086 H 0 0 0 0 0 0 - 29.0334 8.2926 13.4113 N 0 0 0 0 0 0 - 29.1849 7.3041 13.2524 H 0 0 0 0 0 0 - 28.0015 8.9176 12.7152 C 0 0 0 0 0 0 - 27.6064 8.3593 11.4896 C 0 0 0 0 0 0 - 28.0744 7.4593 11.1200 H 0 0 0 0 0 0 - 26.6215 8.9895 10.7190 C 0 0 0 0 0 0 - 26.3839 8.5619 9.7591 H 0 0 0 0 0 0 - 25.9919 10.1712 11.1752 C 0 0 0 0 0 0 - 24.9721 10.8852 10.2862 C 0 0 0 0 0 0 - 25.7685 11.7006 9.2629 C 0 0 0 0 0 0 - 25.1850 12.2615 8.5441 H 0 0 0 0 0 0 - 26.4154 11.0282 8.7187 H 0 0 0 0 0 0 - 26.3849 12.4375 9.7712 H 0 0 0 0 0 0 - 24.0760 11.8274 11.0884 C 0 0 0 0 0 0 - 24.6975 12.5884 11.5194 H 0 0 0 0 0 0 - 23.5851 11.3401 11.9242 H 0 0 0 0 0 0 - 23.3168 12.3089 10.4711 H 0 0 0 0 0 0 - 24.0346 9.8607 9.6499 C 0 0 0 0 0 0 - 23.1879 10.2624 9.1189 H 0 0 0 0 0 0 - 23.5850 9.3883 10.5023 H 0 0 0 0 0 0 - 24.5077 9.1197 9.0090 H 0 0 0 0 0 0 - 26.3813 10.7069 12.4232 C 0 0 0 0 0 0 - 25.9589 11.6155 12.8183 H 0 0 0 0 0 0 - 27.3886 10.1014 13.1842 C 0 0 0 0 0 0 - 27.8259 10.7731 14.4732 C 0 0 1 0 0 0 - 27.8533 11.8496 14.2952 H 0 0 0 0 0 0 - 26.8794 10.5164 15.5097 O 0 0 0 0 0 0 - 27.1625 11.1892 16.7294 C 0 0 0 0 0 0 - 27.1951 12.2677 16.5678 H 0 0 0 0 0 0 - 26.3524 10.9946 17.4323 H 0 0 0 0 0 0 - 28.4911 10.6767 17.2983 C 0 0 0 0 0 0 - 28.7333 11.1954 18.2261 H 0 0 0 0 0 0 - 28.4005 9.6180 17.5453 H 0 0 0 0 0 0 - 29.6124 10.8762 16.2710 C 0 0 0 0 0 0 - 29.8008 11.9464 16.1678 H 0 0 0 0 0 0 - 30.5418 10.4474 16.6445 H 0 0 0 0 0 0 - 29.2323 10.3026 14.8842 C 0 0 1 0 0 0 - 29.9366 10.7258 14.1662 H 0 0 0 0 0 0 - 31.8413 8.6247 14.4221 C 0 0 0 0 0 0 - 31.7566 9.2763 13.5652 H 0 0 0 0 0 0 - 33.1113 8.1894 14.8427 C 0 0 0 0 0 0 - 33.9873 8.5296 14.3176 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 51 1 0 0 0 - 3 4 2 0 0 0 - 4 5 1 0 0 0 - 4 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 2 0 0 0 - 8 9 1 0 0 0 - 8 49 1 0 0 0 - 9 47 1 0 0 0 - 9 10 1 0 0 0 - 9 11 1 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 13 34 1 0 0 0 - 13 14 2 0 0 0 - 14 15 1 0 0 0 - 14 16 1 0 0 0 - 16 17 1 0 0 0 - 16 18 2 0 0 0 - 18 19 1 0 0 0 - 18 32 1 0 0 0 - 19 20 1 0 0 0 - 19 24 1 0 0 0 - 19 28 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 20 23 1 0 0 0 - 24 25 1 0 0 0 - 24 26 1 0 0 0 - 24 27 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 31 1 0 0 0 - 32 33 1 0 0 0 - 32 34 2 0 0 0 - 34 35 1 0 0 0 - 35 47 1 0 0 0 - 35 36 1 0 0 0 - 35 37 1 0 0 0 - 37 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 47 48 1 0 0 0 - 49 50 1 0 0 0 - 49 51 2 0 0 0 - 51 52 1 0 0 0 -M END -> -ligprep_eg5.smi - -> -3 - -> -53161 - -> -0 - -> -W09IXWMxW2NIXVtjSF1jKFtjSF1bY0hdMSlbQ0BIXShbTkhdMilbQ0BIXShbQ0gyXVtDSDJdW0NIMl1PMylbQ0BIXTNjKGMyNClbY0hdYyhbY0hdW2NIXTQpQyhbQ0gzXSkoW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0010 - -> - 0.0000 - -> - 0.0010 - -> - -0.0000 - -> -0 - -> -0 - -> -0 - -> -S-OPLS - -> -34.1252 - -> -1 - -> -lig_CHEMBL1078691-1 - -> -glide-grid_EG5-3L9H - -> -3 - -> -3 - -> --8.97665928402366 - -> --0.359066371360946 - -> --1.04991643792862 - -> --2.12773725908467 - -> --8.97665928402366 - -> --5.06383813021649 - -> --0.431309273878793 - -> --0 - -> --1.28824924773551 - -> --34.2456703186035 - -> --6.52582502365112 - -> -0.49789463728498 - -> -0 - -> --51.6245432573516 - -> --40.7714953422546 - -> -1.23162662982941 - -> -2 - -> -1 - -> --0 - -> -0.0779755402671082 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1078774 - 3D - Schrodinger Suite 2022-3. - 52 55 0 0 1 0 999 V2000 - 35.1317 7.1361 15.9189 H 0 0 0 0 0 0 - 34.3769 7.1037 16.4998 O 0 0 0 0 0 0 - 33.1652 7.3943 15.9602 C 0 0 0 0 0 0 - 32.0523 6.9447 16.6649 C 0 0 0 0 0 0 - 32.1848 6.2954 17.5273 H 0 0 0 0 0 0 - 30.7676 7.3612 16.2917 C 0 0 0 0 0 0 - 29.9132 7.0126 16.8534 H 0 0 0 0 0 0 - 30.6110 8.2402 15.2132 C 0 0 0 0 0 0 - 29.2527 8.7515 14.8401 C 0 0 2 0 0 0 - 28.5177 8.3167 15.5212 H 0 0 0 0 0 0 - 28.9515 8.2587 13.5087 N 0 0 0 0 0 0 - 29.1186 7.2738 13.3365 H 0 0 0 0 0 0 - 27.9696 8.9051 12.7651 C 0 0 0 0 0 0 - 27.6156 8.3613 11.5183 C 0 0 0 0 0 0 - 28.0902 7.4551 11.1617 H 0 0 0 0 0 0 - 26.6584 8.9961 10.7199 C 0 0 0 0 0 0 - 26.4477 8.5667 9.7540 H 0 0 0 0 0 0 - 26.0117 10.1756 11.1654 C 0 0 0 0 0 0 - 24.9931 10.8765 10.2682 C 0 0 0 0 0 0 - 25.7815 11.7127 9.2589 C 0 0 0 0 0 0 - 25.1851 12.2654 8.5382 H 0 0 0 0 0 0 - 26.4421 11.0483 8.7182 H 0 0 0 0 0 0 - 26.3857 12.4520 9.7704 H 0 0 0 0 0 0 - 24.0600 11.7945 11.0720 C 0 0 0 0 0 0 - 24.6348 12.5868 11.5261 H 0 0 0 0 0 0 - 23.5850 11.2763 11.8923 H 0 0 0 0 0 0 - 23.2851 12.2360 10.4513 H 0 0 0 0 0 0 - 24.0847 9.8280 9.6200 C 0 0 0 0 0 0 - 23.2374 10.1884 9.0655 H 0 0 0 0 0 0 - 23.5965 9.3881 10.4568 H 0 0 0 0 0 0 - 24.5681 9.0774 9.0037 H 0 0 0 0 0 0 - 26.3762 10.7143 12.4168 C 0 0 0 0 0 0 - 25.9463 11.6243 12.7961 H 0 0 0 0 0 0 - 27.3553 10.1016 13.2063 C 0 0 0 0 0 0 - 27.7772 10.7805 14.4987 C 0 0 1 0 0 0 - 27.8208 11.8547 14.3064 H 0 0 0 0 0 0 - 26.8226 10.5519 15.5345 O 0 0 0 0 0 0 - 27.1192 11.2365 16.7459 C 0 0 0 0 0 0 - 27.1635 12.3123 16.5691 H 0 0 0 0 0 0 - 26.3120 11.0645 17.4581 H 0 0 0 0 0 0 - 28.4479 10.7181 17.3127 C 0 0 0 0 0 0 - 28.6956 11.2441 18.2357 H 0 0 0 0 0 0 - 28.3556 9.6619 17.5676 H 0 0 0 0 0 0 - 29.5640 10.9118 16.2829 C 0 0 0 0 0 0 - 29.7348 11.9812 16.1491 H 0 0 0 0 0 0 - 30.5011 10.5045 16.6567 H 0 0 0 0 0 0 - 29.1753 10.2968 14.9230 C 0 0 1 0 0 0 - 29.8748 10.6986 14.1896 H 0 0 0 0 0 0 - 31.7232 8.6610 14.4697 C 0 0 0 0 0 0 - 31.6100 9.3232 13.6206 H 0 0 0 0 0 0 - 32.9883 8.2352 14.8420 C 0 0 0 0 0 0 - 33.9851 8.7065 14.1028 F 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 51 1 0 0 0 - 3 4 2 0 0 0 - 4 5 1 0 0 0 - 4 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 2 0 0 0 - 8 9 1 0 0 0 - 8 49 1 0 0 0 - 9 47 1 0 0 0 - 9 10 1 0 0 0 - 9 11 1 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 13 34 1 0 0 0 - 13 14 2 0 0 0 - 14 15 1 0 0 0 - 14 16 1 0 0 0 - 16 17 1 0 0 0 - 16 18 2 0 0 0 - 18 19 1 0 0 0 - 18 32 1 0 0 0 - 19 20 1 0 0 0 - 19 24 1 0 0 0 - 19 28 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 20 23 1 0 0 0 - 24 25 1 0 0 0 - 24 26 1 0 0 0 - 24 27 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 31 1 0 0 0 - 32 33 1 0 0 0 - 32 34 2 0 0 0 - 34 35 1 0 0 0 - 35 47 1 0 0 0 - 35 36 1 0 0 0 - 35 37 1 0 0 0 - 37 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 47 48 1 0 0 0 - 49 50 1 0 0 0 - 49 51 2 0 0 0 - 51 52 1 0 0 0 -M END -> -ligprep_eg5.smi - -> -4 - -> -53161 - -> -0 - -> -W09IXWMxW2NIXVtjSF1jKFtjSF1jMUYpW0NASF0oW05IXTIpW0NASF0oW0NIMl1bQ0gyXVtDSDJdTzMpW0NASF0zYyhjMjQpW2NIXWMoW2NIXVtjSF00KUMoW0NIM10pKFtDSDNdKVtDSDNd - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0129 - -> - 0.0000 - -> - 0.0129 - -> - -0.0000 - -> -0 - -> -0 - -> -0 - -> -S-OPLS - -> -40.6678 - -> -1 - -> -lig_CHEMBL1078774-1 - -> -glide-grid_EG5-3L9H - -> -4 - -> -3 - -> --8.97337207022735 - -> --0.345129695008744 - -> --1.02244536344363 - -> --2.10736698665757 - -> --8.97337207022735 - -> --5.06032647734131 - -> --0.454813574920432 - -> --0 - -> --1.37207791070462 - -> --31.0318450927734 - -> --6.59056234359741 - -> -0.454022498917303 - -> -0 - -> --53.833901517828 - -> --37.6224074363708 - -> -1.32856965065002 - -> -11 - -> -3 - -> --0 - -> -0.0977424974958633 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1085666 - 3D - Schrodinger Suite 2022-3. - 48 51 0 0 1 0 999 V2000 - 34.2668 7.0542 16.1930 H 0 0 0 0 0 0 - 33.2803 7.3943 15.9136 C 0 0 0 0 0 0 - 33.1227 8.2510 14.8101 C 0 0 0 0 0 0 - 33.9835 8.5689 14.2395 H 0 0 0 0 0 0 - 31.8418 8.7068 14.4520 C 0 0 0 0 0 0 - 31.7239 9.3692 13.6070 H 0 0 0 0 0 0 - 30.7089 8.2984 15.1899 C 0 0 0 0 0 0 - 29.3316 8.7895 14.7866 C 0 0 2 0 0 0 - 28.6107 8.3370 15.4686 H 0 0 0 0 0 0 - 28.9952 8.2892 13.4601 N 0 0 0 0 0 0 - 29.1849 7.3087 13.2851 H 0 0 0 0 0 0 - 27.9776 8.9194 12.7341 C 0 0 0 0 0 0 - 27.5881 8.3588 11.5021 C 0 0 0 0 0 0 - 28.0448 7.4496 11.1421 H 0 0 0 0 0 0 - 26.6022 8.9852 10.7185 C 0 0 0 0 0 0 - 26.3134 8.5517 9.7724 H 0 0 0 0 0 0 - 26.0011 10.1852 11.1526 C 0 0 0 0 0 0 - 25.0064 10.9040 10.2610 C 0 0 0 0 0 0 - 25.6737 11.7278 9.4519 F 0 0 0 0 0 0 - 24.3315 10.0254 9.5219 F 0 0 0 0 0 0 - 24.1376 11.6186 10.9777 F 0 0 0 0 0 0 - 26.3847 10.7467 12.3852 C 0 0 0 0 0 0 - 25.9653 11.6925 12.7029 H 0 0 0 0 0 0 - 27.3617 10.1151 13.1803 C 0 0 0 0 0 0 - 27.7884 10.7720 14.4791 C 0 0 1 0 0 0 - 27.7679 11.8516 14.3205 H 0 0 0 0 0 0 - 26.8849 10.4590 15.5356 O 0 0 0 0 0 0 - 27.1479 11.1845 16.7292 C 0 0 1 0 0 0 - 27.1974 12.2448 16.4716 H 0 0 0 0 0 0 - 25.9352 11.0032 17.6677 C 0 0 0 0 0 0 - 25.6632 11.9618 18.1106 H 0 0 0 0 0 0 - 25.0659 10.6731 17.0969 H 0 0 0 0 0 0 - 26.1737 10.0403 18.7580 N 0 3 0 0 0 0 - 25.3407 9.9447 19.3225 H 0 0 0 0 0 0 - 26.9299 10.3843 19.3336 H 0 0 0 0 0 0 - 28.5159 10.7338 17.2874 C 0 0 0 0 0 0 - 28.7617 11.2835 18.1970 H 0 0 0 0 0 0 - 28.4962 9.6733 17.5432 H 0 0 0 0 0 0 - 29.6009 10.9645 16.2332 C 0 0 0 0 0 0 - 29.7356 12.0395 16.0968 H 0 0 0 0 0 0 - 30.5580 10.5910 16.5922 H 0 0 0 0 0 0 - 29.2081 10.3356 14.8760 C 0 0 1 0 0 0 - 29.8874 10.7513 14.1325 H 0 0 0 0 0 0 - 30.8666 7.4176 16.2768 C 0 0 0 0 0 0 - 30.0054 7.0747 16.8306 H 0 0 0 0 0 0 - 32.1535 6.9827 16.6498 C 0 0 0 0 0 0 - 32.2740 6.3133 17.4887 H 0 0 0 0 0 0 - 26.4146 9.1424 18.3603 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 46 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 44 1 0 0 0 - 8 42 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 42 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 36 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 33 48 1 0 0 0 - 36 37 1 0 0 0 - 36 38 1 0 0 0 - 36 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 44 45 1 0 0 0 - 44 46 2 0 0 0 - 46 47 1 0 0 0 -M CHG 1 33 1 -M END -> -ligprep_eg5.smi - -> -17 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BIXShbQ0gyXVtDSDJdW0NAQEhdKE8zKVtDSDJdW05IMl0pW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00 - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0054 - -> - 0.0054 - -> - 0.0000 - -> - -0.0000 - -> -0.00538612 - -> -1 - -> -1 - -> -S-OPLS - -> -34.8838 - -> -1 - -> -lig_CHEMBL1085666-1 - -> -glide-grid_EG5-3L9H - -> -18 - -> -3 - -> --8.9463535501123 - -> --0.344090521158165 - -> --1.01936681500024 - -> --2.10102177586354 - -> --8.9463535501123 - -> --4.56759202898606 - -> --0.141725690997466 - -> --0 - -> --2.00420097938027 - -> --43.7035179138184 - -> --3.22751998901367 - -> -0.436469043294473 - -> -0 - -> --77.9548824440419 - -> --46.931037902832 - -> -1.46975395409754e-07 - -> -8 - -> -8 - -> --0 - -> -0.0634782723184329 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1085895 - 3D - Schrodinger Suite 2022-3. - 61 64 0 0 1 0 999 V2000 - 28.7440 8.1711 24.3081 H 0 0 0 0 0 0 - 28.1603 8.4277 25.0124 O 0 0 0 0 0 0 - 27.4200 9.5818 24.6552 C 0 0 0 0 0 0 - 26.6668 9.7416 25.4281 H 0 0 0 0 0 0 - 28.0705 10.4570 24.6631 H 0 0 0 0 0 0 - 26.7254 9.4427 23.2892 C 0 0 0 0 0 0 - 26.2257 8.4748 23.2242 H 0 0 0 0 0 0 - 25.9400 10.1992 23.2211 H 0 0 0 0 0 0 - 27.6892 9.6325 22.1086 C 0 0 0 0 0 0 - 28.1835 10.6040 22.1888 H 0 0 0 0 0 0 - 28.4745 8.8783 22.1559 H 0 0 0 0 0 0 - 27.0055 9.4972 20.8234 N 0 0 0 0 0 0 - 26.7584 8.5636 20.5334 H 0 0 0 0 0 0 - 26.7060 10.5111 19.9984 C 0 0 0 0 0 0 - 26.9070 11.6950 20.2653 O 0 0 0 0 0 0 - 26.2122 10.0937 18.8248 N 0 0 0 0 0 0 - 26.0805 9.1059 18.6663 H 0 0 0 0 0 0 - 25.9324 10.9738 17.6888 C 0 0 0 0 0 0 - 25.1004 10.5441 17.1289 H 0 0 0 0 0 0 - 25.5623 11.9348 18.0541 H 0 0 0 0 0 0 - 27.1397 11.1968 16.7380 C 0 0 2 0 0 0 - 27.1737 12.2629 16.5055 H 0 0 0 0 0 0 - 26.8772 10.4923 15.5265 O 0 0 0 0 0 0 - 27.7969 10.7813 14.4728 C 0 0 2 0 0 0 - 27.7990 11.8605 14.3066 H 0 0 0 0 0 0 - 27.3619 10.1239 13.1745 C 0 0 0 0 0 0 - 26.3903 10.7553 12.3735 C 0 0 0 0 0 0 - 25.9786 11.7008 12.6933 H 0 0 0 0 0 0 - 26.0017 10.1964 11.1393 C 0 0 0 0 0 0 - 25.0139 10.9162 10.2413 C 0 0 0 0 0 0 - 24.3184 10.0368 9.5237 F 0 0 0 0 0 0 - 24.1647 11.6614 10.9466 F 0 0 0 0 0 0 - 25.6962 11.7062 9.4148 F 0 0 0 0 0 0 - 26.5890 8.9900 10.7143 C 0 0 0 0 0 0 - 26.3060 8.5561 9.7667 H 0 0 0 0 0 0 - 27.5697 8.3576 11.5032 C 0 0 0 0 0 0 - 28.0221 7.4445 11.1450 H 0 0 0 0 0 0 - 27.9657 8.9197 12.7312 C 0 0 0 0 0 0 - 28.9840 8.2856 13.4556 N 0 0 0 0 0 0 - 29.1275 7.2940 13.3079 H 0 0 0 0 0 0 - 29.3275 8.7830 14.7801 C 0 0 1 0 0 0 - 28.5983 8.3409 15.4610 H 0 0 0 0 0 0 - 30.7057 8.2860 15.1745 C 0 0 0 0 0 0 - 30.8584 7.3911 16.2520 C 0 0 0 0 0 0 - 29.9925 7.0327 16.7905 H 0 0 0 0 0 0 - 32.1445 6.9569 16.6224 C 0 0 0 0 0 0 - 32.2627 6.2669 17.4448 H 0 0 0 0 0 0 - 33.2777 7.3920 15.9083 C 0 0 0 0 0 0 - 34.2646 7.0327 16.1792 H 0 0 0 0 0 0 - 33.1212 8.2494 14.8049 C 0 0 0 0 0 0 - 33.9831 8.5649 14.2365 H 0 0 0 0 0 0 - 31.8399 8.7021 14.4429 C 0 0 0 0 0 0 - 31.7289 9.3648 13.5938 H 0 0 0 0 0 0 - 29.2176 10.3293 14.8613 C 0 0 2 0 0 0 - 29.9005 10.7387 14.1157 H 0 0 0 0 0 0 - 29.6187 10.9528 16.2163 C 0 0 0 0 0 0 - 30.5584 10.5432 16.5860 H 0 0 0 0 0 0 - 29.7935 12.0210 16.0750 H 0 0 0 0 0 0 - 28.5250 10.7616 17.2712 C 0 0 0 0 0 0 - 28.7863 11.3329 18.1639 H 0 0 0 0 0 0 - 28.5037 9.7126 17.5640 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 3 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 6 9 1 0 0 0 - 9 10 1 0 0 0 - 9 11 1 0 0 0 - 9 12 1 0 0 0 - 12 13 1 0 0 0 - 12 14 1 0 0 0 - 14 15 2 0 0 0 - 14 16 1 0 0 0 - 16 17 1 0 0 0 - 16 18 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 21 59 1 0 0 0 - 21 22 1 0 0 0 - 21 23 1 0 0 0 - 23 24 1 0 0 0 - 24 54 1 0 0 0 - 24 25 1 0 0 0 - 24 26 1 0 0 0 - 26 38 1 0 0 0 - 26 27 2 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 29 30 1 0 0 0 - 29 34 2 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 36 38 2 0 0 0 - 38 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 54 1 0 0 0 - 43 52 1 0 0 0 - 43 44 2 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 46 47 1 0 0 0 - 46 48 2 0 0 0 - 48 49 1 0 0 0 - 48 50 1 0 0 0 - 50 51 1 0 0 0 - 50 52 2 0 0 0 - 52 53 1 0 0 0 - 54 55 1 0 0 0 - 54 56 1 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 56 59 1 0 0 0 - 59 60 1 0 0 0 - 59 61 1 0 0 0 -M END -> -ligprep_eg5.smi - -> -19 - -> -53161 - -> -0 - -> -W09IXVtDSDJdW0NIMl1bQ0gyXVtOSF1DKD1PKVtOSF1bQ0gyXVtDQEhdKE8xKVtDSDJdW0NIMl1bQ0BIXTJbQ0BASF0oW05IXWMoYzNbQ0BASF0xMilbY0hdW2NIXWMoW2NIXTMpQyhGKShGKUYpYzRbY0hdW2NIXVtjSF1bY0hdW2NIXTQ= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0000 - -> - 0.0000 - -> - 0.0000 - -> - -0.0000 - -> -0 - -> -0 - -> -0 - -> -S-OPLS - -> -37.1053 - -> -1 - -> -lig_CHEMBL1085895-1 - -> -glide-grid_EG5-3L9H - -> -20 - -> -10 - -> --8.60802934172435 - -> --0.260849373991647 - -> --0.836683321060972 - -> --1.9143811556089 - -> --8.60802934172435 - -> --4.58844263498542 - -> --0.47381124969346 - -> --0 - -> --1.33853078340521 - -> --50.4799499511719 - -> --3.43241405487061 - -> -0.844262544778392 - -> --0.0126476126294721 - -> --80.0750471269813 - -> --53.9123640060425 - -> -1.57291257381439 - -> -12 - -> -2 - -> --0 - -> -0.042273896350033 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1093088 - 3D - Schrodinger Suite 2022-3. - 51 55 0 0 1 0 999 V2000 - 23.1233 8.2060 15.5348 H 0 0 0 0 0 0 - 23.4697 9.0841 16.0630 C 0 0 0 0 0 0 - 24.6543 9.1074 16.6754 N 0 0 0 0 0 0 - 24.7366 10.3834 17.1226 N 0 0 0 0 0 0 - 25.9417 10.8830 17.7731 C 0 0 0 0 0 0 - 25.6907 11.8332 18.2453 H 0 0 0 0 0 0 - 26.1820 10.1504 18.7242 H 0 0 0 0 0 0 - 27.1098 11.1380 16.7778 C 0 0 2 0 0 0 - 27.1397 12.2108 16.5788 H 0 0 0 0 0 0 - 26.8813 10.4865 15.5278 O 0 0 0 0 0 0 - 27.8071 10.7978 14.4923 C 0 0 2 0 0 0 - 27.8090 11.8785 14.3368 H 0 0 0 0 0 0 - 27.3756 10.1408 13.1901 C 0 0 0 0 0 0 - 26.3830 10.7544 12.3992 C 0 0 0 0 0 0 - 25.9373 11.6827 12.7254 H 0 0 0 0 0 0 - 26.0020 10.1940 11.1629 C 0 0 0 0 0 0 - 25.0054 10.9099 10.2691 C 0 0 0 0 0 0 - 24.3435 10.0307 9.5195 F 0 0 0 0 0 0 - 24.1272 11.6213 10.9752 F 0 0 0 0 0 0 - 25.6697 11.7408 9.4672 F 0 0 0 0 0 0 - 26.6032 8.9932 10.7304 C 0 0 0 0 0 0 - 26.3242 8.5593 9.7818 H 0 0 0 0 0 0 - 27.5868 8.3711 11.5186 C 0 0 0 0 0 0 - 28.0428 7.4576 11.1675 H 0 0 0 0 0 0 - 27.9860 8.9424 12.7438 C 0 0 0 0 0 0 - 29.0109 8.3165 13.4663 N 0 0 0 0 0 0 - 29.1853 7.3339 13.2938 H 0 0 0 0 0 0 - 29.3365 8.7976 14.8027 C 0 0 1 0 0 0 - 28.6064 8.3482 15.4782 H 0 0 0 0 0 0 - 30.7132 8.2971 15.2038 C 0 0 0 0 0 0 - 30.8688 7.4357 16.3084 C 0 0 0 0 0 0 - 30.0067 7.1194 16.8756 H 0 0 0 0 0 0 - 32.1537 6.9884 16.6738 C 0 0 0 0 0 0 - 32.2724 6.3278 17.5206 H 0 0 0 0 0 0 - 33.2828 7.3879 15.9354 C 0 0 0 0 0 0 - 34.2673 7.0400 16.2165 H 0 0 0 0 0 0 - 33.1263 8.2264 14.8183 C 0 0 0 0 0 0 - 33.9843 8.5277 14.2396 H 0 0 0 0 0 0 - 31.8465 8.6819 14.4560 C 0 0 0 0 0 0 - 31.7352 9.3282 13.5979 H 0 0 0 0 0 0 - 29.2184 10.3417 14.9084 C 0 0 2 0 0 0 - 29.9190 10.7657 14.1872 H 0 0 0 0 0 0 - 29.5826 10.9363 16.2870 C 0 0 0 0 0 0 - 30.5285 10.5441 16.6568 H 0 0 0 0 0 0 - 29.7293 12.0117 16.1771 H 0 0 0 0 0 0 - 28.4761 10.6920 17.3210 C 0 0 0 0 0 0 - 28.7079 11.2228 18.2444 H 0 0 0 0 0 0 - 28.4401 9.6313 17.5716 H 0 0 0 0 0 0 - 23.5816 10.9884 16.8368 C 0 0 0 0 0 0 - 23.3621 12.0065 17.1209 H 0 0 0 0 0 0 - 22.7341 10.2356 16.1477 N 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 51 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 4 5 1 0 0 0 - 4 49 1 0 0 0 - 5 6 1 0 0 0 - 5 7 1 0 0 0 - 5 8 1 0 0 0 - 8 46 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 11 41 1 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 13 25 1 0 0 0 - 13 14 2 0 0 0 - 14 15 1 0 0 0 - 14 16 1 0 0 0 - 16 17 1 0 0 0 - 16 21 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 17 20 1 0 0 0 - 21 22 1 0 0 0 - 21 23 1 0 0 0 - 23 24 1 0 0 0 - 23 25 2 0 0 0 - 25 26 1 0 0 0 - 26 27 1 0 0 0 - 26 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 41 1 0 0 0 - 30 39 1 0 0 0 - 30 31 2 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 33 34 1 0 0 0 - 33 35 2 0 0 0 - 35 36 1 0 0 0 - 35 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 2 0 0 0 - 39 40 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 43 44 1 0 0 0 - 43 45 1 0 0 0 - 43 46 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 49 50 1 0 0 0 - 49 51 2 0 0 0 -M END -> -ligprep_eg5.smi - -> -26 - -> -53161 - -> -0 - -> -W2NIXTFuW2NIXW5uMVtDSDJdW0NASF0oTzIpW0NIMl1bQ0gyXVtDQEhdM1tDQEBIXShbTkhdYyhjNFtDQEBIXTIzKVtjSF1bY0hdYyhbY0hdNClDKEYpKEYpRiljNVtjSF1bY0hdW2NIXVtjSF1bY0hdNQ== - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0000 - -> - 0.0000 - -> - 0.0000 - -> - -0.0000 - -> -0 - -> -0 - -> -0 - -> -S-OPLS - -> -35.6799 - -> -1 - -> -lig_CHEMBL1093088-1 - -> -glide-grid_EG5-3L9H - -> -27 - -> -4 - -> --8.59042334486905 - -> --0.286347444828968 - -> --0.889748087560663 - -> --1.95183778411337 - -> --8.59042334486905 - -> --4.56272675129758 - -> --0.127617495418936 - -> --0 - -> --1.68212726844412 - -> --48.7614250183105 - -> --1.10837352275848 - -> -0.459685504200441 - -> --0.0733100545795587 - -> --73.5253094705828 - -> --49.869798541069 - -> -0.712514519691467 - -> -51 - -> -14 - -> --0 - -> -0.0805815148851532 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084676 - 3D - Schrodinger Suite 2022-3. - 65 68 0 0 1 0 999 V2000 - 34.2631 7.0468 16.1866 H 0 0 0 0 0 0 - 33.2769 7.3898 15.9062 C 0 0 0 0 0 0 - 33.1229 8.2513 14.8062 C 0 0 0 0 0 0 - 33.9834 8.5700 14.2392 H 0 0 0 0 0 0 - 31.8400 8.7037 14.4458 C 0 0 0 0 0 0 - 31.7264 9.3684 13.6005 H 0 0 0 0 0 0 - 30.7070 8.2891 15.1766 C 0 0 0 0 0 0 - 29.3274 8.7863 14.7784 C 0 0 2 0 0 0 - 28.6085 8.3442 15.4682 H 0 0 0 0 0 0 - 28.9879 8.2879 13.4531 N 0 0 0 0 0 0 - 29.1493 7.2983 13.2981 H 0 0 0 0 0 0 - 27.9725 8.9218 12.7263 C 0 0 0 0 0 0 - 27.5793 8.3576 11.4990 C 0 0 0 0 0 0 - 28.0295 7.4416 11.1448 H 0 0 0 0 0 0 - 26.5952 8.9882 10.7152 C 0 0 0 0 0 0 - 26.3089 8.5526 9.7695 H 0 0 0 0 0 0 - 26.0005 10.1908 11.1452 C 0 0 0 0 0 0 - 25.0125 10.9119 10.2493 C 0 0 0 0 0 0 - 24.3257 10.0322 9.5207 F 0 0 0 0 0 0 - 24.1544 11.6446 10.9583 F 0 0 0 0 0 0 - 25.6851 11.7178 9.4277 F 0 0 0 0 0 0 - 26.3848 10.7516 12.3784 C 0 0 0 0 0 0 - 25.9581 11.6921 12.6999 H 0 0 0 0 0 0 - 27.3635 10.1240 13.1716 C 0 0 0 0 0 0 - 27.7978 10.7847 14.4677 C 0 0 1 0 0 0 - 27.7937 11.8640 14.3036 H 0 0 0 0 0 0 - 26.8824 10.4899 15.5192 O 0 0 0 0 0 0 - 27.1446 11.2050 16.7224 C 0 0 1 0 0 0 - 27.1861 12.2704 16.4801 H 0 0 0 0 0 0 - 25.9306 11.0011 17.6657 C 0 0 0 0 0 0 - 25.5991 11.9688 18.0499 H 0 0 0 0 0 0 - 25.0798 10.6110 17.1035 H 0 0 0 0 0 0 - 26.1960 10.1049 18.7857 N 0 0 0 0 0 0 - 26.0900 9.1081 18.6595 H 0 0 0 0 0 0 - 26.6883 10.5366 20.0037 C 0 0 0 0 0 0 - 26.8994 11.7050 20.3304 O 0 0 0 0 0 0 - 26.9366 9.4669 20.7708 O 0 0 0 0 0 0 - 27.5122 9.6246 22.0607 C 0 0 0 0 0 0 - 28.3646 8.9491 22.1102 H 0 0 0 0 0 0 - 27.9243 10.6247 22.2080 H 0 0 0 0 0 0 - 26.4869 9.2961 23.1654 C 0 0 0 0 0 0 - 26.1972 10.2174 23.6689 H 0 0 0 0 0 0 - 25.5739 8.8927 22.7287 H 0 0 0 0 0 0 - 26.9884 8.3264 24.1732 N 0 3 0 0 0 0 - 27.1753 6.9620 23.6256 C 0 0 0 0 0 0 - 27.9548 6.9161 22.8633 H 0 0 0 0 0 0 - 26.2444 6.6075 23.1752 H 0 0 0 0 0 0 - 27.4452 6.2586 24.4164 H 0 0 0 0 0 0 - 28.1437 8.8168 24.9609 C 0 0 0 0 0 0 - 29.0294 8.9765 24.3447 H 0 0 0 0 0 0 - 28.4049 8.1064 25.7498 H 0 0 0 0 0 0 - 27.8984 9.7666 25.4409 H 0 0 0 0 0 0 - 28.5208 10.7548 17.2672 C 0 0 0 0 0 0 - 28.7763 11.3221 18.1627 H 0 0 0 0 0 0 - 28.4909 9.7019 17.5513 H 0 0 0 0 0 0 - 29.6112 10.9584 16.2163 C 0 0 0 0 0 0 - 29.7693 12.0289 16.0784 H 0 0 0 0 0 0 - 30.5556 10.5626 16.5834 H 0 0 0 0 0 0 - 29.2138 10.3328 14.8633 C 0 0 1 0 0 0 - 29.8969 10.7428 14.1205 H 0 0 0 0 0 0 - 30.8626 7.4018 16.2613 C 0 0 0 0 0 0 - 29.9988 7.0547 16.8072 H 0 0 0 0 0 0 - 32.1482 6.9691 16.6335 C 0 0 0 0 0 0 - 32.2665 6.2867 17.4652 H 0 0 0 0 0 0 - 26.2397 8.2281 24.8448 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 63 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 61 1 0 0 0 - 8 59 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 59 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 53 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 35 36 2 0 0 0 - 35 37 1 0 0 0 - 37 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 49 1 0 0 0 - 44 65 1 0 0 0 - 45 46 1 0 0 0 - 45 47 1 0 0 0 - 45 48 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 - 49 52 1 0 0 0 - 53 54 1 0 0 0 - 53 55 1 0 0 0 - 53 56 1 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 56 59 1 0 0 0 - 59 60 1 0 0 0 - 61 62 1 0 0 0 - 61 63 2 0 0 0 - 63 64 1 0 0 0 -M CHG 1 44 1 -M END -> -ligprep_eg5.smi - -> -13 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdQyg9TylPW0NIMl1bQ0gyXU4oW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.0488 - -> - 0.0488 - -> - 0.0000 - -> - 0.0416 - -> -0.0904291 - -> -1 - -> -1 - -> -This compound has an ester and may undergo hydrolysis at high or low pH. - -> -S-OPLS - -> -47.6644 - -> -1 - -> -lig_CHEMBL1084676-1 - -> -glide-grid_EG5-3L9H - -> -13 - -> -9 - -> --8.55748566492015 - -> --0.251690754850593 - -> --0.815380338727976 - -> --1.89058861272343 - -> --8.59908566492015 - -> --4.58537464846225 - -> --0.161843084530482 - -> --0 - -> --1.23519247582576 - -> --51.6746711730957 - -> --4.80143117904663 - -> -0.707987752393848 - -> --0.0207149729837261 - -> --98.75268454923 - -> --56.4761023521423 - -> -4.67261600494385 - -> -22 - -> -62 - -> -0.0416 - -> -0.0479812607239537 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1089056 - 3D - Schrodinger Suite 2022-3. - 51 54 0 0 1 0 999 V2000 - 34.3019 7.0594 16.2258 H 0 0 0 0 0 0 - 33.3120 7.3888 15.9430 C 0 0 0 0 0 0 - 33.1392 8.2168 14.8211 C 0 0 0 0 0 0 - 33.9849 8.5338 14.2351 H 0 0 0 0 0 0 - 31.8523 8.6455 14.4588 C 0 0 0 0 0 0 - 31.7270 9.2859 13.5982 H 0 0 0 0 0 0 - 30.7292 8.2448 15.2123 C 0 0 0 0 0 0 - 29.3507 8.7349 14.8194 C 0 0 2 0 0 0 - 28.6241 8.2859 15.4987 H 0 0 0 0 0 0 - 29.0286 8.2548 13.4823 N 0 0 0 0 0 0 - 29.1852 7.2676 13.3189 H 0 0 0 0 0 0 - 28.0105 8.8883 12.7600 C 0 0 0 0 0 0 - 27.6280 8.3486 11.5188 C 0 0 0 0 0 0 - 28.0991 7.4524 11.1442 H 0 0 0 0 0 0 - 26.6506 8.9881 10.7377 C 0 0 0 0 0 0 - 26.4149 8.5687 9.7733 H 0 0 0 0 0 0 - 26.0062 10.1607 11.1952 C 0 0 0 0 0 0 - 24.9862 10.8795 10.2992 C 0 0 0 0 0 0 - 25.7779 11.6940 9.2710 C 0 0 0 0 0 0 - 25.1850 12.2502 8.5554 H 0 0 0 0 0 0 - 26.4287 11.0295 8.7190 H 0 0 0 0 0 0 - 26.3851 12.4380 9.7778 H 0 0 0 0 0 0 - 24.0950 11.8328 11.0948 C 0 0 0 0 0 0 - 24.7268 12.5883 11.5211 H 0 0 0 0 0 0 - 23.5851 11.3571 11.9267 H 0 0 0 0 0 0 - 23.3488 12.3245 10.4693 H 0 0 0 0 0 0 - 24.0369 9.8694 9.6523 C 0 0 0 0 0 0 - 23.1912 10.2880 9.1189 H 0 0 0 0 0 0 - 23.5850 9.3883 10.4976 H 0 0 0 0 0 0 - 24.5114 9.1299 9.0096 H 0 0 0 0 0 0 - 26.3850 10.6817 12.4539 C 0 0 0 0 0 0 - 25.9551 11.5856 12.8514 H 0 0 0 0 0 0 - 27.3907 10.0720 13.2215 C 0 0 0 0 0 0 - 27.8265 10.7407 14.5114 C 0 0 1 0 0 0 - 27.8500 11.8174 14.3300 H 0 0 0 0 0 0 - 26.8845 10.4850 15.5506 O 0 0 0 0 0 0 - 27.1692 11.1744 16.7604 C 0 0 0 0 0 0 - 27.1846 12.2518 16.5873 H 0 0 0 0 0 0 - 26.3696 10.9769 17.4743 H 0 0 0 0 0 0 - 28.5104 10.6847 17.3204 C 0 0 0 0 0 0 - 28.7511 11.2171 18.2412 H 0 0 0 0 0 0 - 28.4328 9.6285 17.5807 H 0 0 0 0 0 0 - 29.6237 10.8843 16.2893 C 0 0 0 0 0 0 - 29.7955 11.9544 16.1639 H 0 0 0 0 0 0 - 30.5615 10.4755 16.6632 H 0 0 0 0 0 0 - 29.2374 10.2788 14.9223 C 0 0 1 0 0 0 - 29.9327 10.6952 14.1917 H 0 0 0 0 0 0 - 30.8980 7.3883 16.3170 C 0 0 0 0 0 0 - 30.0426 7.0591 16.8883 H 0 0 0 0 0 0 - 32.1897 6.9646 16.6793 C 0 0 0 0 0 0 - 32.3199 6.3079 17.5276 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 50 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 48 1 0 0 0 - 8 46 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 33 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 31 1 0 0 0 - 18 19 1 0 0 0 - 18 23 1 0 0 0 - 18 27 1 0 0 0 - 19 20 1 0 0 0 - 19 21 1 0 0 0 - 19 22 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 23 26 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 31 32 1 0 0 0 - 31 33 2 0 0 0 - 33 34 1 0 0 0 - 34 46 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 40 1 0 0 0 - 40 41 1 0 0 0 - 40 42 1 0 0 0 - 40 43 1 0 0 0 - 43 44 1 0 0 0 - 43 45 1 0 0 0 - 43 46 1 0 0 0 - 46 47 1 0 0 0 - 48 49 1 0 0 0 - 48 50 2 0 0 0 - 50 51 1 0 0 0 -M END -> -ligprep_eg5.smi - -> -23 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BIXShbQ0gyXVtDSDJdW0NIMl1PMylbQ0BIXTNjKGMyNClbY0hdYyhbY0hdW2NIXTQpQyhbQ0gzXSkoW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0005 - -> - 0.0000 - -> - 0.0005 - -> - -0.0000 - -> -0 - -> -0 - -> -0 - -> -S-OPLS - -> -36.7883 - -> -1 - -> -lig_CHEMBL1089056-1 - -> -glide-grid_EG5-3L9H - -> -24 - -> -2 - -> --8.50735624547555 - -> --0.354473176894815 - -> --1.02247757304093 - -> --2.03620072668309 - -> --8.50735624547555 - -> --5.05491622000362 - -> --0.186307935381447 - -> --0 - -> --1.40634349101084 - -> --40.7306938171387 - -> --1.23288214206696 - -> -0.361678413087333 - -> -0 - -> --51.6064948490224 - -> --41.9635759592056 - -> -0.837360858917236 - -> -12 - -> -5 - -> --0 - -> -0.0929053914027625 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084935 - 3D - Schrodinger Suite 2022-3. - 70 73 0 0 1 0 999 V2000 - 25.0798 6.4768 17.5106 H 0 0 0 0 0 0 - 24.3850 6.9813 17.9250 O 0 0 0 0 0 0 - 24.5730 8.3507 17.6135 C 0 0 0 0 0 0 - 25.3544 8.4369 16.8542 H 0 0 0 0 0 0 - 23.6520 8.7262 17.1591 H 0 0 0 0 0 0 - 24.9031 9.1560 18.8964 C 0 0 0 0 0 0 - 24.0404 9.7650 19.1683 H 0 0 0 0 0 0 - 25.0397 8.4566 19.7210 H 0 0 0 0 0 0 - 26.1108 10.0209 18.7712 N 0 3 2 0 0 0 - 26.5673 10.5646 20.0754 C 0 0 0 0 0 0 - 27.2638 11.3822 19.8986 H 0 0 0 0 0 0 - 25.7257 10.9866 20.6286 H 0 0 0 0 0 0 - 27.2992 9.5034 20.9067 C 0 0 0 0 0 0 - 27.7963 9.9607 21.7639 H 0 0 0 0 0 0 - 28.0542 9.0077 20.3011 H 0 0 0 0 0 0 - 26.6212 8.7424 21.2964 H 0 0 0 0 0 0 - 25.9587 11.0564 17.7148 C 0 0 0 0 0 0 - 25.0695 10.9080 17.1118 H 0 0 0 0 0 0 - 25.7827 12.0241 18.2024 H 0 0 0 0 0 0 - 27.1818 11.1927 16.7677 C 0 0 2 0 0 0 - 27.2513 12.2504 16.4973 H 0 0 0 0 0 0 - 26.9041 10.4585 15.5792 O 0 0 0 0 0 0 - 27.8305 10.7250 14.5238 C 0 0 2 0 0 0 - 27.8368 11.8002 14.3399 H 0 0 0 0 0 0 - 27.3981 10.0641 13.2265 C 0 0 0 0 0 0 - 26.3990 10.6726 12.4559 C 0 0 0 0 0 0 - 25.9383 11.5552 12.8703 H 0 0 0 0 0 0 - 26.0361 10.1474 11.2060 C 0 0 0 0 0 0 - 25.0158 10.8436 10.3046 C 0 0 0 0 0 0 - 24.0733 9.7978 9.7104 C 0 0 0 0 0 0 - 23.2521 10.1887 9.1195 H 0 0 0 0 0 0 - 23.5849 9.3905 10.5804 H 0 0 0 0 0 0 - 24.5495 9.0134 9.1157 H 0 0 0 0 0 0 - 25.7906 11.6274 9.2438 C 0 0 0 0 0 0 - 26.4572 10.9524 8.7188 H 0 0 0 0 0 0 - 26.3849 12.4008 9.7258 H 0 0 0 0 0 0 - 25.1881 12.1516 8.5066 H 0 0 0 0 0 0 - 24.1272 11.8268 11.0717 C 0 0 0 0 0 0 - 23.4090 12.3112 10.4051 H 0 0 0 0 0 0 - 24.7435 12.5883 11.5131 H 0 0 0 0 0 0 - 23.5851 11.3576 11.8817 H 0 0 0 0 0 0 - 26.6991 8.9886 10.7364 C 0 0 0 0 0 0 - 26.4948 8.5766 9.7621 H 0 0 0 0 0 0 - 27.6648 8.3508 11.5212 C 0 0 0 0 0 0 - 28.1660 7.4729 11.1410 H 0 0 0 0 0 0 - 28.0275 8.8867 12.7690 C 0 0 0 0 0 0 - 29.0381 8.2449 13.4999 N 0 0 0 0 0 0 - 29.2026 7.2563 13.3375 H 0 0 0 0 0 0 - 29.3656 8.7382 14.8322 C 0 0 1 0 0 0 - 28.6416 8.2922 15.5185 H 0 0 0 0 0 0 - 30.7455 8.2570 15.2299 C 0 0 0 0 0 0 - 31.8743 8.6652 14.4815 C 0 0 0 0 0 0 - 31.7520 9.3092 13.6238 H 0 0 0 0 0 0 - 33.1604 8.2279 14.8521 C 0 0 0 0 0 0 - 34.0060 8.5595 14.2811 H 0 0 0 0 0 0 - 33.3193 7.3889 15.9611 C 0 0 0 0 0 0 - 34.3108 7.0600 16.2514 H 0 0 0 0 0 0 - 32.1919 6.9528 16.6838 C 0 0 0 0 0 0 - 32.3158 6.2811 17.5154 H 0 0 0 0 0 0 - 30.9069 7.3866 16.3191 C 0 0 0 0 0 0 - 30.0444 7.0329 16.8656 H 0 0 0 0 0 0 - 29.2476 10.2810 14.9239 C 0 0 2 0 0 0 - 29.9272 10.6950 14.1785 H 0 0 0 0 0 0 - 29.6473 10.9133 16.2755 C 0 0 0 0 0 0 - 30.5879 10.5139 16.6418 H 0 0 0 0 0 0 - 29.8090 11.9820 16.1240 H 0 0 0 0 0 0 - 28.5497 10.7343 17.3309 C 0 0 0 0 0 0 - 28.8131 11.3124 18.2174 H 0 0 0 0 0 0 - 28.5127 9.6845 17.6290 H 0 0 0 0 0 0 - 26.8329 9.4057 18.4319 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 3 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 6 9 1 0 0 0 - 9 10 1 0 0 0 - 9 17 1 0 0 0 - 9 70 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 10 13 1 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 13 16 1 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 17 20 1 0 0 0 - 20 67 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 22 23 1 0 0 0 - 23 62 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 25 46 1 0 0 0 - 25 26 2 0 0 0 - 26 27 1 0 0 0 - 26 28 1 0 0 0 - 28 29 1 0 0 0 - 28 42 2 0 0 0 - 29 30 1 0 0 0 - 29 34 1 0 0 0 - 29 38 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 2 0 0 0 - 46 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 - 49 62 1 0 0 0 - 51 60 1 0 0 0 - 51 52 2 0 0 0 - 52 53 1 0 0 0 - 52 54 1 0 0 0 - 54 55 1 0 0 0 - 54 56 2 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 58 59 1 0 0 0 - 58 60 2 0 0 0 - 60 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 1 0 0 0 - 64 65 1 0 0 0 - 64 66 1 0 0 0 - 64 67 1 0 0 0 - 67 68 1 0 0 0 - 67 69 1 0 0 0 -M CHG 1 9 1 -M END -> -ligprep_eg5.smi - -> -16 - -> -53161 - -> -0 - -> -W09IXVtDSDJdW0NIMl1OKFtDSDJdW0NIM10pW0NIMl1bQ0BIXShPMSlbQ0gyXVtDSDJdW0NASF0yW0NASF0oYzNbY0hdW2NIXVtjSF1bY0hdW2NIXTMpW05IXWMoYzRbQ0BASF0xMilbY0hdW2NIXWMoW2NIXTQpQyhbQ0gzXSkoW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.2099 - -> - 0.2095 - -> - 0.0003 - -> - 0.1996 - -> -0.409142 - -> -1 - -> -1 - -> -S-OPLS - -> -51.358 - -> -1 - -> -lig_CHEMBL1084935-2 - -> -glide-grid_EG5-3L9H - -> -17 - -> -8 - -> --8.48690949119332 - -> --0.273771273909462 - -> --0.860019782055296 - -> --1.91405818280407 - -> --8.68650949119332 - -> --5.07714386840577 - -> --0.500851312107088 - -> --0 - -> --0.701547662786834 - -> --46.729808807373 - -> --5.62446928024292 - -> -0.773194184511463 - -> -0 - -> --64.5703659518333 - -> --52.354278087616 - -> -5.61762857437134 - -> -51 - -> -232 - -> -0.1996 - -> -0.107332582977005 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084935 - 3D - Schrodinger Suite 2022-3. - 70 73 0 0 1 0 999 V2000 - 28.0227 8.8199 22.3965 H 0 0 0 0 0 0 - 27.9951 9.4556 21.6947 O 0 0 0 0 0 0 - 26.6748 9.5586 21.2226 C 0 0 0 0 0 0 - 26.3977 8.5595 20.9226 H 0 0 0 0 0 0 - 26.0246 9.8414 22.0523 H 0 0 0 0 0 0 - 26.5775 10.5850 20.0780 C 0 0 0 0 0 0 - 25.9096 11.3888 20.3947 H 0 0 0 0 0 0 - 27.5390 11.0579 19.9229 H 0 0 0 0 0 0 - 26.0961 10.0291 18.7918 N 0 3 1 0 0 0 - 24.7892 9.2747 18.9023 C 0 0 0 0 0 0 - 24.6689 8.7726 19.8583 H 0 0 0 0 0 0 - 23.9398 9.9622 18.8570 H 0 0 0 0 0 0 - 24.6524 8.1781 17.8324 C 0 0 0 0 0 0 - 23.7660 7.5742 18.0178 H 0 0 0 0 0 0 - 25.5074 7.5035 17.8464 H 0 0 0 0 0 0 - 24.5618 8.5930 16.8302 H 0 0 0 0 0 0 - 25.9793 11.0483 17.7120 C 0 0 0 0 0 0 - 25.0870 10.9160 17.0922 H 0 0 0 0 0 0 - 25.8202 12.0187 18.1849 H 0 0 0 0 0 0 - 27.2006 11.1830 16.7682 C 0 0 2 0 0 0 - 27.2650 12.2398 16.4974 H 0 0 0 0 0 0 - 26.9221 10.4564 15.5764 O 0 0 0 0 0 0 - 27.8329 10.7402 14.5151 C 0 0 2 0 0 0 - 27.8326 11.8167 14.3329 H 0 0 0 0 0 0 - 27.4033 10.0687 13.2268 C 0 0 0 0 0 0 - 26.4208 10.6904 12.4374 C 0 0 0 0 0 0 - 25.9981 11.6083 12.8039 H 0 0 0 0 0 0 - 26.0590 10.1528 11.1799 C 0 0 0 0 0 0 - 25.0393 10.8521 10.2745 C 0 0 0 0 0 0 - 25.8155 11.6720 9.2413 C 0 0 0 0 0 0 - 25.1901 12.1743 8.5097 H 0 0 0 0 0 0 - 26.5106 11.0315 8.7087 H 0 0 0 0 0 0 - 26.3852 12.4562 9.7445 H 0 0 0 0 0 0 - 24.1072 11.7883 11.0552 C 0 0 0 0 0 0 - 24.6648 12.5884 11.5226 H 0 0 0 0 0 0 - 23.5955 11.2587 11.8546 H 0 0 0 0 0 0 - 23.3485 12.2374 10.4140 H 0 0 0 0 0 0 - 24.1135 9.8016 9.6460 C 0 0 0 0 0 0 - 23.3391 10.1869 9.0217 H 0 0 0 0 0 0 - 23.5849 9.3887 10.4730 H 0 0 0 0 0 0 - 24.6026 9.0117 9.0769 H 0 0 0 0 0 0 - 26.7095 8.9786 10.7390 C 0 0 0 0 0 0 - 26.4943 8.5505 9.7720 H 0 0 0 0 0 0 - 27.6622 8.3446 11.5310 C 0 0 0 0 0 0 - 28.1418 7.4352 11.1693 H 0 0 0 0 0 0 - 28.0222 8.8806 12.7751 C 0 0 0 0 0 0 - 29.0340 8.2454 13.5139 N 0 0 0 0 0 0 - 29.2068 7.2647 13.3492 H 0 0 0 0 0 0 - 29.3635 8.7551 14.8315 C 0 0 1 0 0 0 - 28.6381 8.3202 15.5223 H 0 0 0 0 0 0 - 30.7400 8.2655 15.2240 C 0 0 0 0 0 0 - 31.8638 8.6760 14.4765 C 0 0 0 0 0 0 - 31.7432 9.3286 13.6261 H 0 0 0 0 0 0 - 33.1466 8.2331 14.8325 C 0 0 0 0 0 0 - 33.9935 8.5512 14.2488 H 0 0 0 0 0 0 - 33.3170 7.3902 15.9446 C 0 0 0 0 0 0 - 34.3017 7.0450 16.2161 H 0 0 0 0 0 0 - 32.1927 6.9609 16.6779 C 0 0 0 0 0 0 - 32.3161 6.2889 17.5147 H 0 0 0 0 0 0 - 30.9024 7.3895 16.3143 C 0 0 0 0 0 0 - 30.0416 7.0468 16.8690 H 0 0 0 0 0 0 - 29.2527 10.3003 14.9052 C 0 0 2 0 0 0 - 29.9287 10.7067 14.1506 H 0 0 0 0 0 0 - 29.6597 10.9368 16.2496 C 0 0 0 0 0 0 - 30.6114 10.5478 16.6077 H 0 0 0 0 0 0 - 29.8173 12.0053 16.0947 H 0 0 0 0 0 0 - 28.5758 10.7463 17.3173 C 0 0 0 0 0 0 - 28.8517 11.3346 18.1910 H 0 0 0 0 0 0 - 28.5504 9.7003 17.6210 H 0 0 0 0 0 0 - 26.7554 9.3354 18.4785 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 3 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 6 9 1 0 0 0 - 9 10 1 0 0 0 - 9 17 1 0 0 0 - 9 70 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 10 13 1 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 13 16 1 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 17 20 1 0 0 0 - 20 67 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 22 23 1 0 0 0 - 23 62 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 25 46 1 0 0 0 - 25 26 2 0 0 0 - 26 27 1 0 0 0 - 26 28 1 0 0 0 - 28 29 1 0 0 0 - 28 42 2 0 0 0 - 29 30 1 0 0 0 - 29 34 1 0 0 0 - 29 38 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 2 0 0 0 - 46 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 - 49 62 1 0 0 0 - 51 60 1 0 0 0 - 51 52 2 0 0 0 - 52 53 1 0 0 0 - 52 54 1 0 0 0 - 54 55 1 0 0 0 - 54 56 2 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 58 59 1 0 0 0 - 58 60 2 0 0 0 - 60 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 1 0 0 0 - 64 65 1 0 0 0 - 64 66 1 0 0 0 - 64 67 1 0 0 0 - 67 68 1 0 0 0 - 67 69 1 0 0 0 -M CHG 1 9 1 -M END -> -ligprep_eg5.smi - -> -16 - -> -53161 - -> -0 - -> -W09IXVtDSDJdW0NIMl1OKFtDSDJdW0NIM10pW0NIMl1bQ0BIXShPMSlbQ0gyXVtDSDJdW0NASF0yW0NASF0oYzNbY0hdW2NIXVtjSF1bY0hdW2NIXTMpW05IXWMoYzRbQ0BASF0xMilbY0hdW2NIXWMoW2NIXTQpQyhbQ0gzXSkoW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.2099 - -> - 0.2095 - -> - 0.0003 - -> - 0.1996 - -> -0.409142 - -> -1 - -> -1 - -> -S-OPLS - -> -53.7729 - -> -1 - -> -lig_CHEMBL1084935-1 - -> -glide-grid_EG5-3L9H - -> -16 - -> -8 - -> --8.4504524408849 - -> --0.272595240028545 - -> --0.856325411979456 - -> --1.9058360006851 - -> --8.6500524408849 - -> --5.11195445752728 - -> --0.453621217513014 - -> --0 - -> --0.710757088127667 - -> --44.5950889587402 - -> --6.11439609527588 - -> -0.773194184511463 - -> -0 - -> --62.8328902316395 - -> --50.7094850540161 - -> -6.31344175338745 - -> -103 - -> -394 - -> -0.1996 - -> -0.101821539419745 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1086410 - 3D - Schrodinger Suite 2022-3. - 60 63 0 0 1 0 999 V2000 - 34.3034 7.0460 16.2168 H 0 0 0 0 0 0 - 33.3156 7.3882 15.9426 C 0 0 0 0 0 0 - 32.1922 6.9651 16.6778 C 0 0 0 0 0 0 - 32.3170 6.2969 17.5183 H 0 0 0 0 0 0 - 30.9031 7.4005 16.3189 C 0 0 0 0 0 0 - 30.0444 7.0638 16.8805 H 0 0 0 0 0 0 - 30.7405 8.2749 15.2271 C 0 0 0 0 0 0 - 29.3647 8.7641 14.8317 C 0 0 2 0 0 0 - 28.6412 8.3330 15.5255 H 0 0 0 0 0 0 - 29.0309 8.2521 13.5094 N 0 0 0 0 0 0 - 29.1983 7.2661 13.3467 H 0 0 0 0 0 0 - 28.0238 8.8838 12.7705 C 0 0 0 0 0 0 - 27.6593 8.3476 11.5211 C 0 0 0 0 0 0 - 28.1425 7.4524 11.1518 H 0 0 0 0 0 0 - 26.6986 8.9884 10.7317 C 0 0 0 0 0 0 - 26.4843 8.5701 9.7628 H 0 0 0 0 0 0 - 26.0447 10.1574 11.1873 C 0 0 0 0 0 0 - 25.0202 10.8597 10.2912 C 0 0 0 0 0 0 - 25.7980 11.6768 9.2530 C 0 0 0 0 0 0 - 25.1872 12.1988 8.5262 H 0 0 0 0 0 0 - 26.4733 11.0254 8.7190 H 0 0 0 0 0 0 - 26.3851 12.4480 9.7456 H 0 0 0 0 0 0 - 24.1152 11.8173 11.0744 C 0 0 0 0 0 0 - 24.7209 12.5880 11.5191 H 0 0 0 0 0 0 - 23.5850 11.3359 11.8895 H 0 0 0 0 0 0 - 23.3776 12.2980 10.4313 H 0 0 0 0 0 0 - 24.0854 9.8116 9.6805 C 0 0 0 0 0 0 - 23.2668 10.1885 9.0946 H 0 0 0 0 0 0 - 23.5862 9.3885 10.5344 H 0 0 0 0 0 0 - 24.5652 9.0305 9.0938 H 0 0 0 0 0 0 - 26.4056 10.6803 12.4474 C 0 0 0 0 0 0 - 25.9735 11.5884 12.8336 H 0 0 0 0 0 0 - 27.3977 10.0666 13.2261 C 0 0 0 0 0 0 - 27.8277 10.7418 14.5119 C 0 0 1 0 0 0 - 27.8251 11.8180 14.3240 H 0 0 0 0 0 0 - 26.9175 10.4606 15.5761 O 0 0 0 0 0 0 - 27.1892 11.2057 16.7569 C 0 0 1 0 0 0 - 27.2333 12.2597 16.4759 H 0 0 0 0 0 0 - 25.9858 11.0621 17.7207 C 0 0 0 0 0 0 - 25.7693 12.0180 18.1978 H 0 0 0 0 0 0 - 25.0963 10.8230 17.1352 H 0 0 0 0 0 0 - 26.1402 10.0160 18.7583 N 0 3 0 0 0 0 - 25.2320 9.5992 18.9092 H 0 0 0 0 0 0 - 26.6183 10.5076 20.0694 C 0 0 0 0 0 0 - 26.6969 9.6796 20.7731 H 0 0 0 0 0 0 - 25.9206 11.2363 20.4812 H 0 0 0 0 0 0 - 27.5960 10.9785 19.9937 H 0 0 0 0 0 0 - 28.5688 10.7757 17.3021 C 0 0 0 0 0 0 - 28.8354 11.3639 18.1789 H 0 0 0 0 0 0 - 28.5539 9.7281 17.6041 H 0 0 0 0 0 0 - 29.6518 10.9643 16.2364 C 0 0 0 0 0 0 - 29.7974 12.0335 16.0728 H 0 0 0 0 0 0 - 30.6069 10.5868 16.5982 H 0 0 0 0 0 0 - 29.2505 10.3108 14.8979 C 0 0 1 0 0 0 - 29.9251 10.7147 14.1407 H 0 0 0 0 0 0 - 31.8648 8.6803 14.4789 C 0 0 0 0 0 0 - 31.7444 9.3331 13.6262 H 0 0 0 0 0 0 - 33.1475 8.2346 14.8331 C 0 0 0 0 0 0 - 33.9934 8.5530 14.2485 H 0 0 0 0 0 0 - 26.7514 9.2938 18.4060 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 58 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 56 1 0 0 0 - 8 54 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 33 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 31 1 0 0 0 - 18 19 1 0 0 0 - 18 23 1 0 0 0 - 18 27 1 0 0 0 - 19 20 1 0 0 0 - 19 21 1 0 0 0 - 19 22 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 23 26 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 31 32 1 0 0 0 - 31 33 2 0 0 0 - 33 34 1 0 0 0 - 34 54 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 48 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 60 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 48 49 1 0 0 0 - 48 50 1 0 0 0 - 48 51 1 0 0 0 - 51 52 1 0 0 0 - 51 53 1 0 0 0 - 51 54 1 0 0 0 - 54 55 1 0 0 0 - 56 57 1 0 0 0 - 56 58 2 0 0 0 - 58 59 1 0 0 0 -M CHG 1 42 1 -M END -> -ligprep_eg5.smi - -> -21 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoW2NIXVtjSF00KUMoW0NIM10pKFtDSDNdKVtDSDNdKVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0027 - -> - 0.0023 - -> - 0.0004 - -> - -0.0000 - -> -0.00233856 - -> -1 - -> -1 - -> -S-OPLS - -> -42.9625 - -> -1 - -> -lig_CHEMBL1086410-1 - -> -glide-grid_EG5-3L9H - -> -22 - -> -4 - -> --8.44339112023165 - -> --0.312718189638209 - -> --0.93815456788396 - -> --1.96548225260823 - -> --8.44339112023165 - -> --5.11081688805815 - -> --0.192406234618827 - -> --0 - -> --1.10691026565731 - -> --42.2594757080078 - -> --3.30793595314026 - -> -0.575906446474057 - -> -0 - -> --56.4524812908641 - -> --45.5674116611481 - -> -0.818700671195984 - -> -4 - -> -3 - -> --0 - -> -0.098368472648139 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1086409 - 3D - Schrodinger Suite 2022-3. - 51 54 0 0 1 0 999 V2000 - 33.9825 8.5632 14.3524 H 0 0 0 0 0 0 - 33.0906 8.2280 14.8604 C 0 0 0 0 0 0 - 31.8246 8.6697 14.4384 C 0 0 0 0 0 0 - 31.7460 9.3316 13.5884 H 0 0 0 0 0 0 - 30.6644 8.2651 15.1328 C 0 0 0 0 0 0 - 29.3047 8.7817 14.7172 C 0 0 2 0 0 0 - 28.5580 8.3489 15.3859 H 0 0 0 0 0 0 - 28.9907 8.3067 13.3824 N 0 0 0 0 0 0 - 29.1766 7.3290 13.1982 H 0 0 0 0 0 0 - 27.9609 8.9352 12.6763 C 0 0 0 0 0 0 - 27.5740 8.3747 11.4443 C 0 0 0 0 0 0 - 28.0511 7.4775 11.0792 H 0 0 0 0 0 0 - 26.5727 8.9889 10.6731 C 0 0 0 0 0 0 - 26.2980 8.5637 9.7194 H 0 0 0 0 0 0 - 25.9595 10.1765 11.1211 C 0 0 0 0 0 0 - 24.9528 10.8868 10.2356 C 0 0 0 0 0 0 - 25.6100 11.6912 9.4000 F 0 0 0 0 0 0 - 24.2584 10.0015 9.5199 F 0 0 0 0 0 0 - 24.1089 11.6271 10.9548 F 0 0 0 0 0 0 - 26.3289 10.7260 12.3683 C 0 0 0 0 0 0 - 25.8701 11.6399 12.7175 H 0 0 0 0 0 0 - 27.3321 10.1147 13.1462 C 0 0 0 0 0 0 - 27.7792 10.7745 14.4410 C 0 0 1 0 0 0 - 27.7841 11.8529 14.2758 H 0 0 0 0 0 0 - 26.8824 10.4827 15.5190 O 0 0 0 0 0 0 - 27.1787 11.1986 16.7154 C 0 0 1 0 0 0 - 27.2406 12.2552 16.4490 H 0 0 0 0 0 0 - 25.9880 11.0676 17.7007 C 0 0 0 0 0 0 - 25.8089 12.0277 18.1864 H 0 0 0 0 0 0 - 25.0795 10.8619 17.1347 H 0 0 0 0 0 0 - 26.1393 10.0266 18.7447 N 0 3 0 0 0 0 - 25.2281 9.6164 18.8975 H 0 0 0 0 0 0 - 26.6210 10.5046 20.0555 C 0 0 0 0 0 0 - 26.6896 9.6636 20.7457 H 0 0 0 0 0 0 - 25.9285 11.2323 20.4815 H 0 0 0 0 0 0 - 27.6066 10.9625 19.9850 H 0 0 0 0 0 0 - 28.5558 10.7411 17.2377 C 0 0 0 0 0 0 - 28.8411 11.3068 18.1235 H 0 0 0 0 0 0 - 28.5323 9.6881 17.5186 H 0 0 0 0 0 0 - 29.6251 10.9445 16.1618 C 0 0 0 0 0 0 - 29.7780 12.0157 16.0190 H 0 0 0 0 0 0 - 30.5823 10.5491 16.4992 H 0 0 0 0 0 0 - 29.2042 10.3258 14.8128 C 0 0 1 0 0 0 - 29.8839 10.7318 14.0608 H 0 0 0 0 0 0 - 30.7658 7.3695 16.2131 C 0 0 0 0 0 0 - 29.8773 7.0355 16.7260 H 0 0 0 0 0 0 - 32.0300 6.9363 16.6385 C 0 0 0 0 0 0 - 32.1186 6.2827 17.4952 H 0 0 0 0 0 0 - 33.1872 7.3856 15.9804 C 0 0 0 0 0 0 - 34.3849 7.0437 16.4876 F 0 0 0 0 0 0 - 26.7431 9.2978 18.3920 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 49 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 45 2 0 0 0 - 6 43 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 22 1 0 0 0 - 10 11 2 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 13 14 1 0 0 0 - 13 15 2 0 0 0 - 15 16 1 0 0 0 - 15 20 1 0 0 0 - 16 17 1 0 0 0 - 16 18 1 0 0 0 - 16 19 1 0 0 0 - 20 21 1 0 0 0 - 20 22 2 0 0 0 - 22 23 1 0 0 0 - 23 43 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 25 26 1 0 0 0 - 26 27 1 0 0 0 - 26 28 1 0 0 0 - 26 37 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 31 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 31 51 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 33 36 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 40 1 0 0 0 - 40 41 1 0 0 0 - 40 42 1 0 0 0 - 40 43 1 0 0 0 - 43 44 1 0 0 0 - 45 46 1 0 0 0 - 45 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 2 0 0 0 - 49 50 1 0 0 0 -M CHG 1 31 1 -M END -> -ligprep_eg5.smi - -> -20 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdYyhGKVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0023 - -> - 0.0023 - -> - 0.0000 - -> - -0.0000 - -> -0.00233856 - -> -1 - -> -1 - -> -S-OPLS - -> -39.4847 - -> -1 - -> -lig_CHEMBL1086409-1 - -> -glide-grid_EG5-3L9H - -> -21 - -> -4 - -> --8.36784834764743 - -> --0.298851726701694 - -> --0.907489856520383 - -> --1.93154508934044 - -> --8.36784834764743 - -> --4.55781413171902 - -> --0.103503880092214 - -> --0 - -> --1.85677901672795 - -> --41.599739074707 - -> --1.80024313926697 - -> -0.500272105517158 - -> -0 - -> --64.5760746740241 - -> --43.399982213974 - -> --5.37275042233887e-08 - -> -8 - -> -8 - -> --0 - -> -0.0825077174894544 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1077204 - 3D - Schrodinger Suite 2022-3. - 66 69 0 0 1 0 999 V2000 - 34.2562 7.0347 16.2294 H 0 0 0 0 0 0 - 33.2821 7.3917 15.9444 C 0 0 0 0 0 0 - 33.1297 8.2337 14.8235 C 0 0 0 0 0 0 - 33.9842 8.5209 14.2482 H 0 0 0 0 0 0 - 31.8444 8.6867 14.4514 C 0 0 0 0 0 0 - 31.7395 9.3211 13.5904 H 0 0 0 0 0 0 - 30.7018 8.2986 15.1919 C 0 0 0 0 0 0 - 29.3349 8.7988 14.7881 C 0 0 2 0 0 0 - 28.5933 8.3597 15.4663 H 0 0 0 0 0 0 - 29.0070 8.3086 13.4630 N 0 0 0 0 0 0 - 29.1574 7.3132 13.3063 H 0 0 0 0 0 0 - 27.9809 8.9247 12.7466 C 0 0 0 0 0 0 - 27.5853 8.3573 11.5123 C 0 0 0 0 0 0 - 28.0389 7.4496 11.1533 H 0 0 0 0 0 0 - 26.6000 8.9873 10.7187 C 0 0 0 0 0 0 - 26.3248 8.5670 9.7705 H 0 0 0 0 0 0 - 25.9930 10.1883 11.1477 C 0 0 0 0 0 0 - 25.0012 10.8988 10.2584 C 0 0 0 0 0 0 - 25.6629 11.7243 9.4459 F 0 0 0 0 0 0 - 24.3362 10.0137 9.5184 F 0 0 0 0 0 0 - 24.1223 11.6157 10.9611 F 0 0 0 0 0 0 - 26.3740 10.7533 12.3947 C 0 0 0 0 0 0 - 25.9525 11.6837 12.7053 H 0 0 0 0 0 0 - 27.3631 10.1245 13.1855 C 0 0 0 0 0 0 - 27.7950 10.7877 14.4758 C 0 0 1 0 0 0 - 27.8062 11.8620 14.2948 H 0 0 0 0 0 0 - 26.8832 10.5117 15.5344 O 0 0 0 0 0 0 - 27.1477 11.2242 16.7404 C 0 0 1 0 0 0 - 27.1850 12.2849 16.4827 H 0 0 0 0 0 0 - 25.9308 11.0430 17.6962 C 0 0 0 0 0 0 - 25.6144 12.0199 18.0682 H 0 0 0 0 0 0 - 25.0712 10.6787 17.1251 H 0 0 0 0 0 0 - 26.1520 10.1379 18.8238 N 0 0 0 0 0 0 - 25.9448 9.1625 18.6644 H 0 0 0 0 0 0 - 26.6750 10.5167 20.0003 C 0 0 0 0 0 0 - 26.9446 11.6800 20.2828 O 0 0 0 0 0 0 - 26.9084 9.4845 20.8235 N 0 0 0 0 0 0 - 26.6390 8.5745 20.4891 H 0 0 0 0 0 0 - 27.6747 9.5294 22.0635 C 0 0 0 0 0 0 - 28.4015 8.7304 22.0160 H 0 0 0 0 0 0 - 28.2478 10.4626 22.1563 H 0 0 0 0 0 0 - 26.7887 9.3369 23.3234 C 0 0 0 0 0 0 - 26.2421 10.2685 23.5227 H 0 0 0 0 0 0 - 26.0295 8.5806 23.0824 H 0 0 0 0 0 0 - 27.5544 8.9152 24.5043 N 0 3 0 0 0 0 - 28.5187 9.8964 24.9818 C 0 0 0 0 0 0 - 28.0296 10.8222 25.3144 H 0 0 0 0 0 0 - 29.2668 10.1738 24.2278 H 0 0 0 0 0 0 - 29.0853 9.5071 25.8376 H 0 0 0 0 0 0 - 26.6934 8.4166 25.5707 C 0 0 0 0 0 0 - 26.0653 9.2210 25.9802 H 0 0 0 0 0 0 - 27.2755 7.9999 26.3998 H 0 0 0 0 0 0 - 26.0212 7.6192 25.2228 H 0 0 0 0 0 0 - 28.5220 10.7834 17.2811 C 0 0 0 0 0 0 - 28.7797 11.3718 18.1674 H 0 0 0 0 0 0 - 28.4929 9.7362 17.5813 H 0 0 0 0 0 0 - 29.6196 10.9620 16.2283 C 0 0 0 0 0 0 - 29.8012 12.0245 16.0892 H 0 0 0 0 0 0 - 30.5566 10.5581 16.6027 H 0 0 0 0 0 0 - 29.2135 10.3407 14.8728 C 0 0 1 0 0 0 - 29.9015 10.7486 14.1347 H 0 0 0 0 0 0 - 30.8528 7.4302 16.2936 C 0 0 0 0 0 0 - 29.9916 7.0984 16.8410 H 0 0 0 0 0 0 - 32.1393 6.9883 16.6779 C 0 0 0 0 0 0 - 32.2482 6.3143 17.5164 H 0 0 0 0 0 0 - 28.1027 8.1015 24.1952 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 64 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 62 1 0 0 0 - 8 60 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 60 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 54 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 35 36 2 0 0 0 - 35 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 45 1 0 0 0 - 45 46 1 0 0 0 - 45 50 1 0 0 0 - 45 66 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 53 1 0 0 0 - 54 55 1 0 0 0 - 54 56 1 0 0 0 - 54 57 1 0 0 0 - 57 58 1 0 0 0 - 57 59 1 0 0 0 - 57 60 1 0 0 0 - 60 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 2 0 0 0 - 64 65 1 0 0 0 -M CHG 1 45 1 -M END -> -ligprep_eg5.smi - -> -1 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdQyg9TylbTkhdW0NIMl1bQ0gyXU4oW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0082 - -> - 0.0082 - -> - 0.0000 - -> - -0.0000 - -> -0.00819794 - -> -1 - -> -1 - -> -S-OPLS - -> -45.9171 - -> -1 - -> -lig_CHEMBL1077204-1 - -> -glide-grid_EG5-3L9H - -> -1 - -> -9 - -> --8.36025842742276 - -> --0.245889953747728 - -> --0.796587995040363 - -> --1.84701558392362 - -> --8.36025842742276 - -> --4.57367673946409 - -> --0.151646552204959 - -> --0 - -> --1.23923404152954 - -> --51.0351600646973 - -> --4.12482261657715 - -> -0.799489567595273 - -> --0.0247092660980082 - -> --90.0263182301627 - -> --55.1599826812744 - -> -1.91703847463032e-07 - -> -8 - -> -10 - -> --0 - -> -0.0763132020169883 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1096003 - 3D - Schrodinger Suite 2022-3. - 62 65 0 0 1 0 999 V2000 - 34.2108 7.0139 16.2401 H 0 0 0 0 0 0 - 33.2384 7.3802 15.9455 C 0 0 0 0 0 0 - 32.0951 6.9867 16.6600 C 0 0 0 0 0 0 - 32.1852 6.3313 17.5158 H 0 0 0 0 0 0 - 30.8216 7.4546 16.2761 C 0 0 0 0 0 0 - 29.9477 7.1521 16.8340 H 0 0 0 0 0 0 - 30.6912 8.3234 15.1729 C 0 0 0 0 0 0 - 29.3266 8.8519 14.7633 C 0 0 2 0 0 0 - 28.5887 8.4033 15.4297 H 0 0 0 0 0 0 - 28.9799 8.3924 13.4251 N 0 0 0 0 0 0 - 29.1885 7.4303 13.1973 H 0 0 0 0 0 0 - 27.9425 9.0288 12.7277 C 0 0 0 0 0 0 - 27.4885 8.4689 11.5200 C 0 0 0 0 0 0 - 27.9849 7.2973 11.1235 F 0 0 0 0 0 0 - 26.5041 9.0837 10.7395 C 0 0 0 0 0 0 - 26.1690 8.6260 9.8203 H 0 0 0 0 0 0 - 25.9481 10.2875 11.1918 C 0 0 0 0 0 0 - 24.6811 11.0460 10.3189 Cl 0 0 0 0 0 0 - 26.3733 10.8611 12.4020 C 0 0 0 0 0 0 - 25.9318 11.7926 12.7245 H 0 0 0 0 0 0 - 27.3640 10.2330 13.1828 C 0 0 0 0 0 0 - 27.8115 10.8673 14.4860 C 0 0 1 0 0 0 - 27.8189 11.9494 14.3430 H 0 0 0 0 0 0 - 26.8820 10.5414 15.5172 O 0 0 0 0 0 0 - 27.1348 11.1765 16.7636 C 0 0 1 0 0 0 - 27.1756 12.2540 16.5895 H 0 0 0 0 0 0 - 25.9147 10.9027 17.6756 C 0 0 0 0 0 0 - 25.5493 11.8416 18.0940 H 0 0 0 0 0 0 - 25.0902 10.4808 17.0981 H 0 0 0 0 0 0 - 26.2403 10.0153 18.7915 N 0 0 2 0 0 0 - 26.9647 9.3341 18.5713 H 0 0 0 0 0 0 - 25.0077 9.3764 19.7986 S 0 0 0 0 0 0 - 25.6624 8.9726 21.0519 O 0 0 0 0 0 0 - 23.8983 10.3422 19.8235 O 0 0 0 0 0 0 - 24.4539 7.8667 18.8930 C 0 0 0 0 0 0 - 23.7047 8.1813 18.1665 H 0 0 0 0 0 0 - 25.3066 7.4701 18.3400 H 0 0 0 0 0 0 - 23.9081 6.8181 19.8885 C 0 0 0 0 0 0 - 24.7102 6.4972 20.5507 H 0 0 0 0 0 0 - 23.1696 7.2858 20.5414 H 0 0 0 0 0 0 - 23.2839 5.6191 19.2646 N 0 3 0 0 0 0 - 24.1543 4.8819 18.3191 C 0 0 0 0 0 0 - 24.3881 5.4812 17.4396 H 0 0 0 0 0 0 - 23.6637 3.9677 17.9819 H 0 0 0 0 0 0 - 25.0904 4.5869 18.7899 H 0 0 0 0 0 0 - 21.9386 5.8918 18.7115 C 0 0 0 0 0 0 - 21.9706 6.6453 17.9245 H 0 0 0 0 0 0 - 21.2614 6.2410 19.4906 H 0 0 0 0 0 0 - 21.5096 4.9883 18.2840 H 0 0 0 0 0 0 - 28.5078 10.7000 17.2959 C 0 0 0 0 0 0 - 28.7501 11.1998 18.2352 H 0 0 0 0 0 0 - 28.4915 9.6290 17.5014 H 0 0 0 0 0 0 - 29.6079 10.9729 16.2649 C 0 0 0 0 0 0 - 29.7511 12.0515 16.1753 H 0 0 0 0 0 0 - 30.5578 10.5741 16.6208 H 0 0 0 0 0 0 - 29.2267 10.3965 14.8829 C 0 0 1 0 0 0 - 29.9279 10.8179 14.1595 H 0 0 0 0 0 0 - 31.8413 8.6933 14.4440 C 0 0 0 0 0 0 - 31.7524 9.3424 13.5872 H 0 0 0 0 0 0 - 33.1101 8.2214 14.8259 C 0 0 0 0 0 0 - 33.9852 8.5082 14.2609 H 0 0 0 0 0 0 - 23.1301 4.9718 20.0285 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 60 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 58 1 0 0 0 - 8 56 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 21 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 20 1 0 0 0 - 19 21 2 0 0 0 - 21 22 1 0 0 0 - 22 56 1 0 0 0 - 22 23 1 0 0 0 - 22 24 1 0 0 0 - 24 25 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 50 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 32 33 2 0 0 0 - 32 34 2 0 0 0 - 32 35 1 0 0 0 - 35 36 1 0 0 0 - 35 37 1 0 0 0 - 35 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 46 1 0 0 0 - 41 62 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 45 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 53 1 0 0 0 - 53 54 1 0 0 0 - 53 55 1 0 0 0 - 53 56 1 0 0 0 - 56 57 1 0 0 0 - 58 59 1 0 0 0 - 58 60 2 0 0 0 - 60 61 1 0 0 0 -M CHG 1 41 1 -M END -> -ligprep_eg5.smi - -> -28 - -> -53161 - -> -0 - -> -RmMxW2NIXWMoQ2wpW2NIXWMoYzEyKVtDQEBIXTNbQ0BIXShbQ0BASF0oW05IXTIpYzRbY0hdW2NIXVtjSF1bY0hdW2NIXTQpW0NIMl1bQ0gyXVtDQEBIXShPMylbQ0gyXVtOSF1TKD1PKSg9TylbQ0gyXVtDSDJdTihbQ0gzXSlbQ0gzXQ== - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.1090 - -> - 0.1079 - -> - 0.0011 - -> - 0.0977 - -> -0.205654 - -> -1 - -> -1 - -> -S-OPLS - -> -46.8483 - -> -1 - -> -lig_CHEMBL1096003-1 - -> -glide-grid_EG5-3L9H - -> -29 - -> -7 - -> --8.27683950692293 - -> --0.258651234591341 - -> --0.821166482817689 - -> --1.85340998372382 - -> --8.37453950692293 - -> --4.5888972771767 - -> --0.0301411715814408 - -> --0 - -> --0.54412124830054 - -> --49.2485656738281 - -> --8.29037380218506 - -> -0.521998501557491 - -> --0.0273939574025725 - -> --88.89523856264 - -> --57.5389394760132 - -> -5.58035564422607 - -> -7 - -> -62 - -> -0.0977 - -> -0.0919035435540691 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1093087 - 3D - Schrodinger Suite 2022-3. - 66 70 0 0 1 0 999 V2000 - 23.1299 5.7633 18.3178 H 0 0 0 0 0 0 - 23.7562 6.6395 18.4185 C 0 0 0 0 0 0 - 24.3847 7.1950 17.2909 C 0 0 0 0 0 0 - 24.2947 6.7498 16.3118 H 0 0 0 0 0 0 - 25.2219 8.3094 17.4269 C 0 0 0 0 0 0 - 25.7142 8.6724 16.5394 H 0 0 0 0 0 0 - 25.4337 8.9223 18.6811 C 0 0 0 0 0 0 - 26.2670 10.0659 18.7635 N 0 0 0 0 0 0 - 26.5913 10.5374 20.1134 C 0 0 0 0 0 0 - 25.6767 10.9505 20.5373 H 0 0 0 0 0 0 - 26.8614 9.6757 20.7235 H 0 0 0 0 0 0 - 27.7162 11.5690 20.2663 C 0 0 0 0 0 0 - 28.6780 11.1135 20.0388 H 0 0 0 0 0 0 - 27.5734 12.4324 19.6125 H 0 0 0 0 0 0 - 27.7988 12.0569 21.6550 N 0 3 0 0 0 0 - 28.5622 12.7127 21.7447 H 0 0 0 0 0 0 - 27.9545 11.2778 22.2845 H 0 0 0 0 0 0 - 26.0253 11.0368 17.6907 C 0 0 0 0 0 0 - 25.0942 10.8522 17.1567 H 0 0 0 0 0 0 - 25.8552 12.0041 18.1629 H 0 0 0 0 0 0 - 27.1920 11.2093 16.6719 C 0 0 2 0 0 0 - 27.2111 12.2676 16.4043 H 0 0 0 0 0 0 - 26.8998 10.4907 15.4797 O 0 0 0 0 0 0 - 27.8051 10.7560 14.4114 C 0 0 2 0 0 0 - 27.8141 11.8342 14.2280 H 0 0 0 0 0 0 - 27.3579 10.0864 13.1318 C 0 0 0 0 0 0 - 26.3599 10.7094 12.3608 C 0 0 0 0 0 0 - 25.9129 11.6285 12.7095 H 0 0 0 0 0 0 - 25.9873 10.1746 11.1160 C 0 0 0 0 0 0 - 24.9793 10.8912 10.2387 C 0 0 0 0 0 0 - 24.2941 10.0045 9.5194 F 0 0 0 0 0 0 - 24.1227 11.6143 10.9588 F 0 0 0 0 0 0 - 25.6354 11.7052 9.4156 F 0 0 0 0 0 0 - 26.5985 8.9885 10.6676 C 0 0 0 0 0 0 - 26.3225 8.5699 9.7112 H 0 0 0 0 0 0 - 27.5827 8.3477 11.4429 C 0 0 0 0 0 0 - 28.0368 7.4388 11.0818 H 0 0 0 0 0 0 - 27.9758 8.8942 12.6779 C 0 0 0 0 0 0 - 28.9890 8.2540 13.4063 N 0 0 0 0 0 0 - 29.1781 7.2760 13.2370 H 0 0 0 0 0 0 - 29.3301 8.7599 14.7288 C 0 0 1 0 0 0 - 28.5956 8.3465 15.4225 H 0 0 0 0 0 0 - 30.7004 8.2567 15.1554 C 0 0 0 0 0 0 - 30.8428 7.4097 16.2730 C 0 0 0 0 0 0 - 29.9724 7.0898 16.8234 H 0 0 0 0 0 0 - 32.1238 6.9850 16.6788 C 0 0 0 0 0 0 - 32.2252 6.3393 17.5405 H 0 0 0 0 0 0 - 33.2631 7.3919 15.9618 C 0 0 0 0 0 0 - 34.2447 7.0644 16.2752 H 0 0 0 0 0 0 - 33.1210 8.2084 14.8274 C 0 0 0 0 0 0 - 33.9895 8.5124 14.2643 H 0 0 0 0 0 0 - 31.8460 8.6453 14.4287 C 0 0 0 0 0 0 - 31.7433 9.2753 13.5607 H 0 0 0 0 0 0 - 29.2287 10.3060 14.7795 C 0 0 2 0 0 0 - 29.9006 10.6920 14.0120 H 0 0 0 0 0 0 - 29.6574 10.9603 16.0973 C 0 0 0 0 0 0 - 30.6088 10.5650 16.4547 H 0 0 0 0 0 0 - 29.8251 12.0248 15.9176 H 0 0 0 0 0 0 - 28.5923 10.8030 17.1696 C 0 0 0 0 0 0 - 28.9012 11.4446 17.9820 H 0 0 0 0 0 0 - 28.5954 9.7729 17.5282 H 0 0 0 0 0 0 - 24.7771 8.3618 19.8117 C 0 0 0 0 0 0 - 24.8828 8.7758 20.8029 H 0 0 0 0 0 0 - 23.9563 7.2256 19.6793 C 0 0 0 0 0 0 - 23.4767 6.7957 20.5493 H 0 0 0 0 0 0 - 26.9372 12.5186 21.9048 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 64 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 62 1 0 0 0 - 8 9 1 0 0 0 - 8 18 1 0 0 0 - 9 10 1 0 0 0 - 9 11 1 0 0 0 - 9 12 1 0 0 0 - 12 13 1 0 0 0 - 12 14 1 0 0 0 - 12 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 1 0 0 0 - 15 66 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 21 59 1 0 0 0 - 21 22 1 0 0 0 - 21 23 1 0 0 0 - 23 24 1 0 0 0 - 24 54 1 0 0 0 - 24 25 1 0 0 0 - 24 26 1 0 0 0 - 26 38 1 0 0 0 - 26 27 2 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 29 30 1 0 0 0 - 29 34 2 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 36 38 2 0 0 0 - 38 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 54 1 0 0 0 - 43 52 1 0 0 0 - 43 44 2 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 46 47 1 0 0 0 - 46 48 2 0 0 0 - 48 49 1 0 0 0 - 48 50 1 0 0 0 - 50 51 1 0 0 0 - 50 52 2 0 0 0 - 52 53 1 0 0 0 - 54 55 1 0 0 0 - 54 56 1 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 56 59 1 0 0 0 - 59 60 1 0 0 0 - 59 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 2 0 0 0 - 64 65 1 0 0 0 -M CHG 1 15 1 -M END -> -ligprep_eg5.smi - -> -25 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFOKFtDSDJdW0NIMl1bTkgyXSlbQ0gyXVtDQEhdKE8yKVtDSDJdW0NIMl1bQ0BIXTNbQ0BASF0oW05IXWMoYzRbQ0BASF0yMylbY0hdW2NIXWMoW2NIXTQpQyhGKShGKUYpYzVbY0hdW2NIXVtjSF1bY0hdW2NIXTU= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0028 - -> - 0.0028 - -> - 0.0000 - -> - -0.0000 - -> -0.00279424 - -> -1 - -> -1 - -> -S-OPLS - -> -58.0699 - -> -1 - -> -lig_CHEMBL1093087-1 - -> -glide-grid_EG5-3L9H - -> -26 - -> -7 - -> --8.24502956920352 - -> --0.235572273405815 - -> --0.770572526239078 - -> --1.8099669790123 - -> --8.24502956920352 - -> --4.67177854739875 - -> --0.152309090065506 - -> --0 - -> --1.07138690296262 - -> --50.5483741760254 - -> --2.88129806518555 - -> -0.610058389802459 - -> -0 - -> --71.0152457922421 - -> --53.4296722412109 - -> -1.30132699012756 - -> -41 - -> -3 - -> --0 - -> -0.0842399486295152 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1088740 - 3D - Schrodinger Suite 2022-3. - 42 45 0 0 1 0 999 V2000 - 34.2619 7.0477 16.2093 H 0 0 0 0 0 0 - 33.2766 7.3886 15.9177 C 0 0 0 0 0 0 - 33.1255 8.2428 14.8083 C 0 0 0 0 0 0 - 33.9853 8.5639 14.2426 H 0 0 0 0 0 0 - 31.8470 8.6967 14.4373 C 0 0 0 0 0 0 - 31.7409 9.3558 13.5886 H 0 0 0 0 0 0 - 30.7076 8.2973 15.1684 C 0 0 0 0 0 0 - 29.3288 8.7982 14.7610 C 0 0 2 0 0 0 - 28.5958 8.3569 15.4405 H 0 0 0 0 0 0 - 29.0014 8.3162 13.4256 N 0 0 0 0 0 0 - 29.1585 7.3312 13.2629 H 0 0 0 0 0 0 - 27.9803 8.9440 12.6996 C 0 0 0 0 0 0 - 27.5773 8.3734 11.4772 C 0 0 0 0 0 0 - 28.0276 7.4585 11.1288 H 0 0 0 0 0 0 - 26.5832 8.9901 10.6951 C 0 0 0 0 0 0 - 26.2774 8.5452 9.7580 H 0 0 0 0 0 0 - 25.9885 10.1914 11.1236 C 0 0 0 0 0 0 - 24.9545 10.8779 10.2567 C 0 0 0 0 0 0 - 24.6201 11.8150 10.7049 H 0 0 0 0 0 0 - 24.0852 10.2341 10.1219 H 0 0 0 0 0 0 - 25.3737 11.1026 9.2747 H 0 0 0 0 0 0 - 26.3790 10.7596 12.3520 C 0 0 0 0 0 0 - 25.9302 11.6860 12.6855 H 0 0 0 0 0 0 - 27.3678 10.1415 13.1445 C 0 0 0 0 0 0 - 27.7979 10.8021 14.4430 C 0 0 1 0 0 0 - 27.8163 11.8778 14.2717 H 0 0 0 0 0 0 - 26.8631 10.5387 15.4864 O 0 0 0 0 0 0 - 27.1594 11.2122 16.7041 C 0 0 0 0 0 0 - 27.1933 12.2889 16.5326 H 0 0 0 0 0 0 - 26.3618 11.0220 17.4217 H 0 0 0 0 0 0 - 28.5000 10.7098 17.2538 C 0 0 0 0 0 0 - 28.7443 11.2220 18.1846 H 0 0 0 0 0 0 - 28.4290 9.6473 17.4894 H 0 0 0 0 0 0 - 29.6002 10.9501 16.2186 C 0 0 0 0 0 0 - 29.7299 12.0261 16.0949 H 0 0 0 0 0 0 - 30.5572 10.5710 16.5773 H 0 0 0 0 0 0 - 29.2120 10.3434 14.8537 C 0 0 1 0 0 0 - 29.9060 10.7566 14.1193 H 0 0 0 0 0 0 - 30.8602 7.4347 16.2743 C 0 0 0 0 0 0 - 29.9925 7.1181 16.8368 H 0 0 0 0 0 0 - 32.1444 6.9881 16.6513 C 0 0 0 0 0 0 - 32.2544 6.3476 17.5138 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 41 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 39 1 0 0 0 - 8 37 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 37 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 31 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 31 34 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 37 38 1 0 0 0 - 39 40 1 0 0 0 - 39 41 2 0 0 0 - 41 42 1 0 0 0 -M END -> -ligprep_eg5.smi - -> -22 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BIXShbQ0gyXVtDSDJdW0NIMl1PMylbQ0BIXTNjKGMyNClbY0hdYyhbQ0gzXSlbY0hdW2NIXTQ= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0005 - -> - 0.0000 - -> - 0.0005 - -> - -0.0000 - -> -0 - -> -0 - -> -0 - -> -S-OPLS - -> -29.6784 - -> -1 - -> -lig_CHEMBL1088740-1 - -> -glide-grid_EG5-3L9H - -> -23 - -> -1 - -> --8.23165818726475 - -> --0.391983723203083 - -> --1.08145336959537 - -> --2.03526085316965 - -> --8.23165818726475 - -> --4.56188775934081 - -> --0.126833965248195 - -> --0 - -> --1.60565819902926 - -> --40.0826835632324 - -> --1.09533953666687 - -> -0.23115684501517 - -> -0 - -> --62.2642327335467 - -> --41.1780230998993 - -> -9.09832209572414e-11 - -> -2 - -> -1 - -> --0 - -> -0.0570504166229713 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1089393 - 3D - Schrodinger Suite 2022-3. - 39 42 0 0 1 0 999 V2000 - 34.2647 7.0539 16.2410 H 0 0 0 0 0 0 - 33.2815 7.3880 15.9459 C 0 0 0 0 0 0 - 33.1282 8.2159 14.8193 C 0 0 0 0 0 0 - 33.9850 8.5298 14.2469 H 0 0 0 0 0 0 - 31.8508 8.6610 14.4379 C 0 0 0 0 0 0 - 31.7389 9.3022 13.5805 H 0 0 0 0 0 0 - 30.7123 8.2710 15.1743 C 0 0 0 0 0 0 - 29.3415 8.7718 14.7641 C 0 0 2 0 0 0 - 28.6014 8.3236 15.4302 H 0 0 0 0 0 0 - 29.0331 8.3115 13.4160 N 0 0 0 0 0 0 - 29.1863 7.3265 13.2464 H 0 0 0 0 0 0 - 28.0031 8.9388 12.7035 C 0 0 0 0 0 0 - 27.5847 8.3808 11.4792 C 0 0 0 0 0 0 - 28.0434 7.4764 11.1083 H 0 0 0 0 0 0 - 26.5552 8.9885 10.7351 C 0 0 0 0 0 0 - 26.2320 8.5607 9.7993 H 0 0 0 0 0 0 - 25.9541 10.1660 11.2118 C 0 0 0 0 0 0 - 24.7052 10.9453 10.3189 Cl 0 0 0 0 0 0 - 26.3725 10.7356 12.4244 C 0 0 0 0 0 0 - 25.9103 11.6538 12.7668 H 0 0 0 0 0 0 - 27.3923 10.1259 13.1744 C 0 0 0 0 0 0 - 27.8177 10.7802 14.4718 C 0 0 1 0 0 0 - 27.8424 11.8595 14.3046 H 0 0 0 0 0 0 - 26.8712 10.5102 15.4980 O 0 0 0 0 0 0 - 27.1490 11.1807 16.7189 C 0 0 0 0 0 0 - 27.1777 12.2591 16.5532 H 0 0 0 0 0 0 - 26.3392 10.9870 17.4239 H 0 0 0 0 0 0 - 28.4809 10.6753 17.2845 C 0 0 0 0 0 0 - 28.7130 11.1895 18.2171 H 0 0 0 0 0 0 - 28.4046 9.6133 17.5201 H 0 0 0 0 0 0 - 29.5919 10.9087 16.2626 C 0 0 0 0 0 0 - 29.7403 11.9859 16.1493 H 0 0 0 0 0 0 - 30.5382 10.5215 16.6317 H 0 0 0 0 0 0 - 29.2240 10.3145 14.8839 C 0 0 1 0 0 0 - 29.9266 10.7374 14.1700 H 0 0 0 0 0 0 - 30.8632 7.4239 16.2910 C 0 0 0 0 0 0 - 29.9964 7.1143 16.8574 H 0 0 0 0 0 0 - 32.1445 6.9883 16.6776 C 0 0 0 0 0 0 - 32.2589 6.3463 17.5406 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 38 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 36 1 0 0 0 - 8 34 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 21 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 20 1 0 0 0 - 19 21 2 0 0 0 - 21 22 1 0 0 0 - 22 34 1 0 0 0 - 22 23 1 0 0 0 - 22 24 1 0 0 0 - 24 25 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 31 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 31 34 1 0 0 0 - 34 35 1 0 0 0 - 36 37 1 0 0 0 - 36 38 2 0 0 0 - 38 39 1 0 0 0 -M END -> -ligprep_eg5.smi - -> -24 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BIXShbQ0gyXVtDSDJdW0NIMl1PMylbQ0BIXTNjKGMyNClbY0hdYyhDbClbY0hdW2NIXTQ= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0001 - -> - 0.0000 - -> - 0.0001 - -> - -0.0000 - -> -0 - -> -0 - -> -0 - -> -S-OPLS - -> -31.6196 - -> -1 - -> -lig_CHEMBL1089393-1 - -> -glide-grid_EG5-3L9H - -> -25 - -> -1 - -> --8.22712978487848 - -> --0.391768084994213 - -> --1.08085844012817 - -> --2.03414121483014 - -> --8.22712978487848 - -> --4.48702125982346 - -> --0.121698793447503 - -> --0 - -> --1.46564665851113 - -> --44.6794166564941 - -> --0.82136058807373 - -> -0.204411847939387 - -> -0 - -> --68.9748890326486 - -> --45.5007772445679 - -> -9.60127533033983e-11 - -> -2 - -> -2 - -> --0 - -> -0.0723577521148774 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1078998 - 3D - Schrodinger Suite 2022-3. - 48 51 0 0 1 0 999 V2000 - 34.1947 7.5779 15.4207 H 0 0 0 0 0 0 - 33.1198 7.6381 15.5236 C 0 0 0 0 0 0 - 32.3164 6.9878 16.4206 C 0 0 0 0 0 0 - 32.6650 6.2986 17.1751 H 0 0 0 0 0 0 - 30.9333 7.2942 16.2577 C 0 0 0 0 0 0 - 30.1701 6.8533 16.8808 H 0 0 0 0 0 0 - 30.6929 8.1902 15.2493 C 0 0 0 0 0 0 - 29.3690 8.7453 14.8203 C 0 0 2 0 0 0 - 28.6007 8.3230 15.4679 H 0 0 0 0 0 0 - 29.0556 8.2761 13.4784 N 0 0 0 0 0 0 - 29.1849 7.2869 13.3140 H 0 0 0 0 0 0 - 28.0446 8.9139 12.7545 C 0 0 0 0 0 0 - 27.6625 8.3616 11.5199 C 0 0 0 0 0 0 - 28.1353 7.4641 11.1515 H 0 0 0 0 0 0 - 26.6788 8.9882 10.7435 C 0 0 0 0 0 0 - 26.4438 8.5609 9.7824 H 0 0 0 0 0 0 - 26.0342 10.1623 11.2002 C 0 0 0 0 0 0 - 25.0087 10.8621 10.3025 C 0 0 0 0 0 0 - 25.7904 11.6456 9.2455 C 0 0 0 0 0 0 - 25.1860 12.1562 8.5073 H 0 0 0 0 0 0 - 26.4489 10.9661 8.7190 H 0 0 0 0 0 0 - 26.3851 12.4225 9.7190 H 0 0 0 0 0 0 - 24.1178 11.8326 11.0824 C 0 0 0 0 0 0 - 24.7429 12.5888 11.5212 H 0 0 0 0 0 0 - 23.5853 11.3659 11.9056 H 0 0 0 0 0 0 - 23.3851 12.3246 10.4415 H 0 0 0 0 0 0 - 24.0632 9.8307 9.6878 C 0 0 0 0 0 0 - 23.2452 10.2403 9.1184 H 0 0 0 0 0 0 - 23.5849 9.3883 10.5420 H 0 0 0 0 0 0 - 24.5344 9.0614 9.0788 H 0 0 0 0 0 0 - 26.4161 10.6993 12.4516 C 0 0 0 0 0 0 - 25.9827 11.6028 12.8450 H 0 0 0 0 0 0 - 27.4301 10.1007 13.2153 C 0 0 0 0 0 0 - 27.8767 10.7715 14.5034 C 0 0 1 0 0 0 - 27.9137 11.8471 14.3209 H 0 0 0 0 0 0 - 26.9263 10.5311 15.5384 O 0 0 0 0 0 0 - 27.2149 11.2104 16.7511 C 0 0 0 0 0 0 - 27.2516 12.2880 16.5841 H 0 0 0 0 0 0 - 26.4064 11.0248 17.4577 H 0 0 0 0 0 0 - 28.5412 10.6911 17.3188 C 0 0 0 0 0 0 - 28.7821 11.2104 18.2460 H 0 0 0 0 0 0 - 28.4434 9.6344 17.5691 H 0 0 0 0 0 0 - 29.6691 10.8775 16.2990 C 0 0 0 0 0 0 - 29.8652 11.9448 16.1849 H 0 0 0 0 0 0 - 30.5943 10.4456 16.6785 H 0 0 0 0 0 0 - 29.2820 10.2885 14.9242 C 0 0 1 0 0 0 - 29.9954 10.6901 14.2015 H 0 0 0 0 0 0 - 32.1845 8.6496 14.4604 S 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 48 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 48 1 0 0 0 - 8 46 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 33 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 31 1 0 0 0 - 18 19 1 0 0 0 - 18 23 1 0 0 0 - 18 27 1 0 0 0 - 19 20 1 0 0 0 - 19 21 1 0 0 0 - 19 22 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 23 26 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 31 32 1 0 0 0 - 31 33 2 0 0 0 - 33 34 1 0 0 0 - 34 46 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 40 1 0 0 0 - 40 41 1 0 0 0 - 40 42 1 0 0 0 - 40 43 1 0 0 0 - 43 44 1 0 0 0 - 43 45 1 0 0 0 - 43 46 1 0 0 0 - 46 47 1 0 0 0 -M END -> -ligprep_eg5.smi - -> -5 - -> -53161 - -> -0 - -> -czFbY0hdW2NIXVtjSF1jMVtDQEhdKFtOSF0yKVtDQEhdKFtDSDJdW0NIMl1bQ0gyXU8zKVtDQEhdM2MoYzI0KVtjSF1jKFtjSF1bY0hdNClDKFtDSDNdKShbQ0gzXSlbQ0gzXQ== - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0003 - -> - 0.0000 - -> - 0.0003 - -> - -0.0000 - -> -0 - -> -0 - -> -0 - -> -S-OPLS - -> -32.9936 - -> -1 - -> -lig_CHEMBL1078998-1 - -> -glide-grid_EG5-3L9H - -> -5 - -> -2 - -> --8.19039150669661 - -> --0.356103978552027 - -> --1.01271234493943 - -> --1.98051093268339 - -> --8.19039150669661 - -> --4.78139598955158 - -> --0.17091194085284 - -> --0 - -> --1.3316469676463 - -> --40.4941749572754 - -> --1.54494202136993 - -> -0.350013442423362 - -> -0 - -> --50.3757815013786 - -> --42.0391169786453 - -> -1.03173077106476 - -> -9 - -> -3 - -> --0 - -> -0.10412772554396 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084115 - 3D - Schrodinger Suite 2022-3. - 48 51 0 0 1 0 999 V2000 - 32.6182 6.3238 17.1857 H 0 0 0 0 0 0 - 32.1839 6.9883 16.4549 C 0 0 0 0 0 0 - 30.8663 7.3078 16.2832 C 0 0 0 0 0 0 - 30.0539 6.9250 16.8835 H 0 0 0 0 0 0 - 30.6414 8.2279 15.2203 C 0 0 0 0 0 0 - 29.2922 8.7705 14.8516 C 0 0 2 0 0 0 - 28.5244 8.3282 15.4899 H 0 0 0 0 0 0 - 29.0508 8.2929 13.4958 N 0 0 0 0 0 0 - 29.1849 7.2958 13.3635 H 0 0 0 0 0 0 - 28.0406 8.9174 12.7574 C 0 0 0 0 0 0 - 27.6618 8.3672 11.5211 C 0 0 0 0 0 0 - 28.1486 7.4782 11.1566 H 0 0 0 0 0 0 - 26.6763 8.9884 10.7458 C 0 0 0 0 0 0 - 26.4469 8.5618 9.7863 H 0 0 0 0 0 0 - 26.0297 10.1598 11.2039 C 0 0 0 0 0 0 - 24.9994 10.8579 10.3117 C 0 0 0 0 0 0 - 25.7866 11.6786 9.2840 C 0 0 0 0 0 0 - 25.1851 12.2292 8.5694 H 0 0 0 0 0 0 - 26.4350 11.0126 8.7282 H 0 0 0 0 0 0 - 26.3884 12.4253 9.8037 H 0 0 0 0 0 0 - 24.0937 11.7959 11.1153 C 0 0 0 0 0 0 - 24.6889 12.5881 11.5275 H 0 0 0 0 0 0 - 23.6247 11.2997 11.9581 H 0 0 0 0 0 0 - 23.3130 12.2425 10.5028 H 0 0 0 0 0 0 - 24.0574 9.8107 9.6917 C 0 0 0 0 0 0 - 23.2233 10.1886 9.1186 H 0 0 0 0 0 0 - 23.5867 9.3885 10.5576 H 0 0 0 0 0 0 - 24.5376 9.0346 9.0970 H 0 0 0 0 0 0 - 26.4029 10.6958 12.4560 C 0 0 0 0 0 0 - 25.9642 11.5985 12.8394 H 0 0 0 0 0 0 - 27.4121 10.1053 13.2189 C 0 0 0 0 0 0 - 27.8359 10.7863 14.5065 C 0 0 1 0 0 0 - 27.8749 11.8619 14.3181 H 0 0 0 0 0 0 - 26.8745 10.5452 15.5345 O 0 0 0 0 0 0 - 27.1459 11.2254 16.7533 C 0 0 0 0 0 0 - 27.1918 12.3000 16.5749 H 0 0 0 0 0 0 - 26.3249 11.0526 17.4499 H 0 0 0 0 0 0 - 28.4669 10.7064 17.3376 C 0 0 0 0 0 0 - 28.7034 11.2233 18.2670 H 0 0 0 0 0 0 - 28.3697 9.6473 17.5813 H 0 0 0 0 0 0 - 29.5993 10.9055 16.3274 C 0 0 0 0 0 0 - 29.7825 11.9748 16.2109 H 0 0 0 0 0 0 - 30.5277 10.4844 16.7100 H 0 0 0 0 0 0 - 29.2304 10.3137 14.9492 C 0 0 1 0 0 0 - 29.9522 10.7100 14.2337 H 0 0 0 0 0 0 - 31.8135 8.5880 14.5941 C 0 0 0 0 0 0 - 31.9353 9.2641 13.7647 H 0 0 0 0 0 0 - 33.1905 7.7914 15.2863 S 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 48 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 46 2 0 0 0 - 6 44 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 31 1 0 0 0 - 10 11 2 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 13 14 1 0 0 0 - 13 15 2 0 0 0 - 15 16 1 0 0 0 - 15 29 1 0 0 0 - 16 17 1 0 0 0 - 16 21 1 0 0 0 - 16 25 1 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 17 20 1 0 0 0 - 21 22 1 0 0 0 - 21 23 1 0 0 0 - 21 24 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 28 1 0 0 0 - 29 30 1 0 0 0 - 29 31 2 0 0 0 - 31 32 1 0 0 0 - 32 44 1 0 0 0 - 32 33 1 0 0 0 - 32 34 1 0 0 0 - 34 35 1 0 0 0 - 35 36 1 0 0 0 - 35 37 1 0 0 0 - 35 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 -M END -> -ligprep_eg5.smi - -> -10 - -> -53161 - -> -0 - -> -W2NIXTFzW2NIXVtjSF1jMVtDQEhdKFtOSF0yKVtDQEhdKFtDSDJdW0NIMl1bQ0gyXU8zKVtDQEhdM2MoYzI0KVtjSF1jKFtjSF1bY0hdNClDKFtDSDNdKShbQ0gzXSlbQ0gzXQ== - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0010 - -> - 0.0000 - -> - 0.0010 - -> - -0.0000 - -> -0 - -> -0 - -> -0 - -> -S-OPLS - -> -32.2935 - -> -1 - -> -lig_CHEMBL1084115-1 - -> -glide-grid_EG5-3L9H - -> -10 - -> -2 - -> --8.16885937081563 - -> --0.355167798731114 - -> --1.01004997406231 - -> --1.97530426698476 - -> --8.16885937081563 - -> --4.74310490481154 - -> --0.174712228680572 - -> --0 - -> --1.33930295509936 - -> --42.223560333252 - -> --1.00383138656616 - -> -0.350013442423362 - -> -0 - -> --51.7623913252009 - -> --43.2273917198181 - -> -1.00541388988495 - -> -9 - -> -5 - -> --0 - -> -0.103350336571365 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1083836 - 3D - Schrodinger Suite 2022-3. - 55 59 0 0 1 0 999 V2000 - 34.2956 7.0491 16.2082 H 0 0 0 0 0 0 - 33.3067 7.3881 15.9302 C 0 0 0 0 0 0 - 33.1374 8.2287 14.8140 C 0 0 0 0 0 0 - 33.9858 8.5407 14.2291 H 0 0 0 0 0 0 - 31.8538 8.6740 14.4594 C 0 0 0 0 0 0 - 31.7350 9.3219 13.6023 H 0 0 0 0 0 0 - 30.7280 8.2799 15.2118 C 0 0 0 0 0 0 - 29.3511 8.7830 14.8242 C 0 0 2 0 0 0 - 28.6310 8.3616 15.5262 H 0 0 0 0 0 0 - 28.9935 8.2742 13.5067 N 0 0 0 0 0 0 - 29.1785 7.2947 13.3270 H 0 0 0 0 0 0 - 28.0012 8.9258 12.7619 C 0 0 0 0 0 0 - 27.6144 8.3685 11.5283 C 0 0 0 0 0 0 - 28.0387 7.4360 11.1887 H 0 0 0 0 0 0 - 26.6762 9.0305 10.7188 C 0 0 0 0 0 0 - 26.3849 8.5957 9.7731 H 0 0 0 0 0 0 - 26.1232 10.2625 11.1242 C 0 0 0 0 0 0 - 25.1513 10.9601 10.2335 C 0 0 0 0 0 0 - 25.6318 11.3327 9.3304 H 0 0 0 0 0 0 - 23.8207 10.3233 10.1118 C 0 0 0 0 0 0 - 23.4190 10.1890 9.1189 H 0 0 0 0 0 0 - 23.6510 9.4959 10.7837 H 0 0 0 0 0 0 - 23.9275 11.6953 10.7363 C 0 0 0 0 0 0 - 23.7742 11.7751 11.8086 H 0 0 0 0 0 0 - 23.5474 12.5284 10.1533 H 0 0 0 0 0 0 - 26.4776 10.7980 12.3747 C 0 0 0 0 0 0 - 26.0487 11.7348 12.6988 H 0 0 0 0 0 0 - 27.4177 10.1422 13.1923 C 0 0 0 0 0 0 - 27.8431 10.7906 14.4963 C 0 0 1 0 0 0 - 27.8564 11.8698 14.3283 H 0 0 0 0 0 0 - 26.9222 10.4980 15.5507 O 0 0 0 0 0 0 - 27.1904 11.2175 16.7494 C 0 0 1 0 0 0 - 27.2389 12.2749 16.4841 H 0 0 0 0 0 0 - 25.9869 11.0644 17.7134 C 0 0 0 0 0 0 - 25.0929 10.8369 17.1284 H 0 0 0 0 0 0 - 25.7826 12.0160 18.2031 H 0 0 0 0 0 0 - 26.1417 10.0156 18.7502 N 0 3 0 0 0 0 - 26.7475 9.2923 18.3874 H 0 0 0 0 0 0 - 26.6265 10.4800 20.0660 C 0 0 0 0 0 0 - 26.6984 9.6369 20.7550 H 0 0 0 0 0 0 - 25.9341 11.2078 20.4921 H 0 0 0 0 0 0 - 27.6096 10.9451 19.9934 H 0 0 0 0 0 0 - 28.5697 10.7835 17.2954 C 0 0 0 0 0 0 - 28.8336 11.3707 18.1737 H 0 0 0 0 0 0 - 28.5516 9.7368 17.6008 H 0 0 0 0 0 0 - 29.6604 10.9670 16.2362 C 0 0 0 0 0 0 - 29.8229 12.0353 16.0845 H 0 0 0 0 0 0 - 30.6070 10.5709 16.6014 H 0 0 0 0 0 0 - 29.2572 10.3308 14.8898 C 0 0 1 0 0 0 - 29.9452 10.7276 14.1413 H 0 0 0 0 0 0 - 30.8942 7.4141 16.3116 C 0 0 0 0 0 0 - 30.0373 7.0837 16.8804 H 0 0 0 0 0 0 - 32.1832 6.9779 16.6722 C 0 0 0 0 0 0 - 32.3101 6.3172 17.5190 H 0 0 0 0 0 0 - 25.2315 9.5998 18.8950 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 53 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 51 1 0 0 0 - 8 49 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 28 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 26 1 0 0 0 - 18 23 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 20 23 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 26 27 1 0 0 0 - 26 28 2 0 0 0 - 28 29 1 0 0 0 - 29 49 1 0 0 0 - 29 30 1 0 0 0 - 29 31 1 0 0 0 - 31 32 1 0 0 0 - 32 33 1 0 0 0 - 32 34 1 0 0 0 - 32 43 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 55 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 43 44 1 0 0 0 - 43 45 1 0 0 0 - 43 46 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 49 50 1 0 0 0 - 51 52 1 0 0 0 - 51 53 2 0 0 0 - 53 54 1 0 0 0 -M CHG 1 37 1 -M END -> -ligprep_eg5.smi - -> -9 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BIXShbQ0gyXVtDSDJdW0NAQEhdKE8zKVtDSDJdW05IXVtDSDNdKVtDQEhdM2MoYzI0KVtjSF1jKFtjSF1bY0hdNClbQ0hdNVtDSDJdW0NIMl01 - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0027 - -> - 0.0023 - -> - 0.0004 - -> - -0.0000 - -> -0.00233856 - -> -1 - -> -1 - -> -S-OPLS - -> -43.0329 - -> -1 - -> -lig_CHEMBL1083836-1 - -> -glide-grid_EG5-3L9H - -> -9 - -> -4 - -> --8.11821399640001 - -> --0.312238999861539 - -> --0.925006808488672 - -> --1.90653591902173 - -> --8.11821399640001 - -> --4.9859128801992 - -> --0.163850739216988 - -> --0 - -> --1.12670252259112 - -> --40.803352355957 - -> --2.83613419532776 - -> -0.623839892704311 - -> -0 - -> --60.2541375122534 - -> --43.6394865512848 - -> -0.242533147335052 - -> -5 - -> -2 - -> --0 - -> -0.0861842314775095 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1077227 - 3D - Schrodinger Suite 2022-3. - 57 60 0 0 1 0 999 V2000 - 33.2036 6.3232 16.8098 H 0 0 0 0 0 0 - 32.6142 6.9890 16.1935 C 0 0 0 0 0 0 - 33.0383 7.8715 15.2366 C 0 0 0 0 0 0 - 34.0656 8.0294 14.9506 H 0 0 0 0 0 0 - 31.9591 8.5929 14.6434 C 0 0 0 0 0 0 - 32.1147 9.3396 13.8769 H 0 0 0 0 0 0 - 30.7328 8.2488 15.1532 C 0 0 0 0 0 0 - 29.3857 8.7765 14.8007 C 0 0 2 0 0 0 - 28.6544 8.3264 15.4743 H 0 0 0 0 0 0 - 29.0514 8.3019 13.4693 N 0 0 0 0 0 0 - 29.2210 7.3198 13.2837 H 0 0 0 0 0 0 - 28.0260 8.9310 12.7612 C 0 0 0 0 0 0 - 27.6533 8.3886 11.5188 C 0 0 0 0 0 0 - 28.1393 7.5042 11.1378 H 0 0 0 0 0 0 - 26.6620 9.0114 10.7514 C 0 0 0 0 0 0 - 26.4358 8.5890 9.7861 H 0 0 0 0 0 0 - 26.0083 10.1779 11.2159 C 0 0 0 0 0 0 - 24.9806 10.8710 10.3106 C 0 0 0 0 0 0 - 25.7723 11.6568 9.2605 C 0 0 0 0 0 0 - 25.1858 12.2085 8.5367 H 0 0 0 0 0 0 - 26.4098 10.9734 8.7186 H 0 0 0 0 0 0 - 26.3858 12.4039 9.7555 H 0 0 0 0 0 0 - 24.0968 11.8370 11.0951 C 0 0 0 0 0 0 - 24.7333 12.5902 11.5213 H 0 0 0 0 0 0 - 23.5852 11.3775 11.9327 H 0 0 0 0 0 0 - 23.3524 12.3267 10.4644 H 0 0 0 0 0 0 - 24.0389 9.8314 9.6914 C 0 0 0 0 0 0 - 23.1929 10.2009 9.1191 H 0 0 0 0 0 0 - 23.5859 9.3883 10.5558 H 0 0 0 0 0 0 - 24.5194 9.0588 9.0932 H 0 0 0 0 0 0 - 26.3817 10.7078 12.4767 C 0 0 0 0 0 0 - 25.9403 11.6064 12.8752 H 0 0 0 0 0 0 - 27.3936 10.1032 13.2413 C 0 0 0 0 0 0 - 27.8318 10.7656 14.5376 C 0 0 1 0 0 0 - 27.8428 11.8432 14.3620 H 0 0 0 0 0 0 - 26.9039 10.4942 15.5908 O 0 0 0 0 0 0 - 27.1807 11.1820 16.8101 C 0 0 1 0 0 0 - 27.2456 12.2458 16.5739 H 0 0 0 0 0 0 - 25.9802 11.0033 17.7814 C 0 0 0 0 0 0 - 25.6844 11.9747 18.1781 H 0 0 0 0 0 0 - 25.1194 10.6530 17.2065 H 0 0 0 0 0 0 - 26.2337 10.1012 18.9492 N 0 3 0 0 0 0 - 26.8893 9.4063 18.6222 H 0 0 0 0 0 0 - 25.0333 9.3415 19.3545 C 0 0 0 0 0 0 - 25.2744 8.6673 20.1774 H 0 0 0 0 0 0 - 24.6508 8.7399 18.5282 H 0 0 0 0 0 0 - 24.2433 10.0163 19.6873 H 0 0 0 0 0 0 - 28.5468 10.7094 17.3415 C 0 0 0 0 0 0 - 28.8046 11.2432 18.2565 H 0 0 0 0 0 0 - 28.5049 9.6494 17.5916 H 0 0 0 0 0 0 - 29.6476 10.9161 16.2956 C 0 0 0 0 0 0 - 29.8185 11.9872 16.1725 H 0 0 0 0 0 0 - 30.5873 10.5006 16.6545 H 0 0 0 0 0 0 - 29.2537 10.3147 14.9282 C 0 0 1 0 0 0 - 29.9422 10.7405 14.1941 H 0 0 0 0 0 0 - 30.8818 6.9880 16.3306 S 0 0 0 0 0 0 - 26.6278 10.4979 19.8995 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 56 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 56 1 0 0 0 - 8 54 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 33 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 31 1 0 0 0 - 18 19 1 0 0 0 - 18 23 1 0 0 0 - 18 27 1 0 0 0 - 19 20 1 0 0 0 - 19 21 1 0 0 0 - 19 22 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 23 26 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 31 32 1 0 0 0 - 31 33 2 0 0 0 - 33 34 1 0 0 0 - 34 54 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 48 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 57 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 48 49 1 0 0 0 - 48 50 1 0 0 0 - 48 51 1 0 0 0 - 51 52 1 0 0 0 - 51 53 1 0 0 0 - 51 54 1 0 0 0 - 54 55 1 0 0 0 -M CHG 1 42 1 -M END -> -ligprep_eg5.smi - -> -2 - -> -53161 - -> -0 - -> -W0NIM11bTkhdW0NIMl1bQ0BIXShPMSlbQ0gyXVtDSDJdW0NAQEhdKFtDQEBIXShbTkhdMiljM1tjSF1bY0hdW2NIXXMzKVtDQEhdMWMoYzI0KVtjSF1jKFtjSF1bY0hdNClDKFtDSDNdKShbQ0gzXSlbQ0gzXQ== - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0026 - -> - 0.0023 - -> - 0.0002 - -> - -0.0000 - -> -0.00234437 - -> -1 - -> -1 - -> -S-OPLS - -> -35.8987 - -> -1 - -> -lig_CHEMBL1077227-1 - -> -glide-grid_EG5-3L9H - -> -2 - -> -4 - -> --7.933869842524 - -> --0.305148840097077 - -> --0.904002238084884 - -> --1.86324329936645 - -> --7.933869842524 - -> --4.78353947845621 - -> --0.128973420991137 - -> --0 - -> --1.03980574115753 - -> --43.0146675109863 - -> --2.60091114044189 - -> -0.559318844696476 - -> -0 - -> --55.2445904462782 - -> --45.6155786514282 - -> -2.06124687194824 - -> -38 - -> -37 - -> --0 - -> -0.106644903951531 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1085692 - 3D - Schrodinger Suite 2022-3. - 64 67 0 0 1 0 999 V2000 - 34.2542 7.0460 16.2347 H 0 0 0 0 0 0 - 33.2731 7.3883 15.9413 C 0 0 0 0 0 0 - 32.1391 6.9883 16.6737 C 0 0 0 0 0 0 - 32.2530 6.3417 17.5322 H 0 0 0 0 0 0 - 30.8552 7.4280 16.2941 C 0 0 0 0 0 0 - 29.9909 7.1230 16.8633 H 0 0 0 0 0 0 - 30.7055 8.2812 15.1809 C 0 0 0 0 0 0 - 29.3355 8.8047 14.7912 C 0 0 2 0 0 0 - 28.6052 8.3747 15.4764 H 0 0 0 0 0 0 - 28.9759 8.3401 13.4575 N 0 0 0 0 0 0 - 29.1708 7.3698 13.2383 H 0 0 0 0 0 0 - 27.9461 8.9883 12.7575 C 0 0 0 0 0 0 - 27.4915 8.4449 11.5404 C 0 0 0 0 0 0 - 27.9850 7.2801 11.1189 F 0 0 0 0 0 0 - 26.5200 9.0831 10.7598 C 0 0 0 0 0 0 - 26.1956 8.6573 9.8227 H 0 0 0 0 0 0 - 25.9960 10.2926 11.2170 C 0 0 0 0 0 0 - 24.7848 11.2873 10.1865 Br 0 0 0 0 0 0 - 26.3977 10.8361 12.4476 C 0 0 0 0 0 0 - 25.9875 11.7871 12.7662 H 0 0 0 0 0 0 - 27.3739 10.1890 13.2224 C 0 0 0 0 0 0 - 27.8460 10.8408 14.5042 C 0 0 1 0 0 0 - 27.8814 11.9179 14.3316 H 0 0 0 0 0 0 - 26.9142 10.5734 15.5487 O 0 0 0 0 0 0 - 27.1946 11.2571 16.7623 C 0 0 1 0 0 0 - 27.2815 12.3238 16.5404 H 0 0 0 0 0 0 - 25.9633 11.0805 17.6864 C 0 0 0 0 0 0 - 25.6710 12.0572 18.0766 H 0 0 0 0 0 0 - 25.1038 10.7353 17.1107 H 0 0 0 0 0 0 - 26.1834 10.1607 18.7918 N 0 0 0 0 0 0 - 26.0985 9.1797 18.5751 H 0 0 0 0 0 0 - 26.5446 10.5128 20.0359 C 0 0 0 0 0 0 - 26.7352 11.6835 20.3848 O 0 0 0 0 0 0 - 26.8164 9.3505 20.9951 C 0 0 0 0 0 0 - 27.5182 8.6798 20.5018 H 0 0 0 0 0 0 - 27.3455 9.7432 21.8637 H 0 0 0 0 0 0 - 25.5749 8.5551 21.4820 C 0 0 0 0 0 0 - 25.9435 7.7800 22.1556 H 0 0 0 0 0 0 - 24.9469 9.2037 22.0951 H 0 0 0 0 0 0 - 24.7091 7.8896 20.3809 C 0 0 0 0 0 0 - 23.9897 8.6126 19.9911 H 0 0 0 0 0 0 - 25.3386 7.6233 19.5340 H 0 0 0 0 0 0 - 23.9849 6.6596 20.8171 N 0 3 0 0 0 0 - 23.0803 6.8742 21.9693 C 0 0 0 0 0 0 - 22.3188 7.6210 21.7370 H 0 0 0 0 0 0 - 23.6342 7.2099 22.8457 H 0 0 0 0 0 0 - 22.5793 5.9438 22.2412 H 0 0 0 0 0 0 - 23.2926 5.9937 19.6899 C 0 0 0 0 0 0 - 22.5046 6.6283 19.2785 H 0 0 0 0 0 0 - 22.8435 5.0521 20.0103 H 0 0 0 0 0 0 - 23.9978 5.7601 18.8916 H 0 0 0 0 0 0 - 28.5475 10.7431 17.3045 C 0 0 0 0 0 0 - 28.8121 11.2654 18.2243 H 0 0 0 0 0 0 - 28.4844 9.6841 17.5511 H 0 0 0 0 0 0 - 29.6553 10.9433 16.2654 C 0 0 0 0 0 0 - 29.8364 12.0116 16.1480 H 0 0 0 0 0 0 - 30.5913 10.5213 16.6296 H 0 0 0 0 0 0 - 29.2524 10.3509 14.8973 C 0 0 1 0 0 0 - 29.9506 10.7570 14.1629 H 0 0 0 0 0 0 - 31.8418 8.6565 14.4329 C 0 0 0 0 0 0 - 31.7356 9.2989 13.5712 H 0 0 0 0 0 0 - 33.1203 8.2073 14.8095 C 0 0 0 0 0 0 - 33.9845 8.5043 14.2361 H 0 0 0 0 0 0 - 24.6748 5.9712 21.1189 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 62 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 60 1 0 0 0 - 8 58 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 21 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 20 1 0 0 0 - 19 21 2 0 0 0 - 21 22 1 0 0 0 - 22 58 1 0 0 0 - 22 23 1 0 0 0 - 22 24 1 0 0 0 - 24 25 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 52 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 32 33 2 0 0 0 - 32 34 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 40 1 0 0 0 - 40 41 1 0 0 0 - 40 42 1 0 0 0 - 40 43 1 0 0 0 - 43 44 1 0 0 0 - 43 48 1 0 0 0 - 43 64 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 48 49 1 0 0 0 - 48 50 1 0 0 0 - 48 51 1 0 0 0 - 52 53 1 0 0 0 - 52 54 1 0 0 0 - 52 55 1 0 0 0 - 55 56 1 0 0 0 - 55 57 1 0 0 0 - 55 58 1 0 0 0 - 58 59 1 0 0 0 - 60 61 1 0 0 0 - 60 62 2 0 0 0 - 62 63 1 0 0 0 -M CHG 1 43 1 -M END -> -ligprep_eg5.smi - -> -18 - -> -53161 - -> -0 - -> -RmMxW2NIXWMoQnIpW2NIXWMoYzEyKVtDQEBIXTNbQ0BIXShbQ0BASF0oW05IXTIpYzRbY0hdW2NIXVtjSF1bY0hdW2NIXTQpW0NIMl1bQ0gyXVtDQEBIXShPMylbQ0gyXVtOSF1DKD1PKVtDSDJdW0NIMl1bQ0gyXU4oW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0076 - -> - 0.0076 - -> - 0.0000 - -> - -0.0000 - -> -0.00755766 - -> -1 - -> -1 - -> -S-OPLS - -> -47.4626 - -> -1 - -> -lig_CHEMBL1085692-1 - -> -glide-grid_EG5-3L9H - -> -19 - -> -8 - -> --7.90619738560365 - -> --0.247068668300114 - -> --0.784394127029799 - -> --1.77041310943779 - -> --7.90619738560365 - -> --4.52171243564274 - -> --0.28307585595687 - -> --0 - -> --0.202519619301997 - -> --45.3497924804688 - -> --7.39303827285767 - -> -0.560426754633708 - -> --0.0828708643836668 - -> --81.0586723985029 - -> --52.7428307533264 - -> -3.73035311698914 - -> -10 - -> -29 - -> --0 - -> -0.0914115773960593 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1082248 - 3D - Schrodinger Suite 2022-3. - 48 51 0 0 1 0 999 V2000 - 34.2645 7.0446 16.2096 H 0 0 0 0 0 0 - 33.2802 7.3883 15.9249 C 0 0 0 0 0 0 - 33.1229 8.2179 14.8009 C 0 0 0 0 0 0 - 33.9848 8.5147 14.2230 H 0 0 0 0 0 0 - 31.8413 8.6673 14.4347 C 0 0 0 0 0 0 - 31.7274 9.3080 13.5729 H 0 0 0 0 0 0 - 30.7087 8.2887 15.1874 C 0 0 0 0 0 0 - 29.3320 8.8074 14.8013 C 0 0 2 0 0 0 - 28.6095 8.3700 15.4927 H 0 0 0 0 0 0 - 28.9611 8.3383 13.4711 N 0 0 0 0 0 0 - 29.1463 7.3658 13.2557 H 0 0 0 0 0 0 - 27.9355 8.9888 12.7684 C 0 0 0 0 0 0 - 27.4900 8.4510 11.5440 C 0 0 0 0 0 0 - 27.9849 7.2890 11.1189 F 0 0 0 0 0 0 - 26.5257 9.0900 10.7559 C 0 0 0 0 0 0 - 26.2109 8.6659 9.8148 H 0 0 0 0 0 0 - 25.9959 10.2975 11.2127 C 0 0 0 0 0 0 - 24.7847 11.2882 10.1792 Br 0 0 0 0 0 0 - 26.3839 10.8344 12.4510 C 0 0 0 0 0 0 - 25.9623 11.7734 12.7793 H 0 0 0 0 0 0 - 27.3597 10.1911 13.2317 C 0 0 0 0 0 0 - 27.8211 10.8295 14.5259 C 0 0 1 0 0 0 - 27.8400 11.9091 14.3642 H 0 0 0 0 0 0 - 26.9076 10.5334 15.5817 O 0 0 0 0 0 0 - 27.1881 11.2319 16.7860 C 0 0 1 0 0 0 - 27.2467 12.2944 16.5419 H 0 0 0 0 0 0 - 25.9761 11.0600 17.7355 C 0 0 0 0 0 0 - 25.7625 12.0080 18.2303 H 0 0 0 0 0 0 - 25.0871 10.8364 17.1442 H 0 0 0 0 0 0 - 26.1333 10.0067 18.7655 N 0 3 0 0 0 0 - 25.2253 9.5851 18.9016 H 0 0 0 0 0 0 - 26.5959 10.4700 20.0899 C 0 0 0 0 0 0 - 26.6594 9.6257 20.7768 H 0 0 0 0 0 0 - 25.8958 11.1937 20.5105 H 0 0 0 0 0 0 - 27.5796 10.9353 20.0395 H 0 0 0 0 0 0 - 28.5605 10.7643 17.3218 C 0 0 0 0 0 0 - 28.8353 11.3254 18.2141 H 0 0 0 0 0 0 - 28.5271 9.7105 17.5982 H 0 0 0 0 0 0 - 29.6507 10.9577 16.2635 C 0 0 0 0 0 0 - 29.8282 12.0269 16.1331 H 0 0 0 0 0 0 - 30.5935 10.5425 16.6164 H 0 0 0 0 0 0 - 29.2373 10.3538 14.9045 C 0 0 1 0 0 0 - 29.9246 10.7635 14.1619 H 0 0 0 0 0 0 - 30.8677 7.4318 16.2959 C 0 0 0 0 0 0 - 30.0085 7.1178 16.8682 H 0 0 0 0 0 0 - 32.1527 6.9883 16.6664 C 0 0 0 0 0 0 - 32.2723 6.3360 17.5204 H 0 0 0 0 0 0 - 26.7485 9.2900 18.4051 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 46 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 44 1 0 0 0 - 8 42 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 21 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 20 1 0 0 0 - 19 21 2 0 0 0 - 21 22 1 0 0 0 - 22 42 1 0 0 0 - 22 23 1 0 0 0 - 22 24 1 0 0 0 - 24 25 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 36 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 48 1 0 0 0 - 32 33 1 0 0 0 - 32 34 1 0 0 0 - 32 35 1 0 0 0 - 36 37 1 0 0 0 - 36 38 1 0 0 0 - 36 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 44 45 1 0 0 0 - 44 46 2 0 0 0 - 46 47 1 0 0 0 -M CHG 1 30 1 -M END -> -ligprep_eg5.smi - -> -6 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQnIpW2NIXWM0RilbQ0gyXVtDSDJdW0NAQEhdKE8zKVtDSDJdW05IXVtDSDNd - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0025 - -> - 0.0025 - -> - 0.0000 - -> - -0.0000 - -> -0.00245839 - -> -1 - -> -1 - -> -S-OPLS - -> -42.3512 - -> -1 - -> -lig_CHEMBL1082248-1 - -> -glide-grid_EG5-3L9H - -> -6 - -> -3 - -> --7.64620594616547 - -> --0.305848237846619 - -> --0.894305671705108 - -> --1.8123799475431 - -> --7.64620594616547 - -> --4.52933187182784 - -> --0.0935460694148881 - -> --0 - -> --0.831644008056144 - -> --39.7532691955566 - -> --3.74200963973999 - -> -0.357280908872234 - -> -0 - -> --65.8197927106689 - -> --43.4952788352966 - -> --7.21261770308956e-08 - -> -2 - -> -2 - -> --0 - -> -0.0937033031326501 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1096002 - 3D - Schrodinger Suite 2022-3. - 52 55 0 0 1 0 999 V2000 - 27.7289 8.9773 22.7156 H 0 0 0 0 0 0 - 27.5847 9.7211 22.1457 O 0 0 0 0 0 0 - 26.9302 9.2880 20.9755 C 0 0 0 0 0 0 - 27.5850 8.5883 20.4571 H 0 0 0 0 0 0 - 26.0175 8.7530 21.2428 H 0 0 0 0 0 0 - 26.6264 10.4826 20.0649 C 0 0 0 0 0 0 - 25.8828 11.1314 20.5308 H 0 0 0 0 0 0 - 27.5284 11.0795 19.9386 H 0 0 0 0 0 0 - 26.1312 10.0210 18.7503 N 0 3 0 0 0 0 - 26.7429 9.3070 18.3788 H 0 0 0 0 0 0 - 25.9674 11.0714 17.7200 C 0 0 0 0 0 0 - 25.0772 10.8410 17.1322 H 0 0 0 0 0 0 - 25.7483 12.0145 18.2164 H 0 0 0 0 0 0 - 27.1764 11.2502 16.7650 C 0 0 2 0 0 0 - 27.2311 12.3145 16.5287 H 0 0 0 0 0 0 - 26.8985 10.5612 15.5506 O 0 0 0 0 0 0 - 27.8134 10.8642 14.4942 C 0 0 2 0 0 0 - 27.8256 11.9446 14.3384 H 0 0 0 0 0 0 - 27.3570 10.2269 13.1955 C 0 0 0 0 0 0 - 26.3671 10.8553 12.4169 C 0 0 0 0 0 0 - 25.9200 11.7798 12.7520 H 0 0 0 0 0 0 - 25.9531 10.2888 11.1958 C 0 0 0 0 0 0 - 24.6991 11.0650 10.3189 Cl 0 0 0 0 0 0 - 26.5027 9.0830 10.7467 C 0 0 0 0 0 0 - 26.1617 8.6252 9.8297 H 0 0 0 0 0 0 - 27.4895 8.4688 11.5242 C 0 0 0 0 0 0 - 27.9850 7.3018 11.1189 F 0 0 0 0 0 0 - 27.9392 9.0241 12.7366 C 0 0 0 0 0 0 - 28.9721 8.3836 13.4377 N 0 0 0 0 0 0 - 29.1846 7.4222 13.1998 H 0 0 0 0 0 0 - 29.3273 8.8467 14.7724 C 0 0 1 0 0 0 - 28.5948 8.4090 15.4532 H 0 0 0 0 0 0 - 30.6970 8.3194 15.1723 C 0 0 0 0 0 0 - 30.8373 7.4471 16.2719 C 0 0 0 0 0 0 - 29.9724 7.1317 16.8333 H 0 0 0 0 0 0 - 32.1148 6.9884 16.6502 C 0 0 0 0 0 0 - 32.2191 6.3264 17.4996 H 0 0 0 0 0 0 - 33.2535 7.3883 15.9266 C 0 0 0 0 0 0 - 34.2317 7.0317 16.2167 H 0 0 0 0 0 0 - 33.1148 8.2312 14.8096 C 0 0 0 0 0 0 - 33.9850 8.5284 14.2445 H 0 0 0 0 0 0 - 31.8416 8.6992 14.4360 C 0 0 0 0 0 0 - 31.7436 9.3516 13.5815 H 0 0 0 0 0 0 - 29.2302 10.3926 14.8770 C 0 0 2 0 0 0 - 29.9194 10.8021 14.1356 H 0 0 0 0 0 0 - 29.6386 10.9941 16.2372 C 0 0 0 0 0 0 - 30.5857 10.5867 16.5890 H 0 0 0 0 0 0 - 29.8065 12.0643 16.1104 H 0 0 0 0 0 0 - 28.5518 10.7883 17.2943 C 0 0 0 0 0 0 - 28.8294 11.3474 18.1874 H 0 0 0 0 0 0 - 28.5249 9.7332 17.5675 H 0 0 0 0 0 0 - 25.2266 9.5964 18.9050 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 3 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 6 9 1 0 0 0 - 9 10 1 0 0 0 - 9 11 1 0 0 0 - 9 52 1 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 11 14 1 0 0 0 - 14 49 1 0 0 0 - 14 15 1 0 0 0 - 14 16 1 0 0 0 - 16 17 1 0 0 0 - 17 44 1 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 28 1 0 0 0 - 19 20 2 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 24 26 1 0 0 0 - 26 27 1 0 0 0 - 26 28 2 0 0 0 - 28 29 1 0 0 0 - 29 30 1 0 0 0 - 29 31 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 31 44 1 0 0 0 - 33 42 1 0 0 0 - 33 34 2 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 36 38 2 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 40 41 1 0 0 0 - 40 42 2 0 0 0 - 42 43 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 -M CHG 1 9 1 -M END -> -ligprep_eg5.smi - -> -27 - -> -53161 - -> -0 - -> -W09IXVtDSDJdW0NIMl1bTkhdW0NIMl1bQ0BIXShPMSlbQ0gyXVtDSDJdW0NASF0yW0NAQEhdKFtOSF1jKGMzW0NAQEhdMTIpYyhGKVtjSF1jKENsKVtjSF0zKWM0W2NIXVtjSF1bY0hdW2NIXVtjSF00 - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.0354 - -> - 0.0353 - -> - 0.0000 - -> - 0.0295 - -> -0.064809 - -> -1 - -> -1 - -> -S-OPLS - -> -44.334 - -> -1 - -> -lig_CHEMBL1096002-1 - -> -glide-grid_EG5-3L9H - -> -28 - -> -6 - -> --7.61390683929108 - -> --0.281996549603373 - -> --0.845989647880705 - -> --1.7723919871224 - -> --7.64340683929108 - -> --4.61347521137857 - -> --0.0359021116715872 - -> --0 - -> --0.936020864218221 - -> --42.5991706848145 - -> --3.75695514678955 - -> -0.635493154236459 - -> -0 - -> --65.9276886742258 - -> --46.356125831604 - -> -0.522859871387482 - -> -10 - -> -2 - -> -0.0295 - -> -0.093194489622196 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1082249 - 3D - Schrodinger Suite 2022-3. - 58 61 0 0 1 0 999 V2000 - 34.2516 7.0480 16.2407 H 0 0 0 0 0 0 - 33.2700 7.3878 15.9441 C 0 0 0 0 0 0 - 33.1208 8.2123 14.8154 C 0 0 0 0 0 0 - 33.9852 8.5108 14.2434 H 0 0 0 0 0 0 - 31.8431 8.6608 14.4362 C 0 0 0 0 0 0 - 31.7395 9.3024 13.5739 H 0 0 0 0 0 0 - 30.7042 8.2819 15.1795 C 0 0 0 0 0 0 - 29.3329 8.8036 14.7827 C 0 0 2 0 0 0 - 28.6015 8.3693 15.4668 H 0 0 0 0 0 0 - 28.9740 8.3392 13.4481 N 0 0 0 0 0 0 - 29.1600 7.3678 13.2234 H 0 0 0 0 0 0 - 27.9519 8.9926 12.7444 C 0 0 0 0 0 0 - 27.4978 8.4503 11.5275 C 0 0 0 0 0 0 - 27.9850 7.2801 11.1189 F 0 0 0 0 0 0 - 26.5126 9.0763 10.7531 C 0 0 0 0 0 0 - 26.1593 8.6230 9.8392 H 0 0 0 0 0 0 - 25.9663 10.2751 11.2173 C 0 0 0 0 0 0 - 24.5301 11.1112 10.3189 Br 0 0 0 0 0 0 - 26.3846 10.8297 12.4393 C 0 0 0 0 0 0 - 25.9347 11.7477 12.7869 H 0 0 0 0 0 0 - 27.3768 10.1948 13.2084 C 0 0 0 0 0 0 - 27.8322 10.8314 14.5056 C 0 0 1 0 0 0 - 27.8542 11.9112 14.3444 H 0 0 0 0 0 0 - 26.9119 10.5394 15.5582 O 0 0 0 0 0 0 - 27.1871 11.2368 16.7664 C 0 0 1 0 0 0 - 27.2533 12.2986 16.5203 H 0 0 0 0 0 0 - 25.9646 11.0756 17.7107 C 0 0 0 0 0 0 - 25.7435 12.0295 18.1935 H 0 0 0 0 0 0 - 25.0828 10.8430 17.1121 H 0 0 0 0 0 0 - 26.1084 10.0349 18.7547 N 0 3 0 0 0 0 - 25.1934 9.6416 18.9279 H 0 0 0 0 0 0 - 26.6327 10.5135 20.0519 C 0 0 0 0 0 0 - 27.5335 11.1056 19.9073 H 0 0 0 0 0 0 - 25.8953 11.1729 20.5131 H 0 0 0 0 0 0 - 26.9337 9.3346 20.9797 C 0 0 0 0 0 0 - 26.0086 8.8027 21.2109 H 0 0 0 0 0 0 - 27.5913 8.6278 20.4745 H 0 0 0 0 0 0 - 27.5915 9.7745 22.2033 N 0 0 0 0 0 0 - 28.1183 10.6349 22.1777 H 0 0 0 0 0 0 - 27.5845 9.0812 23.3501 C 0 0 0 0 0 0 - 26.9602 8.0341 23.4991 O 0 0 0 0 0 0 - 28.4080 9.6461 24.5016 C 0 0 0 0 0 0 - 28.7872 10.6444 24.2772 H 0 0 0 0 0 0 - 29.2581 8.9934 24.7029 H 0 0 0 0 0 0 - 27.8018 9.7048 25.4067 H 0 0 0 0 0 0 - 28.5584 10.7639 17.3032 C 0 0 0 0 0 0 - 28.8426 11.3272 18.1901 H 0 0 0 0 0 0 - 28.5175 9.7113 17.5858 H 0 0 0 0 0 0 - 29.6536 10.9530 16.2469 C 0 0 0 0 0 0 - 29.8320 12.0218 16.1159 H 0 0 0 0 0 0 - 30.5966 10.5408 16.6027 H 0 0 0 0 0 0 - 29.2441 10.3500 14.8882 C 0 0 1 0 0 0 - 29.9353 10.7553 14.1469 H 0 0 0 0 0 0 - 30.8534 7.4269 16.2913 C 0 0 0 0 0 0 - 29.9891 7.1119 16.8557 H 0 0 0 0 0 0 - 32.1359 6.9881 16.6735 C 0 0 0 0 0 0 - 32.2478 6.3369 17.5280 H 0 0 0 0 0 0 - 26.6930 9.2959 18.3885 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 56 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 54 1 0 0 0 - 8 52 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 21 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 20 1 0 0 0 - 19 21 2 0 0 0 - 21 22 1 0 0 0 - 22 52 1 0 0 0 - 22 23 1 0 0 0 - 22 24 1 0 0 0 - 24 25 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 46 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 58 1 0 0 0 - 32 33 1 0 0 0 - 32 34 1 0 0 0 - 32 35 1 0 0 0 - 35 36 1 0 0 0 - 35 37 1 0 0 0 - 35 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 40 41 2 0 0 0 - 40 42 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 45 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 - 49 52 1 0 0 0 - 52 53 1 0 0 0 - 54 55 1 0 0 0 - 54 56 2 0 0 0 - 56 57 1 0 0 0 -M CHG 1 30 1 -M END -> -ligprep_eg5.smi - -> -7 - -> -53161 - -> -0 - -> -RmMxW2NIXWMoQnIpW2NIXWMoYzEyKVtDQEBIXTNbQ0BIXShbQ0BASF0oW05IXTIpYzRbY0hdW2NIXVtjSF1bY0hdW2NIXTQpW0NIMl1bQ0gyXVtDQEBIXShPMylbQ0gyXVtOSF1bQ0gyXVtDSDJdW05IXUMoPU8pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0077 - -> - 0.0077 - -> - 0.0000 - -> - -0.0000 - -> -0.00765215 - -> -1 - -> -1 - -> -S-OPLS - -> -33.3357 - -> -1 - -> -lig_CHEMBL1082249-1 - -> -glide-grid_EG5-3L9H - -> -7 - -> -7 - -> --7.11232702404811 - -> --0.23707756746827 - -> --0.736655123234709 - -> --1.61599819487352 - -> --7.11232702404811 - -> --4.55664998253593 - -> --0.0816780435388489 - -> --0 - -> --0.348176918870169 - -> --46.5956993103027 - -> --2.19561052322388 - -> -0.533304464895562 - -> -0 - -> --67.8709711424982 - -> --48.7913098335266 - -> -0.845360338687897 - -> -30 - -> -28 - -> --0 - -> -0.0850935331009369 - -> -snapped_core_restrain - -$$$$ diff --git a/cookbook/assets/cofactors/eg5_ligands_charged.sdf b/cookbook/assets/cofactors/eg5_ligands_charged.sdf new file mode 100644 index 0000000..9ee206b --- /dev/null +++ b/cookbook/assets/cofactors/eg5_ligands_charged.sdf @@ -0,0 +1,7321 @@ +lig_CHEMBL1083517 + RDKit 3D + + 52 55 0 0 0 0 0 0 0 0999 V2000 + 35.2150 7.0627 16.1224 H 0 0 0 0 0 0 0 0 0 0 0 0 + 34.3851 7.0863 16.6133 O 0 0 0 0 0 0 0 0 0 0 0 0 + 33.2187 7.3991 15.9900 C 0 0 0 0 0 0 0 0 0 0 0 0 + 32.0532 6.9700 16.6427 C 0 0 0 0 0 0 0 0 0 0 0 0 + 32.1269 6.3432 17.5198 H 0 0 0 0 0 0 0 0 0 0 0 0 + 30.7902 7.3882 16.2019 C 0 0 0 0 0 0 0 0 0 0 0 0 + 29.9035 7.0674 16.7268 H 0 0 0 0 0 0 0 0 0 0 0 0 + 30.6956 8.2539 15.1011 C 0 0 0 0 0 0 0 0 0 0 0 0 + 29.3360 8.7758 14.6921 C 0 0 2 0 0 0 0 0 0 0 0 0 + 28.5956 8.3334 15.3606 H 0 0 0 0 0 0 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+-0.12151725862068966 0.13098274137931035 -0.11951725862068965 0.14548274137931033 0.47428274137931037 + +$$$$ diff --git a/cookbook/assets/cofactors/eg5_ligands_positive.sdf b/cookbook/assets/cofactors/eg5_ligands_positive.sdf deleted file mode 100644 index faa7dff..0000000 --- a/cookbook/assets/cofactors/eg5_ligands_positive.sdf +++ /dev/null @@ -1,4864 +0,0 @@ -lig_CHEMBL1084677 - 3D - Schrodinger Suite 2022-3. - 62 65 0 0 1 0 999 V2000 - 34.2542 7.0437 16.2339 H 0 0 0 0 0 0 - 33.2715 7.3883 15.9458 C 0 0 0 0 0 0 - 32.1380 6.9883 16.6772 C 0 0 0 0 0 0 - 32.2499 6.3285 17.5256 H 0 0 0 0 0 0 - 30.8557 7.4292 16.2989 C 0 0 0 0 0 0 - 29.9912 7.1088 16.8615 H 0 0 0 0 0 0 - 30.7062 8.2894 15.1925 C 0 0 0 0 0 0 - 29.3313 8.7880 14.7833 C 0 0 2 0 0 0 - 28.6004 8.3418 15.4588 H 0 0 0 0 0 0 - 29.0044 8.3026 13.4488 N 0 0 0 0 0 0 - 29.1849 7.3206 13.2786 H 0 0 0 0 0 0 - 27.9860 8.9333 12.7222 C 0 0 0 0 0 0 - 27.5855 8.3637 11.4988 C 0 0 0 0 0 0 - 28.0386 7.4499 11.1440 H 0 0 0 0 0 0 - 26.5960 8.9881 10.7181 C 0 0 0 0 0 0 - 26.3100 8.5553 9.7715 H 0 0 0 0 0 0 - 25.9966 10.1902 11.1482 C 0 0 0 0 0 0 - 24.9967 10.9078 10.2617 C 0 0 0 0 0 0 - 24.3239 10.0297 9.5193 F 0 0 0 0 0 0 - 24.1307 11.6216 10.9820 F 0 0 0 0 0 0 - 25.6561 11.7367 9.4531 F 0 0 0 0 0 0 - 26.3831 10.7503 12.3807 C 0 0 0 0 0 0 - 25.9427 11.6792 12.7138 H 0 0 0 0 0 0 - 27.3766 10.1330 13.1649 C 0 0 0 0 0 0 - 27.7988 10.7860 14.4654 C 0 0 1 0 0 0 - 27.8007 11.8677 14.3097 H 0 0 0 0 0 0 - 26.8580 10.4746 15.4889 O 0 0 0 0 0 0 - 27.0928 11.1374 16.7245 C 0 0 1 0 0 0 - 27.1324 12.2104 16.5278 H 0 0 0 0 0 0 - 25.8590 10.8714 17.6225 C 0 0 0 0 0 0 - 25.4112 11.8150 17.9353 H 0 0 0 0 0 0 - 25.0855 10.3441 17.0626 H 0 0 0 0 0 0 - 26.1853 10.1005 18.8244 N 0 0 2 0 0 0 - 27.0764 9.6113 18.7919 H 0 0 0 0 0 0 - 24.9719 9.2915 19.7374 S 0 0 0 0 0 0 - 25.5924 8.9242 21.0181 O 0 0 0 0 0 0 - 23.7609 10.1244 19.7158 O 0 0 0 0 0 0 - 24.6388 7.7414 18.7894 C 0 0 0 0 0 0 - 23.9878 7.9819 17.9480 H 0 0 0 0 0 0 - 25.5857 7.3890 18.3782 H 0 0 0 0 0 0 - 24.0180 6.6801 19.7211 C 0 0 0 0 0 0 - 24.6238 6.5917 20.6237 H 0 0 0 0 0 0 - 23.0282 6.9919 20.0587 H 0 0 0 0 0 0 - 23.9849 5.3305 19.1168 N 0 3 0 0 0 0 - 24.6079 5.2929 18.3232 H 0 0 0 0 0 0 - 22.6414 4.8701 18.7249 C 0 0 0 0 0 0 - 22.6853 3.8588 18.3177 H 0 0 0 0 0 0 - 22.2023 5.5270 17.9747 H 0 0 0 0 0 0 - 21.9849 4.8552 19.5947 H 0 0 0 0 0 0 - 28.4632 10.6801 17.2790 C 0 0 0 0 0 0 - 28.6908 11.2040 18.2079 H 0 0 0 0 0 0 - 28.4445 9.6151 17.5109 H 0 0 0 0 0 0 - 29.5727 10.9364 16.2549 C 0 0 0 0 0 0 - 29.7064 12.0140 16.1439 H 0 0 0 0 0 0 - 30.5223 10.5541 16.6259 H 0 0 0 0 0 0 - 29.2119 10.3320 14.8821 C 0 0 1 0 0 0 - 29.9134 10.7527 14.1598 H 0 0 0 0 0 0 - 31.8434 8.6760 14.4516 C 0 0 0 0 0 0 - 31.7359 9.3184 13.5900 H 0 0 0 0 0 0 - 33.1218 8.2241 14.8254 C 0 0 0 0 0 0 - 33.9850 8.5255 14.2529 H 0 0 0 0 0 0 - 24.3474 4.6960 19.8319 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 60 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 58 1 0 0 0 - 8 56 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 56 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 50 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 35 36 2 0 0 0 - 35 37 2 0 0 0 - 35 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 62 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 53 1 0 0 0 - 53 54 1 0 0 0 - 53 55 1 0 0 0 - 53 56 1 0 0 0 - 56 57 1 0 0 0 - 58 59 1 0 0 0 - 58 60 2 0 0 0 - 60 61 1 0 0 0 -M CHG 1 44 1 -M END -> -ligprep_eg5.smi - -> -14 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdUyg9TykoPU8pW0NIMl1bQ0gyXVtOSF1bQ0gzXQ== - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0112 - -> - 0.0108 - -> - 0.0003 - -> - -0.0000 - -> -0.0108481 - -> -1 - -> -1 - -> -S-OPLS - -> -31.394 - -> -1 - -> -lig_CHEMBL1084677-1 - -> -glide-grid_EG5-3L9H - -> -14 - -> -8 - -> --9.52685998914813 - -> --0.288692726943883 - -> --0.925991831413369 - -> --2.11872433414547 - -> --9.52685998914813 - -> --4.55621898545261 - -> --0.332915304848589 - -> --0 - -> --1.18169917993037 - -> --51.0294227600098 - -> --10.0400190353394 - -> -0.605472246693747 - -> --0.00402477230891625 - -> --102.064413920816 - -> --61.0694417953491 - -> -6.86161708831787 - -> -32 - -> -272 - -> --0 - -> -0.0708102401621492 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1083517 - 3D - Schrodinger Suite 2022-3. - 52 55 0 0 1 0 999 V2000 - 35.2150 7.0627 16.1224 H 0 0 0 0 0 0 - 34.3851 7.0863 16.6133 O 0 0 0 0 0 0 - 33.2187 7.3991 15.9900 C 0 0 0 0 0 0 - 32.0532 6.9700 16.6427 C 0 0 0 0 0 0 - 32.1269 6.3432 17.5198 H 0 0 0 0 0 0 - 30.7902 7.3882 16.2019 C 0 0 0 0 0 0 - 29.9035 7.0674 16.7268 H 0 0 0 0 0 0 - 30.6956 8.2539 15.1011 C 0 0 0 0 0 0 - 29.3360 8.7758 14.6921 C 0 0 2 0 0 0 - 28.5956 8.3334 15.3606 H 0 0 0 0 0 0 - 29.0087 8.3044 13.3589 N 0 0 0 0 0 0 - 29.1850 7.3248 13.1712 H 0 0 0 0 0 0 - 27.9670 8.9305 12.6690 C 0 0 0 0 0 0 - 27.5512 8.3641 11.4514 C 0 0 0 0 0 0 - 28.0014 7.4495 11.0971 H 0 0 0 0 0 0 - 26.5551 8.9915 10.6838 C 0 0 0 0 0 0 - 26.2576 8.5653 9.7373 H 0 0 0 0 0 0 - 25.9698 10.1944 11.1294 C 0 0 0 0 0 0 - 24.9691 10.9274 10.2592 C 0 0 0 0 0 0 - 24.2743 10.0646 9.5189 F 0 0 0 0 0 0 - 24.1286 11.6470 11.0028 F 0 0 0 0 0 0 - 25.6292 11.7532 9.4489 F 0 0 0 0 0 0 - 26.3599 10.7421 12.3670 C 0 0 0 0 0 0 - 25.9220 11.6682 12.7092 H 0 0 0 0 0 0 - 27.3562 10.1191 13.1405 C 0 0 0 0 0 0 - 27.8061 10.7739 14.4356 C 0 0 1 0 0 0 - 27.8143 11.8524 14.2661 H 0 0 0 0 0 0 - 26.8951 10.4887 15.5032 O 0 0 0 0 0 0 - 27.1855 11.1940 16.7075 C 0 0 1 0 0 0 - 27.2620 12.2523 16.4497 H 0 0 0 0 0 0 - 25.9840 11.0721 17.6855 C 0 0 0 0 0 0 - 25.7994 12.0375 18.1592 H 0 0 0 0 0 0 - 25.0809 10.8564 17.1119 H 0 0 0 0 0 0 - 26.1267 10.0401 18.7390 N 0 3 0 0 0 0 - 25.2144 9.6269 18.8832 H 0 0 0 0 0 0 - 26.5903 10.5324 20.0533 C 0 0 0 0 0 0 - 26.6588 9.7015 20.7563 H 0 0 0 0 0 0 - 25.8875 11.2595 20.4616 H 0 0 0 0 0 0 - 27.5710 11.0015 19.9899 H 0 0 0 0 0 0 - 28.5544 10.7150 17.2353 C 0 0 0 0 0 0 - 28.8333 11.2672 18.1319 H 0 0 0 0 0 0 - 28.5125 9.6597 17.5055 H 0 0 0 0 0 0 - 29.6411 10.9156 16.1734 C 0 0 0 0 0 0 - 29.8138 11.9852 16.0476 H 0 0 0 0 0 0 - 30.5861 10.5046 16.5250 H 0 0 0 0 0 0 - 29.2294 10.3181 14.8100 C 0 0 1 0 0 0 - 29.9142 10.7354 14.0691 H 0 0 0 0 0 0 - 31.8630 8.6324 14.3985 C 0 0 0 0 0 0 - 31.7885 9.2808 13.5377 H 0 0 0 0 0 0 - 33.1307 8.2013 14.8381 C 0 0 0 0 0 0 - 34.0146 8.5386 14.3232 H 0 0 0 0 0 0 - 26.7380 9.3111 18.3991 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 50 1 0 0 0 - 3 4 2 0 0 0 - 4 5 1 0 0 0 - 4 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 2 0 0 0 - 8 9 1 0 0 0 - 8 48 1 0 0 0 - 9 46 1 0 0 0 - 9 10 1 0 0 0 - 9 11 1 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 13 25 1 0 0 0 - 13 14 2 0 0 0 - 14 15 1 0 0 0 - 14 16 1 0 0 0 - 16 17 1 0 0 0 - 16 18 2 0 0 0 - 18 19 1 0 0 0 - 18 23 1 0 0 0 - 19 20 1 0 0 0 - 19 21 1 0 0 0 - 19 22 1 0 0 0 - 23 24 1 0 0 0 - 23 25 2 0 0 0 - 25 26 1 0 0 0 - 26 46 1 0 0 0 - 26 27 1 0 0 0 - 26 28 1 0 0 0 - 28 29 1 0 0 0 - 29 30 1 0 0 0 - 29 31 1 0 0 0 - 29 40 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 31 34 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 52 1 0 0 0 - 36 37 1 0 0 0 - 36 38 1 0 0 0 - 36 39 1 0 0 0 - 40 41 1 0 0 0 - 40 42 1 0 0 0 - 40 43 1 0 0 0 - 43 44 1 0 0 0 - 43 45 1 0 0 0 - 43 46 1 0 0 0 - 46 47 1 0 0 0 - 48 49 1 0 0 0 - 48 50 2 0 0 0 - 50 51 1 0 0 0 -M CHG 1 34 1 -M END -> -ligprep_eg5.smi - -> -8 - -> -53161 - -> -0 - -> -W09IXWMxW2NIXVtjSF1jKFtjSF1bY0hdMSlbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0030 - -> - 0.0023 - -> - 0.0006 - -> - -0.0000 - -> -0.00234401 - -> -1 - -> -1 - -> -S-OPLS - -> -37.6632 - -> -1 - -> -lig_CHEMBL1083517-1 - -> -glide-grid_EG5-3L9H - -> -8 - -> -5 - -> --9.27353612538142 - -> --0.331197718763622 - -> --1.00571133919091 - -> --2.1406044205901 - -> --9.27353612538142 - -> --4.56840923087722 - -> --0.348796882604425 - -> --0 - -> --1.78888792667203 - -> --37.3650360107422 - -> --8.86820888519287 - -> -0.631041048088293 - -> -0 - -> --49.8936169088365 - -> --46.2332448959351 - -> -0.289697885513306 - -> -2 - -> -1 - -> --0 - -> -0.0821186776411881 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084143 - 3D - Schrodinger Suite 2022-3. - 74 77 0 0 1 0 999 V2000 - 34.2890 7.0549 16.2089 H 0 0 0 0 0 0 - 33.2984 7.3883 15.9243 C 0 0 0 0 0 0 - 32.1748 6.9864 16.6702 C 0 0 0 0 0 0 - 32.3011 6.3366 17.5241 H 0 0 0 0 0 0 - 30.8852 7.4111 16.2998 C 0 0 0 0 0 0 - 30.0283 7.0927 16.8776 H 0 0 0 0 0 0 - 30.7181 8.2597 15.1890 C 0 0 0 0 0 0 - 29.3371 8.7553 14.7970 C 0 0 2 0 0 0 - 28.6147 8.3142 15.4846 H 0 0 0 0 0 0 - 28.9954 8.2646 13.4668 N 0 0 0 0 0 0 - 29.1817 7.2859 13.2856 H 0 0 0 0 0 0 - 27.9850 8.9027 12.7335 C 0 0 0 0 0 0 - 27.5838 8.3471 11.5048 C 0 0 0 0 0 0 - 28.0245 7.4273 11.1494 H 0 0 0 0 0 0 - 26.6054 8.9883 10.7188 C 0 0 0 0 0 0 - 26.3155 8.5593 9.7706 H 0 0 0 0 0 0 - 26.0246 10.2002 11.1471 C 0 0 0 0 0 0 - 25.0447 10.9358 10.2428 C 0 0 0 0 0 0 - 24.5209 10.1894 9.6425 H 0 0 0 0 0 0 - 25.8202 11.8722 9.3174 C 0 0 0 0 0 0 - 26.5217 11.3047 8.7190 H 0 0 0 0 0 0 - 26.3842 12.5889 9.9073 H 0 0 0 0 0 0 - 25.1858 12.4509 8.6482 H 0 0 0 0 0 0 - 23.9982 11.7308 11.0279 C 0 0 0 0 0 0 - 23.5851 11.1146 11.8148 H 0 0 0 0 0 0 - 23.1856 12.0850 10.3954 H 0 0 0 0 0 0 - 24.4472 12.5883 11.5172 H 0 0 0 0 0 0 - 26.4188 10.7448 12.3854 C 0 0 0 0 0 0 - 26.0129 11.6846 12.7263 H 0 0 0 0 0 0 - 27.3915 10.1074 13.1771 C 0 0 0 0 0 0 - 27.8193 10.7625 14.4739 C 0 0 1 0 0 0 - 27.8404 11.8400 14.3009 H 0 0 0 0 0 0 - 26.8751 10.4887 15.5085 O 0 0 0 0 0 0 - 27.1349 11.2013 16.7104 C 0 0 1 0 0 0 - 27.2230 12.2583 16.4512 H 0 0 0 0 0 0 - 25.9065 11.0792 17.6423 C 0 0 0 0 0 0 - 25.6969 12.0572 18.0783 H 0 0 0 0 0 0 - 25.0158 10.7989 17.0789 H 0 0 0 0 0 0 - 26.1209 10.1352 18.7397 N 0 0 2 0 0 0 - 26.5354 9.2575 18.4329 H 0 0 0 0 0 0 - 24.8976 9.9019 19.9272 S 0 0 0 0 0 0 - 25.5502 9.2695 21.0852 O 0 0 0 0 0 0 - 24.1680 11.1677 20.0755 O 0 0 0 0 0 0 - 23.7931 8.6664 19.1292 C 0 0 0 0 0 0 - 22.8511 8.6615 19.6775 H 0 0 0 0 0 0 - 23.5836 8.9936 18.1103 H 0 0 0 0 0 0 - 24.4548 7.2835 19.1769 C 0 0 0 0 0 0 - 25.4377 7.3882 18.7187 H 0 0 0 0 0 0 - 24.6483 7.0012 20.2152 H 0 0 0 0 0 0 - 23.7014 6.1590 18.4469 C 0 0 0 0 0 0 - 22.8764 6.5536 17.8506 H 0 0 0 0 0 0 - 24.3926 5.7064 17.7347 H 0 0 0 0 0 0 - 23.2128 5.1113 19.3791 N 0 3 0 0 0 0 - 21.9566 5.5037 20.0506 C 0 0 0 0 0 0 - 21.1631 5.6873 19.3242 H 0 0 0 0 0 0 - 22.0949 6.4065 20.6434 H 0 0 0 0 0 0 - 21.6157 4.7174 20.7189 H 0 0 0 0 0 0 - 23.1062 3.7878 18.7314 C 0 0 0 0 0 0 - 22.3851 3.7976 17.9183 H 0 0 0 0 0 0 - 22.7907 3.0286 19.4476 H 0 0 0 0 0 0 - 24.0648 3.4746 18.3206 H 0 0 0 0 0 0 - 28.4845 10.7217 17.2882 C 0 0 0 0 0 0 - 28.7225 11.2681 18.2016 H 0 0 0 0 0 0 - 28.4314 9.6659 17.5566 H 0 0 0 0 0 0 - 29.6040 10.9126 16.2590 C 0 0 0 0 0 0 - 29.7788 11.9821 16.1283 H 0 0 0 0 0 0 - 30.5385 10.5037 16.6411 H 0 0 0 0 0 0 - 29.2265 10.2992 14.8915 C 0 0 1 0 0 0 - 29.9262 10.7113 14.1625 H 0 0 0 0 0 0 - 31.8450 8.6445 14.4306 C 0 0 0 0 0 0 - 31.7244 9.2812 13.5660 H 0 0 0 0 0 0 - 33.1304 8.2083 14.7950 C 0 0 0 0 0 0 - 33.9836 8.5120 14.2094 H 0 0 0 0 0 0 - 23.9189 4.9883 20.1044 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 72 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 70 1 0 0 0 - 8 68 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 30 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 28 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 24 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 20 23 1 0 0 0 - 24 25 1 0 0 0 - 24 26 1 0 0 0 - 24 27 1 0 0 0 - 28 29 1 0 0 0 - 28 30 2 0 0 0 - 30 31 1 0 0 0 - 31 68 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 33 34 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 62 1 0 0 0 - 36 37 1 0 0 0 - 36 38 1 0 0 0 - 36 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 41 42 2 0 0 0 - 41 43 2 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 1 0 0 0 - 47 50 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 53 1 0 0 0 - 53 54 1 0 0 0 - 53 58 1 0 0 0 - 53 74 1 0 0 0 - 54 55 1 0 0 0 - 54 56 1 0 0 0 - 54 57 1 0 0 0 - 58 59 1 0 0 0 - 58 60 1 0 0 0 - 58 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 1 0 0 0 - 62 65 1 0 0 0 - 65 66 1 0 0 0 - 65 67 1 0 0 0 - 65 68 1 0 0 0 - 68 69 1 0 0 0 - 70 71 1 0 0 0 - 70 72 2 0 0 0 - 72 73 1 0 0 0 -M CHG 1 53 1 -M END -> -ligprep_eg5.smi - -> -11 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoW2NIXVtjSF00KVtDSF0oW0NIM10pW0NIM10pW0NIMl1bQ0gyXVtDQEBIXShPMylbQ0gyXVtOSF1TKD1PKSg9TylbQ0gyXVtDSDJdW0NIMl1OKFtDSDNdKVtDSDNd - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0133 - -> - 0.0127 - -> - 0.0006 - -> - -0.0000 - -> -0.0127395 - -> -1 - -> -1 - -> -S-OPLS - -> -44.0586 - -> -1 - -> -lig_CHEMBL1084143-1 - -> -glide-grid_EG5-3L9H - -> -11 - -> -9 - -> --9.17707146718083 - -> --0.269913866681789 - -> --0.874416146802926 - -> --2.02747249523591 - -> --9.17707146718083 - -> --5.19710641060366 - -> --0.35763212329897 - -> --0 - -> --0.276346688977199 - -> --52.4617805480957 - -> --9.07236576080322 - -> -0.686425891697789 - -> --0.0484682444735191 - -> --86.3049340602711 - -> --61.5341463088989 - -> -10.7834968566895 - -> -289 - -> -91 - -> --0 - -> -0.0671303869202424 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084678 - 3D - Schrodinger Suite 2022-3. - 65 68 0 0 1 0 999 V2000 - 34.2901 7.0565 16.2136 H 0 0 0 0 0 0 - 33.2995 7.3873 15.9295 C 0 0 0 0 0 0 - 32.1778 6.9787 16.6753 C 0 0 0 0 0 0 - 32.3050 6.3301 17.5322 H 0 0 0 0 0 0 - 30.8866 7.4067 16.3086 C 0 0 0 0 0 0 - 30.0301 7.0823 16.8801 H 0 0 0 0 0 0 - 30.7145 8.2568 15.1962 C 0 0 0 0 0 0 - 29.3293 8.7443 14.8041 C 0 0 2 0 0 0 - 28.6081 8.2941 15.4920 H 0 0 0 0 0 0 - 28.9931 8.2645 13.4713 N 0 0 0 0 0 0 - 29.1869 7.2880 13.2845 H 0 0 0 0 0 0 - 27.9692 8.8970 12.7508 C 0 0 0 0 0 0 - 27.5882 8.3519 11.5097 C 0 0 0 0 0 0 - 28.0549 7.4502 11.1422 H 0 0 0 0 0 0 - 26.6126 8.9887 10.7240 C 0 0 0 0 0 0 - 26.3484 8.5772 9.7601 H 0 0 0 0 0 0 - 25.9978 10.1764 11.1739 C 0 0 0 0 0 0 - 25.0086 10.9022 10.2778 C 0 0 0 0 0 0 - 24.3521 10.0288 9.5189 F 0 0 0 0 0 0 - 24.1311 11.6175 10.9771 F 0 0 0 0 0 0 - 25.6753 11.7419 9.4872 F 0 0 0 0 0 0 - 26.3591 10.7125 12.4272 C 0 0 0 0 0 0 - 25.9084 11.6313 12.7667 H 0 0 0 0 0 0 - 27.3466 10.0831 13.2149 C 0 0 0 0 0 0 - 27.7805 10.7322 14.5166 C 0 0 1 0 0 0 - 27.7884 11.8109 14.3449 H 0 0 0 0 0 0 - 26.8584 10.4471 15.5733 O 0 0 0 0 0 0 - 27.1415 11.1474 16.7856 C 0 0 1 0 0 0 - 27.2231 12.2033 16.5214 H 0 0 0 0 0 0 - 25.9199 11.0574 17.7473 C 0 0 0 0 0 0 - 25.7172 12.0397 18.1713 H 0 0 0 0 0 0 - 25.0336 10.8167 17.1554 H 0 0 0 0 0 0 - 26.0557 10.0953 18.8632 N 0 0 1 0 0 0 - 26.6812 10.6336 20.0756 C 0 0 0 0 0 0 - 27.4336 11.3930 19.8512 H 0 0 0 0 0 0 - 27.1585 9.8367 20.6515 H 0 0 0 0 0 0 - 25.9231 11.1026 20.7053 H 0 0 0 0 0 0 - 24.7771 8.9769 19.1435 S 0 0 0 0 0 0 - 24.9663 8.4020 20.4811 O 0 0 0 0 0 0 - 23.4957 9.6156 18.7933 O 0 0 0 0 0 0 - 25.1849 7.7114 17.9133 C 0 0 0 0 0 0 - 25.2672 8.2114 16.9528 H 0 0 0 0 0 0 - 26.1848 7.3883 18.1628 H 0 0 0 0 0 0 - 24.1255 6.5997 17.8066 C 0 0 0 0 0 0 - 23.1743 7.0772 17.5655 H 0 0 0 0 0 0 - 24.3850 5.9897 16.9491 H 0 0 0 0 0 0 - 23.9442 5.6681 19.0135 C 0 0 0 0 0 0 - 24.7849 4.9897 19.1183 H 0 0 0 0 0 0 - 23.8338 6.2194 19.9454 H 0 0 0 0 0 0 - 22.7559 4.8180 18.8438 N 0 3 0 0 0 0 - 22.6304 4.2164 19.6444 H 0 0 0 0 0 0 - 22.8369 4.2362 18.0220 H 0 0 0 0 0 0 - 28.5122 10.6850 17.3186 C 0 0 0 0 0 0 - 28.7961 11.2429 18.2115 H 0 0 0 0 0 0 - 28.4729 9.6284 17.5935 H 0 0 0 0 0 0 - 29.6049 10.8986 16.2626 C 0 0 0 0 0 0 - 29.7590 11.9716 16.1323 H 0 0 0 0 0 0 - 30.5547 10.5046 16.6223 H 0 0 0 0 0 0 - 29.2027 10.2853 14.9065 C 0 0 1 0 0 0 - 29.8840 10.7043 14.1647 H 0 0 0 0 0 0 - 31.8398 8.6541 14.4419 C 0 0 0 0 0 0 - 31.7177 9.2919 13.5834 H 0 0 0 0 0 0 - 33.1291 8.2148 14.8055 C 0 0 0 0 0 0 - 33.9844 8.5276 14.2288 H 0 0 0 0 0 0 - 21.9230 5.3877 18.7539 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 63 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 61 1 0 0 0 - 8 59 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 59 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 53 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 38 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 38 39 2 0 0 0 - 38 40 2 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 1 0 0 0 - 47 50 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 65 1 0 0 0 - 53 54 1 0 0 0 - 53 55 1 0 0 0 - 53 56 1 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 56 59 1 0 0 0 - 59 60 1 0 0 0 - 61 62 1 0 0 0 - 61 63 2 0 0 0 - 63 64 1 0 0 0 -M CHG 1 50 1 -M END -> -ligprep_eg5.smi - -> -15 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1OKFtDSDNdKVMoPU8pKD1PKVtDSDJdW0NIMl1bQ0gyXVtOSDJd - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0036 - -> - 0.0036 - -> - 0.0000 - -> - -0.0000 - -> -0.00359995 - -> -1 - -> -1 - -> -S-OPLS - -> -43.8047 - -> -1 - -> -lig_CHEMBL1084678-1 - -> -glide-grid_EG5-3L9H - -> -15 - -> -8 - -> --9.0727226745557 - -> --0.266844784545756 - -> --0.86447351210763 - -> --2.00441892006052 - -> --9.0727226745557 - -> --4.58223689535746 - -> --0.153504303299394 - -> --0 - -> --1.08986131754344 - -> --50.2855339050293 - -> --8.04208660125732 - -> -0.574649666667813 - -> --0.101180139583156 - -> --92.3566109530651 - -> --58.3276205062866 - -> -3.94855976104736 - -> -6 - -> -13 - -> --0 - -> -0.0908595054518094 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1085666 - 3D - Schrodinger Suite 2022-3. - 48 51 0 0 1 0 999 V2000 - 34.2668 7.0542 16.1930 H 0 0 0 0 0 0 - 33.2803 7.3943 15.9136 C 0 0 0 0 0 0 - 33.1227 8.2510 14.8101 C 0 0 0 0 0 0 - 33.9835 8.5689 14.2395 H 0 0 0 0 0 0 - 31.8418 8.7068 14.4520 C 0 0 0 0 0 0 - 31.7239 9.3692 13.6070 H 0 0 0 0 0 0 - 30.7089 8.2984 15.1899 C 0 0 0 0 0 0 - 29.3316 8.7895 14.7866 C 0 0 2 0 0 0 - 28.6107 8.3370 15.4686 H 0 0 0 0 0 0 - 28.9952 8.2892 13.4601 N 0 0 0 0 0 0 - 29.1849 7.3087 13.2851 H 0 0 0 0 0 0 - 27.9776 8.9194 12.7341 C 0 0 0 0 0 0 - 27.5881 8.3588 11.5021 C 0 0 0 0 0 0 - 28.0448 7.4496 11.1421 H 0 0 0 0 0 0 - 26.6022 8.9852 10.7185 C 0 0 0 0 0 0 - 26.3134 8.5517 9.7724 H 0 0 0 0 0 0 - 26.0011 10.1852 11.1526 C 0 0 0 0 0 0 - 25.0064 10.9040 10.2610 C 0 0 0 0 0 0 - 25.6737 11.7278 9.4519 F 0 0 0 0 0 0 - 24.3315 10.0254 9.5219 F 0 0 0 0 0 0 - 24.1376 11.6186 10.9777 F 0 0 0 0 0 0 - 26.3847 10.7467 12.3852 C 0 0 0 0 0 0 - 25.9653 11.6925 12.7029 H 0 0 0 0 0 0 - 27.3617 10.1151 13.1803 C 0 0 0 0 0 0 - 27.7884 10.7720 14.4791 C 0 0 1 0 0 0 - 27.7679 11.8516 14.3205 H 0 0 0 0 0 0 - 26.8849 10.4590 15.5356 O 0 0 0 0 0 0 - 27.1479 11.1845 16.7292 C 0 0 1 0 0 0 - 27.1974 12.2448 16.4716 H 0 0 0 0 0 0 - 25.9352 11.0032 17.6677 C 0 0 0 0 0 0 - 25.6632 11.9618 18.1106 H 0 0 0 0 0 0 - 25.0659 10.6731 17.0969 H 0 0 0 0 0 0 - 26.1737 10.0403 18.7580 N 0 3 0 0 0 0 - 25.3407 9.9447 19.3225 H 0 0 0 0 0 0 - 26.9299 10.3843 19.3336 H 0 0 0 0 0 0 - 28.5159 10.7338 17.2874 C 0 0 0 0 0 0 - 28.7617 11.2835 18.1970 H 0 0 0 0 0 0 - 28.4962 9.6733 17.5432 H 0 0 0 0 0 0 - 29.6009 10.9645 16.2332 C 0 0 0 0 0 0 - 29.7356 12.0395 16.0968 H 0 0 0 0 0 0 - 30.5580 10.5910 16.5922 H 0 0 0 0 0 0 - 29.2081 10.3356 14.8760 C 0 0 1 0 0 0 - 29.8874 10.7513 14.1325 H 0 0 0 0 0 0 - 30.8666 7.4176 16.2768 C 0 0 0 0 0 0 - 30.0054 7.0747 16.8306 H 0 0 0 0 0 0 - 32.1535 6.9827 16.6498 C 0 0 0 0 0 0 - 32.2740 6.3133 17.4887 H 0 0 0 0 0 0 - 26.4146 9.1424 18.3603 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 46 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 44 1 0 0 0 - 8 42 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 42 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 36 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 33 48 1 0 0 0 - 36 37 1 0 0 0 - 36 38 1 0 0 0 - 36 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 44 45 1 0 0 0 - 44 46 2 0 0 0 - 46 47 1 0 0 0 -M CHG 1 33 1 -M END -> -ligprep_eg5.smi - -> -17 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BIXShbQ0gyXVtDSDJdW0NAQEhdKE8zKVtDSDJdW05IMl0pW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00 - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0054 - -> - 0.0054 - -> - 0.0000 - -> - -0.0000 - -> -0.00538612 - -> -1 - -> -1 - -> -S-OPLS - -> -34.8838 - -> -1 - -> -lig_CHEMBL1085666-1 - -> -glide-grid_EG5-3L9H - -> -18 - -> -3 - -> --8.9463535501123 - -> --0.344090521158165 - -> --1.01936681500024 - -> --2.10102177586354 - -> --8.9463535501123 - -> --4.56759202898606 - -> --0.141725690997466 - -> --0 - -> --2.00420097938027 - -> --43.7035179138184 - -> --3.22751998901367 - -> -0.436469043294473 - -> -0 - -> --77.9548824440419 - -> --46.931037902832 - -> -1.46975395409754e-07 - -> -8 - -> -8 - -> --0 - -> -0.0634782723184329 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084676 - 3D - Schrodinger Suite 2022-3. - 65 68 0 0 1 0 999 V2000 - 34.2631 7.0468 16.1866 H 0 0 0 0 0 0 - 33.2769 7.3898 15.9062 C 0 0 0 0 0 0 - 33.1229 8.2513 14.8062 C 0 0 0 0 0 0 - 33.9834 8.5700 14.2392 H 0 0 0 0 0 0 - 31.8400 8.7037 14.4458 C 0 0 0 0 0 0 - 31.7264 9.3684 13.6005 H 0 0 0 0 0 0 - 30.7070 8.2891 15.1766 C 0 0 0 0 0 0 - 29.3274 8.7863 14.7784 C 0 0 2 0 0 0 - 28.6085 8.3442 15.4682 H 0 0 0 0 0 0 - 28.9879 8.2879 13.4531 N 0 0 0 0 0 0 - 29.1493 7.2983 13.2981 H 0 0 0 0 0 0 - 27.9725 8.9218 12.7263 C 0 0 0 0 0 0 - 27.5793 8.3576 11.4990 C 0 0 0 0 0 0 - 28.0295 7.4416 11.1448 H 0 0 0 0 0 0 - 26.5952 8.9882 10.7152 C 0 0 0 0 0 0 - 26.3089 8.5526 9.7695 H 0 0 0 0 0 0 - 26.0005 10.1908 11.1452 C 0 0 0 0 0 0 - 25.0125 10.9119 10.2493 C 0 0 0 0 0 0 - 24.3257 10.0322 9.5207 F 0 0 0 0 0 0 - 24.1544 11.6446 10.9583 F 0 0 0 0 0 0 - 25.6851 11.7178 9.4277 F 0 0 0 0 0 0 - 26.3848 10.7516 12.3784 C 0 0 0 0 0 0 - 25.9581 11.6921 12.6999 H 0 0 0 0 0 0 - 27.3635 10.1240 13.1716 C 0 0 0 0 0 0 - 27.7978 10.7847 14.4677 C 0 0 1 0 0 0 - 27.7937 11.8640 14.3036 H 0 0 0 0 0 0 - 26.8824 10.4899 15.5192 O 0 0 0 0 0 0 - 27.1446 11.2050 16.7224 C 0 0 1 0 0 0 - 27.1861 12.2704 16.4801 H 0 0 0 0 0 0 - 25.9306 11.0011 17.6657 C 0 0 0 0 0 0 - 25.5991 11.9688 18.0499 H 0 0 0 0 0 0 - 25.0798 10.6110 17.1035 H 0 0 0 0 0 0 - 26.1960 10.1049 18.7857 N 0 0 0 0 0 0 - 26.0900 9.1081 18.6595 H 0 0 0 0 0 0 - 26.6883 10.5366 20.0037 C 0 0 0 0 0 0 - 26.8994 11.7050 20.3304 O 0 0 0 0 0 0 - 26.9366 9.4669 20.7708 O 0 0 0 0 0 0 - 27.5122 9.6246 22.0607 C 0 0 0 0 0 0 - 28.3646 8.9491 22.1102 H 0 0 0 0 0 0 - 27.9243 10.6247 22.2080 H 0 0 0 0 0 0 - 26.4869 9.2961 23.1654 C 0 0 0 0 0 0 - 26.1972 10.2174 23.6689 H 0 0 0 0 0 0 - 25.5739 8.8927 22.7287 H 0 0 0 0 0 0 - 26.9884 8.3264 24.1732 N 0 3 0 0 0 0 - 27.1753 6.9620 23.6256 C 0 0 0 0 0 0 - 27.9548 6.9161 22.8633 H 0 0 0 0 0 0 - 26.2444 6.6075 23.1752 H 0 0 0 0 0 0 - 27.4452 6.2586 24.4164 H 0 0 0 0 0 0 - 28.1437 8.8168 24.9609 C 0 0 0 0 0 0 - 29.0294 8.9765 24.3447 H 0 0 0 0 0 0 - 28.4049 8.1064 25.7498 H 0 0 0 0 0 0 - 27.8984 9.7666 25.4409 H 0 0 0 0 0 0 - 28.5208 10.7548 17.2672 C 0 0 0 0 0 0 - 28.7763 11.3221 18.1627 H 0 0 0 0 0 0 - 28.4909 9.7019 17.5513 H 0 0 0 0 0 0 - 29.6112 10.9584 16.2163 C 0 0 0 0 0 0 - 29.7693 12.0289 16.0784 H 0 0 0 0 0 0 - 30.5556 10.5626 16.5834 H 0 0 0 0 0 0 - 29.2138 10.3328 14.8633 C 0 0 1 0 0 0 - 29.8969 10.7428 14.1205 H 0 0 0 0 0 0 - 30.8626 7.4018 16.2613 C 0 0 0 0 0 0 - 29.9988 7.0547 16.8072 H 0 0 0 0 0 0 - 32.1482 6.9691 16.6335 C 0 0 0 0 0 0 - 32.2665 6.2867 17.4652 H 0 0 0 0 0 0 - 26.2397 8.2281 24.8448 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 63 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 61 1 0 0 0 - 8 59 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 59 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 53 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 35 36 2 0 0 0 - 35 37 1 0 0 0 - 37 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 44 1 0 0 0 - 44 45 1 0 0 0 - 44 49 1 0 0 0 - 44 65 1 0 0 0 - 45 46 1 0 0 0 - 45 47 1 0 0 0 - 45 48 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 - 49 52 1 0 0 0 - 53 54 1 0 0 0 - 53 55 1 0 0 0 - 53 56 1 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 56 59 1 0 0 0 - 59 60 1 0 0 0 - 61 62 1 0 0 0 - 61 63 2 0 0 0 - 63 64 1 0 0 0 -M CHG 1 44 1 -M END -> -ligprep_eg5.smi - -> -13 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdQyg9TylPW0NIMl1bQ0gyXU4oW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.0488 - -> - 0.0488 - -> - 0.0000 - -> - 0.0416 - -> -0.0904291 - -> -1 - -> -1 - -> -This compound has an ester and may undergo hydrolysis at high or low pH. - -> -S-OPLS - -> -47.6644 - -> -1 - -> -lig_CHEMBL1084676-1 - -> -glide-grid_EG5-3L9H - -> -13 - -> -9 - -> --8.55748566492015 - -> --0.251690754850593 - -> --0.815380338727976 - -> --1.89058861272343 - -> --8.59908566492015 - -> --4.58537464846225 - -> --0.161843084530482 - -> --0 - -> --1.23519247582576 - -> --51.6746711730957 - -> --4.80143117904663 - -> -0.707987752393848 - -> --0.0207149729837261 - -> --98.75268454923 - -> --56.4761023521423 - -> -4.67261600494385 - -> -22 - -> -62 - -> -0.0416 - -> -0.0479812607239537 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084935 - 3D - Schrodinger Suite 2022-3. - 70 73 0 0 1 0 999 V2000 - 25.0798 6.4768 17.5106 H 0 0 0 0 0 0 - 24.3850 6.9813 17.9250 O 0 0 0 0 0 0 - 24.5730 8.3507 17.6135 C 0 0 0 0 0 0 - 25.3544 8.4369 16.8542 H 0 0 0 0 0 0 - 23.6520 8.7262 17.1591 H 0 0 0 0 0 0 - 24.9031 9.1560 18.8964 C 0 0 0 0 0 0 - 24.0404 9.7650 19.1683 H 0 0 0 0 0 0 - 25.0397 8.4566 19.7210 H 0 0 0 0 0 0 - 26.1108 10.0209 18.7712 N 0 3 2 0 0 0 - 26.5673 10.5646 20.0754 C 0 0 0 0 0 0 - 27.2638 11.3822 19.8986 H 0 0 0 0 0 0 - 25.7257 10.9866 20.6286 H 0 0 0 0 0 0 - 27.2992 9.5034 20.9067 C 0 0 0 0 0 0 - 27.7963 9.9607 21.7639 H 0 0 0 0 0 0 - 28.0542 9.0077 20.3011 H 0 0 0 0 0 0 - 26.6212 8.7424 21.2964 H 0 0 0 0 0 0 - 25.9587 11.0564 17.7148 C 0 0 0 0 0 0 - 25.0695 10.9080 17.1118 H 0 0 0 0 0 0 - 25.7827 12.0241 18.2024 H 0 0 0 0 0 0 - 27.1818 11.1927 16.7677 C 0 0 2 0 0 0 - 27.2513 12.2504 16.4973 H 0 0 0 0 0 0 - 26.9041 10.4585 15.5792 O 0 0 0 0 0 0 - 27.8305 10.7250 14.5238 C 0 0 2 0 0 0 - 27.8368 11.8002 14.3399 H 0 0 0 0 0 0 - 27.3981 10.0641 13.2265 C 0 0 0 0 0 0 - 26.3990 10.6726 12.4559 C 0 0 0 0 0 0 - 25.9383 11.5552 12.8703 H 0 0 0 0 0 0 - 26.0361 10.1474 11.2060 C 0 0 0 0 0 0 - 25.0158 10.8436 10.3046 C 0 0 0 0 0 0 - 24.0733 9.7978 9.7104 C 0 0 0 0 0 0 - 23.2521 10.1887 9.1195 H 0 0 0 0 0 0 - 23.5849 9.3905 10.5804 H 0 0 0 0 0 0 - 24.5495 9.0134 9.1157 H 0 0 0 0 0 0 - 25.7906 11.6274 9.2438 C 0 0 0 0 0 0 - 26.4572 10.9524 8.7188 H 0 0 0 0 0 0 - 26.3849 12.4008 9.7258 H 0 0 0 0 0 0 - 25.1881 12.1516 8.5066 H 0 0 0 0 0 0 - 24.1272 11.8268 11.0717 C 0 0 0 0 0 0 - 23.4090 12.3112 10.4051 H 0 0 0 0 0 0 - 24.7435 12.5883 11.5131 H 0 0 0 0 0 0 - 23.5851 11.3576 11.8817 H 0 0 0 0 0 0 - 26.6991 8.9886 10.7364 C 0 0 0 0 0 0 - 26.4948 8.5766 9.7621 H 0 0 0 0 0 0 - 27.6648 8.3508 11.5212 C 0 0 0 0 0 0 - 28.1660 7.4729 11.1410 H 0 0 0 0 0 0 - 28.0275 8.8867 12.7690 C 0 0 0 0 0 0 - 29.0381 8.2449 13.4999 N 0 0 0 0 0 0 - 29.2026 7.2563 13.3375 H 0 0 0 0 0 0 - 29.3656 8.7382 14.8322 C 0 0 1 0 0 0 - 28.6416 8.2922 15.5185 H 0 0 0 0 0 0 - 30.7455 8.2570 15.2299 C 0 0 0 0 0 0 - 31.8743 8.6652 14.4815 C 0 0 0 0 0 0 - 31.7520 9.3092 13.6238 H 0 0 0 0 0 0 - 33.1604 8.2279 14.8521 C 0 0 0 0 0 0 - 34.0060 8.5595 14.2811 H 0 0 0 0 0 0 - 33.3193 7.3889 15.9611 C 0 0 0 0 0 0 - 34.3108 7.0600 16.2514 H 0 0 0 0 0 0 - 32.1919 6.9528 16.6838 C 0 0 0 0 0 0 - 32.3158 6.2811 17.5154 H 0 0 0 0 0 0 - 30.9069 7.3866 16.3191 C 0 0 0 0 0 0 - 30.0444 7.0329 16.8656 H 0 0 0 0 0 0 - 29.2476 10.2810 14.9239 C 0 0 2 0 0 0 - 29.9272 10.6950 14.1785 H 0 0 0 0 0 0 - 29.6473 10.9133 16.2755 C 0 0 0 0 0 0 - 30.5879 10.5139 16.6418 H 0 0 0 0 0 0 - 29.8090 11.9820 16.1240 H 0 0 0 0 0 0 - 28.5497 10.7343 17.3309 C 0 0 0 0 0 0 - 28.8131 11.3124 18.2174 H 0 0 0 0 0 0 - 28.5127 9.6845 17.6290 H 0 0 0 0 0 0 - 26.8329 9.4057 18.4319 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 3 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 6 9 1 0 0 0 - 9 10 1 0 0 0 - 9 17 1 0 0 0 - 9 70 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 10 13 1 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 13 16 1 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 17 20 1 0 0 0 - 20 67 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 22 23 1 0 0 0 - 23 62 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 25 46 1 0 0 0 - 25 26 2 0 0 0 - 26 27 1 0 0 0 - 26 28 1 0 0 0 - 28 29 1 0 0 0 - 28 42 2 0 0 0 - 29 30 1 0 0 0 - 29 34 1 0 0 0 - 29 38 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 2 0 0 0 - 46 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 - 49 62 1 0 0 0 - 51 60 1 0 0 0 - 51 52 2 0 0 0 - 52 53 1 0 0 0 - 52 54 1 0 0 0 - 54 55 1 0 0 0 - 54 56 2 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 58 59 1 0 0 0 - 58 60 2 0 0 0 - 60 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 1 0 0 0 - 64 65 1 0 0 0 - 64 66 1 0 0 0 - 64 67 1 0 0 0 - 67 68 1 0 0 0 - 67 69 1 0 0 0 -M CHG 1 9 1 -M END -> -ligprep_eg5.smi - -> -16 - -> -53161 - -> -0 - -> -W09IXVtDSDJdW0NIMl1OKFtDSDJdW0NIM10pW0NIMl1bQ0BIXShPMSlbQ0gyXVtDSDJdW0NASF0yW0NASF0oYzNbY0hdW2NIXVtjSF1bY0hdW2NIXTMpW05IXWMoYzRbQ0BASF0xMilbY0hdW2NIXWMoW2NIXTQpQyhbQ0gzXSkoW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.2099 - -> - 0.2095 - -> - 0.0003 - -> - 0.1996 - -> -0.409142 - -> -1 - -> -1 - -> -S-OPLS - -> -51.358 - -> -1 - -> -lig_CHEMBL1084935-2 - -> -glide-grid_EG5-3L9H - -> -17 - -> -8 - -> --8.48690949119332 - -> --0.273771273909462 - -> --0.860019782055296 - -> --1.91405818280407 - -> --8.68650949119332 - -> --5.07714386840577 - -> --0.500851312107088 - -> --0 - -> --0.701547662786834 - -> --46.729808807373 - -> --5.62446928024292 - -> -0.773194184511463 - -> -0 - -> --64.5703659518333 - -> --52.354278087616 - -> -5.61762857437134 - -> -51 - -> -232 - -> -0.1996 - -> -0.107332582977005 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1084935 - 3D - Schrodinger Suite 2022-3. - 70 73 0 0 1 0 999 V2000 - 28.0227 8.8199 22.3965 H 0 0 0 0 0 0 - 27.9951 9.4556 21.6947 O 0 0 0 0 0 0 - 26.6748 9.5586 21.2226 C 0 0 0 0 0 0 - 26.3977 8.5595 20.9226 H 0 0 0 0 0 0 - 26.0246 9.8414 22.0523 H 0 0 0 0 0 0 - 26.5775 10.5850 20.0780 C 0 0 0 0 0 0 - 25.9096 11.3888 20.3947 H 0 0 0 0 0 0 - 27.5390 11.0579 19.9229 H 0 0 0 0 0 0 - 26.0961 10.0291 18.7918 N 0 3 1 0 0 0 - 24.7892 9.2747 18.9023 C 0 0 0 0 0 0 - 24.6689 8.7726 19.8583 H 0 0 0 0 0 0 - 23.9398 9.9622 18.8570 H 0 0 0 0 0 0 - 24.6524 8.1781 17.8324 C 0 0 0 0 0 0 - 23.7660 7.5742 18.0178 H 0 0 0 0 0 0 - 25.5074 7.5035 17.8464 H 0 0 0 0 0 0 - 24.5618 8.5930 16.8302 H 0 0 0 0 0 0 - 25.9793 11.0483 17.7120 C 0 0 0 0 0 0 - 25.0870 10.9160 17.0922 H 0 0 0 0 0 0 - 25.8202 12.0187 18.1849 H 0 0 0 0 0 0 - 27.2006 11.1830 16.7682 C 0 0 2 0 0 0 - 27.2650 12.2398 16.4974 H 0 0 0 0 0 0 - 26.9221 10.4564 15.5764 O 0 0 0 0 0 0 - 27.8329 10.7402 14.5151 C 0 0 2 0 0 0 - 27.8326 11.8167 14.3329 H 0 0 0 0 0 0 - 27.4033 10.0687 13.2268 C 0 0 0 0 0 0 - 26.4208 10.6904 12.4374 C 0 0 0 0 0 0 - 25.9981 11.6083 12.8039 H 0 0 0 0 0 0 - 26.0590 10.1528 11.1799 C 0 0 0 0 0 0 - 25.0393 10.8521 10.2745 C 0 0 0 0 0 0 - 25.8155 11.6720 9.2413 C 0 0 0 0 0 0 - 25.1901 12.1743 8.5097 H 0 0 0 0 0 0 - 26.5106 11.0315 8.7087 H 0 0 0 0 0 0 - 26.3852 12.4562 9.7445 H 0 0 0 0 0 0 - 24.1072 11.7883 11.0552 C 0 0 0 0 0 0 - 24.6648 12.5884 11.5226 H 0 0 0 0 0 0 - 23.5955 11.2587 11.8546 H 0 0 0 0 0 0 - 23.3485 12.2374 10.4140 H 0 0 0 0 0 0 - 24.1135 9.8016 9.6460 C 0 0 0 0 0 0 - 23.3391 10.1869 9.0217 H 0 0 0 0 0 0 - 23.5849 9.3887 10.4730 H 0 0 0 0 0 0 - 24.6026 9.0117 9.0769 H 0 0 0 0 0 0 - 26.7095 8.9786 10.7390 C 0 0 0 0 0 0 - 26.4943 8.5505 9.7720 H 0 0 0 0 0 0 - 27.6622 8.3446 11.5310 C 0 0 0 0 0 0 - 28.1418 7.4352 11.1693 H 0 0 0 0 0 0 - 28.0222 8.8806 12.7751 C 0 0 0 0 0 0 - 29.0340 8.2454 13.5139 N 0 0 0 0 0 0 - 29.2068 7.2647 13.3492 H 0 0 0 0 0 0 - 29.3635 8.7551 14.8315 C 0 0 1 0 0 0 - 28.6381 8.3202 15.5223 H 0 0 0 0 0 0 - 30.7400 8.2655 15.2240 C 0 0 0 0 0 0 - 31.8638 8.6760 14.4765 C 0 0 0 0 0 0 - 31.7432 9.3286 13.6261 H 0 0 0 0 0 0 - 33.1466 8.2331 14.8325 C 0 0 0 0 0 0 - 33.9935 8.5512 14.2488 H 0 0 0 0 0 0 - 33.3170 7.3902 15.9446 C 0 0 0 0 0 0 - 34.3017 7.0450 16.2161 H 0 0 0 0 0 0 - 32.1927 6.9609 16.6779 C 0 0 0 0 0 0 - 32.3161 6.2889 17.5147 H 0 0 0 0 0 0 - 30.9024 7.3895 16.3143 C 0 0 0 0 0 0 - 30.0416 7.0468 16.8690 H 0 0 0 0 0 0 - 29.2527 10.3003 14.9052 C 0 0 2 0 0 0 - 29.9287 10.7067 14.1506 H 0 0 0 0 0 0 - 29.6597 10.9368 16.2496 C 0 0 0 0 0 0 - 30.6114 10.5478 16.6077 H 0 0 0 0 0 0 - 29.8173 12.0053 16.0947 H 0 0 0 0 0 0 - 28.5758 10.7463 17.3173 C 0 0 0 0 0 0 - 28.8517 11.3346 18.1910 H 0 0 0 0 0 0 - 28.5504 9.7003 17.6210 H 0 0 0 0 0 0 - 26.7554 9.3354 18.4785 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 3 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 6 9 1 0 0 0 - 9 10 1 0 0 0 - 9 17 1 0 0 0 - 9 70 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 10 13 1 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 13 16 1 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 17 20 1 0 0 0 - 20 67 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 22 23 1 0 0 0 - 23 62 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 25 46 1 0 0 0 - 25 26 2 0 0 0 - 26 27 1 0 0 0 - 26 28 1 0 0 0 - 28 29 1 0 0 0 - 28 42 2 0 0 0 - 29 30 1 0 0 0 - 29 34 1 0 0 0 - 29 38 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 44 45 1 0 0 0 - 44 46 2 0 0 0 - 46 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 - 49 62 1 0 0 0 - 51 60 1 0 0 0 - 51 52 2 0 0 0 - 52 53 1 0 0 0 - 52 54 1 0 0 0 - 54 55 1 0 0 0 - 54 56 2 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 58 59 1 0 0 0 - 58 60 2 0 0 0 - 60 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 1 0 0 0 - 64 65 1 0 0 0 - 64 66 1 0 0 0 - 64 67 1 0 0 0 - 67 68 1 0 0 0 - 67 69 1 0 0 0 -M CHG 1 9 1 -M END -> -ligprep_eg5.smi - -> -16 - -> -53161 - -> -0 - -> -W09IXVtDSDJdW0NIMl1OKFtDSDJdW0NIM10pW0NIMl1bQ0BIXShPMSlbQ0gyXVtDSDJdW0NASF0yW0NASF0oYzNbY0hdW2NIXVtjSF1bY0hdW2NIXTMpW05IXWMoYzRbQ0BASF0xMilbY0hdW2NIXWMoW2NIXTQpQyhbQ0gzXSkoW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.2099 - -> - 0.2095 - -> - 0.0003 - -> - 0.1996 - -> -0.409142 - -> -1 - -> -1 - -> -S-OPLS - -> -53.7729 - -> -1 - -> -lig_CHEMBL1084935-1 - -> -glide-grid_EG5-3L9H - -> -16 - -> -8 - -> --8.4504524408849 - -> --0.272595240028545 - -> --0.856325411979456 - -> --1.9058360006851 - -> --8.6500524408849 - -> --5.11195445752728 - -> --0.453621217513014 - -> --0 - -> --0.710757088127667 - -> --44.5950889587402 - -> --6.11439609527588 - -> -0.773194184511463 - -> -0 - -> --62.8328902316395 - -> --50.7094850540161 - -> -6.31344175338745 - -> -103 - -> -394 - -> -0.1996 - -> -0.101821539419745 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1086410 - 3D - Schrodinger Suite 2022-3. - 60 63 0 0 1 0 999 V2000 - 34.3034 7.0460 16.2168 H 0 0 0 0 0 0 - 33.3156 7.3882 15.9426 C 0 0 0 0 0 0 - 32.1922 6.9651 16.6778 C 0 0 0 0 0 0 - 32.3170 6.2969 17.5183 H 0 0 0 0 0 0 - 30.9031 7.4005 16.3189 C 0 0 0 0 0 0 - 30.0444 7.0638 16.8805 H 0 0 0 0 0 0 - 30.7405 8.2749 15.2271 C 0 0 0 0 0 0 - 29.3647 8.7641 14.8317 C 0 0 2 0 0 0 - 28.6412 8.3330 15.5255 H 0 0 0 0 0 0 - 29.0309 8.2521 13.5094 N 0 0 0 0 0 0 - 29.1983 7.2661 13.3467 H 0 0 0 0 0 0 - 28.0238 8.8838 12.7705 C 0 0 0 0 0 0 - 27.6593 8.3476 11.5211 C 0 0 0 0 0 0 - 28.1425 7.4524 11.1518 H 0 0 0 0 0 0 - 26.6986 8.9884 10.7317 C 0 0 0 0 0 0 - 26.4843 8.5701 9.7628 H 0 0 0 0 0 0 - 26.0447 10.1574 11.1873 C 0 0 0 0 0 0 - 25.0202 10.8597 10.2912 C 0 0 0 0 0 0 - 25.7980 11.6768 9.2530 C 0 0 0 0 0 0 - 25.1872 12.1988 8.5262 H 0 0 0 0 0 0 - 26.4733 11.0254 8.7190 H 0 0 0 0 0 0 - 26.3851 12.4480 9.7456 H 0 0 0 0 0 0 - 24.1152 11.8173 11.0744 C 0 0 0 0 0 0 - 24.7209 12.5880 11.5191 H 0 0 0 0 0 0 - 23.5850 11.3359 11.8895 H 0 0 0 0 0 0 - 23.3776 12.2980 10.4313 H 0 0 0 0 0 0 - 24.0854 9.8116 9.6805 C 0 0 0 0 0 0 - 23.2668 10.1885 9.0946 H 0 0 0 0 0 0 - 23.5862 9.3885 10.5344 H 0 0 0 0 0 0 - 24.5652 9.0305 9.0938 H 0 0 0 0 0 0 - 26.4056 10.6803 12.4474 C 0 0 0 0 0 0 - 25.9735 11.5884 12.8336 H 0 0 0 0 0 0 - 27.3977 10.0666 13.2261 C 0 0 0 0 0 0 - 27.8277 10.7418 14.5119 C 0 0 1 0 0 0 - 27.8251 11.8180 14.3240 H 0 0 0 0 0 0 - 26.9175 10.4606 15.5761 O 0 0 0 0 0 0 - 27.1892 11.2057 16.7569 C 0 0 1 0 0 0 - 27.2333 12.2597 16.4759 H 0 0 0 0 0 0 - 25.9858 11.0621 17.7207 C 0 0 0 0 0 0 - 25.7693 12.0180 18.1978 H 0 0 0 0 0 0 - 25.0963 10.8230 17.1352 H 0 0 0 0 0 0 - 26.1402 10.0160 18.7583 N 0 3 0 0 0 0 - 25.2320 9.5992 18.9092 H 0 0 0 0 0 0 - 26.6183 10.5076 20.0694 C 0 0 0 0 0 0 - 26.6969 9.6796 20.7731 H 0 0 0 0 0 0 - 25.9206 11.2363 20.4812 H 0 0 0 0 0 0 - 27.5960 10.9785 19.9937 H 0 0 0 0 0 0 - 28.5688 10.7757 17.3021 C 0 0 0 0 0 0 - 28.8354 11.3639 18.1789 H 0 0 0 0 0 0 - 28.5539 9.7281 17.6041 H 0 0 0 0 0 0 - 29.6518 10.9643 16.2364 C 0 0 0 0 0 0 - 29.7974 12.0335 16.0728 H 0 0 0 0 0 0 - 30.6069 10.5868 16.5982 H 0 0 0 0 0 0 - 29.2505 10.3108 14.8979 C 0 0 1 0 0 0 - 29.9251 10.7147 14.1407 H 0 0 0 0 0 0 - 31.8648 8.6803 14.4789 C 0 0 0 0 0 0 - 31.7444 9.3331 13.6262 H 0 0 0 0 0 0 - 33.1475 8.2346 14.8331 C 0 0 0 0 0 0 - 33.9934 8.5530 14.2485 H 0 0 0 0 0 0 - 26.7514 9.2938 18.4060 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 58 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 56 1 0 0 0 - 8 54 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 33 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 31 1 0 0 0 - 18 19 1 0 0 0 - 18 23 1 0 0 0 - 18 27 1 0 0 0 - 19 20 1 0 0 0 - 19 21 1 0 0 0 - 19 22 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 23 26 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 31 32 1 0 0 0 - 31 33 2 0 0 0 - 33 34 1 0 0 0 - 34 54 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 48 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 60 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 48 49 1 0 0 0 - 48 50 1 0 0 0 - 48 51 1 0 0 0 - 51 52 1 0 0 0 - 51 53 1 0 0 0 - 51 54 1 0 0 0 - 54 55 1 0 0 0 - 56 57 1 0 0 0 - 56 58 2 0 0 0 - 58 59 1 0 0 0 -M CHG 1 42 1 -M END -> -ligprep_eg5.smi - -> -21 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoW2NIXVtjSF00KUMoW0NIM10pKFtDSDNdKVtDSDNdKVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0027 - -> - 0.0023 - -> - 0.0004 - -> - -0.0000 - -> -0.00233856 - -> -1 - -> -1 - -> -S-OPLS - -> -42.9625 - -> -1 - -> -lig_CHEMBL1086410-1 - -> -glide-grid_EG5-3L9H - -> -22 - -> -4 - -> --8.44339112023165 - -> --0.312718189638209 - -> --0.93815456788396 - -> --1.96548225260823 - -> --8.44339112023165 - -> --5.11081688805815 - -> --0.192406234618827 - -> --0 - -> --1.10691026565731 - -> --42.2594757080078 - -> --3.30793595314026 - -> -0.575906446474057 - -> -0 - -> --56.4524812908641 - -> --45.5674116611481 - -> -0.818700671195984 - -> -4 - -> -3 - -> --0 - -> -0.098368472648139 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1086409 - 3D - Schrodinger Suite 2022-3. - 51 54 0 0 1 0 999 V2000 - 33.9825 8.5632 14.3524 H 0 0 0 0 0 0 - 33.0906 8.2280 14.8604 C 0 0 0 0 0 0 - 31.8246 8.6697 14.4384 C 0 0 0 0 0 0 - 31.7460 9.3316 13.5884 H 0 0 0 0 0 0 - 30.6644 8.2651 15.1328 C 0 0 0 0 0 0 - 29.3047 8.7817 14.7172 C 0 0 2 0 0 0 - 28.5580 8.3489 15.3859 H 0 0 0 0 0 0 - 28.9907 8.3067 13.3824 N 0 0 0 0 0 0 - 29.1766 7.3290 13.1982 H 0 0 0 0 0 0 - 27.9609 8.9352 12.6763 C 0 0 0 0 0 0 - 27.5740 8.3747 11.4443 C 0 0 0 0 0 0 - 28.0511 7.4775 11.0792 H 0 0 0 0 0 0 - 26.5727 8.9889 10.6731 C 0 0 0 0 0 0 - 26.2980 8.5637 9.7194 H 0 0 0 0 0 0 - 25.9595 10.1765 11.1211 C 0 0 0 0 0 0 - 24.9528 10.8868 10.2356 C 0 0 0 0 0 0 - 25.6100 11.6912 9.4000 F 0 0 0 0 0 0 - 24.2584 10.0015 9.5199 F 0 0 0 0 0 0 - 24.1089 11.6271 10.9548 F 0 0 0 0 0 0 - 26.3289 10.7260 12.3683 C 0 0 0 0 0 0 - 25.8701 11.6399 12.7175 H 0 0 0 0 0 0 - 27.3321 10.1147 13.1462 C 0 0 0 0 0 0 - 27.7792 10.7745 14.4410 C 0 0 1 0 0 0 - 27.7841 11.8529 14.2758 H 0 0 0 0 0 0 - 26.8824 10.4827 15.5190 O 0 0 0 0 0 0 - 27.1787 11.1986 16.7154 C 0 0 1 0 0 0 - 27.2406 12.2552 16.4490 H 0 0 0 0 0 0 - 25.9880 11.0676 17.7007 C 0 0 0 0 0 0 - 25.8089 12.0277 18.1864 H 0 0 0 0 0 0 - 25.0795 10.8619 17.1347 H 0 0 0 0 0 0 - 26.1393 10.0266 18.7447 N 0 3 0 0 0 0 - 25.2281 9.6164 18.8975 H 0 0 0 0 0 0 - 26.6210 10.5046 20.0555 C 0 0 0 0 0 0 - 26.6896 9.6636 20.7457 H 0 0 0 0 0 0 - 25.9285 11.2323 20.4815 H 0 0 0 0 0 0 - 27.6066 10.9625 19.9850 H 0 0 0 0 0 0 - 28.5558 10.7411 17.2377 C 0 0 0 0 0 0 - 28.8411 11.3068 18.1235 H 0 0 0 0 0 0 - 28.5323 9.6881 17.5186 H 0 0 0 0 0 0 - 29.6251 10.9445 16.1618 C 0 0 0 0 0 0 - 29.7780 12.0157 16.0190 H 0 0 0 0 0 0 - 30.5823 10.5491 16.4992 H 0 0 0 0 0 0 - 29.2042 10.3258 14.8128 C 0 0 1 0 0 0 - 29.8839 10.7318 14.0608 H 0 0 0 0 0 0 - 30.7658 7.3695 16.2131 C 0 0 0 0 0 0 - 29.8773 7.0355 16.7260 H 0 0 0 0 0 0 - 32.0300 6.9363 16.6385 C 0 0 0 0 0 0 - 32.1186 6.2827 17.4952 H 0 0 0 0 0 0 - 33.1872 7.3856 15.9804 C 0 0 0 0 0 0 - 34.3849 7.0437 16.4876 F 0 0 0 0 0 0 - 26.7431 9.2978 18.3920 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 49 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 45 2 0 0 0 - 6 43 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 22 1 0 0 0 - 10 11 2 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 13 14 1 0 0 0 - 13 15 2 0 0 0 - 15 16 1 0 0 0 - 15 20 1 0 0 0 - 16 17 1 0 0 0 - 16 18 1 0 0 0 - 16 19 1 0 0 0 - 20 21 1 0 0 0 - 20 22 2 0 0 0 - 22 23 1 0 0 0 - 23 43 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 25 26 1 0 0 0 - 26 27 1 0 0 0 - 26 28 1 0 0 0 - 26 37 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 31 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 31 51 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 33 36 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 40 1 0 0 0 - 40 41 1 0 0 0 - 40 42 1 0 0 0 - 40 43 1 0 0 0 - 43 44 1 0 0 0 - 45 46 1 0 0 0 - 45 47 1 0 0 0 - 47 48 1 0 0 0 - 47 49 2 0 0 0 - 49 50 1 0 0 0 -M CHG 1 31 1 -M END -> -ligprep_eg5.smi - -> -20 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdYyhGKVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0023 - -> - 0.0023 - -> - 0.0000 - -> - -0.0000 - -> -0.00233856 - -> -1 - -> -1 - -> -S-OPLS - -> -39.4847 - -> -1 - -> -lig_CHEMBL1086409-1 - -> -glide-grid_EG5-3L9H - -> -21 - -> -4 - -> --8.36784834764743 - -> --0.298851726701694 - -> --0.907489856520383 - -> --1.93154508934044 - -> --8.36784834764743 - -> --4.55781413171902 - -> --0.103503880092214 - -> --0 - -> --1.85677901672795 - -> --41.599739074707 - -> --1.80024313926697 - -> -0.500272105517158 - -> -0 - -> --64.5760746740241 - -> --43.399982213974 - -> --5.37275042233887e-08 - -> -8 - -> -8 - -> --0 - -> -0.0825077174894544 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1077204 - 3D - Schrodinger Suite 2022-3. - 66 69 0 0 1 0 999 V2000 - 34.2562 7.0347 16.2294 H 0 0 0 0 0 0 - 33.2821 7.3917 15.9444 C 0 0 0 0 0 0 - 33.1297 8.2337 14.8235 C 0 0 0 0 0 0 - 33.9842 8.5209 14.2482 H 0 0 0 0 0 0 - 31.8444 8.6867 14.4514 C 0 0 0 0 0 0 - 31.7395 9.3211 13.5904 H 0 0 0 0 0 0 - 30.7018 8.2986 15.1919 C 0 0 0 0 0 0 - 29.3349 8.7988 14.7881 C 0 0 2 0 0 0 - 28.5933 8.3597 15.4663 H 0 0 0 0 0 0 - 29.0070 8.3086 13.4630 N 0 0 0 0 0 0 - 29.1574 7.3132 13.3063 H 0 0 0 0 0 0 - 27.9809 8.9247 12.7466 C 0 0 0 0 0 0 - 27.5853 8.3573 11.5123 C 0 0 0 0 0 0 - 28.0389 7.4496 11.1533 H 0 0 0 0 0 0 - 26.6000 8.9873 10.7187 C 0 0 0 0 0 0 - 26.3248 8.5670 9.7705 H 0 0 0 0 0 0 - 25.9930 10.1883 11.1477 C 0 0 0 0 0 0 - 25.0012 10.8988 10.2584 C 0 0 0 0 0 0 - 25.6629 11.7243 9.4459 F 0 0 0 0 0 0 - 24.3362 10.0137 9.5184 F 0 0 0 0 0 0 - 24.1223 11.6157 10.9611 F 0 0 0 0 0 0 - 26.3740 10.7533 12.3947 C 0 0 0 0 0 0 - 25.9525 11.6837 12.7053 H 0 0 0 0 0 0 - 27.3631 10.1245 13.1855 C 0 0 0 0 0 0 - 27.7950 10.7877 14.4758 C 0 0 1 0 0 0 - 27.8062 11.8620 14.2948 H 0 0 0 0 0 0 - 26.8832 10.5117 15.5344 O 0 0 0 0 0 0 - 27.1477 11.2242 16.7404 C 0 0 1 0 0 0 - 27.1850 12.2849 16.4827 H 0 0 0 0 0 0 - 25.9308 11.0430 17.6962 C 0 0 0 0 0 0 - 25.6144 12.0199 18.0682 H 0 0 0 0 0 0 - 25.0712 10.6787 17.1251 H 0 0 0 0 0 0 - 26.1520 10.1379 18.8238 N 0 0 0 0 0 0 - 25.9448 9.1625 18.6644 H 0 0 0 0 0 0 - 26.6750 10.5167 20.0003 C 0 0 0 0 0 0 - 26.9446 11.6800 20.2828 O 0 0 0 0 0 0 - 26.9084 9.4845 20.8235 N 0 0 0 0 0 0 - 26.6390 8.5745 20.4891 H 0 0 0 0 0 0 - 27.6747 9.5294 22.0635 C 0 0 0 0 0 0 - 28.4015 8.7304 22.0160 H 0 0 0 0 0 0 - 28.2478 10.4626 22.1563 H 0 0 0 0 0 0 - 26.7887 9.3369 23.3234 C 0 0 0 0 0 0 - 26.2421 10.2685 23.5227 H 0 0 0 0 0 0 - 26.0295 8.5806 23.0824 H 0 0 0 0 0 0 - 27.5544 8.9152 24.5043 N 0 3 0 0 0 0 - 28.5187 9.8964 24.9818 C 0 0 0 0 0 0 - 28.0296 10.8222 25.3144 H 0 0 0 0 0 0 - 29.2668 10.1738 24.2278 H 0 0 0 0 0 0 - 29.0853 9.5071 25.8376 H 0 0 0 0 0 0 - 26.6934 8.4166 25.5707 C 0 0 0 0 0 0 - 26.0653 9.2210 25.9802 H 0 0 0 0 0 0 - 27.2755 7.9999 26.3998 H 0 0 0 0 0 0 - 26.0212 7.6192 25.2228 H 0 0 0 0 0 0 - 28.5220 10.7834 17.2811 C 0 0 0 0 0 0 - 28.7797 11.3718 18.1674 H 0 0 0 0 0 0 - 28.4929 9.7362 17.5813 H 0 0 0 0 0 0 - 29.6196 10.9620 16.2283 C 0 0 0 0 0 0 - 29.8012 12.0245 16.0892 H 0 0 0 0 0 0 - 30.5566 10.5581 16.6027 H 0 0 0 0 0 0 - 29.2135 10.3407 14.8728 C 0 0 1 0 0 0 - 29.9015 10.7486 14.1347 H 0 0 0 0 0 0 - 30.8528 7.4302 16.2936 C 0 0 0 0 0 0 - 29.9916 7.0984 16.8410 H 0 0 0 0 0 0 - 32.1393 6.9883 16.6779 C 0 0 0 0 0 0 - 32.2482 6.3143 17.5164 H 0 0 0 0 0 0 - 28.1027 8.1015 24.1952 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 64 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 62 1 0 0 0 - 8 60 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 24 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 22 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 25 60 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 27 28 1 0 0 0 - 28 29 1 0 0 0 - 28 30 1 0 0 0 - 28 54 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 33 34 1 0 0 0 - 33 35 1 0 0 0 - 35 36 2 0 0 0 - 35 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 45 1 0 0 0 - 45 46 1 0 0 0 - 45 50 1 0 0 0 - 45 66 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 53 1 0 0 0 - 54 55 1 0 0 0 - 54 56 1 0 0 0 - 54 57 1 0 0 0 - 57 58 1 0 0 0 - 57 59 1 0 0 0 - 57 60 1 0 0 0 - 60 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 2 0 0 0 - 64 65 1 0 0 0 -M CHG 1 45 1 -M END -> -ligprep_eg5.smi - -> -1 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQyhGKShGKUYpW2NIXVtjSF00KVtDSDJdW0NIMl1bQ0BASF0oTzMpW0NIMl1bTkhdQyg9TylbTkhdW0NIMl1bQ0gyXU4oW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0082 - -> - 0.0082 - -> - 0.0000 - -> - -0.0000 - -> -0.00819794 - -> -1 - -> -1 - -> -S-OPLS - -> -45.9171 - -> -1 - -> -lig_CHEMBL1077204-1 - -> -glide-grid_EG5-3L9H - -> -1 - -> -9 - -> --8.36025842742276 - -> --0.245889953747728 - -> --0.796587995040363 - -> --1.84701558392362 - -> --8.36025842742276 - -> --4.57367673946409 - -> --0.151646552204959 - -> --0 - -> --1.23923404152954 - -> --51.0351600646973 - -> --4.12482261657715 - -> -0.799489567595273 - -> --0.0247092660980082 - -> --90.0263182301627 - -> --55.1599826812744 - -> -1.91703847463032e-07 - -> -8 - -> -10 - -> --0 - -> -0.0763132020169883 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1096003 - 3D - Schrodinger Suite 2022-3. - 62 65 0 0 1 0 999 V2000 - 34.2108 7.0139 16.2401 H 0 0 0 0 0 0 - 33.2384 7.3802 15.9455 C 0 0 0 0 0 0 - 32.0951 6.9867 16.6600 C 0 0 0 0 0 0 - 32.1852 6.3313 17.5158 H 0 0 0 0 0 0 - 30.8216 7.4546 16.2761 C 0 0 0 0 0 0 - 29.9477 7.1521 16.8340 H 0 0 0 0 0 0 - 30.6912 8.3234 15.1729 C 0 0 0 0 0 0 - 29.3266 8.8519 14.7633 C 0 0 2 0 0 0 - 28.5887 8.4033 15.4297 H 0 0 0 0 0 0 - 28.9799 8.3924 13.4251 N 0 0 0 0 0 0 - 29.1885 7.4303 13.1973 H 0 0 0 0 0 0 - 27.9425 9.0288 12.7277 C 0 0 0 0 0 0 - 27.4885 8.4689 11.5200 C 0 0 0 0 0 0 - 27.9849 7.2973 11.1235 F 0 0 0 0 0 0 - 26.5041 9.0837 10.7395 C 0 0 0 0 0 0 - 26.1690 8.6260 9.8203 H 0 0 0 0 0 0 - 25.9481 10.2875 11.1918 C 0 0 0 0 0 0 - 24.6811 11.0460 10.3189 Cl 0 0 0 0 0 0 - 26.3733 10.8611 12.4020 C 0 0 0 0 0 0 - 25.9318 11.7926 12.7245 H 0 0 0 0 0 0 - 27.3640 10.2330 13.1828 C 0 0 0 0 0 0 - 27.8115 10.8673 14.4860 C 0 0 1 0 0 0 - 27.8189 11.9494 14.3430 H 0 0 0 0 0 0 - 26.8820 10.5414 15.5172 O 0 0 0 0 0 0 - 27.1348 11.1765 16.7636 C 0 0 1 0 0 0 - 27.1756 12.2540 16.5895 H 0 0 0 0 0 0 - 25.9147 10.9027 17.6756 C 0 0 0 0 0 0 - 25.5493 11.8416 18.0940 H 0 0 0 0 0 0 - 25.0902 10.4808 17.0981 H 0 0 0 0 0 0 - 26.2403 10.0153 18.7915 N 0 0 2 0 0 0 - 26.9647 9.3341 18.5713 H 0 0 0 0 0 0 - 25.0077 9.3764 19.7986 S 0 0 0 0 0 0 - 25.6624 8.9726 21.0519 O 0 0 0 0 0 0 - 23.8983 10.3422 19.8235 O 0 0 0 0 0 0 - 24.4539 7.8667 18.8930 C 0 0 0 0 0 0 - 23.7047 8.1813 18.1665 H 0 0 0 0 0 0 - 25.3066 7.4701 18.3400 H 0 0 0 0 0 0 - 23.9081 6.8181 19.8885 C 0 0 0 0 0 0 - 24.7102 6.4972 20.5507 H 0 0 0 0 0 0 - 23.1696 7.2858 20.5414 H 0 0 0 0 0 0 - 23.2839 5.6191 19.2646 N 0 3 0 0 0 0 - 24.1543 4.8819 18.3191 C 0 0 0 0 0 0 - 24.3881 5.4812 17.4396 H 0 0 0 0 0 0 - 23.6637 3.9677 17.9819 H 0 0 0 0 0 0 - 25.0904 4.5869 18.7899 H 0 0 0 0 0 0 - 21.9386 5.8918 18.7115 C 0 0 0 0 0 0 - 21.9706 6.6453 17.9245 H 0 0 0 0 0 0 - 21.2614 6.2410 19.4906 H 0 0 0 0 0 0 - 21.5096 4.9883 18.2840 H 0 0 0 0 0 0 - 28.5078 10.7000 17.2959 C 0 0 0 0 0 0 - 28.7501 11.1998 18.2352 H 0 0 0 0 0 0 - 28.4915 9.6290 17.5014 H 0 0 0 0 0 0 - 29.6079 10.9729 16.2649 C 0 0 0 0 0 0 - 29.7511 12.0515 16.1753 H 0 0 0 0 0 0 - 30.5578 10.5741 16.6208 H 0 0 0 0 0 0 - 29.2267 10.3965 14.8829 C 0 0 1 0 0 0 - 29.9279 10.8179 14.1595 H 0 0 0 0 0 0 - 31.8413 8.6933 14.4440 C 0 0 0 0 0 0 - 31.7524 9.3424 13.5872 H 0 0 0 0 0 0 - 33.1101 8.2214 14.8259 C 0 0 0 0 0 0 - 33.9852 8.5082 14.2609 H 0 0 0 0 0 0 - 23.1301 4.9718 20.0285 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 60 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 58 1 0 0 0 - 8 56 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 21 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 20 1 0 0 0 - 19 21 2 0 0 0 - 21 22 1 0 0 0 - 22 56 1 0 0 0 - 22 23 1 0 0 0 - 22 24 1 0 0 0 - 24 25 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 50 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 32 33 2 0 0 0 - 32 34 2 0 0 0 - 32 35 1 0 0 0 - 35 36 1 0 0 0 - 35 37 1 0 0 0 - 35 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 38 41 1 0 0 0 - 41 42 1 0 0 0 - 41 46 1 0 0 0 - 41 62 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 45 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 50 51 1 0 0 0 - 50 52 1 0 0 0 - 50 53 1 0 0 0 - 53 54 1 0 0 0 - 53 55 1 0 0 0 - 53 56 1 0 0 0 - 56 57 1 0 0 0 - 58 59 1 0 0 0 - 58 60 2 0 0 0 - 60 61 1 0 0 0 -M CHG 1 41 1 -M END -> -ligprep_eg5.smi - -> -28 - -> -53161 - -> -0 - -> -RmMxW2NIXWMoQ2wpW2NIXWMoYzEyKVtDQEBIXTNbQ0BIXShbQ0BASF0oW05IXTIpYzRbY0hdW2NIXVtjSF1bY0hdW2NIXTQpW0NIMl1bQ0gyXVtDQEBIXShPMylbQ0gyXVtOSF1TKD1PKSg9TylbQ0gyXVtDSDJdTihbQ0gzXSlbQ0gzXQ== - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.1090 - -> - 0.1079 - -> - 0.0011 - -> - 0.0977 - -> -0.205654 - -> -1 - -> -1 - -> -S-OPLS - -> -46.8483 - -> -1 - -> -lig_CHEMBL1096003-1 - -> -glide-grid_EG5-3L9H - -> -29 - -> -7 - -> --8.27683950692293 - -> --0.258651234591341 - -> --0.821166482817689 - -> --1.85340998372382 - -> --8.37453950692293 - -> --4.5888972771767 - -> --0.0301411715814408 - -> --0 - -> --0.54412124830054 - -> --49.2485656738281 - -> --8.29037380218506 - -> -0.521998501557491 - -> --0.0273939574025725 - -> --88.89523856264 - -> --57.5389394760132 - -> -5.58035564422607 - -> -7 - -> -62 - -> -0.0977 - -> -0.0919035435540691 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1093087 - 3D - Schrodinger Suite 2022-3. - 66 70 0 0 1 0 999 V2000 - 23.1299 5.7633 18.3178 H 0 0 0 0 0 0 - 23.7562 6.6395 18.4185 C 0 0 0 0 0 0 - 24.3847 7.1950 17.2909 C 0 0 0 0 0 0 - 24.2947 6.7498 16.3118 H 0 0 0 0 0 0 - 25.2219 8.3094 17.4269 C 0 0 0 0 0 0 - 25.7142 8.6724 16.5394 H 0 0 0 0 0 0 - 25.4337 8.9223 18.6811 C 0 0 0 0 0 0 - 26.2670 10.0659 18.7635 N 0 0 0 0 0 0 - 26.5913 10.5374 20.1134 C 0 0 0 0 0 0 - 25.6767 10.9505 20.5373 H 0 0 0 0 0 0 - 26.8614 9.6757 20.7235 H 0 0 0 0 0 0 - 27.7162 11.5690 20.2663 C 0 0 0 0 0 0 - 28.6780 11.1135 20.0388 H 0 0 0 0 0 0 - 27.5734 12.4324 19.6125 H 0 0 0 0 0 0 - 27.7988 12.0569 21.6550 N 0 3 0 0 0 0 - 28.5622 12.7127 21.7447 H 0 0 0 0 0 0 - 27.9545 11.2778 22.2845 H 0 0 0 0 0 0 - 26.0253 11.0368 17.6907 C 0 0 0 0 0 0 - 25.0942 10.8522 17.1567 H 0 0 0 0 0 0 - 25.8552 12.0041 18.1629 H 0 0 0 0 0 0 - 27.1920 11.2093 16.6719 C 0 0 2 0 0 0 - 27.2111 12.2676 16.4043 H 0 0 0 0 0 0 - 26.8998 10.4907 15.4797 O 0 0 0 0 0 0 - 27.8051 10.7560 14.4114 C 0 0 2 0 0 0 - 27.8141 11.8342 14.2280 H 0 0 0 0 0 0 - 27.3579 10.0864 13.1318 C 0 0 0 0 0 0 - 26.3599 10.7094 12.3608 C 0 0 0 0 0 0 - 25.9129 11.6285 12.7095 H 0 0 0 0 0 0 - 25.9873 10.1746 11.1160 C 0 0 0 0 0 0 - 24.9793 10.8912 10.2387 C 0 0 0 0 0 0 - 24.2941 10.0045 9.5194 F 0 0 0 0 0 0 - 24.1227 11.6143 10.9588 F 0 0 0 0 0 0 - 25.6354 11.7052 9.4156 F 0 0 0 0 0 0 - 26.5985 8.9885 10.6676 C 0 0 0 0 0 0 - 26.3225 8.5699 9.7112 H 0 0 0 0 0 0 - 27.5827 8.3477 11.4429 C 0 0 0 0 0 0 - 28.0368 7.4388 11.0818 H 0 0 0 0 0 0 - 27.9758 8.8942 12.6779 C 0 0 0 0 0 0 - 28.9890 8.2540 13.4063 N 0 0 0 0 0 0 - 29.1781 7.2760 13.2370 H 0 0 0 0 0 0 - 29.3301 8.7599 14.7288 C 0 0 1 0 0 0 - 28.5956 8.3465 15.4225 H 0 0 0 0 0 0 - 30.7004 8.2567 15.1554 C 0 0 0 0 0 0 - 30.8428 7.4097 16.2730 C 0 0 0 0 0 0 - 29.9724 7.0898 16.8234 H 0 0 0 0 0 0 - 32.1238 6.9850 16.6788 C 0 0 0 0 0 0 - 32.2252 6.3393 17.5405 H 0 0 0 0 0 0 - 33.2631 7.3919 15.9618 C 0 0 0 0 0 0 - 34.2447 7.0644 16.2752 H 0 0 0 0 0 0 - 33.1210 8.2084 14.8274 C 0 0 0 0 0 0 - 33.9895 8.5124 14.2643 H 0 0 0 0 0 0 - 31.8460 8.6453 14.4287 C 0 0 0 0 0 0 - 31.7433 9.2753 13.5607 H 0 0 0 0 0 0 - 29.2287 10.3060 14.7795 C 0 0 2 0 0 0 - 29.9006 10.6920 14.0120 H 0 0 0 0 0 0 - 29.6574 10.9603 16.0973 C 0 0 0 0 0 0 - 30.6088 10.5650 16.4547 H 0 0 0 0 0 0 - 29.8251 12.0248 15.9176 H 0 0 0 0 0 0 - 28.5923 10.8030 17.1696 C 0 0 0 0 0 0 - 28.9012 11.4446 17.9820 H 0 0 0 0 0 0 - 28.5954 9.7729 17.5282 H 0 0 0 0 0 0 - 24.7771 8.3618 19.8117 C 0 0 0 0 0 0 - 24.8828 8.7758 20.8029 H 0 0 0 0 0 0 - 23.9563 7.2256 19.6793 C 0 0 0 0 0 0 - 23.4767 6.7957 20.5493 H 0 0 0 0 0 0 - 26.9372 12.5186 21.9048 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 64 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 62 1 0 0 0 - 8 9 1 0 0 0 - 8 18 1 0 0 0 - 9 10 1 0 0 0 - 9 11 1 0 0 0 - 9 12 1 0 0 0 - 12 13 1 0 0 0 - 12 14 1 0 0 0 - 12 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 1 0 0 0 - 15 66 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 18 21 1 0 0 0 - 21 59 1 0 0 0 - 21 22 1 0 0 0 - 21 23 1 0 0 0 - 23 24 1 0 0 0 - 24 54 1 0 0 0 - 24 25 1 0 0 0 - 24 26 1 0 0 0 - 26 38 1 0 0 0 - 26 27 2 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 29 30 1 0 0 0 - 29 34 2 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 33 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 36 38 2 0 0 0 - 38 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 41 42 1 0 0 0 - 41 43 1 0 0 0 - 41 54 1 0 0 0 - 43 52 1 0 0 0 - 43 44 2 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 46 47 1 0 0 0 - 46 48 2 0 0 0 - 48 49 1 0 0 0 - 48 50 1 0 0 0 - 50 51 1 0 0 0 - 50 52 2 0 0 0 - 52 53 1 0 0 0 - 54 55 1 0 0 0 - 54 56 1 0 0 0 - 56 57 1 0 0 0 - 56 58 1 0 0 0 - 56 59 1 0 0 0 - 59 60 1 0 0 0 - 59 61 1 0 0 0 - 62 63 1 0 0 0 - 62 64 2 0 0 0 - 64 65 1 0 0 0 -M CHG 1 15 1 -M END -> -ligprep_eg5.smi - -> -25 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFOKFtDSDJdW0NIMl1bTkgyXSlbQ0gyXVtDQEhdKE8yKVtDSDJdW0NIMl1bQ0BIXTNbQ0BASF0oW05IXWMoYzRbQ0BASF0yMylbY0hdW2NIXWMoW2NIXTQpQyhGKShGKUYpYzVbY0hdW2NIXVtjSF1bY0hdW2NIXTU= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0028 - -> - 0.0028 - -> - 0.0000 - -> - -0.0000 - -> -0.00279424 - -> -1 - -> -1 - -> -S-OPLS - -> -58.0699 - -> -1 - -> -lig_CHEMBL1093087-1 - -> -glide-grid_EG5-3L9H - -> -26 - -> -7 - -> --8.24502956920352 - -> --0.235572273405815 - -> --0.770572526239078 - -> --1.8099669790123 - -> --8.24502956920352 - -> --4.67177854739875 - -> --0.152309090065506 - -> --0 - -> --1.07138690296262 - -> --50.5483741760254 - -> --2.88129806518555 - -> -0.610058389802459 - -> -0 - -> --71.0152457922421 - -> --53.4296722412109 - -> -1.30132699012756 - -> -41 - -> -3 - -> --0 - -> -0.0842399486295152 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1083836 - 3D - Schrodinger Suite 2022-3. - 55 59 0 0 1 0 999 V2000 - 34.2956 7.0491 16.2082 H 0 0 0 0 0 0 - 33.3067 7.3881 15.9302 C 0 0 0 0 0 0 - 33.1374 8.2287 14.8140 C 0 0 0 0 0 0 - 33.9858 8.5407 14.2291 H 0 0 0 0 0 0 - 31.8538 8.6740 14.4594 C 0 0 0 0 0 0 - 31.7350 9.3219 13.6023 H 0 0 0 0 0 0 - 30.7280 8.2799 15.2118 C 0 0 0 0 0 0 - 29.3511 8.7830 14.8242 C 0 0 2 0 0 0 - 28.6310 8.3616 15.5262 H 0 0 0 0 0 0 - 28.9935 8.2742 13.5067 N 0 0 0 0 0 0 - 29.1785 7.2947 13.3270 H 0 0 0 0 0 0 - 28.0012 8.9258 12.7619 C 0 0 0 0 0 0 - 27.6144 8.3685 11.5283 C 0 0 0 0 0 0 - 28.0387 7.4360 11.1887 H 0 0 0 0 0 0 - 26.6762 9.0305 10.7188 C 0 0 0 0 0 0 - 26.3849 8.5957 9.7731 H 0 0 0 0 0 0 - 26.1232 10.2625 11.1242 C 0 0 0 0 0 0 - 25.1513 10.9601 10.2335 C 0 0 0 0 0 0 - 25.6318 11.3327 9.3304 H 0 0 0 0 0 0 - 23.8207 10.3233 10.1118 C 0 0 0 0 0 0 - 23.4190 10.1890 9.1189 H 0 0 0 0 0 0 - 23.6510 9.4959 10.7837 H 0 0 0 0 0 0 - 23.9275 11.6953 10.7363 C 0 0 0 0 0 0 - 23.7742 11.7751 11.8086 H 0 0 0 0 0 0 - 23.5474 12.5284 10.1533 H 0 0 0 0 0 0 - 26.4776 10.7980 12.3747 C 0 0 0 0 0 0 - 26.0487 11.7348 12.6988 H 0 0 0 0 0 0 - 27.4177 10.1422 13.1923 C 0 0 0 0 0 0 - 27.8431 10.7906 14.4963 C 0 0 1 0 0 0 - 27.8564 11.8698 14.3283 H 0 0 0 0 0 0 - 26.9222 10.4980 15.5507 O 0 0 0 0 0 0 - 27.1904 11.2175 16.7494 C 0 0 1 0 0 0 - 27.2389 12.2749 16.4841 H 0 0 0 0 0 0 - 25.9869 11.0644 17.7134 C 0 0 0 0 0 0 - 25.0929 10.8369 17.1284 H 0 0 0 0 0 0 - 25.7826 12.0160 18.2031 H 0 0 0 0 0 0 - 26.1417 10.0156 18.7502 N 0 3 0 0 0 0 - 26.7475 9.2923 18.3874 H 0 0 0 0 0 0 - 26.6265 10.4800 20.0660 C 0 0 0 0 0 0 - 26.6984 9.6369 20.7550 H 0 0 0 0 0 0 - 25.9341 11.2078 20.4921 H 0 0 0 0 0 0 - 27.6096 10.9451 19.9934 H 0 0 0 0 0 0 - 28.5697 10.7835 17.2954 C 0 0 0 0 0 0 - 28.8336 11.3707 18.1737 H 0 0 0 0 0 0 - 28.5516 9.7368 17.6008 H 0 0 0 0 0 0 - 29.6604 10.9670 16.2362 C 0 0 0 0 0 0 - 29.8229 12.0353 16.0845 H 0 0 0 0 0 0 - 30.6070 10.5709 16.6014 H 0 0 0 0 0 0 - 29.2572 10.3308 14.8898 C 0 0 1 0 0 0 - 29.9452 10.7276 14.1413 H 0 0 0 0 0 0 - 30.8942 7.4141 16.3116 C 0 0 0 0 0 0 - 30.0373 7.0837 16.8804 H 0 0 0 0 0 0 - 32.1832 6.9779 16.6722 C 0 0 0 0 0 0 - 32.3101 6.3172 17.5190 H 0 0 0 0 0 0 - 25.2315 9.5998 18.8950 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 53 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 51 1 0 0 0 - 8 49 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 28 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 26 1 0 0 0 - 18 23 1 0 0 0 - 18 19 1 0 0 0 - 18 20 1 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 20 23 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 26 27 1 0 0 0 - 26 28 2 0 0 0 - 28 29 1 0 0 0 - 29 49 1 0 0 0 - 29 30 1 0 0 0 - 29 31 1 0 0 0 - 31 32 1 0 0 0 - 32 33 1 0 0 0 - 32 34 1 0 0 0 - 32 43 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 55 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 43 44 1 0 0 0 - 43 45 1 0 0 0 - 43 46 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 49 50 1 0 0 0 - 51 52 1 0 0 0 - 51 53 2 0 0 0 - 53 54 1 0 0 0 -M CHG 1 37 1 -M END -> -ligprep_eg5.smi - -> -9 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BIXShbQ0gyXVtDSDJdW0NAQEhdKE8zKVtDSDJdW05IXVtDSDNdKVtDQEhdM2MoYzI0KVtjSF1jKFtjSF1bY0hdNClbQ0hdNVtDSDJdW0NIMl01 - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0027 - -> - 0.0023 - -> - 0.0004 - -> - -0.0000 - -> -0.00233856 - -> -1 - -> -1 - -> -S-OPLS - -> -43.0329 - -> -1 - -> -lig_CHEMBL1083836-1 - -> -glide-grid_EG5-3L9H - -> -9 - -> -4 - -> --8.11821399640001 - -> --0.312238999861539 - -> --0.925006808488672 - -> --1.90653591902173 - -> --8.11821399640001 - -> --4.9859128801992 - -> --0.163850739216988 - -> --0 - -> --1.12670252259112 - -> --40.803352355957 - -> --2.83613419532776 - -> -0.623839892704311 - -> -0 - -> --60.2541375122534 - -> --43.6394865512848 - -> -0.242533147335052 - -> -5 - -> -2 - -> --0 - -> -0.0861842314775095 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1077227 - 3D - Schrodinger Suite 2022-3. - 57 60 0 0 1 0 999 V2000 - 33.2036 6.3232 16.8098 H 0 0 0 0 0 0 - 32.6142 6.9890 16.1935 C 0 0 0 0 0 0 - 33.0383 7.8715 15.2366 C 0 0 0 0 0 0 - 34.0656 8.0294 14.9506 H 0 0 0 0 0 0 - 31.9591 8.5929 14.6434 C 0 0 0 0 0 0 - 32.1147 9.3396 13.8769 H 0 0 0 0 0 0 - 30.7328 8.2488 15.1532 C 0 0 0 0 0 0 - 29.3857 8.7765 14.8007 C 0 0 2 0 0 0 - 28.6544 8.3264 15.4743 H 0 0 0 0 0 0 - 29.0514 8.3019 13.4693 N 0 0 0 0 0 0 - 29.2210 7.3198 13.2837 H 0 0 0 0 0 0 - 28.0260 8.9310 12.7612 C 0 0 0 0 0 0 - 27.6533 8.3886 11.5188 C 0 0 0 0 0 0 - 28.1393 7.5042 11.1378 H 0 0 0 0 0 0 - 26.6620 9.0114 10.7514 C 0 0 0 0 0 0 - 26.4358 8.5890 9.7861 H 0 0 0 0 0 0 - 26.0083 10.1779 11.2159 C 0 0 0 0 0 0 - 24.9806 10.8710 10.3106 C 0 0 0 0 0 0 - 25.7723 11.6568 9.2605 C 0 0 0 0 0 0 - 25.1858 12.2085 8.5367 H 0 0 0 0 0 0 - 26.4098 10.9734 8.7186 H 0 0 0 0 0 0 - 26.3858 12.4039 9.7555 H 0 0 0 0 0 0 - 24.0968 11.8370 11.0951 C 0 0 0 0 0 0 - 24.7333 12.5902 11.5213 H 0 0 0 0 0 0 - 23.5852 11.3775 11.9327 H 0 0 0 0 0 0 - 23.3524 12.3267 10.4644 H 0 0 0 0 0 0 - 24.0389 9.8314 9.6914 C 0 0 0 0 0 0 - 23.1929 10.2009 9.1191 H 0 0 0 0 0 0 - 23.5859 9.3883 10.5558 H 0 0 0 0 0 0 - 24.5194 9.0588 9.0932 H 0 0 0 0 0 0 - 26.3817 10.7078 12.4767 C 0 0 0 0 0 0 - 25.9403 11.6064 12.8752 H 0 0 0 0 0 0 - 27.3936 10.1032 13.2413 C 0 0 0 0 0 0 - 27.8318 10.7656 14.5376 C 0 0 1 0 0 0 - 27.8428 11.8432 14.3620 H 0 0 0 0 0 0 - 26.9039 10.4942 15.5908 O 0 0 0 0 0 0 - 27.1807 11.1820 16.8101 C 0 0 1 0 0 0 - 27.2456 12.2458 16.5739 H 0 0 0 0 0 0 - 25.9802 11.0033 17.7814 C 0 0 0 0 0 0 - 25.6844 11.9747 18.1781 H 0 0 0 0 0 0 - 25.1194 10.6530 17.2065 H 0 0 0 0 0 0 - 26.2337 10.1012 18.9492 N 0 3 0 0 0 0 - 26.8893 9.4063 18.6222 H 0 0 0 0 0 0 - 25.0333 9.3415 19.3545 C 0 0 0 0 0 0 - 25.2744 8.6673 20.1774 H 0 0 0 0 0 0 - 24.6508 8.7399 18.5282 H 0 0 0 0 0 0 - 24.2433 10.0163 19.6873 H 0 0 0 0 0 0 - 28.5468 10.7094 17.3415 C 0 0 0 0 0 0 - 28.8046 11.2432 18.2565 H 0 0 0 0 0 0 - 28.5049 9.6494 17.5916 H 0 0 0 0 0 0 - 29.6476 10.9161 16.2956 C 0 0 0 0 0 0 - 29.8185 11.9872 16.1725 H 0 0 0 0 0 0 - 30.5873 10.5006 16.6545 H 0 0 0 0 0 0 - 29.2537 10.3147 14.9282 C 0 0 1 0 0 0 - 29.9422 10.7405 14.1941 H 0 0 0 0 0 0 - 30.8818 6.9880 16.3306 S 0 0 0 0 0 0 - 26.6278 10.4979 19.8995 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 56 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 56 1 0 0 0 - 8 54 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 33 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 31 1 0 0 0 - 18 19 1 0 0 0 - 18 23 1 0 0 0 - 18 27 1 0 0 0 - 19 20 1 0 0 0 - 19 21 1 0 0 0 - 19 22 1 0 0 0 - 23 24 1 0 0 0 - 23 25 1 0 0 0 - 23 26 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 31 32 1 0 0 0 - 31 33 2 0 0 0 - 33 34 1 0 0 0 - 34 54 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 48 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 57 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 48 49 1 0 0 0 - 48 50 1 0 0 0 - 48 51 1 0 0 0 - 51 52 1 0 0 0 - 51 53 1 0 0 0 - 51 54 1 0 0 0 - 54 55 1 0 0 0 -M CHG 1 42 1 -M END -> -ligprep_eg5.smi - -> -2 - -> -53161 - -> -0 - -> -W0NIM11bTkhdW0NIMl1bQ0BIXShPMSlbQ0gyXVtDSDJdW0NAQEhdKFtDQEBIXShbTkhdMiljM1tjSF1bY0hdW2NIXXMzKVtDQEhdMWMoYzI0KVtjSF1jKFtjSF1bY0hdNClDKFtDSDNdKShbQ0gzXSlbQ0gzXQ== - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0026 - -> - 0.0023 - -> - 0.0002 - -> - -0.0000 - -> -0.00234437 - -> -1 - -> -1 - -> -S-OPLS - -> -35.8987 - -> -1 - -> -lig_CHEMBL1077227-1 - -> -glide-grid_EG5-3L9H - -> -2 - -> -4 - -> --7.933869842524 - -> --0.305148840097077 - -> --0.904002238084884 - -> --1.86324329936645 - -> --7.933869842524 - -> --4.78353947845621 - -> --0.128973420991137 - -> --0 - -> --1.03980574115753 - -> --43.0146675109863 - -> --2.60091114044189 - -> -0.559318844696476 - -> -0 - -> --55.2445904462782 - -> --45.6155786514282 - -> -2.06124687194824 - -> -38 - -> -37 - -> --0 - -> -0.106644903951531 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1085692 - 3D - Schrodinger Suite 2022-3. - 64 67 0 0 1 0 999 V2000 - 34.2542 7.0460 16.2347 H 0 0 0 0 0 0 - 33.2731 7.3883 15.9413 C 0 0 0 0 0 0 - 32.1391 6.9883 16.6737 C 0 0 0 0 0 0 - 32.2530 6.3417 17.5322 H 0 0 0 0 0 0 - 30.8552 7.4280 16.2941 C 0 0 0 0 0 0 - 29.9909 7.1230 16.8633 H 0 0 0 0 0 0 - 30.7055 8.2812 15.1809 C 0 0 0 0 0 0 - 29.3355 8.8047 14.7912 C 0 0 2 0 0 0 - 28.6052 8.3747 15.4764 H 0 0 0 0 0 0 - 28.9759 8.3401 13.4575 N 0 0 0 0 0 0 - 29.1708 7.3698 13.2383 H 0 0 0 0 0 0 - 27.9461 8.9883 12.7575 C 0 0 0 0 0 0 - 27.4915 8.4449 11.5404 C 0 0 0 0 0 0 - 27.9850 7.2801 11.1189 F 0 0 0 0 0 0 - 26.5200 9.0831 10.7598 C 0 0 0 0 0 0 - 26.1956 8.6573 9.8227 H 0 0 0 0 0 0 - 25.9960 10.2926 11.2170 C 0 0 0 0 0 0 - 24.7848 11.2873 10.1865 Br 0 0 0 0 0 0 - 26.3977 10.8361 12.4476 C 0 0 0 0 0 0 - 25.9875 11.7871 12.7662 H 0 0 0 0 0 0 - 27.3739 10.1890 13.2224 C 0 0 0 0 0 0 - 27.8460 10.8408 14.5042 C 0 0 1 0 0 0 - 27.8814 11.9179 14.3316 H 0 0 0 0 0 0 - 26.9142 10.5734 15.5487 O 0 0 0 0 0 0 - 27.1946 11.2571 16.7623 C 0 0 1 0 0 0 - 27.2815 12.3238 16.5404 H 0 0 0 0 0 0 - 25.9633 11.0805 17.6864 C 0 0 0 0 0 0 - 25.6710 12.0572 18.0766 H 0 0 0 0 0 0 - 25.1038 10.7353 17.1107 H 0 0 0 0 0 0 - 26.1834 10.1607 18.7918 N 0 0 0 0 0 0 - 26.0985 9.1797 18.5751 H 0 0 0 0 0 0 - 26.5446 10.5128 20.0359 C 0 0 0 0 0 0 - 26.7352 11.6835 20.3848 O 0 0 0 0 0 0 - 26.8164 9.3505 20.9951 C 0 0 0 0 0 0 - 27.5182 8.6798 20.5018 H 0 0 0 0 0 0 - 27.3455 9.7432 21.8637 H 0 0 0 0 0 0 - 25.5749 8.5551 21.4820 C 0 0 0 0 0 0 - 25.9435 7.7800 22.1556 H 0 0 0 0 0 0 - 24.9469 9.2037 22.0951 H 0 0 0 0 0 0 - 24.7091 7.8896 20.3809 C 0 0 0 0 0 0 - 23.9897 8.6126 19.9911 H 0 0 0 0 0 0 - 25.3386 7.6233 19.5340 H 0 0 0 0 0 0 - 23.9849 6.6596 20.8171 N 0 3 0 0 0 0 - 23.0803 6.8742 21.9693 C 0 0 0 0 0 0 - 22.3188 7.6210 21.7370 H 0 0 0 0 0 0 - 23.6342 7.2099 22.8457 H 0 0 0 0 0 0 - 22.5793 5.9438 22.2412 H 0 0 0 0 0 0 - 23.2926 5.9937 19.6899 C 0 0 0 0 0 0 - 22.5046 6.6283 19.2785 H 0 0 0 0 0 0 - 22.8435 5.0521 20.0103 H 0 0 0 0 0 0 - 23.9978 5.7601 18.8916 H 0 0 0 0 0 0 - 28.5475 10.7431 17.3045 C 0 0 0 0 0 0 - 28.8121 11.2654 18.2243 H 0 0 0 0 0 0 - 28.4844 9.6841 17.5511 H 0 0 0 0 0 0 - 29.6553 10.9433 16.2654 C 0 0 0 0 0 0 - 29.8364 12.0116 16.1480 H 0 0 0 0 0 0 - 30.5913 10.5213 16.6296 H 0 0 0 0 0 0 - 29.2524 10.3509 14.8973 C 0 0 1 0 0 0 - 29.9506 10.7570 14.1629 H 0 0 0 0 0 0 - 31.8418 8.6565 14.4329 C 0 0 0 0 0 0 - 31.7356 9.2989 13.5712 H 0 0 0 0 0 0 - 33.1203 8.2073 14.8095 C 0 0 0 0 0 0 - 33.9845 8.5043 14.2361 H 0 0 0 0 0 0 - 24.6748 5.9712 21.1189 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 62 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 60 1 0 0 0 - 8 58 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 21 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 20 1 0 0 0 - 19 21 2 0 0 0 - 21 22 1 0 0 0 - 22 58 1 0 0 0 - 22 23 1 0 0 0 - 22 24 1 0 0 0 - 24 25 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 52 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 32 33 2 0 0 0 - 32 34 1 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 34 37 1 0 0 0 - 37 38 1 0 0 0 - 37 39 1 0 0 0 - 37 40 1 0 0 0 - 40 41 1 0 0 0 - 40 42 1 0 0 0 - 40 43 1 0 0 0 - 43 44 1 0 0 0 - 43 48 1 0 0 0 - 43 64 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 44 47 1 0 0 0 - 48 49 1 0 0 0 - 48 50 1 0 0 0 - 48 51 1 0 0 0 - 52 53 1 0 0 0 - 52 54 1 0 0 0 - 52 55 1 0 0 0 - 55 56 1 0 0 0 - 55 57 1 0 0 0 - 55 58 1 0 0 0 - 58 59 1 0 0 0 - 60 61 1 0 0 0 - 60 62 2 0 0 0 - 62 63 1 0 0 0 -M CHG 1 43 1 -M END -> -ligprep_eg5.smi - -> -18 - -> -53161 - -> -0 - -> -RmMxW2NIXWMoQnIpW2NIXWMoYzEyKVtDQEBIXTNbQ0BIXShbQ0BASF0oW05IXTIpYzRbY0hdW2NIXVtjSF1bY0hdW2NIXTQpW0NIMl1bQ0gyXVtDQEBIXShPMylbQ0gyXVtOSF1DKD1PKVtDSDJdW0NIMl1bQ0gyXU4oW0NIM10pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0076 - -> - 0.0076 - -> - 0.0000 - -> - -0.0000 - -> -0.00755766 - -> -1 - -> -1 - -> -S-OPLS - -> -47.4626 - -> -1 - -> -lig_CHEMBL1085692-1 - -> -glide-grid_EG5-3L9H - -> -19 - -> -8 - -> --7.90619738560365 - -> --0.247068668300114 - -> --0.784394127029799 - -> --1.77041310943779 - -> --7.90619738560365 - -> --4.52171243564274 - -> --0.28307585595687 - -> --0 - -> --0.202519619301997 - -> --45.3497924804688 - -> --7.39303827285767 - -> -0.560426754633708 - -> --0.0828708643836668 - -> --81.0586723985029 - -> --52.7428307533264 - -> -3.73035311698914 - -> -10 - -> -29 - -> --0 - -> -0.0914115773960593 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1082248 - 3D - Schrodinger Suite 2022-3. - 48 51 0 0 1 0 999 V2000 - 34.2645 7.0446 16.2096 H 0 0 0 0 0 0 - 33.2802 7.3883 15.9249 C 0 0 0 0 0 0 - 33.1229 8.2179 14.8009 C 0 0 0 0 0 0 - 33.9848 8.5147 14.2230 H 0 0 0 0 0 0 - 31.8413 8.6673 14.4347 C 0 0 0 0 0 0 - 31.7274 9.3080 13.5729 H 0 0 0 0 0 0 - 30.7087 8.2887 15.1874 C 0 0 0 0 0 0 - 29.3320 8.8074 14.8013 C 0 0 2 0 0 0 - 28.6095 8.3700 15.4927 H 0 0 0 0 0 0 - 28.9611 8.3383 13.4711 N 0 0 0 0 0 0 - 29.1463 7.3658 13.2557 H 0 0 0 0 0 0 - 27.9355 8.9888 12.7684 C 0 0 0 0 0 0 - 27.4900 8.4510 11.5440 C 0 0 0 0 0 0 - 27.9849 7.2890 11.1189 F 0 0 0 0 0 0 - 26.5257 9.0900 10.7559 C 0 0 0 0 0 0 - 26.2109 8.6659 9.8148 H 0 0 0 0 0 0 - 25.9959 10.2975 11.2127 C 0 0 0 0 0 0 - 24.7847 11.2882 10.1792 Br 0 0 0 0 0 0 - 26.3839 10.8344 12.4510 C 0 0 0 0 0 0 - 25.9623 11.7734 12.7793 H 0 0 0 0 0 0 - 27.3597 10.1911 13.2317 C 0 0 0 0 0 0 - 27.8211 10.8295 14.5259 C 0 0 1 0 0 0 - 27.8400 11.9091 14.3642 H 0 0 0 0 0 0 - 26.9076 10.5334 15.5817 O 0 0 0 0 0 0 - 27.1881 11.2319 16.7860 C 0 0 1 0 0 0 - 27.2467 12.2944 16.5419 H 0 0 0 0 0 0 - 25.9761 11.0600 17.7355 C 0 0 0 0 0 0 - 25.7625 12.0080 18.2303 H 0 0 0 0 0 0 - 25.0871 10.8364 17.1442 H 0 0 0 0 0 0 - 26.1333 10.0067 18.7655 N 0 3 0 0 0 0 - 25.2253 9.5851 18.9016 H 0 0 0 0 0 0 - 26.5959 10.4700 20.0899 C 0 0 0 0 0 0 - 26.6594 9.6257 20.7768 H 0 0 0 0 0 0 - 25.8958 11.1937 20.5105 H 0 0 0 0 0 0 - 27.5796 10.9353 20.0395 H 0 0 0 0 0 0 - 28.5605 10.7643 17.3218 C 0 0 0 0 0 0 - 28.8353 11.3254 18.2141 H 0 0 0 0 0 0 - 28.5271 9.7105 17.5982 H 0 0 0 0 0 0 - 29.6507 10.9577 16.2635 C 0 0 0 0 0 0 - 29.8282 12.0269 16.1331 H 0 0 0 0 0 0 - 30.5935 10.5425 16.6164 H 0 0 0 0 0 0 - 29.2373 10.3538 14.9045 C 0 0 1 0 0 0 - 29.9246 10.7635 14.1619 H 0 0 0 0 0 0 - 30.8677 7.4318 16.2959 C 0 0 0 0 0 0 - 30.0085 7.1178 16.8682 H 0 0 0 0 0 0 - 32.1527 6.9883 16.6664 C 0 0 0 0 0 0 - 32.2723 6.3360 17.5204 H 0 0 0 0 0 0 - 26.7485 9.2900 18.4051 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 46 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 44 1 0 0 0 - 8 42 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 21 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 20 1 0 0 0 - 19 21 2 0 0 0 - 21 22 1 0 0 0 - 22 42 1 0 0 0 - 22 23 1 0 0 0 - 22 24 1 0 0 0 - 24 25 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 36 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 48 1 0 0 0 - 32 33 1 0 0 0 - 32 34 1 0 0 0 - 32 35 1 0 0 0 - 36 37 1 0 0 0 - 36 38 1 0 0 0 - 36 39 1 0 0 0 - 39 40 1 0 0 0 - 39 41 1 0 0 0 - 39 42 1 0 0 0 - 42 43 1 0 0 0 - 44 45 1 0 0 0 - 44 46 2 0 0 0 - 46 47 1 0 0 0 -M CHG 1 30 1 -M END -> -ligprep_eg5.smi - -> -6 - -> -53161 - -> -0 - -> -W2NIXTFbY0hdW2NIXVtjSF1bY0hdYzFbQ0BIXShbTkhdMilbQ0BASF0oW0NASF0zYyhjMjQpW2NIXWMoQnIpW2NIXWM0RilbQ0gyXVtDSDJdW0NAQEhdKE8zKVtDSDJdW05IXVtDSDNd - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0025 - -> - 0.0025 - -> - 0.0000 - -> - -0.0000 - -> -0.00245839 - -> -1 - -> -1 - -> -S-OPLS - -> -42.3512 - -> -1 - -> -lig_CHEMBL1082248-1 - -> -glide-grid_EG5-3L9H - -> -6 - -> -3 - -> --7.64620594616547 - -> --0.305848237846619 - -> --0.894305671705108 - -> --1.8123799475431 - -> --7.64620594616547 - -> --4.52933187182784 - -> --0.0935460694148881 - -> --0 - -> --0.831644008056144 - -> --39.7532691955566 - -> --3.74200963973999 - -> -0.357280908872234 - -> -0 - -> --65.8197927106689 - -> --43.4952788352966 - -> --7.21261770308956e-08 - -> -2 - -> -2 - -> --0 - -> -0.0937033031326501 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1096002 - 3D - Schrodinger Suite 2022-3. - 52 55 0 0 1 0 999 V2000 - 27.7289 8.9773 22.7156 H 0 0 0 0 0 0 - 27.5847 9.7211 22.1457 O 0 0 0 0 0 0 - 26.9302 9.2880 20.9755 C 0 0 0 0 0 0 - 27.5850 8.5883 20.4571 H 0 0 0 0 0 0 - 26.0175 8.7530 21.2428 H 0 0 0 0 0 0 - 26.6264 10.4826 20.0649 C 0 0 0 0 0 0 - 25.8828 11.1314 20.5308 H 0 0 0 0 0 0 - 27.5284 11.0795 19.9386 H 0 0 0 0 0 0 - 26.1312 10.0210 18.7503 N 0 3 0 0 0 0 - 26.7429 9.3070 18.3788 H 0 0 0 0 0 0 - 25.9674 11.0714 17.7200 C 0 0 0 0 0 0 - 25.0772 10.8410 17.1322 H 0 0 0 0 0 0 - 25.7483 12.0145 18.2164 H 0 0 0 0 0 0 - 27.1764 11.2502 16.7650 C 0 0 2 0 0 0 - 27.2311 12.3145 16.5287 H 0 0 0 0 0 0 - 26.8985 10.5612 15.5506 O 0 0 0 0 0 0 - 27.8134 10.8642 14.4942 C 0 0 2 0 0 0 - 27.8256 11.9446 14.3384 H 0 0 0 0 0 0 - 27.3570 10.2269 13.1955 C 0 0 0 0 0 0 - 26.3671 10.8553 12.4169 C 0 0 0 0 0 0 - 25.9200 11.7798 12.7520 H 0 0 0 0 0 0 - 25.9531 10.2888 11.1958 C 0 0 0 0 0 0 - 24.6991 11.0650 10.3189 Cl 0 0 0 0 0 0 - 26.5027 9.0830 10.7467 C 0 0 0 0 0 0 - 26.1617 8.6252 9.8297 H 0 0 0 0 0 0 - 27.4895 8.4688 11.5242 C 0 0 0 0 0 0 - 27.9850 7.3018 11.1189 F 0 0 0 0 0 0 - 27.9392 9.0241 12.7366 C 0 0 0 0 0 0 - 28.9721 8.3836 13.4377 N 0 0 0 0 0 0 - 29.1846 7.4222 13.1998 H 0 0 0 0 0 0 - 29.3273 8.8467 14.7724 C 0 0 1 0 0 0 - 28.5948 8.4090 15.4532 H 0 0 0 0 0 0 - 30.6970 8.3194 15.1723 C 0 0 0 0 0 0 - 30.8373 7.4471 16.2719 C 0 0 0 0 0 0 - 29.9724 7.1317 16.8333 H 0 0 0 0 0 0 - 32.1148 6.9884 16.6502 C 0 0 0 0 0 0 - 32.2191 6.3264 17.4996 H 0 0 0 0 0 0 - 33.2535 7.3883 15.9266 C 0 0 0 0 0 0 - 34.2317 7.0317 16.2167 H 0 0 0 0 0 0 - 33.1148 8.2312 14.8096 C 0 0 0 0 0 0 - 33.9850 8.5284 14.2445 H 0 0 0 0 0 0 - 31.8416 8.6992 14.4360 C 0 0 0 0 0 0 - 31.7436 9.3516 13.5815 H 0 0 0 0 0 0 - 29.2302 10.3926 14.8770 C 0 0 2 0 0 0 - 29.9194 10.8021 14.1356 H 0 0 0 0 0 0 - 29.6386 10.9941 16.2372 C 0 0 0 0 0 0 - 30.5857 10.5867 16.5890 H 0 0 0 0 0 0 - 29.8065 12.0643 16.1104 H 0 0 0 0 0 0 - 28.5518 10.7883 17.2943 C 0 0 0 0 0 0 - 28.8294 11.3474 18.1874 H 0 0 0 0 0 0 - 28.5249 9.7332 17.5675 H 0 0 0 0 0 0 - 25.2266 9.5964 18.9050 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 3 1 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 3 6 1 0 0 0 - 6 7 1 0 0 0 - 6 8 1 0 0 0 - 6 9 1 0 0 0 - 9 10 1 0 0 0 - 9 11 1 0 0 0 - 9 52 1 0 0 0 - 11 12 1 0 0 0 - 11 13 1 0 0 0 - 11 14 1 0 0 0 - 14 49 1 0 0 0 - 14 15 1 0 0 0 - 14 16 1 0 0 0 - 16 17 1 0 0 0 - 17 44 1 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 28 1 0 0 0 - 19 20 2 0 0 0 - 20 21 1 0 0 0 - 20 22 1 0 0 0 - 22 23 1 0 0 0 - 22 24 2 0 0 0 - 24 25 1 0 0 0 - 24 26 1 0 0 0 - 26 27 1 0 0 0 - 26 28 2 0 0 0 - 28 29 1 0 0 0 - 29 30 1 0 0 0 - 29 31 1 0 0 0 - 31 32 1 0 0 0 - 31 33 1 0 0 0 - 31 44 1 0 0 0 - 33 42 1 0 0 0 - 33 34 2 0 0 0 - 34 35 1 0 0 0 - 34 36 1 0 0 0 - 36 37 1 0 0 0 - 36 38 2 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 40 41 1 0 0 0 - 40 42 2 0 0 0 - 42 43 1 0 0 0 - 44 45 1 0 0 0 - 44 46 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 -M CHG 1 9 1 -M END -> -ligprep_eg5.smi - -> -27 - -> -53161 - -> -0 - -> -W09IXVtDSDJdW0NIMl1bTkhdW0NIMl1bQ0BIXShPMSlbQ0gyXVtDSDJdW0NASF0yW0NAQEhdKFtOSF1jKGMzW0NAQEhdMTIpYyhGKVtjSF1jKENsKVtjSF0zKWM0W2NIXVtjSF1bY0hdW2NIXVtjSF00 - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> - 0.0354 - -> - 0.0353 - -> - 0.0000 - -> - 0.0295 - -> -0.064809 - -> -1 - -> -1 - -> -S-OPLS - -> -44.334 - -> -1 - -> -lig_CHEMBL1096002-1 - -> -glide-grid_EG5-3L9H - -> -28 - -> -6 - -> --7.61390683929108 - -> --0.281996549603373 - -> --0.845989647880705 - -> --1.7723919871224 - -> --7.64340683929108 - -> --4.61347521137857 - -> --0.0359021116715872 - -> --0 - -> --0.936020864218221 - -> --42.5991706848145 - -> --3.75695514678955 - -> -0.635493154236459 - -> -0 - -> --65.9276886742258 - -> --46.356125831604 - -> -0.522859871387482 - -> -10 - -> -2 - -> -0.0295 - -> -0.093194489622196 - -> -snapped_core_restrain - -$$$$ -lig_CHEMBL1082249 - 3D - Schrodinger Suite 2022-3. - 58 61 0 0 1 0 999 V2000 - 34.2516 7.0480 16.2407 H 0 0 0 0 0 0 - 33.2700 7.3878 15.9441 C 0 0 0 0 0 0 - 33.1208 8.2123 14.8154 C 0 0 0 0 0 0 - 33.9852 8.5108 14.2434 H 0 0 0 0 0 0 - 31.8431 8.6608 14.4362 C 0 0 0 0 0 0 - 31.7395 9.3024 13.5739 H 0 0 0 0 0 0 - 30.7042 8.2819 15.1795 C 0 0 0 0 0 0 - 29.3329 8.8036 14.7827 C 0 0 2 0 0 0 - 28.6015 8.3693 15.4668 H 0 0 0 0 0 0 - 28.9740 8.3392 13.4481 N 0 0 0 0 0 0 - 29.1600 7.3678 13.2234 H 0 0 0 0 0 0 - 27.9519 8.9926 12.7444 C 0 0 0 0 0 0 - 27.4978 8.4503 11.5275 C 0 0 0 0 0 0 - 27.9850 7.2801 11.1189 F 0 0 0 0 0 0 - 26.5126 9.0763 10.7531 C 0 0 0 0 0 0 - 26.1593 8.6230 9.8392 H 0 0 0 0 0 0 - 25.9663 10.2751 11.2173 C 0 0 0 0 0 0 - 24.5301 11.1112 10.3189 Br 0 0 0 0 0 0 - 26.3846 10.8297 12.4393 C 0 0 0 0 0 0 - 25.9347 11.7477 12.7869 H 0 0 0 0 0 0 - 27.3768 10.1948 13.2084 C 0 0 0 0 0 0 - 27.8322 10.8314 14.5056 C 0 0 1 0 0 0 - 27.8542 11.9112 14.3444 H 0 0 0 0 0 0 - 26.9119 10.5394 15.5582 O 0 0 0 0 0 0 - 27.1871 11.2368 16.7664 C 0 0 1 0 0 0 - 27.2533 12.2986 16.5203 H 0 0 0 0 0 0 - 25.9646 11.0756 17.7107 C 0 0 0 0 0 0 - 25.7435 12.0295 18.1935 H 0 0 0 0 0 0 - 25.0828 10.8430 17.1121 H 0 0 0 0 0 0 - 26.1084 10.0349 18.7547 N 0 3 0 0 0 0 - 25.1934 9.6416 18.9279 H 0 0 0 0 0 0 - 26.6327 10.5135 20.0519 C 0 0 0 0 0 0 - 27.5335 11.1056 19.9073 H 0 0 0 0 0 0 - 25.8953 11.1729 20.5131 H 0 0 0 0 0 0 - 26.9337 9.3346 20.9797 C 0 0 0 0 0 0 - 26.0086 8.8027 21.2109 H 0 0 0 0 0 0 - 27.5913 8.6278 20.4745 H 0 0 0 0 0 0 - 27.5915 9.7745 22.2033 N 0 0 0 0 0 0 - 28.1183 10.6349 22.1777 H 0 0 0 0 0 0 - 27.5845 9.0812 23.3501 C 0 0 0 0 0 0 - 26.9602 8.0341 23.4991 O 0 0 0 0 0 0 - 28.4080 9.6461 24.5016 C 0 0 0 0 0 0 - 28.7872 10.6444 24.2772 H 0 0 0 0 0 0 - 29.2581 8.9934 24.7029 H 0 0 0 0 0 0 - 27.8018 9.7048 25.4067 H 0 0 0 0 0 0 - 28.5584 10.7639 17.3032 C 0 0 0 0 0 0 - 28.8426 11.3272 18.1901 H 0 0 0 0 0 0 - 28.5175 9.7113 17.5858 H 0 0 0 0 0 0 - 29.6536 10.9530 16.2469 C 0 0 0 0 0 0 - 29.8320 12.0218 16.1159 H 0 0 0 0 0 0 - 30.5966 10.5408 16.6027 H 0 0 0 0 0 0 - 29.2441 10.3500 14.8882 C 0 0 1 0 0 0 - 29.9353 10.7553 14.1469 H 0 0 0 0 0 0 - 30.8534 7.4269 16.2913 C 0 0 0 0 0 0 - 29.9891 7.1119 16.8557 H 0 0 0 0 0 0 - 32.1359 6.9881 16.6735 C 0 0 0 0 0 0 - 32.2478 6.3369 17.5280 H 0 0 0 0 0 0 - 26.6930 9.2959 18.3885 H 0 0 0 0 0 0 - 1 2 1 0 0 0 - 2 56 1 0 0 0 - 2 3 2 0 0 0 - 3 4 1 0 0 0 - 3 5 1 0 0 0 - 5 6 1 0 0 0 - 5 7 2 0 0 0 - 7 8 1 0 0 0 - 7 54 1 0 0 0 - 8 52 1 0 0 0 - 8 9 1 0 0 0 - 8 10 1 0 0 0 - 10 11 1 0 0 0 - 10 12 1 0 0 0 - 12 21 1 0 0 0 - 12 13 2 0 0 0 - 13 14 1 0 0 0 - 13 15 1 0 0 0 - 15 16 1 0 0 0 - 15 17 2 0 0 0 - 17 18 1 0 0 0 - 17 19 1 0 0 0 - 19 20 1 0 0 0 - 19 21 2 0 0 0 - 21 22 1 0 0 0 - 22 52 1 0 0 0 - 22 23 1 0 0 0 - 22 24 1 0 0 0 - 24 25 1 0 0 0 - 25 26 1 0 0 0 - 25 27 1 0 0 0 - 25 46 1 0 0 0 - 27 28 1 0 0 0 - 27 29 1 0 0 0 - 27 30 1 0 0 0 - 30 31 1 0 0 0 - 30 32 1 0 0 0 - 30 58 1 0 0 0 - 32 33 1 0 0 0 - 32 34 1 0 0 0 - 32 35 1 0 0 0 - 35 36 1 0 0 0 - 35 37 1 0 0 0 - 35 38 1 0 0 0 - 38 39 1 0 0 0 - 38 40 1 0 0 0 - 40 41 2 0 0 0 - 40 42 1 0 0 0 - 42 43 1 0 0 0 - 42 44 1 0 0 0 - 42 45 1 0 0 0 - 46 47 1 0 0 0 - 46 48 1 0 0 0 - 46 49 1 0 0 0 - 49 50 1 0 0 0 - 49 51 1 0 0 0 - 49 52 1 0 0 0 - 52 53 1 0 0 0 - 54 55 1 0 0 0 - 54 56 2 0 0 0 - 56 57 1 0 0 0 -M CHG 1 30 1 -M END -> -ligprep_eg5.smi - -> -7 - -> -53161 - -> -0 - -> -RmMxW2NIXWMoQnIpW2NIXWMoYzEyKVtDQEBIXTNbQ0BIXShbQ0BASF0oW05IXTIpYzRbY0hdW2NIXVtjSF1bY0hdW2NIXTQpW0NIMl1bQ0gyXVtDQEBIXShPMylbQ0gyXVtOSF1bQ0gyXVtDSDJdW05IXUMoPU8pW0NIM10= - -> -J2VwaWtfcHl0aG9uJywgJy1waHQnLCAnMC4wJywgJy1waCcsICc3LjQnLCAnLXRuJywgJzgnLCAnLW1hJywgJzUwMCcsICctaW1hZScsICc8aW5maWxlLm1hZT4nLCAnLW9tYWUnLCAnPG91dGZpbGUubWFlPic= - -> -1 - -> - 0.0077 - -> - 0.0077 - -> - 0.0000 - -> - -0.0000 - -> -0.00765215 - -> -1 - -> -1 - -> -S-OPLS - -> -33.3357 - -> -1 - -> -lig_CHEMBL1082249-1 - -> -glide-grid_EG5-3L9H - -> -7 - -> -7 - -> --7.11232702404811 - -> --0.23707756746827 - -> --0.736655123234709 - -> --1.61599819487352 - -> --7.11232702404811 - -> --4.55664998253593 - -> --0.0816780435388489 - -> --0 - -> --0.348176918870169 - -> --46.5956993103027 - -> --2.19561052322388 - -> -0.533304464895562 - -> -0 - -> --67.8709711424982 - -> --48.7913098335266 - -> -0.845360338687897 - -> -30 - -> -28 - -> --0 - -> -0.0850935331009369 - -> -snapped_core_restrain - -$$$$ diff --git a/cookbook/cofactors_rbfe.ipynb b/cookbook/cofactors_rbfe.ipynb index 2237276..ac4e3e6 100644 --- a/cookbook/cofactors_rbfe.ipynb +++ b/cookbook/cofactors_rbfe.ipynb @@ -53,16 +53,7 @@ "execution_count": 1, "id": "fc97de03", "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/Users/atravitz/micromamba/envs/openfe-notebooks/lib/python3.13/site-packages/mdtraj/core/selection.py:47: DeprecationWarning: 'enablePackrat' deprecated - use 'enable_packrat'\n", - " ParserElement.enablePackrat(cache_size_limit=304)\n" - ] - } - ], + "outputs": [], "source": [ "import openfe" ] @@ -80,12 +71,14 @@ "id": "f7490fec-f420-466b-8e5b-5465f37f3d9b", "metadata": {}, "source": [ - "Define the ligands, protein, and solvent in the same way as a typical RBFE calculation:" + "Define the ligands, protein, and solvent in the same way as a typical RBFE calculation. \n", + "\n", + "Note that partial charges are already assigned for both the ligands and cofactors." ] }, { "cell_type": "code", - "execution_count": null, + "execution_count": 2, "id": "371dc488-80a5-40ad-bf51-9cd5d8d4aeea", "metadata": { "scrolled": true @@ -98,13 +91,9 @@ "# Create a list of OpenFF molecules\n", "offmols = [\n", " Molecule.from_rdkit(m)\n", - " for m in Chem.SDMolSupplier(\"assets/cofactors/eg5_ligands_positive.sdf\", removeHs=False)\n", + " for m in Chem.SDMolSupplier(\"assets/cofactors/eg5_ligands_charged.sdf\", removeHs=False)\n", "]\n", "\n", - "# Assign partial charges via AM1BCC\n", - "for mol in offmols:\n", - " mol.assign_partial_charges('am1bcc')\n", - "\n", "# Now we convert them to SmallMoleculeComponent\n", "ligands = [openfe.SmallMoleculeComponent.from_openff(mol) for mol in offmols]\n", "\n", @@ -132,8 +121,8 @@ "source": [ "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", "# We also go through OpenFF to assign partial charges\n", - "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"assets/cofactors/eg5_cofactor.sdf\", removeHs=False))\n", - "offmol.assign_partial_charges('am1bcc', use_conformers=offmol.conformers)\n", + "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"assets/cofactors/eg5_cofactor_charged.sdf\", removeHs=False))\n", + "offmol.assign_partial_charges('am1bcc')\n", "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)\n", "cofactor" ] @@ -231,7 +220,7 @@ " transformation = openfe.Transformation(\n", " stateA=sysA,\n", " stateB=sysB,\n", - " mapping={'ligand': mapping},\n", + " mapping=mapping,\n", " protocol=protocol, # use protocol created above\n", " name=f\"{prefix}{sysA.name}_{sysB.name}\"\n", " )\n", @@ -240,6 +229,14 @@ "network = openfe.AlchemicalNetwork(transformations)" ] }, + { + "cell_type": "markdown", + "id": "c9ed73fc-13da-4a13-a433-51157cc88fad", + "metadata": {}, + "source": [ + "Cofactors can now be seen in the complex nodes of the alchemical network:" + ] + }, { "cell_type": "code", "execution_count": null, @@ -247,13 +244,13 @@ "metadata": {}, "outputs": [], "source": [ - "network" + "network.nodes" ] }, { "cell_type": "code", "execution_count": null, - "id": "43bc4e63-4517-40bd-9d2e-db7d4ac5eb24", + "id": "71b3826e-9bb5-464e-a0e2-121a05217db6", "metadata": {}, "outputs": [], "source": [] @@ -275,7 +272,7 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.13.11" + "version": "3.12.12" } }, "nbformat": 4, From 0c9ead214b3845431fbd659babf008cb09968246 Mon Sep 17 00:00:00 2001 From: Alyssa Travitz Date: Tue, 20 Jan 2026 09:32:04 -0800 Subject: [PATCH 09/12] pre-charge molecules --- cookbook/cofactors_rbfe.ipynb | 108 +++++++++++++++++++++++++++++++--- 1 file changed, 100 insertions(+), 8 deletions(-) diff --git a/cookbook/cofactors_rbfe.ipynb b/cookbook/cofactors_rbfe.ipynb index ac4e3e6..c1d2309 100644 --- a/cookbook/cofactors_rbfe.ipynb +++ b/cookbook/cofactors_rbfe.ipynb @@ -114,10 +114,21 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 3, "id": "1523c2dc-b71a-473e-b02f-77475245ae43", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "SmallMoleculeComponent(name=3L9H)" + ] + }, + "execution_count": 3, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", "# We also go through OpenFF to assign partial charges\n", @@ -139,10 +150,25 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 4, "id": "e7c5da37-eff9-4f63-a8b8-00248d193972", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "application/vnd.jupyter.widget-view+json": { + "model_id": "73790a2760374adc9857060c83fc8527", + "version_major": 2, + "version_minor": 0 + }, + "text/plain": [ + "Mapping: 28%|##8 | 107/378 [00:01<00:03, 71.05it/s]" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], "source": [ "mapper = openfe.LomapAtomMapper(max3d=1.0, element_change=False, threed=True)\n", "scorer = openfe.lomap_scorers.default_lomap_score\n", @@ -167,7 +193,7 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 5, "id": "32f36cd0-fb77-4d26-8354-3282bc2f1db4", "metadata": {}, "outputs": [], @@ -190,7 +216,7 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 6, "id": "c7f13bd1-5bd4-493a-bbc5-9a11a9b1adfe", "metadata": {}, "outputs": [], @@ -239,10 +265,76 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 7, "id": "775f4201-7fad-4e2e-801b-56696524ed8d", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "frozenset({ChemicalSystem(name=lig_CHEMBL1096002_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1096002), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1083517_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1083517), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1096003_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1096003), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1085692_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1085692), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1077227_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1077227), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1086409_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1086409), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1089393_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1089393), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084935_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084935), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1078998_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1078998), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1088740_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1088740), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1085666_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1085666), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1082249_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1082249), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084143_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084143), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1078998_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1078998), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1083836_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1083836), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1077227_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1077227), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1088740_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1088740), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1078774_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1078774), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1077204_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1077204), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1096003_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1096003), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1093087_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1093087), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084677_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084677), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1086409_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1086409), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084935_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084935), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1085895_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1085895), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084676_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084676), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084935_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084935), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084115_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084115), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084676_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084676), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1093088_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1093088), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1085666_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1085666), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1093088_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1093088), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1083517_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1083517), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1093087_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1093087), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1082249_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1082249), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1077204_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1077204), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1078774_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1078774), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1083836_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1083836), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1089056_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1089056), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084115_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084115), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084677_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084677), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084143_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084143), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084678_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084678), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1078691_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1078691), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1089056_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1089056), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1089393_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1089393), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1082248_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1082248), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1085692_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1085692), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084678_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084678), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1086410_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1086410), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1082248_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1082248), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1096002_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1096002), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1086410_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1086410), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1084935_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1084935), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)}),\n", + " ChemicalSystem(name=lig_CHEMBL1078691_solvent, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1078691), 'solvent': SolventComponent(name=O, Na+, Cl-)}),\n", + " ChemicalSystem(name=lig_CHEMBL1085895_complex, components={'ligand': SmallMoleculeComponent(name=lig_CHEMBL1085895), 'solvent': SolventComponent(name=O, Na+, Cl-), 'protein': ProteinComponent(name=), 'cofactor': SmallMoleculeComponent(name=3L9H)})})" + ] + }, + "execution_count": 7, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "network.nodes" ] From b4875b40dfd499c947614086fd56b9dee8a48bb1 Mon Sep 17 00:00:00 2001 From: Alyssa Travitz Date: Thu, 22 Jan 2026 16:08:02 -0800 Subject: [PATCH 10/12] address comments from @jhorton --- cookbook/cofactors_rbfe.ipynb | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/cookbook/cofactors_rbfe.ipynb b/cookbook/cofactors_rbfe.ipynb index c1d2309..bab5af1 100644 --- a/cookbook/cofactors_rbfe.ipynb +++ b/cookbook/cofactors_rbfe.ipynb @@ -25,7 +25,7 @@ "id": "bf120991-50ab-4e6a-af73-2cf471c3d3c4", "metadata": {}, "source": [ - "When using openfe's CLI, including cofactors in an RBFE calculation is as simple as passing in the ``-C`` argument with the path to the SDf file containing cofactors:\n", + "When using openfe's CLI, including cofactors in an RBFE calculation is as simple as passing in the ``-C`` argument with the path to the SDF file containing cofactors:\n", "\n", "```bash\n", "openfe plan-rbfe-network -M ligands.sdf -p protein.pdb -C cofactors.sdf\n", @@ -133,7 +133,6 @@ "# load in the cofactor from eg5_cofactors.sdf, here we know that there is only one cofactor in the file\n", "# We also go through OpenFF to assign partial charges\n", "offmol = Molecule.from_rdkit(Chem.MolFromMolFile(\"assets/cofactors/eg5_cofactor_charged.sdf\", removeHs=False))\n", - "offmol.assign_partial_charges('am1bcc')\n", "cofactor = openfe.SmallMoleculeComponent.from_openff(offmol)\n", "cofactor" ] From 7791d41900aa2f5448f86bfbc8b9f9934ba33c17 Mon Sep 17 00:00:00 2001 From: Alyssa Travitz Date: Thu, 22 Jan 2026 16:17:24 -0800 Subject: [PATCH 11/12] add warning --- cookbook/cofactors_rbfe.ipynb | 18 ++++++------------ 1 file changed, 6 insertions(+), 12 deletions(-) diff --git a/cookbook/cofactors_rbfe.ipynb b/cookbook/cofactors_rbfe.ipynb index bab5af1..bd238c8 100644 --- a/cookbook/cofactors_rbfe.ipynb +++ b/cookbook/cofactors_rbfe.ipynb @@ -48,16 +48,6 @@ "If using the ``openfe`` Python API to set up an RBFE network, cofactors need to be included when constructing the ``ChemicalSystem``s." ] }, - { - "cell_type": "code", - "execution_count": 1, - "id": "fc97de03", - "metadata": {}, - "outputs": [], - "source": [ - "import openfe" - ] - }, { "cell_type": "markdown", "id": "7e56bd3b-9897-4761-a97b-fa6162bfa31b", @@ -73,18 +63,22 @@ "source": [ "Define the ligands, protein, and solvent in the same way as a typical RBFE calculation. \n", "\n", - "Note that partial charges are already assigned for both the ligands and cofactors." + "\n", + "
\n", + "Note that partial charges are already assigned for both the ligands and cofactors. See Assigning partial charges to an OpenFF Molecule, but note that this parametrizes cofactors using the small molecule force field, which may not be applicable in all situations.\n", + "
\n" ] }, { "cell_type": "code", - "execution_count": 2, + "execution_count": null, "id": "371dc488-80a5-40ad-bf51-9cd5d8d4aeea", "metadata": { "scrolled": true }, "outputs": [], "source": [ + "import openfe\n", "from rdkit import Chem\n", "from openff.toolkit import Molecule\n", "\n", From fa05cd843af900fddf43f28da1f2015296fe5845 Mon Sep 17 00:00:00 2001 From: Alyssa Travitz Date: Fri, 23 Jan 2026 07:11:19 -0800 Subject: [PATCH 12/12] address review from @jhorton --- cookbook/cofactors_rbfe.ipynb | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/cookbook/cofactors_rbfe.ipynb b/cookbook/cofactors_rbfe.ipynb index bd238c8..36a8313 100644 --- a/cookbook/cofactors_rbfe.ipynb +++ b/cookbook/cofactors_rbfe.ipynb @@ -65,7 +65,9 @@ "\n", "\n", "
\n", - "Note that partial charges are already assigned for both the ligands and cofactors. See Assigning partial charges to an OpenFF Molecule, but note that this parametrizes cofactors using the small molecule force field, which may not be applicable in all situations.\n", + "Note that partial charges are already assigned for both the ligands and cofactors. See Assigning partial charges to an OpenFF Molecule.\n", + "\n", + "Supplying cofactors as SmallMoleculeCompoents means they will be parameterized using the small molecule force field, which might not be applicable in all situations.\n", "
\n" ] },